{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:35:58Z","timestamp":1791210958344,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0105662","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T18:45:56Z","timestamp":1408646756000},"page":"e105662","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Reduced Motivation in the BACHD Rat Model of Huntington Disease Is Dependent on the Choice of Food Deprivation Strategy"],"prefix":"10.1371","volume":"9","author":[{"given":"Erik Karl H\u00e5kan","family":"Jansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Emily","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Riess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huu Phuc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/mds.25075","article-title":"The incidence and prevalence of huntington&apos;s disease: a systematic review and meta-analysis","volume":"9","author":"T Pringsheim","year":"2012","journal-title":"Mov Disord"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on huntington&apos;s disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanism and potential therapeutocal targets in huntington&apos;s disease","volume":"90","author":"C Zuccato","year":"2010","journal-title":"Physiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1212\/01.WNL.0000031791.10922.CF","article-title":"Weight loss in early stage of huntington&apos;s disease","volume":"59","author":"L Djouss\u00e9","year":"2002","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archneur.58.2.273","article-title":"Progression of symptoms in the early and middle stages of huntington disease","volume":"58","author":"SC Kirkwood","year":"2001","journal-title":"Arch Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1212\/01.wnl.0000334276.09729.0e","article-title":"Weight loss in huntington disease increases with higher CAG repeat number","volume":"71","author":"NA Aziz","year":"2008","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1111\/j.1468-1331.2006.01319.x","article-title":"Weight changes in huntington&apos;s disease","volume":"13","author":"AO Robbins","year":"2006","journal-title":"Eur J Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the brain: widespread pathology in huntington&apos;s disease","volume":"8","author":"JMM van der Burg","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1007\/s00415-009-0062-8","article-title":"Weight loss in neurodegenerative disorders","volume":"255","author":"NA Aziz","year":"2008","journal-title":"J Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"M Gray","year":"2008","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nbd.2006.12.010","article-title":"Pheontypic abnormalities in the YAC128 mouse model of huntington disease are penetrant on multiple genetic backgrounds and modulated by strain","volume":"26","author":"JM van Raamsdonk","year":"2007","journal-title":"Neurobiol Dis"},{"key":"ref12","first-page":"5","article-title":"Increased body weight of the BAC HD transgenic mouse model of huntington&apos;s disease accounts for some but not all of the observed HD-like motor deficits","volume":"30","author":"AE Kudwa","year":"2013","journal-title":"PLoS Curr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1034\/j.1601-183X.2003.00028.x","article-title":"Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod","volume":"2","author":"MP McFadyen","year":"2003","journal-title":"Genes Brain Behav"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.brainresbull.2011.03.015","article-title":"Operant-based instrumental learning for analysis of genetically modified models of huntington&apos;s disease","volume":"88","author":"RC Trueman","year":"2012","journal-title":"Brain Res Bull"},{"key":"ref15","first-page":"397","article-title":"Finding the right motivation: Genotype-dependent differences in effective reinforcements for spatial learning","volume":"Res226","author":"J Youn","year":"2011","journal-title":"Behav Brain"},{"key":"ref16","first-page":"4","article-title":"A mixed fixed ratio\/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington&apos;s disease","volume":"25","author":"S Oakeshott","year":"2012","journal-title":"PLoS Curr"},{"key":"ref17","first-page":"5","article-title":"Deficits in a simple visual Go\/No-go discrimination task in two mouse models of huntington&apos;s disease","volume":"7","author":"S Oakeshott","year":"2013","journal-title":"PLoS Curr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnbeh.2014.00010","article-title":"Reduced expression of Nogo-A leads to motivational deficits in rats","volume":"8","author":"T Enkel","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1124\/jpet.104.076406","article-title":"Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice","volume":"313","author":"MJ Bradbury","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1463-1326.2012.01570.x","article-title":"Interactions of amylinergic and melanocortinergic systems in the control of food intake and body weight in rodents","volume":"14","author":"JD Roth","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brainresbull.2011.09.011","article-title":"Profiles of motor and cognitive impairment in the transgenic rat model of huntingtin&apos;s disease","volume":"88","author":"SA Fielding","year":"2012","journal-title":"Brain Res Bull"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15426","DOI":"10.1523\/JNEUROSCI.1148-12.2012","article-title":"A novel BACHD transgenic rat exhibits characteristic neuropathological features of huntington disease","volume":"32","author":"L Yu-Taeger","year":"2012","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/journal.pone.0071633","article-title":"Reversal learning and associative memory impairments in a BACHD rat model for huntington disease","volume":"8","author":"YK Abada","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/gbb.12093","article-title":"A behavioral comparison of the common laboratory rat strains lister hooded, lewis, fischer 344 and wistar in an automated homecage system","volume":"13","author":"LE Clemens","year":"2014","journal-title":"Genes Brain Behav"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"E49","DOI":"10.1152\/ajpendo.00630.2010","article-title":"Molecular characterization of skeletal muscle atrophy in the R6\/2 mouse model of huntington&apos;s disease","volume":"301","author":"P She","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref26","first-page":"397","article-title":"Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin","volume":"8","author":"G Schilling","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/hmg\/ddg075","article-title":"Transgenic rat model of huntington&apos;s disease","volume":"12","author":"S von H\u00f6rsten","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cmet.2011.02.013","article-title":"Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits","volume":"13","author":"S Hult","year":"2011","journal-title":"Cell Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/hmg\/ddl072","article-title":"Body