{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:04:04Z","timestamp":1781499844986,"version":"3.54.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0104083","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T17:45:45Z","timestamp":1410803145000},"page":"e104083","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Mice"],"prefix":"10.1371","volume":"9","author":[{"given":"Ming-Che","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene P.","family":"Siegal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Desmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1023\/A:1020239211145","article-title":"Obesity, body size, and risk of postmenopausal breast cancer: the Women&apos;s Health Initiative (United States)","volume":"13","author":"LM Morimoto","year":"2002","journal-title":"Cancer Causes Control"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/bmj.39367.495995.AE","article-title":"Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study","volume":"335","author":"GK Reeves","year":"2007","journal-title":"BMJ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/annonc\/mdh222","article-title":"Body mass index as a prognostic feature in operable breast cancer: the International Breast Cancer Study Group experience","volume":"15","author":"G Berclaz","year":"2004","journal-title":"Ann Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1158\/1055-9965.EPI-06-0889","article-title":"Weight gain prior to diagnosis and survival from breast cancer","volume":"16","author":"RJ Cleveland","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1301\/nr.2003.febr.73-76","article-title":"The relationship between obesity and breast cancer risk and mortality","volume":"61","author":"JB Barnett","year":"2003","journal-title":"Nutr Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"EE Calle","year":"2003","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/1097-0142(20010815)92:4<720::AID-CNCR1375>3.0.CO;2-T","article-title":"Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma","volume":"92","author":"JR Daling","year":"2001","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1158\/1055-9965.EPI-07-0051","article-title":"Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures","volume":"16","author":"KW Reeves","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1634\/theoncologist.2010-0227","article-title":"Visceral fat area as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with antiangiogenic agents","volume":"16","author":"S Ladoire","year":"2011","journal-title":"Oncologist"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1007\/s11605-010-1297-5","article-title":"Intra-abdominal fat predicts survival in pancreatic cancer","volume":"14","author":"CJ Balentine","year":"2010","journal-title":"J Gastrointest Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/gut.2009.188946","article-title":"Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer","volume":"59","author":"B Guiu","year":"2010","journal-title":"Gut"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1586\/14779072.6.3.343","article-title":"Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity","volume":"6","author":"HE Bays","year":"2008","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10585-009-9239-x","article-title":"Dietary Stearic acid reduces breast cancer metastasis burden in athymic nude mice","volume":"26","author":"LM Evans","year":"2009","journal-title":"Clin Exp Metastasis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/carcin\/bgr092","article-title":"Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearic acid","volume":"32","author":"C Li","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10520290802451085","article-title":"Immunohistochemistry for the evaluation of neovascularization in tumor xenografts","volume":"83","author":"D Wang","year":"2008","journal-title":"Biotech Histochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1210\/endo.142.8.8293","article-title":"Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells","volume":"142","author":"YM Mu","year":"2001","journal-title":"Endocrinology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0006-291X(03)00449-2","article-title":"Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell","volume":"303","author":"ZH Lu","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00424468","article-title":"Metabolic response to heavy physical exercise before and after a 3-month training period","volume":"41","author":"A Wirth","year":"1979","journal-title":"Eur J Appl Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0003-2697(69)90089-X","article-title":"An improved method for the addition of long chain free fatty acid to protein solutions","volume":"32","author":"AA Spector","year":"1969","journal-title":"Anal Biochem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17958","DOI":"10.1073\/pnas.0506440102","article-title":"Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy","volume":"102","author":"JR Simard","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0031-9384(01)00412-7","article-title":"Nutrient preference and diet-induced adiposity in C57BL\/6ByJ and 129P3\/J mice","volume":"72","author":"AA Bachmanov","year":"2001","journal-title":"Physiol Behav"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1210\/jc.2006-1811","article-title":"Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity","volume":"92","author":"I Harman-Boehm","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1593\/neo.81282","article-title":"Monocyte chemotactic protein 1 promotes lung cancer- induced bone resorptive lesions in vivo","volume":"11","author":"Z Cai","year":"2009","journal-title":"Neoplasia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1158\/1078-0432.CCR-05-1425","article-title":"Correlations between serum monocyte chemotactic protein-1 levels, clinical prognostic factors, and HER-2\/neu vaccine-related immunity in breast cancer patients","volume":"12","author":"ZA Dehqanzada","year":"2006","journal-title":"Clin Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jcb.21911","article-title":"Leptin signaling in breast cancer: an overview","volume":"105","author":"D Cirillo","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"E576","DOI":"10.1152\/ajpendo.00523.2006","article-title":"Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes","volume":"293","author":"W Guo","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1074\/jbc.M610158200","article-title":"Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat","volume":"282","author":"H Sampath","year":"2007","journal-title":"J Biol Chem"},{"key":"ref28","first-page":"159","article-title":"Stearic acid unlike shorter-chain saturated fatty acids is poorly utilized for triacylglycerol synthesis and beta-oxidation in cultured rat hepatocytes","volume":"31","author":"T Pai","year":"1996","journal-title":"Lipids 1996"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2337\/diab.47.8.1365","article-title":"Human preadipocytes display a depot-specific susceptibility to apoptosis","volume":"47","author":"CU Niesler","year":"1998","journal-title":"Diabetes"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/sj.ijo.0801649","article-title":"Adipose depot-specific expression of cIAP2 in human preadipocytes and modulation of expression by serum factors and TNFalpha","volume":"25","author":"CU Niesler","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/cdd.2011.10","article-title":"Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2","volume":"18","author":"M Darding","year":"2011","journal-title":"Cell Death Differ"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1080\/01635580902825597","article-title":"Stearic acid preferentially induces apoptosis in human breast cancer cells","volume":"61","author":"LM Evans","year":"2009","journal-title":"Nutrition and Cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJM198805123181905","article-title":"Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels","volume":"318","author":"A Bonanome","year":"1988","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0026-0495(98)90235-9","article-title":"A high-stearic acid diet does not impair glucose tolerance and insulin sensitivity in healthy women","volume":"47","author":"AM Louheranta","year":"1998","journal-title":"Metabolism"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.ejcn.1601122","article-title":"A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males","volume":"55","author":"FD Kelly","year":"2001","journal-title":"Eur J Clin Nutr"},{"key":"ref36","first-page":"437","article-title":"Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men","volume":"47","author":"PL Zock","year":"1993","journal-title":"Eur J Clin Nutr 1993"},{"key":"ref37","first-page":"148","article-title":"Modulation of mouse mammary tumor growth and linoleic acid enhanced metastasis by oleic acid","volume":"120","author":"DK Buckman","year":"1990","journal-title":"J Nutr 1990"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3945\/ajcn.2009.27661","article-title":"Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review","volume":"91","author":"JE Hunter","year":"2010","journal-title":"Am J Clin Nutr 2010"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0104083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:49:46Z","timestamp":1588970986000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0104083"}},"subtitle":[],"editor":[{"given":"Stefan F.T.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,15]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0104083","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,15]]}}}