{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:12:59Z","timestamp":1791180779163,"version":"4.1.0"},"reference-count":132,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102837","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T19:02:05Z","timestamp":1405623725000},"page":"e102837","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dietary Methanol Regulates Human Gene Activity"],"prefix":"10.1371","volume":"9","author":[{"given":"Anastasia V.","family":"Shindyapina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor V.","family":"Petrunia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana V.","family":"Komarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina V.","family":"Sheshukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyacheslav S.","family":"Kosorukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb I.","family":"Kiryanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri L.","family":"Dorokhov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Boyle R (1661) The sceptical chymist: or Chymico-physical doubts &amp; paradoxes, touching the spagyrist&apos;s principles commonly call&apos;d hypostatical, as they are wont to be propos&apos;d and defended by the generality of alchymists. Whereunto is praemis&apos;d part of another discourse. London: Printed by J. Cadwell for J. Crooke.","DOI":"10.5479\/sil.140935.39088002863561"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e1002640","DOI":"10.1371\/journal.ppat.1002640","article-title":"Airborne signals from a wounded leaf facilitate viral spreading and induce antibacterial resistance in neighboring plants","volume":"8","author":"YL Dorokhov","year":"2012","journal-title":"PLoS Pathogens"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e36122","DOI":"10.1371\/journal.pone.0036122","article-title":"Methanol may function as a cross-kingdom signal","volume":"7","author":"YL Dorokhov","year":"2012","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S1360-1385(96)88175-0","article-title":"Leaf methanol\u2013the simplest natural product from plants","volume":"1","author":"R Fall","year":"1996","journal-title":"Trends in Plant Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1029\/94JD02950","article-title":"A global model of natural volatile organic compound emissions","volume":"100","author":"A Guenther","year":"1995","journal-title":"J Geophys Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-313X.2011.04486.x","article-title":"Methanol is an endogenous elicitor molecule for the synthesis of tryptophan and tryptophan-derived secondary metabolites upon senescence of detached rice leaves","volume":"66","author":"K Kang","year":"2011","journal-title":"Plant J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1093\/jxb\/erp106","article-title":"Pectin methylesterase NaPME1 contributes to the emission of methanol during insect herbivory and to the elicitation of defence responses in Nicotiana attenuata","volume":"60","author":"E K\u00f6rner","year":"2009","journal-title":"J Exp Bot"},{"key":"ref8","first-page":"1359","article-title":"Methanol emission from leaves","volume":"108","author":"M Neme\u010dek-Marshall","year":"1995","journal-title":"Plant Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1365-313X.2006.02760.x","article-title":"Caterpillar-elicited methanol emission: a new signal in plant-herbivore interactions?","volume":"46","author":"CC von Dahl","year":"2006","journal-title":"Plant J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0009-2541(01)00310-2","article-title":"Experimental abiotic synthesis of methanol in seafloor hydrothermal systems during diking events","volume":"180","author":"KM Voglesonger","year":"2001","journal-title":"Chemical Geology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1130\/G21751.1","article-title":"Organic molecules formed in a primordial womb","volume":"33","author":"LB Williams","year":"2005","journal-title":"Geology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-90-481-8794-2_4","article-title":"Birth of Biomolecules from the Warm Wet Sheets of Clays Near Spreading Centers","volume":"1","author":"LB Williams","year":"2011","journal-title":"In: Earliest life on earth: habitats, environmrnts and methods of detection Part"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Heikes BG, Chang W, Pilson MEQ, Swift E, Singh HB, <etal>et al<\/etal>.. (2002) Atmospheric methanol budget and ocean implication. Global Biogeochemical Cycles 16: 1133, 13 PP.","DOI":"10.1029\/2002GB001895"},{"key":"ref14","first-page":"11145","article-title":"Sources and seasonality of atmospheric methanol based on tall tower measurements in the US Upper Midwest Atmos Chem Phys","volume":"11","author":"L