{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:56:19Z","timestamp":1792659379915,"version":"4.5.0"},"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0104154","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T21:02:10Z","timestamp":1407186130000},"page":"e104154","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":104,"title":["Osteocyte-Specific Deletion of Fgfr1 Suppresses FGF23"],"prefix":"10.1371","volume":"9","author":[{"given":"Zhousheng","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh Darryl","family":"Quarles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jcb.10606","article-title":"Integrative nuclear FGFR1 signaling (INFS) as a part of a universal \u201cfeed-forward-and-gate\u201d signaling module that controls cell growth and differentiation","volume":"90","author":"MK Stachowiak","year":"2003","journal-title":"J Cell Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/dvdy.21388","article-title":"Functional evolutionary history of the mouse Fgf gene family","volume":"237","author":"N Itoh","year":"2008","journal-title":"Dev Dyn"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-010-1024-2","article-title":"Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease","volume":"342","author":"N Itoh","year":"2010","journal-title":"Cell Tissue Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1006\/bbrc.2000.3696","article-title":"Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain","volume":"277","author":"T Yamashita","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"37419","DOI":"10.1074\/jbc.M304544200","article-title":"Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX","volume":"278","author":"S Liu","year":"2003","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia","volume":"98","author":"T Shimada","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1046\/j.1523-1755.2001.00064.x","article-title":"Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23","volume":"60","author":"KE White","year":"2001","journal-title":"Kidney Int"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1210\/me.2007-0313","article-title":"{beta}Klotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c","volume":"22","author":"M Suzuki","year":"2008","journal-title":"Mol Endocrinol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"T Shimada","year":"2004","journal-title":"J Clin Invest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.00474.2004","article-title":"Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism","volume":"289","author":"T Shimada","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1073\/pnas.0913986107","article-title":"Relevant use of Klotho in FGF19 subfamily signaling system in vivo","volume":"107","author":"K Tomiyama","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1021\/bi960658i","article-title":"Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme","volume":"35","author":"MJ Beckman","year":"1996","journal-title":"Biochemistry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1523-1755.2004.00402.x","article-title":"Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1 alpha-hydroxylase knockout mice","volume":"65","author":"JG Hoenderop","year":"2004","journal-title":"Kidney Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2005111185","article-title":"Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D","volume":"17","author":"S Liu","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1681\/ASN.2007121301","article-title":"FGFR3 and FGFR4 do not mediate renal effects of FGF23","volume":"19","author":"S Liu","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nm0411-428","article-title":"The bone and beyond: \u2018Dem bones\u2019 are made for more than walking","volume":"17","author":"LD Quarles","year":"2011","journal-title":"Nat Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1210\/en.2013-1627","article-title":"Calcium regulates FGF-23 expression in bone","volume":"154","author":"V David","year":"2013","journal-title":"Endocrinology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrendo.2011.218","article-title":"Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism","volume":"8","author":"LD Quarles","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"G1036","DOI":"10.1152\/ajpgi.00243.2005","article-title":"1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport","volume":"289","author":"OI Kolek","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1210\/jc.2008-0220","article-title":"Hypophosphatemia with Elevations in Serum Fibroblast Growth Factor 23 in a Child with Jansen's Metaphyseal Chondrodysplasia","volume":"94","author":"WW Brown","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1681\/ASN.2006070783","article-title":"Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism","volume":"18","author":"T Kawata","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"F882","DOI":"10.1152\/ajprenal.00360.2010","article-title":"PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop","volume":"299","author":"V Lavi-Moshayoff","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0272-6386(04)00817-0","article-title":"Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism","volume":"44","author":"T Sato","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nature05315","article-title":"Klotho converts canonical FGF receptor into a specific receptor for FGF23","volume":"444","author":"I Urakawa","year":"2006","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"M Kuro-o","year":"1997","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1247\/csf.29.91","article-title":"Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice","volume":"29","author":"SA Li","year":"2004","journal-title":"Cell Struct Funct"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1210\/en.2009-0472","article-title":"Bone formation regulates circulating concentrations of fibroblast growth factor 23","volume":"150","author":"R Samadfam","year":"2009","journal-title":"Endocrinology"},{"key":"ref28","first-page":"4003","article-title":"The parathyroid is a target organ for