{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:51:32Z","timestamp":1771541492487,"version":"3.50.1"},"reference-count":94,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102814","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T19:01:12Z","timestamp":1405623672000},"page":"e102814","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Glaucomatous and Age-Related Changes in Corneal Pulsation Shape. The Ocular Dicrotism"],"prefix":"10.1371","volume":"9","author":[{"given":"Monika E.","family":"Danielewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Krzy\u017canowska-Berkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Robert","family":"Iskander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0002-9394(37)90425-2","article-title":"Contribution to the theory and practice of tonometry","volume":"20","author":"JS Friedenwald","year":"1937","journal-title":"Am J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0925-4439(92)90041-K","article-title":"Ageing of the human corneal stroma: structural and biochemical changes","volume":"1138","author":"NS Malik","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref3","first-page":"644","article-title":"Collagen fibrils in the human corneal stroma: structure and aging","volume":"39","author":"A Daxer","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref4","first-page":"285","article-title":"Electron microscopic studies of corneal stroma: aging changes of collagen fibers","volume":"5","author":"A Kanai","year":"1973","journal-title":"Ann Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/02713680601077145","article-title":"Assessment of corneal biomechanical properties and their variation with age","volume":"32","author":"A Elsheikh","year":"1973","journal-title":"Curr Eye Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1167\/iovs.08-1970","article-title":"Structural factors that mediate scleral stiffness","volume":"49","author":"DS Schultz","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","first-page":"2645","article-title":"Age-related ocular blood flow changes","volume":"37","author":"G Ravalico","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00006324-200304000-00008","article-title":"The effect of age on ocular blood supply determined by pulsatile ocular blood flow and color Doppler ultrasonography","volume":"80","author":"AK Lam","year":"2003","journal-title":"Optometry Vision Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1001\/archopht.116.2.150","article-title":"Effect of aging on foveolar choroidal circulation","volume":"116","author":"JE Grunwald","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"ref10","first-page":"46","article-title":"Volume and depth of the anterior chamber in the normal aging human eye","volume":"102","author":"ST Fontana","year":"1984","journal-title":"Arch Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0002-9394(98)00436-X","article-title":"Aqueous humor dynamics in the aging human eye","volume":"127","author":"CB Toris","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/geronj\/38.3.318","article-title":"The effect of increasing age on the latency for saccadic eye movements","volume":"38","author":"JE Carter","year":"1983","journal-title":"J Gerontol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1167\/iovs.04-0162","article-title":"Ocular rigidity in living human eyes","volume":"46","author":"IG Pallikaris","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1167\/iovs.09-3760","article-title":"Ocular rigidity, ocular pulse amplitude, and pulsatile ocular blood flow: the effect of intraocular pressure","volume":"50","author":"AI Dastiridou","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","first-page":"1018","article-title":"Noncontact detection of ocular pulse\u2013correlation with carotid stenosis","volume":"16","author":"J Zuckerman","year":"1977","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1109\/TBME.1977.326118","article-title":"A no-touch ocular pulse measurement system for the diagnosis of carotid occlusions","volume":"24","author":"RB Northrop","year":"1977","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Langham ME, Farell RA, O\u2019Brien V, Silver DM, Schilder P (1989) Blood flow in the human eye. Acta Ophthalmol Suppl: 191: 9\u201313.","DOI":"10.1111\/j.1755-3768.1989.tb07080.x"},{"key":"ref18","unstructured":"Kiel JW (2010) The Ocular Circulation. San Rafael CA: Morgan &amp; Claypool Life Sciences. 69p."},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Silver DM, Farrell RA, Langham ME, O\u2019Brien V, Schilder P (1989). Estimation of pulsatile ocular blood flow from intraocular pressure. Acta Ophthalmol Suppl: 191: 25\u201329.","DOI":"10.1111\/j.1755-3768.1989.tb07083.x"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/0039-6257(94)90049-3","article-title":"Validity of pulsatile ocular blood flow measurements","volume":"38","author":"DM Silver","year":"1994","journal-title":"Surv Ophthalmol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mvre.2000.2269","article-title":"Ocular hemodynamics during isometric exercise","volume":"61(1)","author":"B Kiss","year":"2001","journal-title":"Microvasc Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1755-3768.2009.01577.x","article-title":"A study comparing ocular pressure pulse and ocular fundus pulse in dependence of axial eye length and ocular volume","volume":"88(7)","author":"F Berisha","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF00203321","article-title":"Factors