{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:55:34Z","timestamp":1792079734498,"version":"4.4.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0104691","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T13:59:39Z","timestamp":1407851979000},"page":"e104691","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Failed Stabilization for Long-Term Potentiation in the Auditory Cortex of Fmr1 Knockout Mice"],"prefix":"10.1371","volume":"9","author":[{"given":"Sungchil","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunggu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Kirkwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowen","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0968-0004(03)00033-1","article-title":"New insights into fragile X syndrome: from molecules to neurobehaviors","volume":"28","author":"P Jin","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuron.2010.01.024","article-title":"Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice","volume":"65","author":"EG Harlow","year":"2010","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mcn.2007.01.001","article-title":"Developmental synaptic plasticity at the thalamocortical input to barrel cortex: mechanisms and roles","volume":"34","author":"MI Daw","year":"2007","journal-title":"Mol Cell Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"MF Bear","year":"2004","journal-title":"Trends Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15616","DOI":"10.1523\/JNEUROSCI.3888-10.2010","article-title":"Hypersensitivity to mGluR5 and ERK1\/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome","volume":"30","author":"EK Osterweil","year":"2010","journal-title":"J Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1300\/J006v28n01_06","article-title":"Developmental trajectories and correlates of sensory processing in young boys with fragile X syndrome","volume":"28","author":"GT Baranek","year":"2008","journal-title":"Phys Occup Ther Pediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-8993(01)03309-1","article-title":"Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome","volume":"927","author":"DM Nielsen","year":"2002","journal-title":"Brain Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0306-4522(01)00036-7","article-title":"Fragile X mice develop sensory hyperreactivity to auditory stimuli","volume":"103","author":"L Chen","year":"2001","journal-title":"Neuroscience"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.0.CO;2-K","article-title":"Electrodermal responses to sensory stimuli in individuals with fragile X syndrome: a preliminary report","volume":"83","author":"LJ Miller","year":"1999","journal-title":"Am J Med Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2007.12.001","article-title":"Correction of fragile X syndrome in mice","volume":"56","author":"G Dolen","year":"2007","journal-title":"Neuron"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1073\/pnas.0610875104","article-title":"Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice","volume":"104","author":"BM Wilson","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"15686","DOI":"10.1523\/JNEUROSCI.3246-12.2013","article-title":"Impaired Critical Period Plasticity in Primary Auditory Cortex of Fragile X Model Mice","volume":"33","author":"H Kim","year":"2013","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1126\/science.8502997","article-title":"Common forms of synaptic plasticity in the hippocampus and neocortex in vitro","volume":"260","author":"A Kirkwood","year":"1993","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/375328a0","article-title":"Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience","volume":"375","author":"A Kirkwood","year":"1995","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"11433","DOI":"10.1523\/JNEUROSCI.4084-05.2005","article-title":"Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex","volume":"25","author":"SY Choi","year":"2005","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1523\/JNEUROSCI.4500-12.2013","article-title":"Thalamocortical long-term potentiation becomes gated after the early critical period in the auditory cortex","volume":"33","author":"S Chun","year":"2013","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/375325a0","article-title":"A critical period for long-term potentiation at thalamocortical synapses","volume":"375","author":"MC Crair","year":"1995","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"9648","DOI":"10.1523\/JNEUROSCI.2655-07.2007","article-title":"Sequential development of long-term potentiation and depression in different layers of the mouse visual cortex","volume":"27","author":"B Jiang","year":"2007","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nrn1787","article-title":"Critical period plasticity in local cortical circuits","volume":"6","author":"TK Hensch","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.1072699","article-title":"Reactivation of ocular dominance plasticity in the adult visual cortex","volume":"298","author":"T Pizzorusso","year":"2002","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1523\/JNEUROSCI.12-12-04651.1992","article-title":"Nerve growth factor (NGF) prevents the shift in ocular dominance distribution of visual cortical neurons in monocularly deprived rats","volume":"12","author":"L Maffei","year":"1992","journal-title":"J Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/nn.2882","article-title":"A critical period for auditory thalamocortical connectivity","volume":"14","author":"TR Barkat","year":"2011","journal-title":"Nat Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1126\/science.1115807","article-title":"Map plasticity in somatosensory cortex","volume":"310","author":"DE Feldman","year":"2005","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.282.5393.1504","article-title":"Local GABA circuit control of experience-dependent plasticity in developing visual cortex","volume":"282","author":"TK Hensch","year":"1998","journal-title":"Science"},{"key":"ref25","article-title":"Impaired Development and Competitive Refinement of the Cortical Frequency Map in Tumor Necrosis Factor-alpha-Deficient Mice","author":"S Yang","year":"2013","journal-title":"Cereb Cortex"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1073\/pnas.0607177104","article-title":"Developmental hearing loss eliminates long-term potentiation in the auditory cortex","volume":"104","author":"VC Kotak","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0304-3940(94)90594-0","article-title":"Long-term potentiation in the auditory cortex of adult rats","volume":"171","author":"M Kudoh","year":"1994","journal-title":"Neurosci Lett"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00241370","article-title":"Long-term potentiation of supragranular pyramidal outputs in the rat auditory cortex","volume":"110","author":"M Kudoh","year":"1996","journal-title":"Exp Brain Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1523\/JNEUROSCI.3227-06.2007","article-title":"Critical period window for spectral tuning defined in the primary auditory cortex (A1) in the rat","volume":"27","author":"E de Villers-Sidani","year":"2007","journal-title":"J Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.neuron.2010.02.019","article-title":"Monaural deprivation disrupts development of binaural selectivity in auditory midbrain and cortex","volume":"65","author":"MV Popescu","year":"2010","journal-title":"Neuron"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1038\/ncomms3547","article-title":"Brief hearing loss disrupts binaural integration during two early critical periods of auditory cortex development","volume":"4","author":"DB Polley","year":"2013","journal-title":"Nat Commun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1523\/JNEUROSCI.5311-08.2009","article-title":"Feature-dependent sensitive periods in the development of complex sound representation","volume":"29","author":"MN Insanally","year":"2009","journal-title":"J Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nn1667","article-title":"Neuronal activity determines the protein synthesis dependence of long-term potentiation","volume":"9","author":"R Fonseca","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0006-8993(88)90008-X","article-title":"Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro","volume":"452","author":"U Frey","year":"1988","journal-title":"Brain Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"10263","DOI":"10.1523\/JNEUROSCI.1125-10.2010","article-title":"Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b","volume":"30","author":"JG Strumbos","year":"2010","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuron.2013.11.023","article-title":"Crossmodal induction of thalamocortical potentiation leads to enhanced information processing in the auditory cortex","volume":"81","author":"E Petrus","year":"2014","journal-title":"Neuron"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nn1941","article-title":"Early experience impairs perceptual discrimination","volume":"10","author":"YK Han","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1523\/JNEUROSCI.3166-12.2013","article-title":"Perceptual and neuronal boundary learned from higher-order stimulus probabilities","volume":"33","author":"H Kover","year":"2013","journal-title":"J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/TLD.0b013e3181a72016","article-title":"Language Development in Individuals with Fragile X Syndrome","volume":"29","author":"LH Finestack","year":"2009","journal-title":"Top Lang Disord"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2165\/00023210-200418110-00001","article-title":"Neuropsychiatric symptoms of fragile X syndrome: pathophysiology and pharmacotherapy","volume":"18","author":"JA Tsiouris","year":"2004","journal-title":"CNS Drugs"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0104691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T17:13:14Z","timestamp":1565716394000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0104691"}},"subtitle":[],"editor":[{"given":"Li I.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,12]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0104691","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,12]]}}}