FGF23 in rats","volume":"117","author":"IZ Ben-Dov","year":"2007","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1096\/fj.10-177816","article-title":"Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling","volume":"25","author":"A Martin","year":"2011","journal-title":"FASEB J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/ng1905","article-title":"Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism","volume":"38","author":"JQ Feng","year":"2006","journal-title":"Nat Genet"},{"key":"ref31","first-page":"722","article-title":"Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia","volume":"118","author":"B Yuan","year":"2008","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajhg.2010.01.006","article-title":"Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets","volume":"86","author":"B Lorenz-Depiereux","year":"2010","journal-title":"Am J Hum Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajhg.2010.01.010","article-title":"Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene","volume":"86","author":"V Levy-Litan","year":"2010","journal-title":"Am J Hum Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00002.2011","article-title":"Regulation and Function of the FGF23\/Klotho Endocrine Pathways","volume":"92","author":"A Martin","year":"2012","journal-title":"Physiol Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1086\/427956","article-title":"Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation","volume":"76","author":"KE White","year":"2005","journal-title":"Am J Hum Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1210\/me.2003-0137","article-title":"Thyroid hormone activates fibroblast growth factor receptor-1 in bone","volume":"17","author":"DA Stevens","year":"2003","journal-title":"Mol Endocrinol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jbmr.1721","article-title":"Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23\/FGFR\/MAPK in vitro","volume":"28","author":"L Xiao","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1074\/jbc.M109.030577","article-title":"Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO","volume":"285","author":"L Xiao","year":"2010","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1210\/me.2009-0085","article-title":"Novel regulators of Fgf23 expression and mineralization in Hyp bone","volume":"23","author":"S Liu","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1002\/jbmr.478","article-title":"FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone","volume":"26","author":"S Wohrle","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jbmr.1810","article-title":"Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets","volume":"28","author":"S Wohrle","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e57322","DOI":"10.1371\/journal.pone.0057322","article-title":"Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia","volume":"8","author":"AL Wu","year":"2013","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1177\/154405910708600404","article-title":"DMP1-targeted Cre expression in odontoblasts and osteocytes","volume":"86","author":"Y Lu","year":"2007","journal-title":"J Dent Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1096\/fj.10-180299","article-title":"Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice","volume":"25","author":"Z Xiao","year":"2011","journal-title":"FASEB J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/JOE-10-0308","article-title":"Targeted ablation of the PTH\/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses","volume":"209","author":"WF Powell Jr","year":"2011","journal-title":"J Endocrinol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbmr.1665","article-title":"Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts","volume":"27","author":"SW Kim","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"E38","DOI":"10.1152\/ajpendo.00008.2006","article-title":"Pathogenic role of Fgf23 in Hyp mice","volume":"291","author":"S Liu","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"20307","DOI":"10.1074\/jbc.M401109200","article-title":"Selective deficiency of the \u201cbone-related\u201d Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis","volume":"279","author":"ZS Xiao","year":"2004","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1359\/jbmr.090502","article-title":"Dose-dependent effects of Runx2 on bone development","volume":"24","author":"S Zhang","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1359\/jbmr.080708","article-title":"Impaired energetic metabolism after central leptin signaling leads to massive appendicular bone loss in hindlimb-suspended rats","volume":"23","author":"A Martin","year":"2008","journal-title":"J Bone Miner Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1083\/jcb.96.1.191","article-title":"In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria","volume":"96","author":"H Sudo","year":"1983","journal-title":"J Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/jbmr.5650070613","article-title":"Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development","volume":"7","author":"LD Quarles","year":"1992","journal-title":"J Bone Miner Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1046\/j.1471-4159.2003.01624.x","article-title":"cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1)","volume":"84","author":"EK Stachowiak","year":"2003","journal-title":"J Neurochem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1242\/dev.128.19.3867","article-title":"Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains","volume":"128","author":"Q Wang","year":"2001","journal-title":"Development"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e93840","DOI":"10.1371\/journal.pone.0093840","article-title":"Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic hyp mice","volume":"9","author":"K Miyagawa","year":"2014","journal-title":"PLoS One"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/en.2008-0877","article-title":"Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression","volume":"150","author":"S