{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:31:13Z","timestamp":1788877873800,"version":"build-2803163510"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102995","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T19:56:02Z","timestamp":1406836562000},"page":"e102995","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["Widespread Disruption of Functional Brain Organization in Early-Onset Alzheimer\u2019s Disease"],"prefix":"10.1371","volume":"9","author":[{"given":"Sofie M.","family":"Adriaanse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja A. A.","family":"Binnewijzend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Ossenkoppele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teddy","family":"Koene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke L.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alle Meije","family":"Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N. M.","family":"van Berckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,31]]},"reference":[{"key":"ref1","first-page":"2112","article-title":"Alzheimer\u2019s Disease International. Global prevalence of dementia: a Delphi consensus study. Lancet","volume":"366","author":"CP Ferri","year":"2005"},{"key":"ref2","first-page":"2811","article-title":"Alzheimer\u2019s centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects. Brain","volume":"129","author":"JR Hodges","year":"2006"},{"key":"ref3","first-page":"1401","article-title":"Early-versus late-onset Alzheimer\u2019s disease: more than age alone. J Alzheimers Dis","volume":"19","author":"EL Koedam","year":"2010"},{"key":"ref4","first-page":"101","article-title":"Early onset Alzheimer\u2019s disease is associated with a distinct neuropsychological profile. J Alzheimers Dis","volume":"30","author":"LL Smits","year":"2012"},{"key":"ref5","first-page":"136","article-title":"Clinical and neuropsychological differences between patients with earlier and later onset of Alzheimer\u2019s disease: A CERAD analysis, Part XII. Neurology","volume":"46","author":"E Koss","year":"1996"},{"key":"ref6","first-page":"2115","article-title":"Amyloid burden and metabolic function in early-onset Alzheimer\u2019s disease: parietal lobe involvement. Brain","volume":"135","author":"R Ossenkoppele","year":"2012"},{"key":"ref7","first-page":"512","article-title":"Increased metabolic vulnerability in early-onset Alzheimer\u2019s disease is not related to amyloid burden. Brain","volume":"133","author":"GD Rabinovici","year":"2010"},{"key":"ref8","first-page":"548","article-title":"Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients. J Neurol","volume":"252","author":"G Kalpouzos","year":"2005"},{"key":"ref9","first-page":"1790","article-title":"Glucose metabolism in early onset versus late onset Alzheimer\u2019s disease: an SPM analysis of 120 patients. Brain","volume":"128","author":"EJ Kim","year":"2005"},{"key":"ref10","first-page":"306","article-title":"Imaging brain amyloid in Alzheimer\u2019s disease with Pittsburgh Compound-B. Ann Neurol","volume":"55","author":"WE Klunk","year":"2004"},{"key":"ref11","first-page":"1008","article-title":"Young Alzheimer patients show distinct regional changes of oscillatory brain dynamics. Neurobiol Aging","volume":"33","author":"H de Waal","year":"2012"},{"key":"ref12","first-page":"720","article-title":"The topography of grey matter involvement in early and late onset Alzheimer\u2019s disease. Brain","volume":"130","author":"GB Frisoni","year":"2007"},{"key":"ref13","first-page":"967","article-title":"Precuneus atrophy in early-onset Alzheimer\u2019s disease: a morphometric structural MRI study. Neuroradiology","volume":"49","author":"G Karas","year":"2007"},{"key":"ref14","first-page":"10238","article-title":"Neural basis of global resting-state fMRI activity. Proc Natl Acad Sci USA","volume":"107","author":"ML Scholvinck","year":"2010"},{"key":"ref15","first-page":"4734","article-title":"Toward discovery science of human brain function. Proc Natl Acad Sci USA","volume":"107","author":"BB Biswal","year":"2010"},{"key":"ref16","first-page":"1001","article-title":"Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci","volume":"360","author":"CF Beckmann","year":"2005"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Gour N, Felician O, Didic M, Koric L, Gueriot C, et al. (2013) Functional connectivity changes differ in early and late-onset alzheimer\u2019s disease. Hum Brain Mapp. doi: 10.1002\/hbm.22379. Epub ahead of print.","DOI":"10.1002\/hbm.22379"},{"key":"ref18","first-page":"2018","article-title":"Resting-state fMRI changes in Alzheimer\u2019s disease and mild cognitive impairment. Neurobiol Aging","volume":"33","author":"MA Binnewijzend","year":"2012"},{"key":"ref19","first-page":"939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer\u2019s disease. Neurology","volume":"34","author":"G