{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T08:10:09Z","timestamp":1769674209299,"version":"3.49.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0105828","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T19:37:06Z","timestamp":1408736226000},"page":"e105828","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of Naturally Acquired IgG Antibodies to a Chimeric and Non-Chimeric Recombinant Species of Plasmodium vivax Reticulocyte Binding Protein-1: Lack of Association with HLA-DRB1*\/DQB1* in Malaria Exposed Individuals from the Brazilian Amazon"],"prefix":"10.1371","volume":"9","author":[{"given":"Amanda Ribeiro","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balwan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Cabrera-Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana Cristina","family":"Magri De Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Queiroz Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Cristov\u00e3o Sobrino","family":"Porto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalma Maria","family":"Banic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Mauricio","family":"Calvo-Calle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseli","family":"Oliveira-Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josu\u00e9","family":"Da Costa Lima-Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,8,22]]},"reference":[{"key":"ref1","unstructured":"WHO (2013) World malaria report 2013. In: WHO, editor. Switzerland: World Health Organization."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1016\/j.vaccine.2004.12.019","article-title":"Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria","volume":"23","author":"EM Malkin","year":"2005","journal-title":"Vaccine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e2636","DOI":"10.1371\/journal.pone.0002636","article-title":"Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51","volume":"3","author":"Y Wu","year":"2008","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4269\/ajtmh.1990.42.527","article-title":"Safety and Immunogenicity of a <italic>Plasmodium vivax<\/italic> Sporozoite Vaccine","volume":"42","author":"DM Gordon","year":"1990","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.4269\/ajtmh.1991.45.695","article-title":"Safety and Immunogenicity of a Recombinant Sporozoite Malaria Vaccine against <italic>Plasmodium vivax<\/italic>","volume":"45","author":"DA Herrington","year":"1991","journal-title":"Am J Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4269\/ajtmh.2011.09-0507","article-title":"Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein","volume":"84","author":"M Arevalo-Herrera","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","first-page":"3","article-title":"Safety and elicitation of humoral and cellular responses in colombian malaria-naive volunteers by a <italic>Plasmodium vivax<\/italic> circumsporozoite protein-derived synthetic vaccine Am J Trop Med Hyg","volume":"73","author":"S Herrera","year":"2005"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nsmb.2088","article-title":"Dimerization of Plasmodium vivaxDBP is induced upon receptor binding and drives recognition of DARC","volume":"18","author":"JD Batchelor","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1073\/pnas.0800371105","article-title":"Naturally acquired Duffy-binding protein-specific binding inhibitory antibodies confer protection from blood-stage Plasmodium vivax infection","volume":"105","author":"CL King","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1073\/pnas.0912496107","article-title":"Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people","volume":"107","author":"D Menard","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0166-6851(99)00063-8","article-title":"Plasmodium vivax merozoite surface protein-3 contains coiled-coil motifs in an alanine-rich central domain","volume":"101","author":"MR Galinski","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.vaccine.2010.12.099","article-title":"B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax merozoite surface protein-3alpha (PvMSP-3alpha) in malaria exposed individuals from Brazilian Amazon","volume":"29","author":"JC Lima-Junior","year":"2011","journal-title":"Vaccine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e2498","DOI":"10.1371\/journal.pntd.0002498","article-title":"Naturally acquired immune responses to P. vivax merozoite surface protein 3alpha and merozoite surface protein 9 are associated with reduced risk of P. vivax malaria in young Papua New Guinean children","volume":"7","author":"DI Stanisic","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e63888","DOI":"10.1371\/journal.pone.0063888","article-title":"Plasmodium vivax merozoite surface protein-3 (PvMSP3): expression of an 11 member multigene family in blood-stage parasites","volume":"8","author":"J Jiang","year":"2013","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1016\/j.vaccine.2008.09.029","article-title":"Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals","volume":"26","author":"JC Lima-Junior","year":"2008","journal-title":"Vaccine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0166-6851(01)00433-9","article-title":"Merozoite surface protein-9 of <italic>Plasmodium vivax<\/italic> and related simian malaria parasites is orthologous to