Hu","year":"2011"},{"key":"ref15","first-page":"857","article-title":"Global distributions of methanol and formic acid retrieved for the first time from the IASI\/MetOp thermal infrared sounder Atmos Chem Phys","volume":"11","author":"A Razavi","year":"2011"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/jxb\/erm038","article-title":"Simultaneous growth and emission measurements demonstrate an interactive control of methanol release by leaf expansion and stomata","volume":"58","author":"K H\u00fcve","year":"2007","journal-title":"J Exp Bot"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/0955-0674(92)90111-O","article-title":"Synthesis, assembly and function of plant cell wall macromolecules","volume":"4","author":"S Levy","year":"1992","journal-title":"Curr Opin Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cbi.2011.01.028","article-title":"Mammalian alcohol dehydrogenases - a comparative investigation at gene and protein levels","volume":"191","author":"JO H\u00f6\u00f6g","year":"2011","journal-title":"Chem Biol Interact"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.forsciint.2008.05.014","article-title":"Fatal methanol intoxication with different survival times - morphological findings and postmortem methanol distribution","volume":"179","author":"H Andresen","year":"2008","journal-title":"Forensic Sci Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1081\/CLT-120006745","article-title":"American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning","volume":"40","author":"DG Barceloux","year":"2002","journal-title":"J Toxicol Clin Toxicol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-0773.1987.tb01737.x","article-title":"Elimination half-life of methanol during hangover","volume":"60","author":"A Jones","year":"1987","journal-title":"Pharmacol Toxicol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/10408449009089872","article-title":"The toxicity of inhaled methanol vapors","volume":"21","author":"R Kavet","year":"1990","journal-title":"Crit Rev Toxicol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/109158101750300955","article-title":"Final report on the safety assessment of methyl alcohol","volume":"20","author":"S Lanigan","year":"2001","journal-title":"Int J Toxicol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0024-3205(91)90504-5","article-title":"The toxicity of methanol","volume":"48","author":"TR Tephly","year":"1991","journal-title":"Life Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jnc.12356","article-title":"Formaldehyde in brain: an overlooked player in neurodegeneration?","volume":"127","author":"K Tulpule","year":"2013","journal-title":"J Neurochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/jat\/32.3.241","article-title":"Formic acid and methanol concentrations in death investigations","volume":"32","author":"HR Wallage","year":"2008","journal-title":"J Anal Toxicol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-genom-090711-163844","article-title":"The genetics of substance dependence","volume":"13","author":"JC Wang","year":"2012","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2009.11.023","article-title":"Formaldehyde dehydrogenase: beyond phase I metabolism","volume":"193","author":"CM Thompson","year":"2010","journal-title":"Toxicol Lett"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jat.2550140412","article-title":"Methanol","volume":"14","author":"R Von Burg","year":"1994","journal-title":"J Appl Toxicol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1111\/j.1556-4029.2007.00554.x","article-title":"The relationship of methanol and formate concentrations in fatalities where methanol is detected","volume":"52","author":"GR Jones","year":"2007","journal-title":"J Forensic Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1080\/15287397709529518","article-title":"Methanol poisoning. VI. Role of folic acid in the production of methanol poisoning in the rat","volume":"2","author":"AB Makar","year":"1977","journal-title":"J Toxicol Environ Health"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"McMartin KE, Martin-Amat G, Makar AB, Tephly TR (1977) Methanol poisoning: role of formate metabolism in the monkey. In: Alcohol and Aldehyde Metabolizing Systems, Vol. 2, Thurman RG, Williamson JR, Drott H, Chance B, Eds, Academic Press, New York, pp. 429\u2013439.","DOI":"10.1016\/B978-0-12-691402-3.50045-7"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0006-2952(79)90149-7","article-title":"Lack of role for formaldehyde in methanol poison ing in the monkey","volume":"28","author":"KE McMartin","year":"1979","journal-title":"Biochem Pharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/15563650.2012.683197","article-title":"Kinetics and metabolism