{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:57:04Z","timestamp":1783072624471,"version":"3.54.6"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0105172","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T19:00:15Z","timestamp":1408042815000},"page":"e105172","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats"],"prefix":"10.1371","volume":"9","author":[{"given":"Sheila A.","family":"Engi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio C.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo M.","family":"Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds C.","family":"Spolidorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleopatra S.","family":"Planeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos C.","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-009-1585-5","article-title":"Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models","volume":"206","author":"NL Schramm-Sapyta","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1177\/109019819702400609","article-title":"Patterns of onset and cessation of drug use over the early part of the life course","volume":"24","author":"DJ DeWit","year":"1997","journal-title":"Health Educ Behav"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"464","DOI":"10.15288\/jsa.1997.58.464","article-title":"Prevalence and correlates of alcohol use and DSM-IV alcohol dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey","volume":"58","author":"BF Grant","year":"1997","journal-title":"J Stud Alcohol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0376-8716(95)01194-3","article-title":"Early-onset drug use and risk of later drug problems","volume":"40","author":"JC Anthony","year":"1995","journal-title":"Drug Alcohol Depend"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1038\/sj.npp.1301037","article-title":"Is there epidemiological evidence to support the idea that a cocaine dependence syndrome emerges soon after onset of cocaine use?","volume":"31","author":"BA Reboussin","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0376-8716(96)01315-4","article-title":"Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U.S. population","volume":"44","author":"D Kandel","year":"1997","journal-title":"Drug Alcohol Depend"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1176\/appi.ajp.160.6.1041","article-title":"Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability","volume":"160","author":"RA Chambers","year":"2003","journal-title":"Am J Psychiatry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1542\/peds.96.1.23","article-title":"Anabolic-steroid use, strength training, and multiple drug use among adolescents in the United States","volume":"96","author":"RH DuRant","year":"1995","journal-title":"Pediatrics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1056\/NEJM199304013281304","article-title":"Use of multiple drugs among adolescents who use anabolic steroids","volume":"328","author":"RH DuRant","year":"1993","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/01.CIR.85.2.407","article-title":"The effects of acute and chronic cocaine use on the heart","volume":"85","author":"RA Kloner","year":"1992","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/clc.20746","article-title":"Cocaine and the heart","volume":"33","author":"S Maraj","year":"2010","journal-title":"Clin Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.yrtph.2010.02.001","article-title":"Adverse health effects of anabolic-androgenic steroids","volume":"57","author":"J van Amsterdam","year":"2010","journal-title":"Regul Toxicol Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.semdp.2008.12.001","article-title":"Cocaine: history, social implications, and toxicity: a review","volume":"26","author":"RA Goldstein","year":"2009","journal-title":"Semin Diagn Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/FJC.0b013e31823cc58b","article-title":"Effect of the single or combined administration of cocaine and testosterone on cardiovascular function and baroreflex activity in unanesthetized rats","volume":"59","author":"SA Engi","year":"2012","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0033-0620(98)80019-4","article-title":"The cardiac toxicity of anabolic steroids","volume":"41","author":"ML Sullivan","year":"1998","journal-title":"Prog Cardiovasc Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.amjcard.2010.05.013","article-title":"Cardiac and metabolic effects of anabolic-androgenic steroid abuse on lipids, blood pressure, left ventricular dimensions, and rhythm","volume":"106","author":"S Achar","year":"2010","journal-title":"Am J Cardiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-2999(00)00294-6","article-title":"Combined cardiac effects of cocaine and the anabolic steroid, nandrolone, in the rat","volume":"398","author":"BD Phillis","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0049-3848(03)00184-1","article-title":"Testosterone and cocaine: vascular toxicity of their concomitant abuse","volume":"109","author":"GI Togna","year":"2003","journal-title":"Thromb Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/faat.1994.1014","article-title":"Cardiovascular toxicities of nandrolone and cocaine in spontaneously hypertensive rats","volume":"22","author":"YT Tseng","year":"1994","journal-title":"Fundam Appl Toxicol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1177\/0269881112453210","article-title":"Influence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acute restraint stress","volume":"26","author":"FC Cruz","year":"2012","journal-title":"J Psychopharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"LP Spear","year":"2000","journal-title":"Neurosci Biobehav Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0149-7634(03)00018-6","article-title":"Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents","volume":"27","author":"E Tirelli","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bandc.2009.06.003","article-title":"Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models","volume":"72","author":"CM McCormick","year":"2010","journal-title":"Brain Cogn"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuroscience.2013.08.034","article-title":"Role of the bed nucleus of the stria terminalis in cardiovascular changes following chronic treatment with cocaine and testosterone: a role beyond drug seeking in addiction?","volume":"253","author":"FC Cruz","year":"2013","journal-title":"Neuroscience"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0165-1838(87)90023-3","article-title":"Vagal and sympathetic components of the heart rate range and gain of the baroreceptor-heart rate reflex in conscious rats","volume":"21","author":"GA Head","year":"1987","journal-title":"J Auton Nerv Syst"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neures.2010.05.001","article-title":"N-methyl-D-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats","volume":"67","author":"CC Crestani","year":"2010","journal-title":"Neurosci Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejphar.2011.09.030","article-title":"Chronic fluoxetine treatment alters cardiovascular functions in unanesthetized rats","volume":"670","author":"CC Crestani","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jcpe.12203","article-title":"Clopidogrel enhances periodontal repair in rats through decreased inflammation","volume":"41","author":"LS Coimbra","year":"2014","journal-title":"J Clin Periodontol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00213-008-1327-0","article-title":"Evaluation