p101\/ABRA of <italic>P. falciparum<\/italic>","volume":"120","author":"E Vargas-Serrato","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/0092-8674(92)90642-P","article-title":"A reticulocyte-binding protein complex of <italic>Plasmodium vivax<\/italic> merozoites","volume":"69","author":"MR Galinski","year":"1992","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1084\/jem.194.11.1571","article-title":"A Plasmodium falciparum homologue of Plasmodium vivax reticulocyte binding protein (PvRBP1) defines a trypsin-resistant erythrocyte invasion pathway","volume":"194","author":"JC Rayner","year":"2001","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1111\/j.1365-2958.2005.04523.x","article-title":"Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion","volume":"55","author":"AP Singh","year":"2005","journal-title":"Molecular Microbiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.4269\/ajtmh.2005.72.666","article-title":"Dramatic difference in diversity between <italic>Plasmodium falciparum<\/italic> and <italic>Plasmodium vivax<\/italic> reticulocyte binding-like genes","volume":"72","author":"JC Rayner","year":"2005","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4269\/ajtmh.2005.73.244","article-title":"Comparison of IgG reactivities to <italic>Plasmodium vivax<\/italic> merozoite invasion antigens in a Brazilian Amazon population","volume":"73","author":"TM Tran","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/CVI.00243-07","article-title":"Antigenic Polymorphism and Naturally Acquired Antibodies to Plasmodium vivax Merozoite Surface Protein 1 in Rural Amazonians","volume":"14","author":"MS Bastos","year":"2007","journal-title":"Clinical and Vaccine Immunology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.vaccine.2010.01.019","article-title":"Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate","volume":"28","author":"B Singh","year":"2010","journal-title":"Vaccine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.micinf.2008.10.009","article-title":"Recombinant peptide replicates immunogenicity of synthetic linear peptide chimera for use as pre-erythrocytic stage malaria vaccine","volume":"11","author":"LM Silva-Flannery","year":"2009","journal-title":"Microbes and Infection"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/nar\/15.3.1281","article-title":"The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications","volume":"15","author":"PM Sharp","year":"1987","journal-title":"Nucleic Acids Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0168-1656(01)00275-9","article-title":"Long and accurate PCR with a mixture of KOD DNA polymerase and its exonuclease deficient mutant enzyme","volume":"88","author":"M Nishioka","year":"2001","journal-title":"Journal of Biotechnology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.micinf.2005.04.020","article-title":"Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria","volume":"7","author":"I Caro-Aguilar","year":"2005","journal-title":"Microbes Infect"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/17.12.1236","article-title":"ProPred: prediction of HLA-DR binding sites","volume":"17","author":"H Singh","year":"2001","journal-title":"Bioinformatics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1000048","DOI":"10.1371\/journal.pcbi.1000048","article-title":"A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach","volume":"4","author":"P Wang","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1471-2105-7-153","article-title":"Predicting population coverage of T-cell epitope-based diagnostics and vaccines","volume":"7","author":"H-H Bui","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1475-2875-9-115","article-title":"Malaria in Brazil: an overview","volume":"9","author":"J Oliveira-Ferreira","year":"2010","journal-title":"Malar J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1126\/science.2902690","article-title":"Limited immunological recognition of critical malaria vaccine candidate antigens","volume":"242","author":"MF Good","year":"1988","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1128\/IAI.71.10.5700-5713.2003","article-title":"Analysis of immunological nonresponsiveness to the 19-kilodalton fragment of merozoite surface Protein 1 of Plasmodium yoelii: rescue by chemical conjugation to diphtheria toxoid (DT) and enhancement of immunogenicity by prior DT vaccination","volume":"71","author":"DI Stanisic","year":"2003","journal-title":"Infect Immun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/eji.200324514","article-title":"Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect the in vivo antibody response","volume":"34","author":"M Hensmann","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1016\/j.vaccine.2007.02.073","article-title":"Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: A strategy for enhancing immunogenicity of malaria vaccine candidates","volume":"25","author":"F Qian","year":"2007","journal-title":"Vaccine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1128\/IAI.05980-11","article-title":"A hybrid multistage protein vaccine induces protective immunity against murine malaria","volume":"80","author":"B Singh","year":"2012","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1128\/IAI.73.4.2281-2287.2005","article-title":"Immunoglobulin G isotype responses to erythrocyte