of fomepizole in healthy humans","volume":"50","author":"KE McMartin","year":"2012","journal-title":"Clin Toxicol (Phila)"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/10408440701516184","article-title":"Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies","volume":"37","author":"BA Magnuson","year":"2007","journal-title":"Crit Rev Toxicol"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Restani P, Galli CL (1991) Oral toxicity of formaldehyde and its derivatives. CRC Crit Rev Toxicol 21, 315\u2013328.","DOI":"10.3109\/10408449109019569"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1126\/science.141.3581.639","article-title":"Methanol in Normal Human Breath","volume":"141","author":"SP Eriksen","year":"1963","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"036001","DOI":"10.1088\/1752-7155\/3\/3\/036001","article-title":"Concentrations of some metabolites in the breath of healthy children aged 7\u201318 years measured using selected ion flow tube mass spectrometry (SIFT-MS)","volume":"3","author":"B Enderby","year":"2009","journal-title":"J Breath Res"},{"key":"ref39","first-page":"185","article-title":"Analysis of respiratory exchange of methanol in the lung of the monkey using a physiological model Toxicol Sci","volume":"52","author":"JW Fisher","year":"2000"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1530-0277.1995.tb01593.x","article-title":"Methanol in human breath. Alcohol Clin","volume":"19","author":"J Taucher","year":"1995","journal-title":"Exp Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1088\/0967-3334\/27\/7\/007","article-title":"A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS","volume":"27","author":"C Turner","year":"2006","journal-title":"Physiol Meas"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/rcm.3402","article-title":"An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry","volume":"22","author":"C Turner","year":"2008","journal-title":"Rapid Commun Mass Spectrom"},{"key":"ref43","first-page":"574","article-title":"Methanol and formaldehyde in normal body tissues and fluids","volume":"49","author":"OC Western","year":"1949","journal-title":"U S Nav Med Bull"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1081\/CLT-120025344","article-title":"Rethinking the toxic methanol level","volume":"41","author":"MA Kostic","year":"2003","journal-title":"J Toxicol Clin Toxicol"},{"key":"ref45","unstructured":"Clary JJ, Sullivan JB Jr. (1999) Formaldehyde. In: Clinical Environmental Health and Toxic Exposures (JB Sullivan and GR Krieger, Eds). Lippincott Williams &amp;Wilkins, Philadelphia PA, pp. 1007\u20131014."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neurobiolaging.2009.07.013","article-title":"Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia","volume":"32(1)","author":"Z Tong","year":"2011","journal-title":"Neurobiol Aging"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e90239","DOI":"10.1371\/journal.pone.0090239","article-title":"Endogenous methanol regulates mammalian gene activity","volume":"9(2)","author":"TV Komarova","year":"2014","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1126\/science.150.3698.892","article-title":"Pituitary Gland: Enzymic Formation of Methanol from S-Adenosylmethionine","volume":"150","author":"J Axelrod","year":"1965","journal-title":"Science"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/215773b0","article-title":"Formation of methanol by an enzyme in an ectopic pinealoma","volume":"215","author":"SH Snyder","year":"1967","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s11357-012-9463-1","article-title":"Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians&apos; offspring","volume":"35","author":"D Gentilini","year":"2012","journal-title":"Age (Dordr)"},{"key":"ref51","first-page":"10522","article-title":"Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A","volume":"109","author":"H Heyn","year":"2012"},{"key":"ref52","first-page":"455","article-title":"Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution. Am J Hum Genet","volume":"91","author":"J Zeng","year":"2012"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/1875397301005010085","article-title":"Structural Chemistry of Human SET Domain Protein Methyltransferases","volume":"5","author":"M Schapira","year":"2011","journal-title":"Curr Chem Genomics"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1073\/pnas.71.5.1701","article-title":"Characterization and substrate specificity of a protein carboxymethylase in the pituitary gland","volume":"71","author":"EJ Diliberto Jr","year":"1974","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1471-4159.1976.tb07001.x","article-title":"Regional and subcellular distribution of