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Matsumoto","year":"2008","journal-title":"Biochemistry"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12104-012-9365-2","article-title":"(1)H, (15)N and (13)C assignments of the calcium bound S100P","volume":"7","author":"SR Penumutchu","year":"2013","journal-title":"Biomol NMR Assign"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1021\/bi00471a022","article-title":"A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. 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Journal of Cellular Biochemistry: 254\u2013254."},{"key":"ref55","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1073\/pnas.0501459102","article-title":"Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor","volume":"102","author":"MR Fernandez-Fernandez","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0079-6565(00)00020-0","article-title":"Isotope-filtered NMR methods for the study of biomolecular structure and interactions","volume":"36","author":"AL Breeze","year":"2000","journal-title":"Progress in Nuclear Magnetic Resonance Spectroscopy"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nprot.2010.32","article-title":"The HADDOCK web server for data-driven biomolecular docking","volume":"5","author":"SJ de Vries","year":"2010","journal-title":"Nat Protoc"},{"key":"ref58","unstructured":"Hubbard S, Thornton JM (1993) \u2018{NACCESS}\u2019, {C}omputer {P}rogram, {D}epartment of {B}iochemistry and {M}olecular {B}iology, {U}niversity {C}ollege {L}ondon."},{"key":"ref59","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/prot.10299","article-title":"Refinement of protein structures in explicit solvent","volume":"50","author":"JP Linge","year":"2003","journal-title":"Proteins"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","article-title":"AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR","volume":"8","author":"RA Laskowski","year":"1996","journal-title":"J Biomol NMR"},{"key":"ref61","first-page":"U313","article-title":"Use of PYMOL as a communications tool for molecular science","volume":"228","author":"WL DeLano","year":"2004","journal-title":"Abstracts of Papers of the American Chemical Society"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/meth.1999.0852","article-title":"Isothermal titration calorimetry of protein-protein interactions","volume":"19","author":"MM Pierce","year":"1999","journal-title":"Methods"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1021\/bi00017a015","article-title":"Enthalpy of antibody\u2013cytochrome c binding","volume":"34","author":"CS Raman","year":"1995","journal-title":"Biochemistry"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"40762","DOI":"10.1074\/jbc.M110.169276","article-title":"The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding","volume":"285","author":"H Park","year":"2010","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbamcr.2008.11.016","article-title":"Binding of S100 proteins to RAGE: an update","volume":"1793","author":"E Leclerc","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Lakowicz JR (2006) Principles of Fluorescence Spectroscopy: Principles of Fluorescence Spectroscopy, by J.R.\u223cLakowicz.\u223cISBN 0\u2013387\u201331278\u20131.\u223c Berlin: Springer, 2006.","DOI":"10.1007\/978-0-387-46312-4"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0006-3495(01)76183-8","article-title":"Mechanisms of tryptophan fluorescence shifts in proteins","volume":"80","author":"JT Vivian","year":"2001","journal-title":"Biophys J"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbapap.2011.02.011","article-title":"Binding studies of truncated variants of the Abeta peptide to the V-domain of the RAGE receptor reveal Abeta residues responsible for binding","volume":"1814","author":"E Gospodarska","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ref69","first-page":"7877","article-title":"Structure of the soluble methane monooxygenase regulatory protein B. Proc Natl Acad Sci U S A","volume":"96","author":"KJ Walters","year":"1999"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/protein\/13.3.143","article-title":"NMR study of the differential contributions of residues of transforming growth factor alpha to association with its receptor","volume":"13","author":"C McInnes","year":"2000","journal-title":"Protein Engineering"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0076-6879(94)39023-1","article-title":"Nuclear magnetic resonance measurements of slow conformational dynamics in macromolecules","volume":"239","author":"AN Lane","year":"1994","journal-title":"Methods Enzymol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/jmbi.2001.5126","article-title":"Novel mechanism of regulation of the non-receptor protein tyrosine kinase Csk: insights from NMR mapping studies and site-directed mutagenesis","volume":"314","author":"A Shekhtman","year":"2001","journal-title":"J Mol Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.sbi.2006.01.006","article-title":"NMR studies of protein interactions","volume":"16","author":"K Takeuchi","year":"2006","journal-title":"Curr Opin Struct Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1021\/cb4001553","article-title":"Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction","volume":"8","author":"D Xu","year":"2013","journal-title":"ACS Chemical Biology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbrc.2013.03.049","article-title":"Interaction of the S100A6 mutant (C3S) with the V domain of the receptor for advanced glycation end products (RAGE)","volume":"434","author":"SK Mohan","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein-protein docking approach based on biochemical or biophysical information","volume":"125","author":"C Dominguez","year":"2003","journal-title":"J Am Chem Soc"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1021\/ja028893d","article-title":"Docking of protein-protein complexes on the basis of highly ambiguous intermolecular distance restraints derived from 1H\/15N chemical shift mapping and backbone 15N-1H residual dipolar couplings using conjoined rigid body\/torsion angle dynamics","volume":"125","author":"GM Clore","year":"2003","journal-title":"J Am Chem Soc"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbamcr.2004.09.002","article-title":"Target selectivity in EF-hand calcium binding proteins","volume":"1742","author":"S Bhattacharya","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1021\/cr960387h","article-title":"Protein-protein interactions: interface structure, binding thermodynamics, and mutational analysis","volume":"97","author":"WE Stites","year":"1997","journal-title":"Chemical reviews"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.chembiol.2003.10.009","article-title":"Cooperativity, Partially Bound States, and Enthalpy-Entropy Compensation","volume":"10","author":"CA Hunter","year":"2003","journal-title":"Chemistry & Biology"},{"key":"ref81","first-page":"19581","article-title":"Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. J Biol Chem","volume":"283","author":"FE Reyes-Turcu","year":"2008"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI58642","article-title":"A multimodal RAGE-specific inhibitor reduces amyloid beta-mediated brain disorder in a mouse model of Alzheimer disease","volume":"122","author":"R Deane","year":"2012","journal-title":"J Clin Invest"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1042\/bj3380583","article-title":"Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family","volume":"3)","author":"T Shishibori","year":"1999","journal-title":"Biochem J 338 (Pt"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/cmdc.200700096","article-title":"Fragment docking to s100 proteins reveals a wide diversity of weak interaction sites","volume":"2","author":"Y Arendt","year":"2007","journal-title":"Chemmedchem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1021\/jm0497038","article-title":"Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction","volume":"47","author":"J Markowitz","year":"2004","journal-title":"Journal of Medicinal Chemistry"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 proteins","volume":"13","author":"R Donato","year":"2013","journal-title":"Curr Mol Med"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00726-010-0496-4","article-title":"S100P: a novel therapeutic target for cancer","volume":"41","author":"T Arumugam","year":"2011","journal-title":"Amino Acids"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1074\/jbc.M608888200","article-title":"Hexameric calgranulin C (S100A12) binds to the receptor for advanced glycated end products (RAGE) using symmetric hydrophobic target-binding patches","volume":"282","author":"J Xie","year":"2007","journal-title":"J Biol Chem"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10858-012-9661-2","article-title":"NMR structure note: the structure of human calcium-bound S100A11","volume":"54","author":"KW Hung","year":"2012","journal-title":"J Biomol NMR"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0103947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:12:18Z","timestamp":1649855538000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0103947"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Motta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,1]]},"references-count":89,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0103947","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,1]]}}}