surface-expressed variant antigens of Plasmodium falciparum predict protection from malaria in African children","volume":"73","author":"CL Yone","year":"2005","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4269\/ajtmh.2002.66.461","article-title":"Association of the IgG response to Plasmodium falciparum merozoite protein (C-terminal 19 kD) with clinical immunity to malaria in the Brazilian Amazon region","volume":"66","author":"EM Braga","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1128\/IAI.72.9.5135-5142.2004","article-title":"Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria","volume":"72","author":"CC John","year":"2004","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/00034989859366","article-title":"Age-dependent characteristics of protection v. susceptibility to Plasmodium falciparum","volume":"92","author":"JK Baird","year":"1998","journal-title":"Ann Trop Med Parasitol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1128\/IAI.72.1.247-252.2004","article-title":"Association between protection against clinical malaria and antibodies to merozoite surface antigens in an area of hyperendemicity in Myanmar: complementarity between responses to merozoite surface protein 3 and the 220-kilodalton glutamate-rich protein","volume":"72","author":"S Soe","year":"2004","journal-title":"Infect Immun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.actatropica.2011.10.009","article-title":"Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax","volume":"121","author":"LM Storti-Melo","year":"2012","journal-title":"Acta Tropica"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"944","DOI":"10.4269\/ajtmh.2011.11-0001","article-title":"Antibody responses and avidity of naturally acquired anti-Plasmodium vivax Duffy binding protein (PvDBP) antibodies in individuals from an area with unstable malaria transmission","volume":"84","author":"S Zakeri","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.vaccine.2003.07.021","article-title":"Immunogenicity of Plasmodium vivax merozoite surface protein-9 recombinant proteins expressed in E. coli","volume":"22","author":"J Oliveira-Ferreira","year":"2004","journal-title":"Vaccine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1128\/IAI.60.4.1473-1481.1992","article-title":"Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity","volume":"60","author":"H Bouharoun-Tayoun","year":"1992","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4269\/ajtmh.1991.45.57","article-title":"Isotypic analysis, antigen specificity, and inhibitory function of maternally transmitted Plasmodium falciparum-specific antibodies in Gabonese newborns","volume":"45","author":"C Chizzolini","year":"1991","journal-title":"Am J Trop Med Hyg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/infdis\/jit185","article-title":"The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas","volume":"208","author":"MP Jepsen","year":"2013","journal-title":"J Infect Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.0141-9838.2001.00440.x","article-title":"Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2","volume":"24","author":"FM Ndungu","year":"2002","journal-title":"Parasite Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/expr.2001.4619","article-title":"Plasmodium falciparum: a major role for IgG3 in antibody-dependent monocyte-mediated cellular inhibition of parasite growth in vitro","volume":"98","author":"AE Tebo","year":"2001","journal-title":"Exp Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1128\/IAI.66.1.11-17.1998","article-title":"The glutamate-rich protein (GLURP) of Plasmodium falciparum is a target for antibody-dependent monocyte-mediated inhibition of parasite growth in vitro","volume":"66","author":"M Theisen","year":"1998","journal-title":"Infect Immun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.micinf.2012.02.011","article-title":"Naturally acquired antibodies to Plasmodium vivax blood-stage vaccine candidates (PvMSP-1(1)(9) and PvMSP-3alpha(3)(5)(9)(-)(7)(9)(8) and their relationship with hematological features in malaria patients from the Brazilian Amazon","volume":"14","author":"LC Mourao","year":"2012","journal-title":"Microbes Infect"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e36419","DOI":"10.1371\/journal.pone.0036419","article-title":"Influence of HLA-DRB1 and HLA-DQB1 alleles on IgG antibody response to the P. vivax MSP-1, MSP-3alpha and MSP-9 in individuals from Brazilian endemic area","volume":"7","author":"JC Lima-Junior","year":"2012","journal-title":"PLoS One"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.actatropica.2004.02.011","article-title":"HLA class II and antibody responses to circumsporozoite protein repeats of P. vivax (VK210, VK247 and P. vivax-like) in individuals naturally exposed to malaria","volume":"92","author":"J Oliveira-Ferreira","year":"2004","journal-title":"Acta Tropica"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0105828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T16:27:55Z","timestamp":1598200075000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0105828"}},"subtitle":[],"editor":[{"given":"Luzia Helena","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,22]]},"references-count":53,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0105828","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,22]]}}}