{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:59:04Z","timestamp":1790110744114,"version":"4.0.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0104363","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T17:53:24Z","timestamp":1407866004000},"page":"e104363","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["A Simple Repeat Polymorphism in the MITF-M Promoter Is a Key Regulator of White Spotting in Dogs"],"prefix":"10.1371","volume":"9","author":[{"given":"Izabella","family":"Baranowska K\u00f6rberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R. S.","family":"Meadows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerli","family":"Rosengren Pielberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Hedhammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elinor K.","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Seddon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"S\u00f6derberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Vil\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"\u00c5kesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Lindblad-Toh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"ref1","unstructured":"Montoliu L, Oetting WS, Bennett DC (2011) Color Genes. European Society for Pigment Cell Research: WorldWideWeb(URL:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:--www.espcr.org-micemut\" xlink:type=\"simple\">http:\u2014www.espcr.org-micemut<\/ext-link>)."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-animal-031412-103659","article-title":"Genetics of Pigmentation in Dogs and Cats","volume":"1","author":"CB Kaelin","year":"2013","journal-title":"Annual Review of Animal Biosciences"},{"key":"ref3","unstructured":"Andersson L, Plastow G (2011) The Genetics of the Pig. In: Rothschild MF, Ruvinsky A, editors. Molecular genetics of coat colour variation. Oxon, UK: CAB International. pp. 38\u201350."},{"key":"ref4","unstructured":"Little CC (1957) The inheritance of coat colour in the dogs. Comstock Publishing Associates, Cornell University Press, Ithaca, NY."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1365-2052.2006.01534.x","article-title":"Association of MITF with white spotting in Beagle crosses and Newfoundland dogs","volume":"37","author":"MF Rothschild","year":"2006","journal-title":"Anim Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/ng.2007.10","article-title":"Efficient mapping of mendelian traits in dogs through genome-wide association","volume":"39","author":"EK Karlsson","year":"2007","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/jhered\/esm022","article-title":"Localization of White Spotting Locus in Boxer Dogs on CFA20 by Genome-Wide Linkage Analysis with 1500 SNPs","volume":"98","author":"PA Leegwater","year":"2007","journal-title":"Journal of Heredity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molmed.2006.07.008","article-title":"MITF: master regulator of melanocyte development and melanoma oncogene","volume":"12","author":"C Levy","year":"2006","journal-title":"Trends Mol Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.genet.38.072902.092717","article-title":"Melanocytes and the microphthalmia transcription factor network","volume":"38","author":"E Steingr\u00edmsson","year":"2004","journal-title":"Annu Rev Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tvjl.2008.06.004","article-title":"Identification of microphthalmia-associated transcription factor isoforms in dogs","volume":"182","author":"S Tsuchida","year":"2009","journal-title":"The Veterinary Journal"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng1194-256","article-title":"Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences","volume":"8","author":"E Steingr\u00edmsson","year":"1994","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ng1194-251","article-title":"Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene","volume":"8","author":"M Tassabehji","year":"1994","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/jmg.37.6.446","article-title":"Tietz syndrome (hypopigmentation\/deafness) caused by mutation of MITF","volume":"37","author":"SD Smith","year":"2000","journal-title":"J Med Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1090-0233(03)00104-7","article-title":"Deafness prevalence and pigmentation and gender associations in dog breeds at risk","volume":"167","author":"GM Strain","year":"2004","journal-title":"The Veterinary Journal"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"D842","DOI":"10.1093\/nar\/gkq1008","article-title":"The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics","volume":"39","author":"JA Blake","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1038\/sj.onc.1206443","article-title":"Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival","volume":"22","author":"HR Widlund","year":"2003","journal-title":"Oncogene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1093\/jhered\/esp029","article-title":"MITF and White Spotting in Dogs: A Population Study","volume":"100","author":"SM Schmutz","year":"2009","journal-title":"Journal of Heredity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature11837","article-title":"The genomic signature of dog domestication reveals adaptation to a starch-rich diet","volume":"495","author":"E Axelsson","year":"2013","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e1000341","DOI":"10.1371\/journal.pgen.1000341","article-title":"Contrasting mode of evolution at a coat color locus in wild and domestic pigs","volume":"5","author":"M Fang","year":"2009","journal-title":"PLoS Genet"},{"key":"ref20","unstructured":"Forster ES, Heffner, EH (translators) (1968) Lucius Junius Moderatus Columella on agriculture. Vol. II. Loeb Classical Library No. 407. Heinemann, London."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.gde.2013.02.014","article-title":"Molecular consequences of animal breeding","volume":"23","author":"L Andersson","year":"2013","journal-title":"Curr Opin Genet Dev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9882","DOI":"10.1074\/jbc.M508364200","article-title":"Stereochemical analysis of the functional significance of the conserved inverted CCAAT and TATA elements in the rat bone sialoprotein gene promoter","volume":"281","author":"M Su","year":"2006","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"29060","DOI":"10.1074\/jbc.272.46.29060","article-title":"GA-binding protein-dependent transcription initiator elements. Effect of helical spacing between polyomavirus enhancer a factor 3(PEA3)\/Ets-binding sites on initiator activity","volume":"272","author":"M Yu","year":"1997","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/hmg\/ddg107","article-title":"Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer","volume":"12","author":"D Lang","year":"2003","journal-title":"Human Molecular Genetics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1002653","DOI":"10.1371\/journal.pgen.1002653","article-title":"Mutations in MITF and PAX3 cause \u201csplashed white\u201d and other white spotting phenotypes in horses","volume":"8","author":"R Hauswirth","year":"2012","journal-title":"PLoS Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"28787","DOI":"10.1074\/jbc.M203719200","article-title":"Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1","volume":"277","author":"H Saito","year":"2002","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.gde.2010.01.004","article-title":"Genomic gems: SINE RNAs regulate mRNA production","volume":"20","author":"SL Ponicsan","year":"2010","journal-title":"Curr Opin Genet Dev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1101\/gr.1976004","article-title":"Regulatory potential scores from genome-wide three-way alignments of human, mouse, and rat","volume":"14","author":"D Kolbe","year":"2004","journal-title":"Genome Research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1101\/gr.3642605","article-title":"Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences","volume":"15","author":"DC King","year":"2005","journal-title":"Genome Research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.4049\/jimmunol.153.3.1225","article-title":"Loss of HLA haplotype and B locus down-regulation in melanoma cell lines","volume":"153","author":"FM Marincola","year":"1994","journal-title":"J Immunol"},{"key":"ref31","first-page":"79","article-title":"Experimental Design: Procedures for the Behavioral Sciences","author":"RE Kirk","year":"1982","journal-title":"Brooks\/Cole"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/mpev.2000.0792","article-title":"Median networks: speedy construction and greedy reduction, one simulation, and two case studies from human mtDNA","volume":"16","author":"HJ Bandelt","year":"2000","journal-title":"Mol Phylogenet Evol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0104363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T22:24:32Z","timestamp":1689459872000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0104363"}},"subtitle":[],"editor":[{"given":"William J.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,12]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0104363","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,12]]}}}