{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:45:43Z","timestamp":1791276343199,"version":"4.1.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0103229","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T16:25:12Z","timestamp":1406737512000},"page":"e103229","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Inhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells"],"prefix":"10.1371","volume":"9","author":[{"given":"Ya-Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tsau","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"T Kisseleva","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"167sr161","DOI":"10.1126\/scitranslmed.3004700","article-title":"Therapy for fibrotic diseases: nearing the starting line","volume":"5","author":"SL Friedman","year":"2013","journal-title":"Sci Transl Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-12-385233-5.00006-4","article-title":"Fibrosis in the liver: acute protection and chronic disease","volume":"97","author":"Y Lee","year":"2010","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0022-2275(20)32030-7","article-title":"An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro","volume":"41","author":"S Vogel","year":"2000","journal-title":"J Lipid Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"9230","DOI":"10.1073\/pnas.1206645109","article-title":"Fibrogenic cell reversion underlies fibrosis regression in liver","volume":"109","author":"SL Friedman","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"JS Troeger","year":"2012","journal-title":"Gastroenterology"},{"key":"ref7","first-page":"361","article-title":"Molecular Pathogenesis of Liver Fibrosis","volume":"120","author":"DA Brenner","year":"2009","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"T Kawai","year":"2011","journal-title":"Immunity"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1152\/ajpgi.00537.2010","article-title":"Innate immunity in alcoholic liver disease","volume":"300","author":"B Gao","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"E Seki","year":"2008","journal-title":"Hepatology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.it.2012.05.002","article-title":"Dissecting negative regulation of Toll-like receptor signaling","volume":"33","author":"T Kondo","year":"2012","journal-title":"Trends Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MNH.0b013e328344c3d4","article-title":"Mechanisms of fibrosis: The role of the pericyte","volume":"20","author":"C Schrimpf","year":"2011","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2009.06.020","article-title":"Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication","volume":"51","author":"B Wang","year":"2009","journal-title":"J Hepatol"},{"key":"ref14","first-page":"1509","article-title":"Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice","volume":"35","author":"S Inokuchi","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","article-title":"Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells","volume":"37","author":"YH Paik","year":"2003","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-\u03b2 signaling and hepatic fibrosis","volume":"13","author":"E Seki","year":"2007","journal-title":"Nature Medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"L Zhou","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11373-004-8167-7","article-title":"Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats","volume":"12","author":"YC Hsu","year":"2005","journal-title":"J Biomed Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00432-009-0566-8","article-title":"Herbal extract &quot;Songyou Yin&quot; inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential","volume":"135","author":"XY Huang","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.3390\/molecules18022122","article-title":"PF2401-SF, standardized fraction of Salvia miltiorrhiza, induces apoptosis of activated hepatic stellate cells in vitro and in vivo","volume":"6","author":"DR Parajuli","year":"2013","journal-title":"Molecules"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jcb.1176","article-title":"Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells","volume":"82","author":"YH Chen","year":"2001","journal-title":"J Cell Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1254\/jphs.91.202","article-title":"Protective mechanism of salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats","volume":"91","author":"TY Lee","year":"2003","journal-title":"J Pharmacol Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jep.2005.10.021","article-title":"In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells","volume":"21","author":"YL Lin","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1055\/s-2003-45157","article-title":"Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells","volume":"69","author":"SI Jang","year":"2003","journal-title":"Planta Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.lfs.2003.07.035","article-title":"Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL\/6J but not in DBA\/2J mice","volume":"74","author":"YF Ueng","year":"2004","journal-title":"Life Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1211\/jpp.58.4.0012","article-title":"Induction of cytochrome P450-dependent monooxygenase by extracts of the medicinal herb Salvia miltiorrhiza","volume":"58","author":"YH Kuo","year":"2006","journal-title":"J Pharm Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1440-1746.2006.04361.x","article-title":"Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis","volume":"22","author":"YC Hsu","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1478-3231.2011.02485.x","article-title":"Kaerophyllin inhibits hepatic stellate cell activation by apoptotic bodies from hepatocytes","volume":"31","author":"TF Lee","year":"2011","journal-title":"Liver Int"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/ptr.3539","article-title":"Effects of armepavine against hepatic fibrosis induced by