McKhann","year":"1984"},{"key":"ref20","first-page":"812","article-title":"The Mini-Mental State Examination. Arch Gen Psychiatry","volume":"40","author":"MF Folstein","year":"1984"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"SM Smith","year":"2004","journal-title":"Neuroimage"},{"key":"ref22","first-page":"479","article-title":"Accurate, robust and automated longitudinal and cross-sectional brain change analysis. Neuroimage","volume":"17","author":"SM Smith","year":"2002"},{"key":"ref23","first-page":"2375","article-title":"Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. Brain","volume":"130","author":"G Douaud","year":"2007"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"CD Good","year":"2001","journal-title":"Neuroimage"},{"key":"ref25","unstructured":"Andersson JLR, Jenkinson M, Smith S (2007) Non-linear registration, aka Spatial normalisation. FMRIB technical report TR07JA2 from www.fmrib.ox.ac.uk\/analysis\/techrep<\/ext-link>."},{"key":"ref26","first-page":"83","article-title":"Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage","volume":"44","author":"SM Smith","year":"2009"},{"key":"ref27","first-page":"2163","article-title":"Reliable intrinsic connectivity networks: Test-retest evaluation using ICA and dual regression approach. Neuroimage","volume":"49","author":"X Zuo","year":"2010"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Beckmann CF, Mackay CE, Filippini N, Smith SM (2009) Group comparison of resting-state FMRI data using multi-subject ICA and dual regression. OHBM 2011 poster. Ref Type: Abstract.","DOI":"10.1016\/S1053-8119(09)71511-3"},{"key":"ref29","first-page":"7209","article-title":"Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci USA","volume":"106","author":"N Filippini","year":"2009"},{"key":"ref30","first-page":"178","article-title":"Statistical validation of image segmentation quality based on a spatial overlap index. Acad Radiol","volume":"11","author":"KH Zou","year":"2004"},{"key":"ref31","first-page":"103","article-title":"Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer\u2019s disease. Behav Brain Res","volume":"197","author":"HY Zhang","year":"2009"},{"key":"ref32","first-page":"2014","article-title":"Different patterns of gray matter atrophy in early- and late-onset Alzheimer\u2019s disease. Neurobiol Aging","volume":"34","author":"C M\u00f6ller","year":"2013"},{"key":"ref33","first-page":"1613","article-title":"Functional imaging of cognition in Alzheimer\u2019s disease using positron emission tomography. Neuropsychologia","volume":"46","author":"E Salmon","year":"2008"},{"key":"ref34","first-page":"163","article-title":"Age at onset and visuocognitive disturbances in Alzheimer disease. Alzheimer Dis Assoc Disord","volume":"12","author":"M Fujimori","year":"1998"},{"key":"ref35","unstructured":"Bear MF, Connors BW, Paradiso MA (2007) Neuroscience: Exploring the Brain, third ed. Lippincott Williams & Williams, Baltimore."},{"key":"ref36","first-page":"119","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade. Lancet Neurol","volume":"9","author":"CR Jack Jr","year":"2010"},{"key":"ref37","first-page":"1","article-title":"Relationships between human auditory cortical structure and function. Audiol Neurootol","volume":"8","author":"DA Hall","year":"2003"},{"key":"ref38","first-page":"787","article-title":"Apraxia and the supplementary motor area. Arch Neurol","volume":"43","author":"RT Watson","year":"1986"},{"key":"ref39","first-page":"687","article-title":"Basal functional connectivity within the anterior temporal network is associated with performance on declarative memory tasks. Neuroimage","volume":"58","author":"N Gour","year":"2011"},{"key":"ref40","first-page":"409","article-title":"Comparisons between Alzheimer disease, frontotemporal lobar degeneration, and normal aging with brain mapping. Top Magn Reson Imaging","volume":"16","author":"JL Whitwell","year":"2005"},{"key":"ref41","first-page":"515","article-title":"Sensorimotor network rewiring in mild cognitive impairment and alzheimer\u2019s disease. Hum Brain Mapp","volume":"31","author":"F Agosta","year":"2010"},{"key":"ref42","first-page":"1860","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2019s disease. J Neurosci","volume":"29","author":"RL Buckner","year":"2009"},{"key":"ref43","first-page":"3217","article-title":"Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control. J Neurosci","volume":"31","author":"R Leech","year":"2011"},{"key":"ref44","unstructured":"Verhage F (1964) Intelligence and Age: Study With Dutch People Aged 12 to 77 [in Dutch]. van Gorcum, Assen."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T12:09:18Z","timestamp":1565698158000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102995"}},"subtitle":[],"editor":[{"given":"Huafu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102995","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}