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(2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00000478-200103000-00002","article-title":"Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas","volume":"25","author":"WR Macon","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/00000478-200007000-00016","article-title":"Hepatosplenic alphabeta T-cell lymphoma: an unusual case with clinical, histologic, and cytogenetic features of gammadelta hepatosplenic T-cell lymphoma","volume":"24","author":"F Suarez","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1182\/blood-2011-12-396150","article-title":"Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets","volume":"119","author":"M Travert","year":"2012","journal-title":"Blood"},{"key":"ref6","unstructured":"Gaulard P, Jaffe E, Krenacs L, Macon WR (2008) Hepatosplenic T-cell lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, <etal>et al<\/etal>.., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC. pp. 292\u2013293."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/gcc.2870120302","article-title":"Consistent presence of isochromosome 7q in hepatosplenic T gamma\/delta lymphoma: a new cytogenetic-clinicopathologic entity","volume":"12","author":"CC Wang","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/sj.leu.2400742","article-title":"Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic gammadelta T cell lymphoma","volume":"11","author":"EL Alonsozana","year":"1997","journal-title":"Leukemia"},{"key":"ref9","first-page":"1453","article-title":"Isochromosome 7q and trisomy 8 are consistent primary, non-random chromosomal abnormalities associated with hepatosplenic T gamma\/delta lymphoma","volume":"10","author":"P 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Mol Cancer Res e-pub ahead of print. 1541\u20137786.MCR-13\u20130546 [pii];10.1158\/1541-7786.MCR-13-0546 [doi].","DOI":"10.1158\/1541-7786.MCR-13-0546"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood-2008-07-166363","article-title":"Gene expression profiling of peripheral T-cell lymphoma including gammadelta T-cell lymphoma","volume":"113","author":"K Miyazaki","year":"2009","journal-title":"Blood"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0959-437X(96)80091-8","article-title":"P-glycoprotein and multidrug resistance","volume":"6","author":"MM Gottesman","year":"1996","journal-title":"Curr Opin Genet Dev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrd1984","article-title":"Targeting multidrug resistance in cancer","volume":"5","author":"G Szakacs","year":"2006","journal-title":"Nat Rev Drug 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target for rational anti-cancer drug design?","volume":"16","author":"A McCluskey","year":"2001","journal-title":"Anticancer Drug Des"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.canlet.2006.10.012","article-title":"Identification of PEG10 as a progression related biomarker for hepatocellular carcinoma","volume":"250","author":"WK Ip","year":"2007","journal-title":"Cancer Lett"},{"key":"ref58","first-page":"625","article-title":"Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers","volume":"10","author":"AP Tsou","year":"2003","journal-title":"J Biomed Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cancergencyto.2010.01.004","article-title":"PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma","volume":"198","author":"K Tsuji","year":"2010","journal-title":"Cancer Genet 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Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1074-7613(00)80253-8","article-title":"Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice","volume":"4","author":"MR Hodge","year":"1996","journal-title":"Immunity"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1096\/fj.02-0282fje","article-title":"NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expression","volume":"16","author":"MS Caetano","year":"2002","journal-title":"FASEB J"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2456::AID-IMMU2456>3.0.CO;2-9","article-title":"Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice","volume":"28","author":"K Schuh","year":"1998","journal-title":"Eur J 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induces apoptosis in Burkitt&apos;s lymphoma cells through signaling via the B cell antigen receptor","volume":"33","author":"E Kondo","year":"2003","journal-title":"Eur J Immunol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S1097-2765(02)00701-3","article-title":"NFATc2-mediated repression of cyclin-dependent kinase 4 expression","volume":"10","author":"S Baksh","year":"2002","journal-title":"Mol Cell"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.4161\/cc.6.14.4473","article-title":"The NFAT1 transcription factor is a repressor of cyclin A2 gene expression","volume":"6","author":"LD Carvalho","year":"2007","journal-title":"Cell Cycle"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1096\/fj.02-0282fje","article-title":"NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expression","volume":"16","author":"MS Caetano","year":"2002","journal-title":"FASEB J"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/gcc.21994","article-title":"Three-way translocation (X;20;16)(p11;q13;q23) in essential thrombocythemia implicates NFATC2 in dysregulation of CSF2 expression and megakaryocyte proliferation","volume":"51","author":"L Vieira","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.188.3.527","article-title":"Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to Fcepsilon receptor type 1 stimulation of mast cells","volume":"188","author":"H Turner","year":"1998","journal-title":"J Exp Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/imr.12117","article-title":"The role of the cytoskeleton at the immunological synapse","volume":"256","author":"AT Ritter","year":"2013","journal-title":"Immunol Rev"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1182\/blood-2010-03-274506","article-title":"Mutation of inhibitory helix-loop-helix protein Id3 causes gammadelta T-cell lymphoma in mice","volume":"116","author":"J Li","year":"2010","journal-title":"Blood"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1242\/jcs.121988","article-title":"Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway","volume":"126","author":"G Jacquemet","year":"2013","journal-title":"J Cell Sci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"26044","DOI":"10.1074\/jbc.274.37.26044","article-title":"Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin","volume":"274","author":"M Fukata","year":"1999","journal-title":"J Biol Chem"},{"key":"ref84","unstructured":"Shaffer LG, MwGowan-Jordan J, Schmid M (2013) ISCN An International System for Human Cytogenetic Nomenclature (2013). Basel: S. Karger."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T15:36:31Z","timestamp":1649777791000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102977"}},"subtitle":[],"editor":[{"given":"J\u00f6rg D.","family":"Hoheisel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,24]]},"references-count":84,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102977","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,24]]}}}