of a pharmacokinetic hypothesis for reduced locomotor stimulation from methamphetamine and cocaine in adolescent versus adult male C57BL\/6J mice","volume":"201","author":"JA Zombeck","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1523\/JNEUROSCI.1371-12.2013","article-title":"Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence","volume":"33","author":"WC Wong","year":"2013","journal-title":"J Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejphar.2006.08.034","article-title":"Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi","volume":"550","author":"KA Badanich","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/dev.20252","article-title":"Early adolescents show enhanced acute cocaine-induced locomotor activity in comparison to late adolescent and adult rats","volume":"50","author":"KA Badanich","year":"2008","journal-title":"Dev Psychobiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.yhbeh.2007.11.004","article-title":"Anabolic androgenic steroids differentially affect social behaviors in adolescent and adult male Syrian hamsters","volume":"53","author":"KY Salas-Ramirez","year":"2008","journal-title":"Horm Behav"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jsbmb.2004.11.003","article-title":"Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats","volume":"93","author":"A Beutel","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000085771","article-title":"Testosterone and nandrolone sensitization of brain anteroventral area of third ventricle to hypertonic NaCl-induced sympathetic response","volume":"75","author":"F Rosa","year":"2005","journal-title":"Pharmacology"},{"key":"ref36","first-page":"827","article-title":"Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context","volume":"335","author":"R Collins","year":"1990","journal-title":"Lancet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.12816\/0006020","article-title":"Effect of exercise training and anabolic androgenic steroids on hemodynamics, glycogen content, angiogenesis and apoptosis of cardiac muscle in adult male rats","volume":"7","author":"AF Hassan","year":"2013","journal-title":"Int J Health Sci (Qassim)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.physbeh.2013.12.006","article-title":"Administration of an anabolic steroid during the adolescent phase changes the behavior, cardiac autonomic balance and fluid intake in male adult rats","volume":"126","author":"EL Olivares","year":"2014","journal-title":"Physiol Behav"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0895-7061(98)00135-6","article-title":"Prevalence of hypertension in chronic cocaine users","volume":"11","author":"CS Brecklin","year":"1998","journal-title":"Am J Hypertens"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-2999(99)00582-8","article-title":"Cardiovascular responses to cocaine self-administration: acute and chronic tolerance","volume":"383","author":"SR Tella","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1385\/CT:5:4:377","article-title":"Cocaine increases intracellular calcium and reactive oxygen species, depolarizes mitochondria, and activates genes associated with heart failure and remodeling","volume":"5","author":"FA Lattanzio Jr","year":"2005","journal-title":"Cardiovasc Toxicol"},{"key":"ref42","first-page":"225","article-title":"Cocaine long-term administration induces myocardial depressant effects and adrenoceptors desensitization","volume":"53","author":"E Romero Vecchione","year":"2002","journal-title":"Acta Cient Venez"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neulet.2004.08.021","article-title":"Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function","volume":"370","author":"TJ Beveridge","year":"2004","journal-title":"Neurosci Lett"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00213-003-1676-7","article-title":"Patterns of functional activity associated with cocaine self-administration in the rat change over time","volume":"172","author":"DJ Macey","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2006.03.045","article-title":"Acute and repeated cocaine induces alterations in FosB\/DeltaFosB expression in the paraventricular nucleus of the hypothalamus","volume":"1090","author":"A Chocyk","year":"2006","journal-title":"Brain Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.0953-816x.2001.01877.x","article-title":"The anabolic androgenic steroid, nandrolone decanoate, increases the density of Fos-like immunoreactive neurons in limbic regions of guinea-pig brain","volume":"15","author":"P Johansson-Steensland","year":"2002","journal-title":"Eur J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.dr.2007.08.003","article-title":"The adolescent brain","volume":"28","author":"BJ Casey","year":"2008","journal-title":"Dev Rev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pcad.2006.03.002","article-title":"Baroreflex function in hypertension: consequences for antihypertensive therapy","volume":"48","author":"G Grassi","year":"2006","journal-title":"Prog Cardiovasc Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"605","DOI":"10.33549\/physiolres.931700","article-title":"Baroreflex sensitivity and essential hypertension in adolescents","volume":"58","author":"N Honzikova","year":"2009","journal-title":"Physiol Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/oxfordjournals.aje.a113046","article-title":"Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies","volume":"112","author":"AR Dyer","year":"1980","journal-title":"Am J Epidemiol"},{"key":"ref51","first-page":"S19","article-title":"Association of tachycardia with morbidity and mortality: pathophysiological considerations","volume":"11","author":"P Palatini","year":"1997","journal-title":"J Hum Hypertens"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.2174\/1381612043382756","article-title":"Sympathetic and baroreflex function in hypertension: implications for current and new drugs","volume":"10","author":"G Grassi","year":"2004","journal-title":"Curr Pharm Des"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00424-010-0786-4","article-title":"Endothelial dysfunction: a strategic target in the treatment of hypertension?","volume":"459","author":"EH Tang","year":"2010","journal-title":"Pflugers Arch"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2174\/138955711795445862","article-title":"Heart disease induced by AAS abuse, using experimental mice\/rats models and the role of exercise-induced cardiotoxicity","volume":"11","author":"I Riezzo","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1136\/hrt.2011.226977","article-title":"Silent myocardial damage in cocaine addicts","volume":"97","author":"GD Aquaro","year":"2011","journal-title":"Heart"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.etp.2008.09.007","article-title":"Heart lesions associated with anabolic steroid abuse: comparison of post-mortem findings in athletes and norethandrolone-induced lesions in rabbits","volume":"61","author":"L Fanton","year":"2009","journal-title":"Exp Toxicol Pathol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0105172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T14:20:43Z","timestamp":1649946043000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0105172"}},"subtitle":[],"editor":[{"given":"James","family":"West","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,14]]},"references-count":56,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0105172","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,14]]}}}