{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:52:57Z","timestamp":1768809177859,"version":"3.49.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0104736","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T22:14:20Z","timestamp":1407968060000},"page":"e104736","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["CCR5 Controls Immune and Metabolic Functions during Toxoplasma gondii Infection"],"prefix":"10.1371","volume":"9","author":[{"given":"Giuliano","family":"Bonf\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Benevides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Morais","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago Wilson Patriarca","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Ant\u00f4nio","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neide Maria","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Santana","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Ribeiro","family":"de Barros Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/1529-0131(199905)42:5<981::AID-ANR17>3.0.CO;2-4","article-title":"Predominance of mononuclear cells expressing the chemokine receptor CCR5 in synovial effusions of patients with different forms of arthritis","volume":"42","author":"M Mack","year":"1999","journal-title":"Arthritis Rheum"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.4049\/jimmunol.171.5.2571","article-title":"CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells","volume":"171","author":"SY Thomas","year":"2003","journal-title":"J Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/34814","article-title":"CCR5 is characteristic of Th1 lymphocytes","volume":"391","author":"P Loetscher","year":"1998","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/76957","article-title":"CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells","volume":"1","author":"J Aliberti","year":"2000","journal-title":"Nat Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1471-4906(00)01812-3","article-title":"RANTES: a versatile and controversial chemokine","volume":"22","author":"V Appay","year":"2001","journal-title":"Trends Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.4049\/jimmunol.180.5.3049","article-title":"CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression","volume":"180","author":"AP Moreira","year":"2008","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1046\/j.1365-2249.2003.02126.x","article-title":"Regulation of CCR5 expression and MIP-1alpha production in CD4+ T cells from patients with rheumatoid arthritis","volume":"132","author":"CR Wang","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-5728(03)00079-1","article-title":"IL-12 dependent\/IFN gamma independent expression of CCR5 by myelin-reactive T cells correlates with encephalitogenicity","volume":"137","author":"LV Bagaeva","year":"2003","journal-title":"J Neuroimmunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1172\/JCI43027","article-title":"Pivotal role of the CCL5\/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing","volume":"122","author":"Y Ishida","year":"2012","journal-title":"J Clin Invest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1084\/jem.20060956","article-title":"CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence","volume":"203","author":"E Yurchenko","year":"2006","journal-title":"J Exp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.4049\/jimmunol.1100033","article-title":"Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation","volume":"187","author":"NL Sullivan","year":"2011","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0016-5085(03)00903-X","article-title":"CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells","volume":"125","author":"S Luangsay","year":"2003","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1371\/journal.ppat.0020049","article-title":"CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection","volume":"2","author":"IA Khan","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4269\/ajtmh.2007.77.405","article-title":"Toxoplasma gondii infection in the United States, 1999 2004, decline from the prior decade","volume":"77","author":"JL Jones","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"AM Tenter","year":"2000","journal-title":"Int J Parasitol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.ijpara.2009.04.003","article-title":"Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis","volume":"39","author":"G Pappas","year":"2009","journal-title":"Int J Parasitol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/icb.2011.93","article-title":"Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger","volume":"90","author":"CE Egan","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1086\/338006","article-title":"Oral infection of C57BL\/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease?","volume":"185","author":"O Liesenfeld","year":"2002","journal-title":"J Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijpara.2003.11.023","article-title":"Toxoplasma gondii and mucosal immunity","volume":"34","author":"L Kasper","year":"2004","journal-title":"Int J Parasitol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.184.2.597","article-title":"Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii","volume":"184","author":"O Liesenfeld","year":"1996","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-3024.1999.00237.x","article-title":"TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii","volume":"21","author":"O Liesenfeld","year":"1999","journal-title":"Parasite Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.4049\/jimmunol.168.6.2988","article-title":"Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogen","volume":"168","author":"FJ Mennechet","year":"2002","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2353\/ajpath.2008.080129","article-title":"CCR2 receptor is essential to activate microbicidal mechanisms to control Toxoplasma gondii infection in the central nervous system","volume":"173","author":"L Benevides","year":"2008","journal-title":"Am J Pathol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-065X.2010.00992.x","article-title":"Immunology of Toxoplasma gondii","volume":"240","author":"M Munoz","year":"2011","journal-title":"Immunol Rev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ni915","article-title":"Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells","volume":"4","author":"J Aliberti","year":"2003","journal-title":"Nat Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.4049\/jimmunol.181.12.8478","article-title":"Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology","volume":"181","author":"F Yarovinsky","year":"2008","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.immuni.2012.09.016","article-title":"Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii","volume":"38","author":"AA Koblansky","year":"2013","journal-title":"Immunity"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1053\/gast.2001.22432a","article-title":"Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytes","volume":"120","author":"D