protein carboxymethylase in brain and other tissues","volume":"26","author":"EJ Diliberto Jr","year":"1976","journal-title":"J Neurochem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1073\/pnas.73.11.4050","article-title":"Subcellualr distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling","volume":"73","author":"DJ Diliberto Jr","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/0024-3205(78)90566-0","article-title":"Protein carboxymethylation: effects of 2% sodium chloride administration on protein carboxymethylase and its endogenous substrates in rat posterior pituitary","volume":"22","author":"C Gagnon","year":"1978","journal-title":"Life Sciences"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1471-4159.1985.tb07143.x","article-title":"Dopamine autoreceptor stimulation increases protein carboxyl methylation in striatal slices","volume":"44","author":"ME Wolf","year":"1985","journal-title":"J Neurochemistry"},{"key":"ref59","first-page":"10","article-title":"Effects of aspartame metabolites on astrocytes and neurons. Folia Neuropathol","volume":"51(1)","author":"K Rycerz","year":"2013","journal-title":"2013"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Soffritti M, Padovani M, Tibaldi E, Falcioni L, Manservisi F, <etal>et al<\/etal>.. (2014) The carcinogenic effects of aspartame: The urgent need for regulatory re-evaluation. Am J Ind Med. 2014 Jan 16. doi: 10.1002\/ajim.22296. [Epub ahead of print].","DOI":"10.1002\/ajim.22296"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"17","DOI":"10.15288\/qjsa.1962.23.017","article-title":"The concentration of apparent endogenous ethanol","volume":"23","author":"D Lester","year":"1962","journal-title":"Q J Stud Alcohol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/bmj.303.6802.565","article-title":"Alcohol and cardiovascular disease: the status of the U shaped curve","volume":"303","author":"M Marmot","year":"1991","journal-title":"BMJ"},{"key":"ref63","first-page":"42","article-title":"Aspartame, methanol and the public health","volume":"36","author":"WC Monte","year":"1984","journal-title":"J Appl Nutr"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"725","DOI":"10.15288\/jsa.1999.60.725","article-title":"The U-shaped curve: various health measures and alcohol drinking patterns","volume":"60","author":"B San Jos\u00e9","year":"1999","journal-title":"J Stud Alcohol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF03259846","article-title":"Methanol and ethylene glycol poisonings: Mechanism of toxicity, clinical course, diagnosis and treatment","volume":"1","author":"D Jacobsen","year":"1986","journal-title":"Med Toxicol"},{"key":"ref66","first-page":"377","article-title":"Pulmonary excretion of methanol in man, Scand J Clin Lab Invest","volume":"43(5)","author":"D Jacobsen","year":"1983"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/15563658608995388","article-title":"4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man","volume":"24","author":"FJ Baud","year":"1987","journal-title":"J Toxicol Clin Toxicol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1056\/NEJM198807143190206","article-title":"Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole","volume":"319","author":"FJ Baud","year":"1988","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1530-0277.2001.tb02244.x","article-title":"Effect of 4-methylpyrazole on endogenous plasma ethanol and methanol levels in humans","volume":"25","author":"T Sarkola","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/hep.510290420","article-title":"High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced. HeLa cells","volume":"29","author":"A Galli","year":"1999","journal-title":"Hepatology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1530-0277.2010.01319.x","article-title":"Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration","volume":"35","author":"M Matsumoto","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1172\/JCI118272","article-title":"The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells","volume":"96","author":"Q Xiao","year":"1995","journal-title":"J Clin Invest"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3233\/JAD-2010-1375","article-title":"Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer&apos;s disease: many pathways to neurodegeneration","volume":"20","author":"DA Butterfield","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1096\/fj.05-4195fje","article-title":"Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer&apos;s disease","volume":"19","author":"RC Cumming","year":"2005","journal-title":"FASEB J"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jcb.20399","article-title":"New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells","volume":"95","author":"MA