{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:26:49Z","timestamp":1790519209549,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0105079","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T02:02:11Z","timestamp":1409882531000},"page":"e105079","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Detection and Quantitation of Circulating Tumor Cell Dynamics by Bioluminescence Imaging in an Orthotopic Mammary Carcinoma Model"],"prefix":"10.1371","volume":"9","author":[{"given":"Laura Sarah","family":"Sasportas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Seiko","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillem","family":"Pratx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv Sam","family":"Gambhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"ref1","unstructured":"Alix-Panabi\u00e8res C, Pantel K (2012) Circulating Tumor Cells: Liquid Biopsy of Cancer. Clin Chem. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinchem.org\/content\/early\/2012\/09\/20\/clinchem.2012.194258\" xlink:type=\"simple\">http:\/\/www.clinchem.org\/content\/early\/2012\/09\/20\/clinchem.2012.194258<\/ext-link>. Accessed 2012 October 22."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1158\/1078-0432.CCR-12-1587","article-title":"Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer","volume":"18","author":"L Zhang","year":"2012","journal-title":"Clin Cancer Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"10501","DOI":"10.1073\/pnas.0404036101","article-title":"A rare-cell detector for cancer","volume":"101","author":"RT Krivacic","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"D Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S1535-6108(03)00167-3","article-title":"Evidence emerges for early metastasis and parallel evolution of primary and metastatic tumors","volume":"4","author":"JW Gray","year":"2003","journal-title":"Cancer Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2217\/fon.11.32","article-title":"Organ-specific markers in circulating tumor cell screening: an early indicator of metastasis-capable malignancy","volume":"7","author":"P Paterlini-Br\u00e9chot","year":"2011","journal-title":"Future Oncol Lond Engl"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/bcr3102","article-title":"Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers","volume":"14","author":"D Weng","year":"2012","journal-title":"Breast Cancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S1470-2045(12)70209-7","article-title":"Circulating tumour cells in non-metastatic breast cancer: a prospective study","volume":"13","author":"A Lucci","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nrclinonc.2011.167","article-title":"Medical oncology: Clinical value of circulating tumor cells in breast cancer","volume":"8","author":"S Sleijfer","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201010021","article-title":"Circulating tumor cells: approaches to isolation and characterization","volume":"192","author":"M Yu","year":"2011","journal-title":"J Cell Biol"},{"key":"ref11","first-page":"19","article-title":"Method for cytological detection of tumor cells in mouse blood in vitro","volume":"26","author":"MM Romsdahl","year":"1961","journal-title":"J Natl Cancer Inst"},{"key":"ref12","first-page":"105","article-title":"Hydrochloric acid erythrocytolysis for millipore-filter isolation of tumor cells from fluids from wounds","volume":"33","author":"K Sako","year":"1963","journal-title":"Tech Bull Regist Med Technol"},{"key":"ref13","first-page":"997","article-title":"Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation","volume":"34","author":"LA Liotta","year":"1974","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1158\/0008-5472.CAN-09-0801","article-title":"Circulating Tumor Cells Are Transcriptionally Similar to the Primary Tumor in a Murine Prostate Model","volume":"69","author":"KT Helzer","year":"2009","journal-title":"Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e26073","DOI":"10.1371\/journal.pone.0026073","article-title":"Bioluminescent Orthotopic Mouse Models of Human Localized Non-Small Cell Lung Cancer: Feasibility and Identification of Circulating Tumour Cells","volume":"6","author":"P Mordant","year":"2011","journal-title":"PLoS ONE"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1039\/c2lc40072c","article-title":"A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells","volume":"12","author":"JH Kang","year":"2012","journal-title":"Lab Chip"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-3835(96)04319-4","article-title":"Detection of rare circulating human colon tumor cells in a nude mouse xenograft model","volume":"106","author":"J-C Pages","year":"1996","journal-title":"Cancer Lett"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1158\/0008-5472.CAN-08-0630","article-title":"Monitoring Serial Changes in Circulating Human Breast Cancer Cells in Murine Xenograft Models","volume":"68","author":"J-P Eliane","year":"2008","journal-title":"Cancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1038\/sj.onc.1209430","article-title":"Fate and characterization of circulating tumor cells in a NOD\/SCID mouse model of human hepatocellular carcinoma","volume":"25","author":"O Scatton","year":"2006","journal-title":"Oncogene"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/cyto.a.20132","article-title":"Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry","volume":"65","author":"AL Allan","year":"2005","journal-title":"Cytom Part J Int Soc Anal Cytol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1023\/A:1006719800907","article-title":"Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry","volume":"17","author":"CM Schmidt","year":"1999","journal-title":"Clin Exp Metastasis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/71429","article-title":"Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis","volume":"6","author":"AB Al-Mehdi","year":"2000","journal-title":"Nat Med"},{"key":"ref23","first-page":"1225","article-title":"Studies on Cancer Dissemination","volume":"27","author":"R Rosso","year":"1967","journal-title":"Cancer Res"},{"key":"ref24","first-page":"414","article-title":"Quantitative studies on cancer dissemination","volume":"29","author":"MG Donelli","year":"1969","journal-title":"Cancer Res"},{"key":"ref25","first-page":"2053","article-title":"Bioassay for quantitating circulating tumor cells in a syngeneic mouse tumor system","volume":"36","author":"VW Lee","year":"1976","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1158\/1078-0432.CCR-06-2074","article-title":"Garlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer","volume":"13","author":"EW