influencing the ocular pulse \u2013 the heart rate","volume":"229","author":"DR Trew","year":"1991","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/01.STR.24.1.6","article-title":"Amplitude of the ocular pneumoplethysmography waveform is correlated with cardiac output","volume":"24","author":"TM Bosley","year":"1993","journal-title":"Stroke"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/sj.eye.6702578","article-title":"Spectral characteristics of longitudinal corneal apex velocities and their relation to the cardiopulmonary system","volume":"21","author":"H Kasprzak","year":"2007","journal-title":"Eye"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1475-1313.2006.00415.x","article-title":"Dynamics in longitudinal eye movements and corneal shape","volume":"26","author":"D Iskander","year":"2006","journal-title":"Ophthalmic Physiol Opt"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1444-0938.2012.00775.x","article-title":"Phase dependencies between longitudinal corneal apex displacement and cardiovascular signals. Is the ocular pulse influenced by the electrical activity of the heart?","volume":"95","author":"ME Danielewska","year":"2012","journal-title":"Clinic Exp Optom"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1001\/archopht.1971.01000010007002","article-title":"Crest time evaluation of corneal indentation pulse","volume":"86","author":"I H\u00f8rven","year":"1971","journal-title":"Arch Ophthal"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/OPX.0000000000000113","article-title":"Age-related changes in corneal pulsation: Ocular dicrotism","volume":"91","author":"ME Danielewska","year":"2014","journal-title":"Optom Vis Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0161-6420(96)30449-1","article-title":"Prevalence of open-angle glaucoma in Australia \u2013 The Blue Mountains eye study","volume":"103","author":"P Mitchell","year":"1996","journal-title":"Ophthalmology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/archopht.122.4.532","article-title":"Prevalence of open-angle glaucoma among adults in the United States","volume":"122","author":"DS Friedman","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.ophtha.2006.08.051","article-title":"Nine-year incidence of open-angle glaucoma in the Barbados Eye Studies","volume":"114","author":"MC Leske","year":"2007","journal-title":"Ophthalmology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"D Pascolini","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcjo.2012.02.003","article-title":"Epidemiology of glaucoma: what\u2019s new?","volume":"74","author":"C Cook","year":"2012","journal-title":"Can J Ophthalmol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0039-6257(99)00050-8","article-title":"Vascular aspects in the pathophysiology of glaucomatous optic neuropathy","volume":"43","author":"HS Chung","year":"1990","journal-title":"Surv Ophthalmol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00417-002-0460-4","article-title":"Spectral content of the intraocular pressure pulse wave: glaucoma patients versus normal subjects","volume":"240","author":"DW Evans","year":"2002","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00000658-197901000-00009","article-title":"Ocular pneumoplethysmography: detection of carotid occlusive disease","volume":"189","author":"PT McDonald","year":"1979","journal-title":"Ann Surg"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0039-6257(98)00011-3","article-title":"Assessment of human ocular hemodynamics","volume":"42","author":"A Harris","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"10584","DOI":"10.1364\/OE.17.010584","article-title":"Three-dimensional quantitative imaging of retinal and choroidal blond flow velocity using joint Spectral and Time domain Optical Coherence Tomography","volume":"17","author":"A Szkulmowska","year":"2009","journal-title":"Opt Express"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e54207","DOI":"10.1371\/journal.pone.0054207","article-title":"Analysis of pulsatile retinal movements by spectral-domain low-coherence interferometry: influence of age and glaucoma on the pulse wave","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.ijg.0000176936.16015.4e","article-title":"Dynamic contour tonometry: presentation of a new tonometer","volume":"14","author":"HE Kanngiesser","year":"2005","journal-title":"J Glaucoma"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1109\/TBME.2010.2100819","article-title":"Ultrasonic in vivo measurement of ocular surface expansion","volume":"58","author":"MA Kowalska","year":"2011","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.ultras.2011.05.011","article-title":"Ultrasonic system for accurate distance measurement in the air","volume":"51","author":"TJ Licznerski","year":"2011","journal-title":"Ultrasonics"},{"key":"ref44","unstructured":"Conover MB (2003) Electrocardiography. Mosby\u2019s Pocket Guide Series. 5th ed. Mosby Inc: St. Louis. 368p."},{"key":"ref45","unstructured":"Sherwood L (2006) Fundamentals of physiology: A human perspective. 3rd ed. Thomson Brooks\/Cole. 768p."