Sirover","year":"2005","journal-title":"J Cell Biochem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3233\/JAD-121480","article-title":"Minjarez B, Valero Rustarazo ML, Sanchez del Pino MM, Gonz\u00e1lez-Robles A, Sosa-Melgarejo JA, et al. Identification of polypeptides in neurofibrillary tangles and total homogenates of brains with Alzheimer&apos;s disease by tandem mass spectrometry","volume":"34","journal-title":"J Alzheimers Dis"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.advenzreg.2009.10.002","article-title":"The retromer complex","volume":"50","author":"N Attar","year":"2010","journal-title":"Adv Enzyme Regul"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.semcdb.2009.11.009","article-title":"SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting","volume":"21","author":"WeeringJR van","year":"2010","journal-title":"Semin Cell Dev Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"14257","DOI":"10.1074\/jbc.M801531200","article-title":"A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein","volume":"283","author":"S Sch\u00f6bel","year":"2008","journal-title":"J Biol Chem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1083\/jcb.201111121","article-title":"SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways","volume":"197","author":"F Steinberg","year":"2012","journal-title":"J Cell Biol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1073\/pnas.1114410109","article-title":"The human circadian metabolome","volume":"109","author":"R Dallmann","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/2040622311430006","article-title":"Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians","volume":"3","author":"V Habauzit","year":"2012","journal-title":"Ther Adv Chronic Dis"},{"key":"ref83","first-page":"1614","article-title":"Novel role of red wine-derived polyphenols in the prevention of Alzheimer&apos;s disease dementia and brain pathology: experimental approaches and clinical implications","volume":"79","author":"GM Pasinetti","year":"2013","journal-title":"Planta Med"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/emm.2003.53","article-title":"Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity","volume":"35","author":"JR Kim","year":"2003","journal-title":"Exp Mol Med"},{"key":"ref85","first-page":"131","article-title":"Considering the vascular hypothesis of Alzheimer&apos;s disease: effect of copper associated amyloid on red blood cells. Adv Exp Med Biol","volume":"765","author":"HR Lucas","year":"2013"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e33120","DOI":"10.1371\/journal.pone.0033120","article-title":"Interactions between Amyloid-b and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer\u2019s Disease","volume":"7","author":"J-Y Chuang","year":"2012","journal-title":"PLoS ONE"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3233\/JAD-2010-101485","article-title":"Neuronal hemoglobin is reduced in Alzheimer&apos;s disease, argyrophilic grain disease, Parkinson&apos;s disease, and dementia with Lewy bodies","volume":"23","author":"I Ferrer","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"936580","DOI":"10.4061\/2011\/936580","article-title":"Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer&apos;s Disease Brain","volume":"2011","author":"ES Blom","year":"2011","journal-title":"Int J Alzheimers Dis"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"34914","DOI":"10.1074\/jbc.M111.232116","article-title":"A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36","volume":"286","author":"K Wilkinson","year":"2011","journal-title":"J Biol Chem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1365-2141.2011.08725.x","article-title":"Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9","volume":"154","author":"AG Buggins","year":"2011","journal-title":"Br J Haematol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroscience.2012.03.013","article-title":"An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines","volume":"210","author":"I Dafnis","year":"2012","journal-title":"Neuroscience"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1742-2094-8-115","article-title":"Activation of matrix metalloproteinases following anti-A\u03b2 immunotherapy; implications for microhemorrhage occurrence","volume":"8","author":"DM Wilcock","year":"2011","journal-title":"J Neuroinflammation"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"652","DOI":"10.18632\/aging.100069","article-title":"Serum markers of apoptosis decrease with age and cancer stage","volume":"1","author":"N Kavathia","year":"2009","journal-title":"Aging (Albany NY)"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s004010050633","article-title":"Expression