weight is modulated by levels of full-length huntingtin","volume":"15","author":"JM van Raamsdonk","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cmet.2006.10.004","article-title":"Thermoregulatory and metabolic dfects in Huntington&apos;s disease transgenic mice implicate PGC-1alpha in Huntington&apos;s disease neurodegeneration","volume":"4","author":"P Weydt","year":"2006","journal-title":"Cell Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/sj.ijo.0800615","article-title":"Role of neuropeptide Y in diet-, chemical and genetic-induced obesity of mice","volume":"22","author":"G Hollopeter","year":"1998","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-4886(78)90050-X","article-title":"Hypothalamic lesion induced by injection of monosodium glutamate in suckling period and subsequent development of obesity","volume":"62","author":"K Tanaka","year":"1978","journal-title":"Exp Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0167-0115(98)00100-1","article-title":"Reduced BAT as a mechanism for obesity in the hypophagic, neuropeptide Y deficient monosodium glutamate-treated rat","volume":"25","author":"MJ Morris","year":"1998","journal-title":"Regul Pept"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00210-013-0875-y","article-title":"Effect of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats","volume":"8","author":"W Chen","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0006-8993(86)90434-8","article-title":"Components of hypothalamic obesity: bipiperidyl-mustard lesions add hyperphagia to monosodium glutamate-induced hyperinsulinemia","volume":"(2)","author":"AC Scallet","year":"1986","journal-title":"Brain Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1210\/endo.139.11.6324","article-title":"Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin","volume":"139","author":"HT Bergen","year":"1998","journal-title":"Endocrinology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.physbeh.2008.05.021","article-title":"Neonatal food restriction permanently alters rat body dimensions and energy intake","volume":"95","author":"F Remmers","year":"2008","journal-title":"Physiol Behav"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1371\/annotation\/edee8dfa-6b2a-44f4-866a-098f186e27f0","article-title":"Functions of huntingtin in germ layer specification and organogenesis","volume":"8","author":"GD Nguyen","year":"2013","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1212\/WNL.0b013e3182648b65","article-title":"Measures of growth in children at risk for Huntington disease","volume":"79","author":"JK Lee","year":"2012","journal-title":"Neurology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/brain\/119.5.1633","article-title":"Executive and mnemotic functions in early huntington&apos;s disease","volume":"119","author":"AD Lawrence","year":"1996","journal-title":"Brain"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00415-004-0461-9","article-title":"Cognitive changes in patients with huntington&apos;s disease (HD) and asymptomatic carriers of the HD mutation a longitudinal follow-up study","volume":"251","author":"J Lemiere","year":"2004","journal-title":"J Neurol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/jnnp-2011-301732","article-title":"Cognitive domains that predict time to diagnosis in prodromal huntington disease","volume":"83","author":"DL Harrington","year":"2012","journal-title":"J Neurosurg Psychiatry"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/mds.23847","article-title":"Rate of change in early huntington&apos;s disease: a clinicometric analysis","volume":"27","author":"C Meyer","year":"2012","journal-title":"Mov Disord"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/mds.23574","article-title":"An item response analysis of the motor and behavioral subscales of the unified huntington&apos;s disease rating scale in huntington disease gene expansion carriers","volume":"26","author":"AL Vaccarino","year":"2011","journal-title":"Mov Disord"},{"key":"ref45","first-page":"397","article-title":"An optic-fiber photocell detector for measuring tongue protrusion in the rat: evaluation of recovery from localized cortical lesions","volume":"43","author":"IQ Whisaw","year":"1988","journal-title":"Psychol Behav"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbr.2009.05.006","article-title":"Rule learning, visuospatial function and motor performance in the HdhQ92 knock-in mouse model of Huntington&apos;s disease","volume":"203","author":"RC Trueman","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/jnnp.71.3.310","article-title":"Neuropsychiatric aspects of huntington&apos;s disease","volume":"71","author":"JS Paulsen","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1176\/jnp.2009.21.3.266","article-title":"Apathy is not depression in huntington&apos;s disease","volume":"21","author":"P Naarding","year":"2009","journal-title":"J Neuropsuchiatry Clin Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/lmot.1993.1019","article-title":"Reinforcer magnitude and progressive ratio responding in the rat: effect of increased effort, prefeeding, and extinction","volume":"24","author":"P Skjoldager","year":"1993","journal-title":"Learning Motivation"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1037\/0735-7044.113.4.718","article-title":"Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats","volume":"133","author":"DM Eagle","year":"1999","journal-title":"Behav Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1037\/0735-7044.110.5.1049","article-title":"The hippocampus and reward: effects of hippocampal lesions on progressive-ratio responding","volume":"110","author":"MC Schmelzeis","year":"1996","journal-title":"Behav Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene","volume":"269","author":"JL Halaas","year":"1995","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1073\/pnas.94.16.8878","article-title":"Physiological response to long-term peripheral and central leptin infusion in lean and obese mice","volume":"94","author":"JL Halaas","year":"1997","journal-title":"Proc Natl Acad Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","article-title":"Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects","volume":"1","author":"M Maffei","year":"1995","journal-title":"Nat Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/npp.2013.235","article-title":"Leptin signaling in the medial nucleus tractus solitarius reduced food seeking and willingness to work for food","volume":"39","author":"SE Kanoski","year":"2014","journal-title":"Neuropsychopharmacology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0105662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T05:19:01Z","timestamp":1565759941000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0105662"}},"subtitle":[],"editor":[{"given":"Xiao-Jiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,21]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0105662","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,21]]}}}