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1109\/TIM.2009.2022431","article-title":"Ultrasonic measurement of fine head movements in a standard ophthalmic headrest","volume":"59","author":"HT Kasprzak","year":"2010","journal-title":"IEEE Trans Instr Meas"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/jappl.1964.19.3.479","article-title":"Respiratory sinus arrhythmia: a frequency dependent phenomenon","volume":"19","author":"A Angelone","year":"1964","journal-title":"J Appl Physiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1109\/TASSP.1978.1163055","article-title":"Dynamic programming algorithm optimization for spoken word recognition","volume":"ASSP-26","author":"H Sakoe","year":"1978","journal-title":"IEEE Acoust Speech"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1109\/TSP.2005.855106","article-title":"Integral shape averaging and structural average estimation: a comparative study","volume":"53","author":"S Boudaoud","year":"2005","journal-title":"IEEE Trans Signal Process"},{"key":"ref50","first-page":"1","article-title":"The causes of the secondary waves in the pulse","volume":"1)","author":"AL Galabin","year":"1873","journal-title":"J Anat Physiol: 8(Pt"},{"key":"ref51","first-page":"278","article-title":"Pulse dicrotism","volume":"15","author":"WJ Flemming","year":"1881","journal-title":"J Anat Physiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/hrt.56.6.531","article-title":"Mechanism of the dicrotic pulse","volume":"56","author":"D Smith","year":"1986","journal-title":"Br Heart J"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"MacKenzie J (1902) The study of the pulse, arterial, venous and hepatic and of the movement of the heart. Edinburgh: Young J. Pentland. 325p.","DOI":"10.1097\/00000441-190210000-00023"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1113\/jphysiol.1906.sp001165","article-title":"The factors influencing the prominence of the dicrotic wave","volume":"34","author":"T Lewis","year":"1906","journal-title":"J Physiol"},{"key":"ref55","unstructured":"O\u2019Rourke MF, Gallagher DE (1996) Pulse wave analysis. J Hypertens Suppl: 14: S147\u2013S157."},{"key":"ref56","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1161\/01.CIR.39.5.655","article-title":"The dicrotic arterial pulse","volume":"39","author":"GA Ewy","year":"1969","journal-title":"Circulation"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0002-8703(71)90328-0","article-title":"Dicrotism in heart disease","volume":"82","author":"WR Meadows","year":"1971","journal-title":"Am Heart J"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.CIR.62.5.1107","article-title":"Dicrotic pulse after open heart surgery","volume":"62","author":"RC Orchard","year":"1980","journal-title":"Circulation"},{"key":"ref59","unstructured":"Nichols WW, O\u2019Rourke MF (1998) McDonald\u2019s blood flow in arteries. 4. London: Arnold. 607p."},{"key":"ref60","first-page":"211A","article-title":"Change in radial pulse wave contour with glyceryl nitrate as a method to assess severity of left ventricular falure","volume":"33","author":"K Uebaba","year":"1999","journal-title":"Circulation"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/112067210101100108","article-title":"The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study","volume":"11","author":"R1 Altan-Yaycioglu","year":"2001","journal-title":"Eur J Ophthalmol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0014-4835(03)00212-4","article-title":"Scleral structure, organization and disease. A review","volume":"78","author":"PG Watson","year":"2004","journal-title":"Exp Eye Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"42A","DOI":"10.1016\/S0735-1097(87)80447-3","article-title":"Human aging changes in structure and function","volume":"10","author":"E Lakatta","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/01.CIR.88.4.1456","article-title":"Effects of age and aerobic capacity on arterial stiffness in healthy adults","volume":"88","author":"PV Vaitkevicius","year":"1993","journal-title":"Circulation"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/01.CIR.80.6.1652","article-title":"Non-invasive determination of age-related changes in the human arterial pulse","volume":"80","author":"RP Kelly","year":"1989","journal-title":"Circulation"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1109\/10.52332","article-title":"Frequency-analysis of the peripheral pulse-wave detected in the finger with photoplethysmography","volume":"37","author":"MH Sherebrin","year":"1990","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1042\/cs1030371","article-title":"Determination of age-related increases in large artery stiffness by digital pulse contour analysis","volume":"103","author":"SC Millasseau","year":"2002","journal-title":"Clin Sci"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1088\/0967-3334\/24\/2\/306","article-title":"Age-related changes in the characteristics of the photoplethysmographic pulse shape at various body sites","volume":"24","author":"J Allen","year":"2003","journal-title":"Physiol Meas"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","article-title":"Predictors of long-term progression in the early manifest glaucoma trial","volume":"114","author":"MC Leske","year":"2007","journal-title":"Ophthalmology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1167\/iovs.07-1342","article-title":"Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma","volume":"49","author":"A Hommer","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/eye.2008.47","article-title":"Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls","volume":"23","author":"A Ebneter","year":"2009","journal-title":"Eye (Lond)"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1167\/iovs.11-8009","article-title":"Biomechanics of the human posterior