of interleukin-1 receptor antagonist protein in post-mortemhuman brain tissues of Alzheimer&apos;s disease and control cases","volume":"93","author":"O Yasuhara","year":"1997","journal-title":"Acta Neuropathol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","article-title":"Differential regulation of interleukin-1 receptor-associated kinase-1(IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressedhuman astroglial cells and in Alzheimer disease","volume":"285","author":"JG Cui","year":"2010","journal-title":"J Biol Chem"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cell.2009.12.032","article-title":"USP10 regulates p53 localization and stability by deubiquitinating p53","volume":"140","author":"J Yuan","year":"2010","journal-title":"Cell"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/cne.20538","article-title":"Distribution and abundance of metabotropic glutamate receptor subtype2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPgammas binding","volume":"487","author":"G Richards","year":"2005","journal-title":"J Comp Neurol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12035-010-8112-x","article-title":"Arginine metabolizing enzymes as therapeutic tools for Alzheimer&apos;s disease: peptidyl arginine deiminase catalyses fibrillogenesis of beta-amyloid peptides","volume":"41","author":"P Mohlake","year":"2010","journal-title":"Mol Neurobiol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1100\/tsw.2010.154","article-title":"Dysfunction of G protein-coupled receptor kinases in Alzheimer&apos;s disease","volume":"10","author":"WZ Suo","year":"2010","journal-title":"ScientificWorldJournal"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.3233\/JAD-2012-129043","article-title":"Endothelin-Converting Enzymes and Related Metalloproteases inAlzheimer&apos;s Disease","volume":"33","author":"J Pacheco-Quinto","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"ref101","first-page":"383796","article-title":"The Alzheimer&apos;s amyloid-degrading peptidase, neprilysin: can we control it?","volume":"2012","author":"NN Nalivaeva","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/path.2984","article-title":"Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies","volume":"226","author":"MM Wilhelmus","year":"2012","journal-title":"J Pathol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000332017","article-title":"Impact of SORL1 single nucleotide polymorphisms on Alzheimer&apos;sdisease cerebrospinal fluid markers","volume":"32","author":"P Alexopoulos","year":"2011","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","volume":"39","author":"E Rogaeva","year":"2007","journal-title":"Nat Genet"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/sj.cdd.4402180","article-title":"Mutant ubiquitin found in Alzheimer\u2019s disease causes neuritic beading of mitochondria in association with neuronal degeneration","volume":"14","author":"Z Tan","year":"2007","journal-title":"Cell Death Differ"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2990.2011.01236.x","article-title":"Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer&apos;s disease","volume":"38","author":"L Chadwick","year":"2012","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00062752-200203000-00002","article-title":"New insights into erythropoiesis","volume":"9","author":"MJ Koury","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/iub.226","article-title":"Erythropoiesis: model systems, molecular regulators, and developmental programs","volume":"61","author":"AS Tsiftsoglou","year":"2009","journal-title":"IUBMB Life"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1530-0277.1997.tb03862.x","article-title":"Endogenous production of methanol after the consumption of fruit","volume":"21","author":"W Lindinger","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1079\/PNS2005480","article-title":"Biological effects of fruit and vegetables","volume":"65","author":"LO Dragsted","year":"2006","journal-title":"Proc Nutr Soc"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/ajcn\/48.3.712","article-title":"Health aspects of vegetarian diets","volume":"48","author":"JT Dwyer","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fphar.2013.00128","article-title":"Anti-cancer activities of pH- or heat-modified pectin","volume":"4","author":"L Leclere","year":"2013","journal-title":"Front Pharmacol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00394-012-0489-z","article-title":"Intake of whole apples or clear apple juice has contrasting effects on plasmalipids in healthy volunteers","volume":"52","author":"G Ravn-Haren","year":"2012","journal-title":"Eur J