{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:10:26Z","timestamp":1773411026856,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0104703","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T18:43:09Z","timestamp":1408128189000},"page":"e104703","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Novel Compound NSC745885 Exerts an Anti-Tumor Effect on Tongue Cancer SAS Cells In Vitro and In Vivo"],"prefix":"10.1371","volume":"9","author":[{"given":"Yuan-Wu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu-Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Shing","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Hsing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shing-Hwa","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dueng-Yuan","family":"Hueng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey-Kang","family":"Sytwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gu-Jiun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/hed.20275","article-title":"Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature","volume":"27","author":"M Pentenero","year":"2005","journal-title":"Head Neck"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/path.1640","article-title":"Genome-wide profiling of oral squamous cell carcinoma","volume":"204","author":"YJ Chen","year":"2004","journal-title":"J Pathol"},{"key":"ref4","first-page":"577","article-title":"Nonsquamous cell malignant tumours of the oral cavity: an overview","volume":"69","author":"T Daley","year":"2003","journal-title":"J Can Dent Assoc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2982","article-title":"The molecular biology of head and neck cancer","volume":"11","author":"CR Leemans","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref6","first-page":"2307","article-title":"The pathogenetic mechanism of anthracycline-induced palmar-plantar erythrodysesthesia","volume":"29","author":"A Martschick","year":"2009","journal-title":"Anticancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0006-2952(98)00307-4","article-title":"A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin","volume":"57","author":"DA Gewirtz","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"ref8","first-page":"1845","article-title":"Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells","volume":"53","author":"YH Ling","year":"1993","journal-title":"Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0006-2952(93)90512-U","article-title":"Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells","volume":"46","author":"A Skladanowski","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.6093249","article-title":"Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II","volume":"226","author":"KM Tewey","year":"1984","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"11293","DOI":"10.1021\/bi971475e","article-title":"Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin","volume":"36","author":"J Vasquez-Vivar","year":"1997","journal-title":"Biochemistry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"35509","DOI":"10.1074\/jbc.M205477200","article-title":"Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction","volume":"277","author":"LW Elmore","year":"2002","journal-title":"J Biol Chem"},{"key":"ref13","first-page":"343","article-title":"Telomerase activity, expression of Bcl-2 and cell cycle regulation in doxorubicin resistant gastric carcinoma cell lines","volume":"11","author":"KA Yoon","year":"2003","journal-title":"Int J Mol Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"G Minotti","year":"2004","journal-title":"Pharmacol Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1001\/jama.1991.03470120074036","article-title":"Cardiac toxicity 4 to 20 years after completing anthracycline therapy","volume":"266","author":"LJ Steinherz","year":"1991","journal-title":"JAMA"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1177\/002215540205001008","article-title":"Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy","volume":"50","author":"K Meissner","year":"2002","journal-title":"J Histochem Cytochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1568011033353434","article-title":"Cardiac toxicity of antineoplastic anthracyclines","volume":"3","author":"R Zucchi","year":"2003","journal-title":"Curr Med Chem Anticancer Agents"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1016\/j.bmc.2009.09.033","article-title":"Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues","volume":"17","author":"HS Huang","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3835(97)00234-6","article-title":"Alteration of proto-oncogenes during apoptosis in the oral squamous cell carcinoma cell line, SAS, induced by staurosporine","volume":"118","author":"Y Abiko","year":"1997","journal-title":"Cancer Lett"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.canlet.2004.09.048","article-title":"Cytotoxicity of phenolic acid phenethyl esters on oral cancer cells","volume":"223","author":"YT Lee","year":"2005","journal-title":"Cancer Lett"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/227168a0","article-title":"Characteristics of a human diploid cell designated MRC-5","volume":"227","author":"JP Jacobs","year":"1970","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/379349a0","article-title":"Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes","volume":"379","author":"P Liston","year":"1996","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/40901","article-title":"X-linked IAP is a direct inhibitor of cell-death proteases","volume":"388","author":"QL Deveraux","year":"1997","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/A:1011379307472","article-title":"XIAP: apoptotic brake and promising therapeutic target","volume":"6","author":"M Holcik","year":"2001","journal-title":"Apoptosis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e31601","DOI":"10.1371\/journal.pone.0031601","article-title":"XIAP is a predictor of cisplatin-based chemotherapy response and prognosis for patients with advanced head and neck cancer","volume":"7","author":"XH Yang","year":"2012","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"DB Longley","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.biocel.2011.08.006","article-title":"Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin","volume":"43","author":"YL Chang","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"ref28","first-page":"200","article-title":"The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy","volume":"34","author":"MC de Almagro","year":"2012","journal-title":"Exp Oncol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.bi.65.070196.002005","article-title":"Telomere length regulation","volume":"65","author":"CW Greider","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00280-010-1441-7","article-title":"Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation","volume":"67","author":"H Bugger","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e28335","DOI":"10.1371\/journal.pone.0028335","article-title":"Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo","volume":"6","author":"Y Xu","year":"2011","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.yjmcc.2011.05.010","article-title":"Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy","volume":"51","author":"GC van Almen","year":"2011","journal-title":"J Mol Cell Cardiol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0113703","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0104703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:54:42Z","timestamp":1589025282000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0104703"}},"subtitle":[],"editor":[{"given":"Arianna L.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,15]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0104703","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0113703","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,15]]}}}