Buzoni-Gatel","year":"2001","journal-title":"Gastroenterology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.4049\/jimmunol.1201018","article-title":"Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth","volume":"189","author":"E Schlecker","year":"2012","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e75138","DOI":"10.1371\/journal.pone.0075138","article-title":"Toxoplasma gondii soluble tachyzoite antigen triggers protective mechanisms against fatal intestinal pathology in oral infection of C57BL\/6 mice","volume":"8","author":"L Benevides","year":"2013","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jcp.22.2.158","article-title":"Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen","volume":"22","author":"P Trinder","year":"1969","journal-title":"J Clin Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"S Reitman","year":"1957","journal-title":"Am J Clin Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.148.6.1661","article-title":"The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions","volume":"148","author":"D Guy-Grand","year":"1978","journal-title":"J Exp Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.immuni.2008.05.019","article-title":"Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii","volume":"29","author":"IR Dunay","year":"2008","journal-title":"Immunity"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/84219","article-title":"Lymphocyte traffic control by chemokines","volume":"2","author":"B Moser","year":"2001","journal-title":"Nat Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2012.05.013","article-title":"Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes","volume":"37","author":"J Schulthess","year":"2012","journal-title":"Immunity"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.4049\/jimmunol.173.5.3287","article-title":"CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration","volume":"173","author":"HM Algood","year":"2004","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1128\/IAI.72.2.1057-1064.2004","article-title":"Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection","volume":"72","author":"MX Zhong","year":"2004","journal-title":"Infect Immun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1182\/blood-2002-05-1493","article-title":"CCR5 deficiency decreases susceptibility to experimental cerebral malaria","volume":"101","author":"E Belnoue","year":"2003","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0952-7915(02)00353-9","article-title":"Dendritic cells and immunity to leishmaniasis and toxoplasmosis","volume":"14","author":"P Scott","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/IAI.62.7.2818-2824.1994","article-title":"Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha","volume":"62","author":"CA Hunter","year":"1994","journal-title":"Infect Immun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cyto.2006.08.006","article-title":"IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation","volume":"35","author":"AR French","year":"2006","journal-title":"Cytokine"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1567-5769(01)00090-X","article-title":"Nitric oxide in parasitic infections","volume":"1","author":"LR Brunet","year":"2001","journal-title":"Int Immunopharmacol"},{"key":"ref44","first-page":"1721","article-title":"Frequency of the HIV-protective CC chemokine receptor 5-Delta32\/Delta32 genotype is increased in hepatitis C. Gastroenterology","volume":"122","author":"RP Woitas","year":"2002"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/hep.20865","article-title":"CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice","volume":"42","author":"C Moreno","year":"2005","journal-title":"Hepatology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.4049\/jimmunol.174.12.8027","article-title":"Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells","volume":"174","author":"MN Ajuebor","year":"2005","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"L Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ni.1613","article-title":"A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses","volume":"9","author":"E Volpe","year":"2008","journal-title":"Nat Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/j.1460-2075.1992.tb05139.x","article-title":"Evolution of the nuclear receptor gene superfamily","volume":"11","author":"V Laudet","year":"1992","journal-title":"EMBO J"},{"key":"ref50","first-page":"649","article-title":"Peroxisome proliferator-activated receptors: nuclear control of metabolism","volume":"20","author":"B Desvergne","year":"1999","journal-title":"Endocr Rev"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/jme.0.0110037","article-title":"The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs","volume":"11","author":"I Issemann","year":"1993","journal-title":"J Mol Endocrinol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1073\/pnas.94.9.4312","article-title":"Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta","volume":"94","author":"BM Forman","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1067\/mlc.2001.114991","article-title":"Effect of gemfibrozil on the composition and oxidation properties of very-low-density lipoprotein and high-density lipoprotein in patients with hypertriglyceridemia","volume":"137","author":"HC Hsu","year":"2001","journal-title":"J Lab Clin Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.2165\/11208090-000000000-00000","article-title":"Fenofibrate: a review of its use in dyslipidaemia","volume":"71","author":"K McKeage","year":"2011","journal-title":"Drugs"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nri3598","article-title":"Innate immunity to Toxoplasma gondii infection","volume":"14","author":"F Yarovinsky","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e662","DOI":"10.1371\/journal.pone.0000662","article-title":"Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4","volume":"2","author":"MM Heimesaat","year":"2007","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1002\/eji.200940115","article-title":"Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines","volume":"40","author":"VS Boaventura","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.4049\/jimmunol.167.11.6503","article-title":"CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection","volume":"167","author":"L Del Rio","year":"2001","journal-title":"J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.4049\/jimmunol.163.4.2081","article-title":"Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12","volume":"163","author":"SK Bliss","year":"1999","journal-title":"J Immunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1128\/IAI.00472-09","article-title":"Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice","volume":"78","author":"IR Dunay","year":"2010","journal-title":"Infect Immun"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0104736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T22:56:46Z","timestamp":1689461806000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0104736"}},"subtitle":[],"editor":[{"given":"Markus M.","family":"Heimesaat","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,13]]},"references-count":60,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0104736","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,13]]}}}