Howard","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1158\/0008-5472.CAN-04-1058","article-title":"In Vivo Flow Cytometry","volume":"64","author":"I Georgakoudi","year":"2004","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"11760","DOI":"10.1073\/pnas.0703875104","article-title":"In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry","volume":"104","author":"W He","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1158\/0008-5472.CAN-11-3733","article-title":"Real-time monitoring of rare circulating hepatocellular carcinoma cells in an orthotopic model by in vivo flow cytometry assesses resection on metastasis","volume":"72","author":"Z-C Fan","year":"2012","journal-title":"Cancer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1152\/physrev.00049.2010","article-title":"A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications","volume":"92","author":"ML James","year":"2012","journal-title":"Physiol Rev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"12044","DOI":"10.1073\/pnas.96.21.12044","article-title":"Visualizing the kinetics of tumor-cell clearance in living animals","volume":"96","author":"TJ Sweeney","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1117\/1.1413210","article-title":"In vivo imaging of light-emitting probes","volume":"6","author":"BW Rice","year":"2001","journal-title":"J Biomed Opt"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e9364","DOI":"10.1371\/journal.pone.0009364","article-title":"Non-Invasive Detection of a Small Number of Bioluminescent Cancer Cells In Vivo","volume":"5","author":"J-B Kim","year":"2010","journal-title":"PLoS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e86759","DOI":"10.1371\/journal.pone.0086759","article-title":"Imaging Circulating Tumor Cells in Freely Moving Awake Small Animals Using a Miniaturized Intravital Microscope","volume":"9","author":"LS Sasportas","year":"2014","journal-title":"PLoS ONE"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.canlet.2006.12.014","article-title":"Circulating tumor cells (CTC) detection: clinical impact and future directions","volume":"253","author":"P Paterlini-Brechot","year":"2007","journal-title":"Cancer Lett"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Kammerloher W (2008) Bioluminescence microscopy for cellular level circadian analysis in the suprachiasmatic nucleus. Nat Methods 5. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nature.com\/nmeth\/journal\/v5\/n11\/full\/nmeth.f.226.html\" xlink:type=\"simple\">http:\/\/www.nature.com\/nmeth\/journal\/v5\/n11\/full\/nmeth.f.226.html<\/ext-link>. Accessed 3 March 2014.","DOI":"10.1038\/nmeth.f.226"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nbt.2576","article-title":"Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay","volume":"31","author":"I Baccelli","year":"2013","journal-title":"Nat Biotechnol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"180ra48","DOI":"10.1126\/scitranslmed.3005109","article-title":"The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis","volume":"5","author":"L Zhang","year":"2013","journal-title":"Sci Transl Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"041210","DOI":"10.1117\/1.2032388","article-title":"Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo","volume":"10","author":"H Zhao","year":"2005","journal-title":"J Biomed Opt"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1158\/0008-5472.CAN-06-1823","article-title":"Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors","volume":"67","author":"JB Wyckoff","year":"2007","journal-title":"Cancer Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"10377","DOI":"10.1158\/0008-5472.CAN-08-1444","article-title":"Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth","volume":"68","author":"T Tsuji","year":"2008","journal-title":"Cancer Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/1471-2407-8-228","article-title":"Imagable 4T1 model for the study of late stage breast cancer","volume":"8","author":"K Tao","year":"2008","journal-title":"BMC Cancer"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrc2375","article-title":"Detection, clinical relevance and specific biological properties of disseminating tumour cells","volume":"8","author":"K Pantel","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref44","first-page":"1535","article-title":"Circulating human prostate cancer cells from an orthotopic mouse model rapidly captured by immunomagnetic beads and imaged by GFP expression","volume":"31","author":"K Kolostova","year":"2011","journal-title":"Anticancer Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/cancers6010128","article-title":"Dynamic Fluctuation of Circulating Tumor Cells during Cancer Progression","volume":"6","author":"MA Juratli","year":"2014","journal-title":"Cancers"},{"key":"ref46","first-page":"1399","article-title":"Selective Events in the Metastatic Process Defined by Analysis of the Sequential Dissemination of Subpopulations of a Mouse Mammary Tumor","volume":"52","author":"CJ Aslakson","year":"1992","journal-title":"Cancer Res"},{"key":"ref47","unstructured":"Coumans FA (2012) Cathching metastasizing cells in the act [PhD thesis]. University of Twente."},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1038\/onc.2011.540","article-title":"A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer","volume":"31","author":"A Bonnomet","year":"2012","journal-title":"Oncogene"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cyto.a.20369","article-title":"Statistical considerations for enumeration of circulating tumor cells","volume":"71A","author":"AGJ Tibbe","year":"2007","journal-title":"Cytometry A"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"016004","DOI":"10.1088\/1478-3975\/9\/1\/016004","article-title":"High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis","volume":"9","author":"J Nieva","year":"2012","journal-title":"Phys Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.1228522","article-title":"Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition","volume":"339","author":"M Yu","year":"2013","journal-title":"Science"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0105079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:47:40Z","timestamp":1589032060000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0105079"}},"subtitle":[],"editor":[{"given":"Hiromu","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,4]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0105079","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,4]]}}}