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Determination after enzymatic hydrolysis. In: Bergmeyer HU, editor. New York: Academic Press. pp. 1831\u20131835.","DOI":"10.1016\/B978-0-12-091304-6.50036-7"},{"key":"ref28","unstructured":"Gutmann I, Bergmeyer HU (1974) Determination of urea with glutamate dehydrogenase as indicator enzyme. In: Bergmeyer HU, editor. Methods in Enzymatic Analysis (vol 4). New York: Academic Press. pp. 1794\u20131798."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0009-2797(93)90081-9","article-title":"Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin","volume":"88","author":"MC Lans","year":"1993","journal-title":"Chem Biol Interact"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/endo.132.4.8462469","article-title":"A supersensitive immunofluorometric assay for rat luteinizing hormone","volume":"132","author":"AM Haavisto","year":"1993","journal-title":"Endocrinology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1095\/biolreprod62.4.886","article-title":"Development of time-resolved immunofluorometric assays for rat follicle-stimulating hormone and luteinizing hormone and application on sera of cycling rats","volume":"62","author":"JI van Casteren","year":"2000","journal-title":"Biol Reprod"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00204-003-0457-8","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the endogenous metabolism of all-trans-retinoic acid in the rat","volume":"77","author":"CK Schmidt","year":"2003","journal-title":"Arch Toxicol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S8756-3282(98)00076-3","article-title":"Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia","volume":"23","author":"T J\u00e4ms\u00e4","year":"1998","journal-title":"Bone"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1359\/jbmr.1999.14.10.1708","article-title":"Femoral neck is a sensitive indicator of bone loss in immobilized hind limb of mouse","volume":"14","author":"T J\u00e4ms\u00e4","year":"1999","journal-title":"J Bone Miner Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0920-1211(01)00308-4","article-title":"The acute effect of valproate on cerebral energy metabolism in mice","volume":"47","author":"CU Johannessen","year":"2001","journal-title":"Epilepsy Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00004647-199711000-00012","article-title":"Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate","volume":"17","author":"B Hassel","year":"1997","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"PK Smith","journal-title":"Anal Biochem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-8993(91)90753-I","article-title":"Biochemical characterization of the intramembrane interaction between neurotensin and dopamine D2 receptors in the rat brain","volume":"561","author":"G von Euler","year":"1991","journal-title":"Brain Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1471-4159.1994.62010282.x","article-title":"Postmortem stability of monoamines, their metabolites, and receptor binding in rat brain regions","volume":"62","author":"PJ Kontur","year":"1994","journal-title":"J Neurochem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2605.2011.01233.x","article-title":"Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta","volume":"35","author":"HE Virtanen","year":"2012","journal-title":"Int J Androl"},{"key":"ref41","volume":"170","unstructured":"WHO. International Programme on Chemical Safety (1994) Assessing human health risks of chemicals: Derivation of guidance values for health-based exposure limits. Environmental Health Criteria <volume>170<\/volume>.."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/taap.2002.9353","article-title":"The polychlorinated biphenyl mixture Aroclor 1254 induces death of rat cerebellar granule cells: The involvement of the N-methyl-D-aspartate receptor and reactive oxygen species","volume":"179","author":"E Mariussen","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2013.05.034","article-title":"Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes","volume":"272","author":"M G\u00e4hrs","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 world health organization reevaluation of human and mammalian toxic 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Rice","year":"1998","journal-title":"Neurotoxicol Teratol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1289\/ehp.6173","article-title":"Prenatal PCB exposure, the corpus callosum, and response inhibition","volume":"111","author":"P Stewart","year":"2003","journal-title":"Environ Health Perspect"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0892-0362(98)00038-5","article-title":"Behavioral effects following single and combined maternal exposure to PCB 77 (3,4,3\u2032,4\u2032-tetrachlorobiphenyl) and PCB 47 (2,4,2\u2032,4\u2032-tetrachlorobiphenyl) in rats","volume":"21","author":"J Hany","year":"1999","journal-title":"Neurotoxicol Teratol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/syn.20934","article-title":"Lactational and postnatal exposure to polychlorinated biphenyls induces sex-specific anxiolytic behavior and cognitive deficit in mice offspring","volume":"65","author":"YH 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Design, general observations, hematology, and liver concentrations","volume":"151","author":"M Viluksela","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2605.2007.00857.x","article-title":"Thyroid disrupting chemicals: Mechanisms and mixtures","volume":"31","author":"KM Crofton","year":"2008","journal-title":"Int J Androl"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1289\/ehp.0800247","article-title":"Thyroid-disrupting chemicals: Interpreting upstream biomarkers of adverse outcomes","volume":"117","author":"MD Miller","year":"2009","journal-title":"Environ Health Perspect"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/074823379801400107","article-title":"Interactions of persistent environmental organohalogens with the thyroid hormone system: Mechanisms and possible consequences for animal and human health","volume":"14","author":"A Brouwer","year":"1998","journal-title":"Toxicol Ind Health"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1530\/eje.1.02128","article-title":"Environmental chemicals and thyroid function","volume":"154","author":"M Boas","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/taap.1999.8826","article-title":"Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein","volume":"162","author":"KR Chauhan","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1021\/es2016389","article-title":"Blood plasma sample preparation method for the assessment of thyroid hormone-disrupting potency in effect-directed analysis","volume":"45","author":"E Simon","year":"2011","journal-title":"Environ Sci Technol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"8902","DOI":"10.1021\/es401696u","article-title":"Effect-directed analysis to explore the polar bear exposome: Identification of thyroid hormone disrupting compounds in plasma","volume":"47","author":"E Simon","year":"2013","journal-title":"Environ Sci Technol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0009-2797(94)03347-1","article-title":"Metabolism and biochemical effects of 3,3\u2032,4,4\u2032-tetrachlorobiphenyl in pregnant and fetal rats","volume":"95","author":"DC Morse","year":"1995","journal-title":"Chem Biol Interact"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/taap.1996.0034","article-title":"Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254)","volume":"136","author":"DC Morse","year":"1996","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.chemosphere.2007.09.064","article-title":"Polychlorinated biphenyls (PCBs) and hydroxy-PCBs in adipose tissue of women in southeast Spain","volume":"71","author":"MF Fernandez","year":"2008","journal-title":"Chemosphere"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ijheh.2009.04.005","article-title":"Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York state anglers","volume":"212","author":"MS Bloom","year":"2009","journal-title":"Int J Hyg Environ Health"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1289\/ehp.0900611","article-title":"Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in eastern Slovakia","volume":"117","author":"HY Park","year":"2009","journal-title":"Environ Health Perspect"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"OECD (2006) Detailed review paper on thyroid hormone disruption assays. OECD series on testing and assessment. 57.","DOI":"10.1787\/a17a1437-en"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1289\/ehp.8195","article-title":"Thyroid-hormone-disrupting chemicals: Evidence for dose-dependent additivity or synergism","volume":"113","author":"KM Crofton","year":"2005","journal-title":"Environ Health Perspect"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.envint.2007.12.024","article-title":"Disruption of retinoid transport, metabolism and signaling by environmental pollutants","volume":"34","author":"J Novak","year":"2008","journal-title":"Environ Int"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00018-010-0268-z","article-title":"From carrot to clinic: An overview of the retinoic acid signaling pathway","volume":"67","author":"M Theodosiou","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/faat.1995.1099","article-title":"Toxicity of PCB 77 (3,3\u2032,4,4\u2032-tetrachlorobiphenyl) and PCB 118 (2,3\u2032,4,4\u20325-pentachlorobiphenyl) in the rat following subchronic dietary exposure","volume":"26","author":"I Chu","year":"1995","journal-title":"Fundam Appl Toxicol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/toxsci\/kfi183","article-title":"Altered retinoid metabolism in female Long-Evans and Han\/Wistar rats following long-term 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treatment","volume":"86","author":"N Fletcher","year":"2005","journal-title":"Toxicol Sci"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1111\/j.1742-4658.2009.07023.x","article-title":"The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo","volume":"276","author":"JP Schuchardt","year":"2009","journal-title":"FEBS J"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s002040000208","article-title":"Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice","volume":"75","author":"S Hallgren","year":"2001","journal-title":"Arch Toxicol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2014.04.021","article-title":"Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring","volume":"229","author":"J Esteban","year":"2014","journal-title":"Toxicol Lett"},{"key":"ref87","first-page":"2835","article-title":"Aryl hydrocarbon receptor knockout mice (AHR-\/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism","volume":"57","author":"F Andreola","year":"1997","journal-title":"Cancer Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00204-004-0626-4","article-title":"Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice","volume":"79","author":"N Nishimura","year":"2005","journal-title":"Arch Toxicol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/138920011795016881","article-title":"Role of retinoids, rexinoids and thyroid hormone in the expression of cytochrome P450 enzymes","volume":"12","author":"J Brtko","year":"2011","journal-title":"Curr Drug Metab"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cbi.2009.09.004","article-title":"Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells","volume":"182","author":"L Al-Anati","year":"2009","journal-title":"Chem Biol 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