Nutr"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1017\/S0007114508995684","article-title":"Dried plums (prunes) reduce atherosclerosis lesion area in apolipoprotein E-deficient mice","volume":"101","author":"CM Gallaher","year":"2003","journal-title":"Br J Nutr"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"475S","DOI":"10.1093\/ajcn\/70.3.475s","article-title":"Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies","volume":"70","author":"JW Lampe","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"ref116","first-page":"1","article-title":"Dietary patterns: a novel approach to examine the link between nutritionand cognitive function in older ind-ividuals","volume":"4","author":"B All\u00e8s","year":"2012","journal-title":"Nutr Res Rev"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s11064-012-0799-9","article-title":"Neuroprotective effect of natural products against Alzheimer&apos;s disease","volume":"37","author":"MM Essa","year":"2012","journal-title":"Neurochem Res"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1212\/WNL.0b013e318258f7c2","article-title":"Nutrient intake and plasma \u03b2-amyloid","volume":"78","author":"Y Gu","year":"2012","journal-title":"Neurology"},{"key":"ref119","first-page":"626","article-title":"Fruit, vegetables and prevention of cognitive decline or dementia: \u00e0 systematic review of cohort studies. J Nutr Health Aging","volume":"16(7)","author":"M Loef","year":"2012","journal-title":"2012"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s11910-007-0057-8","article-title":"Diet and Alzheimer\u2019s disease","volume":"7","author":"JA Luchsinger","year":"2007","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref121","first-page":"4844","article-title":"Physicochemical determinants of human renal clearance. J Med Chem","volume":"52","author":"MV Varma","year":"2009"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1530-0277.1996.tb05255.x","article-title":"Kinetic interactions between 4-methylpyrazole and ethanol in healthy humans","volume":"20","author":"D Jacobsen","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2217\/bmm.09.84","article-title":"Blood-based biomarkers of Alzheimer\u2019s disease: challenging but feasible","volume":"4","author":"M Thambisetty","year":"2010","journal-title":"Biomark Med"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.nbd.2011.05.023","article-title":"Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer&apos;s disease","volume":"43","author":"KD Chen","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jns.2011.11.001","article-title":"Peripheral markers in neurodegenerative patients and their first-degree relatives","volume":"314","author":"DO Cristalli","year":"2012","journal-title":"Neurol Sci"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00041444-200503000-00001","article-title":"Gene expression profile analysis of lymphocytes from Alzheimer&apos;s patients","volume":"15","author":"J K\u00e1lm\u00e1n","year":"2005","journal-title":"Psychiatr Genet"},{"key":"ref127","first-page":"39","article-title":"Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients Lipids Health Dis","volume":"11","author":"A Mandas","year":"2012"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"e1000873","DOI":"10.1371\/journal.pgen.1000873","article-title":"Deciphering Normal Blood Gene Expression Variation\u2013The NOWAC Postgenome Study","volume":"6","author":"V Dumeaux","year":"2010","journal-title":"PLoS Genet"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/physiolgenomics.00080.2005","article-title":"Variation in gene expression profiles of peripheral blood mononuclear cells from healthy volunteers","volume":"22","author":"JJ Eady","year":"2005","journal-title":"Physiol Genomics"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddp476","article-title":"The effect of food intake on gene expression in human peripheral blood","volume":"19","author":"AS Leonardson","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/cc8926","article-title":"Bench-to-bedside review: carbon dioxide","volume":"14","author":"G Curley","year":"2010","journal-title":"Crit Care"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/sj.onc.1209174","article-title":"RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3","volume":"25","author":"M Huang","year":"2006","journal-title":"Oncogene"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T21:14:36Z","timestamp":1746306876000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102837"}},"subtitle":[],"editor":[{"given":"Klaus","family":"Roemer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,17]]},"references-count":132,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102837","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,17]]}}}