thioacetamide in rats","volume":"26","author":"TC Weng","year":"2012","journal-title":"Phytother Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.2353\/ajpath.2007.060887","article-title":"Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells","volume":"170","author":"E Novo","year":"2007","journal-title":"Am J Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jep.2013.08.049","article-title":"Scutellariae radix suppresses LPS-induced liver endothelial cell activation and inhibits hepatic stellate cell migration","volume":"150","author":"HJ Chen","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1440-1746.2008.05573.x","article-title":"Effects of rhubarb on migration of rat hepatic stellate cells","volume":"24","author":"YL Lin","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"M Cargnello","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"G18","DOI":"10.1152\/ajpgi.00336.2003","article-title":"Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells","volume":"287","author":"F Marra","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1478-811X-11-68","article-title":"AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma","volume":"11","author":"CJ Hsu","year":"2013","journal-title":"Cell Commun Signal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.4049\/jimmunol.0901564","article-title":"Ethanol augments RANTES\/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1","volume":"183","author":"SM Yeligar","year":"2009","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1242\/jcs.01481","article-title":"MAP kinases and cell migration","volume":"117","author":"C Huang","year":"2004","journal-title":"J Cell Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1113\/jphysiol.2011.219691","article-title":"Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut","volume":"590","author":"E Seki","year":"2012","journal-title":"J Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"O Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"240365","DOI":"10.1155\/2010\/240365","article-title":"Current views of toll-like receptor signaling pathways","volume":"2010","author":"M Yamamoto","year":"2010","journal-title":"Gastroenterol Res Pract"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ni.1819","article-title":"Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines","author":"PH Tseng","year":"2010","journal-title":"Nat Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pharmthera.2007.09.008","article-title":"Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion","volume":"117","author":"JY Han","year":"2008","journal-title":"Pharmacol Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1749-8546-4-16","article-title":"Chinese medicines as a resource for liver fibrosis treatment","volume":"4","author":"Y Feng","year":"2009","journal-title":"Chin Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/BF02975887","article-title":"Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells","volume":"27","author":"HS Choi","year":"2004","journal-title":"Arch Pharm Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e40165","DOI":"10.1371\/journal.pone.0040165","article-title":"Neuroprotection of tanshinone IIA against cerebral ischemia\/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats","volume":"7","author":"Y Chen","year":"2012","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s10875-008-9206-3","article-title":"Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma\/STAT1 pathways","volume":"28","author":"Y Xu","year":"2008","journal-title":"J Clin Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12272-001-1209-2","article-title":"Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease","volume":"31","author":"HQ Yin","year":"2008","journal-title":"Arch Pharm Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1124\/jpet.111.190736","article-title":"Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities","volume":"341","author":"Y Joe","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"ref49","first-page":"1858","article-title":"CCR1 and CCR5 promote hepatic fibrosis in mice","volume":"119","author":"E Seki","year":"2009","journal-title":"J Clin Invest 2009 Jul;119(7):1858-70"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2174\/187152811798104890","article-title":"Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis","volume":"10","author":"HW Zimmermann","year":"2011","journal-title":"Inflamm Allergy Drug Targets"},{"key":"ref51","first-page":"1060","article-title":"The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C","volume":"125","author":"A Bonacchi","year":"2003","journal-title":"Gastroenterology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jsbmb.2009.01.011","article-title":"The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS","volume":"113","author":"GW Fan","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ni1014","article-title":"Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3","volume":"5","author":"Q Huang","year":"2004","journal-title":"Nat Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1470-2045(12)70582-X","article-title":"Cytokine patterns in patients with cancer: a systematic review","volume":"14","author":"BE Lippitz","year":"2013","journal-title":"Lancet Oncol"},{"key":"ref55","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells","author":"JP Pradere","year":"2013","journal-title":"Hepatology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fphys.2012.00069","article-title":"Cytokines and STATs in Liver Fibrosis","volume":"3","author":"X Kong","year":"2012","journal-title":"Front Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0103229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T13:37:36Z","timestamp":1717162656000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0103229"}},"subtitle":[],"editor":[{"given":"Wenyu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0103229","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,30]]}}}