Ichikawa","year":"2009","journal-title":"Endocrinology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jbmr.544","article-title":"A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells","volume":"27","author":"S Ichikawa","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref58","first-page":"E700","article-title":"Intrinsic mineralization defect in Hyp mouse osteoblasts","volume":"275","author":"ZS Xiao","year":"1998","journal-title":"Am J Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/jcp.21825","article-title":"The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis","volume":"220","author":"LM Haupt","year":"2009","journal-title":"J Cell Physiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-011-9501-5","article-title":"Fibroblast growth factor 23 (FGF23) and alpha-klotho stimulate osteoblastic MC3T3.E1 cell proliferation and inhibit mineralization","volume":"89","author":"V Shalhoub","year":"2011","journal-title":"Calcif Tissue Int"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00018-008-8440-4","article-title":"High molecular weight FGF2: the biology of a nuclear growth factor","volume":"66","author":"K Chlebova","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1158\/0008-5472.CAN-09-4404","article-title":"Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer","volume":"70","author":"AC Pond","year":"2010","journal-title":"Cancer Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"LF Bonewald","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1101\/gad.990702","article-title":"FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease","volume":"16","author":"DM Ornitz","year":"2002","journal-title":"Genes Dev"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ydbio.2006.05.031","article-title":"Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation","volume":"296","author":"AL Jacob","year":"2006","journal-title":"Dev Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1210\/jc.2006-1183","article-title":"A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant normosmic isolated hypogonadotropic hypogonadism","volume":"92","author":"N Xu","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/hmg\/9.13.2001","article-title":"A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures","volume":"9","author":"YX Zhou","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.3390\/ijms14035978","article-title":"Integration of multiple signaling pathways determines differences in the osteogenic potential and tissue regeneration of neural crest-derived and mesoderm-derived calvarial bones","volume":"14","author":"K Senarath-Yapa","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"E254","DOI":"10.1152\/ajpendo.90201.2008","article-title":"Pathogenic role of Fgf23 in Dmp1-null mice","volume":"295","author":"S Liu","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1525-139X.2007.00308.x","article-title":"Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease","volume":"20","author":"J Stubbs","year":"2007","journal-title":"Semin Dial"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1359\/jbmr.090509","article-title":"Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets\/osteomalacia","volume":"24","author":"Y Aono","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/ddt429","article-title":"Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia","volume":"23","author":"YH Lim","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1182\/blood.V94.2.579","article-title":"Regulation of tissue factor pathway inhibitor expression in smooth muscle cells","volume":"94","author":"UR Pendurthi","year":"1999","journal-title":"Blood"},{"key":"ref74","first-page":"6237","article-title":"Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation","volume":"63","author":"KW Freeman","year":"2003","journal-title":"Cancer Res"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jbmr.516","article-title":"Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease","volume":"27","author":"JR Stubbs","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jbmr.1738","article-title":"Hexa-D-arginine treatment increases 7B2*PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype","volume":"28","author":"B Yuan","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref77","article-title":"Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling","author":"A Martin","year":"2011","journal-title":"Faseb J"},{"key":"ref78","article-title":"FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF23 signaling and regulating FGF23 expression in bone","author":"S Wohrle","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1242\/jcs.118596","article-title":"Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells","volume":"126","author":"W Yang","year":"2013","journal-title":"J Cell Sci"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(00)81169-1","article-title":"MMP-9\/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes","volume":"93","author":"TH Vu","year":"1998","journal-title":"Cell"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1242\/dev.00491","article-title":"Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth","volume":"130","author":"K Yu","year":"2003","journal-title":"Development"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"E508","DOI":"10.1152\/ajpendo.00499.2010","article-title":"Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype","volume":"300","author":"H Li","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"F371","DOI":"10.1152\/ajprenal.00740.2010","article-title":"Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4","volume":"301","author":"J Gattineni","year":"2011","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0104154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T15:57:50Z","timestamp":1649865470000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0104154"}},"subtitle":[],"editor":[{"given":"Makoto","family":"Makishima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,4]]},"references-count":83,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0104154","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,4]]}}}