sclera: age- and glaucoma-related changes measured using inflation testing","volume":"53","author":"B Coudrillier","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1001\/archopht.1960.00950020670008","article-title":"The coefficient of scleral rigidity in normal and glaucomatous eyes","volume":"63","author":"SM Drance","year":"1960","journal-title":"Arch Ophthalmol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1755-3768.1984.tb08452.x","article-title":"Changes in the content and composition of collagen in the glaucomatous eye \u2013 basis for a new hypothesis for the genesis of chronic open angle glaucoma \u2013 a preliminary report","volume":"62","author":"B Tengroth","year":"1984","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"ref75","first-page":"1093","article-title":"Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model","volume":"18","author":"MR Steinhart","year":"2012","journal-title":"Mol Vis"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exer.2012.04.016","article-title":"Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice","volume":"100","author":"CM McDowell","year":"2012","journal-title":"Exp Eye Res"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1167\/iovs.10-6927","article-title":"Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations","volume":"52","author":"MJ Girard","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1167\/iovs.10-5411","article-title":"Changes in the biomechanical response of the optic nerve head in early experimental glaucoma","volume":"51(11)","author":"MD Roberts","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0002-9394(00)00636-X","article-title":"Assessment of optic disc blood flow in patients with open angle glaucoma","volume":"130","author":"O Findl","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0002-9394(01)00871-6","article-title":"Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects","volume":"132","author":"JR Piltz-seymour","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/archopht.121.12.1711","article-title":"Ocular hemodynamics and glaucoma prognosis: a color Doppler imaging study","volume":"121","author":"F Galassi","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0002-9394(02)02156-6","article-title":"Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure","volume":"135","author":"M Satilmis","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref83","first-page":"487","article-title":"Association between lower optic nerve laser Doppler blood volume measurements and glaucomatous visual field progression","volume":"87","author":"JM Zink","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.ophtha.2012.06.007","article-title":"Relationship of intraocular pressure and frequency of spontaneous retinal venous pulsation in primary open-angle glaucoma","volume":"119","author":"JH Seo","year":"2012","journal-title":"Ophthalmology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0002-9394(14)71077-3","article-title":"A comparison of retinal and choroidal hemodynamics in patients with primary open-angle glaucoma and normal-pressure glaucoma","volume":"123","author":"HF Duijm","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0161-6420(00)00138-X","article-title":"Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study","volume":"107","author":"L Bonomi","year":"2000","journal-title":"Ophthalmology"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1350-9462(01)00005-2","article-title":"Blood flow in the optic nerve head and factors that may influence it","volume":"20","author":"SS Hayreh","year":"2001","journal-title":"Prog Retin Eye Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1001\/archopht.125.6.805","article-title":"Blood pressure, arterial stiffness, and open-angle glaucoma: the Rotterdam study","volume":"125","author":"CA Hulsman","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3129\/i08-051","article-title":"Measuring and interpreting ocular blood flow and metabolism in glaucoma","volume":"43","author":"A Harris","year":"2008","journal-title":"Can J Ophthalmol"},{"key":"ref90","first-page":"849","article-title":"Dysfunctional regulation of ocular blood flow: a risk factor for glaucoma?","volume":"2","author":"D Moore","year":"2008","journal-title":"Clin Ophthalmol"},{"key":"ref91","first-page":"704","article-title":"Blood Flow in Glaucoma Discussion","volume":"149","author":"J Caprioli","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"ref92","first-page":"e1","article-title":"Angle-closure glaucoma-simpler answers to complex mechanisms: LXVI Edward Jackson Memorial Lecture","volume":"657\u2013669","author":"HA Quigley","year":"2009","journal-title":"Am J Ophthalmol: 148"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00061198-200304000-00013","article-title":"Possible mechanisms of primary angle-closure and malignant glaucoma","volume":"12","author":"HA Quigley","year":"2003","journal-title":"J Glaucoma"},{"key":"ref94","unstructured":"Danielewska ME, Szlag D, Iskander DR, Wojtkowski M. <italic>IOVS<\/italic> 2012; 53: ARVO E-Abstract 5649."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T23:10:15Z","timestamp":1565651415000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102814"}},"subtitle":[],"editor":[{"given":"Sanjoy","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,17]]},"references-count":94,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102814","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,17]]}}}