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Atlanta: U.S. Cancer Statistitcs Working Group."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","year":"2012","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"E Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa1113216","article-title":"Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer","volume":"366","author":"J Baselga","year":"2012","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S1470-2045(12)70489-8","article-title":"Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study","volume":"14","author":"PA Janne","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1073\/pnas.92.10.4482","article-title":"Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene","volume":"92","author":"M Oshima","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.tips.2012.05.001","article-title":"Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development","volume":"33","author":"J Roper","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrclinonc.2012.61","article-title":"Patient-derived tumour xenografts as models for oncology drug development","volume":"9","author":"JJ Tentler","year":"2012","journal-title":"Nat Rev Clin Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1158\/0008-5472.CAN-06-0594","article-title":"Establishment of human colon cancer cell lines from fresh tumors versus xenografts: comparison of success rate and cell line features","volume":"67","author":"V Dangles-Marie","year":"2007","journal-title":"Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ng.115","article-title":"Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon","volume":"40","author":"KM Haigis","year":"2008","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nbt.1595","article-title":"Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas","volume":"28","author":"Y Zhou","year":"2010","journal-title":"Nat Biotechnol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"8949","DOI":"10.1158\/0008-5472.CAN-09-1544","article-title":"De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model","volume":"69","author":"JW Watters","year":"2009","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1101\/gad.1987211","article-title":"Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress","volume":"25","author":"K Zaugg","year":"2011","journal-title":"Genes Dev"},{"key":"ref14","unstructured":"Meeske C, Growney J, Sengooba A, Yalavarthi S, Kong L, <etal>et al<\/etal>.. (2009) Abstract #4922: Population based in vivo genetic models of tumor metastasis. AACR Meeting Abstracts 2009: 4922-."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Goncalves R, Bose R Using multigene tests to select treatment for early-stage breast cancer. J Natl Compr Canc Netw 11: 174\u2013182; quiz 182.","DOI":"10.6004\/jnccn.2013.0025"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1634\/theoncologist.2014-0011","article-title":"Johnson DB, Dahlman KH, Knol J, Gilbert J, Puzanov I, et al. Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel","volume":"19","journal-title":"Oncologist"},{"key":"ref17","first-page":"4506","article-title":"Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer","volume":"59","author":"M Miyaki","year":"1999","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/1097-0142(20010901)92:5<1331::AID-CNCR1455>3.0.CO;2-M","article-title":"Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system","volume":"92","author":"NS Goldstein","year":"2001","journal-title":"Cancer"},{"key":"ref19","first-page":"1480","article-title":"c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases","volume":"9","author":"H Takeuchi","year":"2003","journal-title":"Clin Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3109\/07357909709047592","article-title":"Expression of the HGF\/SF receptor, c-met, and its ligand in human colorectal cancers","volume":"15","author":"SE Hiscox","year":"1997","journal-title":"Cancer Invest"},{"key":"ref21","first-page":"147","article-title":"Overexpression and amplification of the met\/HGF receptor gene during the progression of colorectal cancer","volume":"1","author":"MF Di Renzo","year":"1995","journal-title":"Clin Cancer Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/1535-7163.1427.3.11","article-title":"Specific inhibition of cyclin-dependent kinase 4\/6 by PD 0332991 and associated antitumor activity in human tumor xenografts","volume":"3","author":"DW Fry","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1158\/0008-5472.CAN-08-4765","article-title":"PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers","volume":"69","author":"S Wee","year":"2009","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/sj.onc.1206193","article-title":"Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation","volume":"22","author":"Q Chen","year":"2003","journal-title":"Oncogene"},{"key":"ref25","first-page":"361","article-title":"Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines","volume":"8","author":"S Timmermann","year":"1997","journal-title":"Cell Growth Differ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/bjc.2012.35","article-title":"Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma","volume":"106","author":"H Miyagaki","year":"2012","journal-title":"Br J Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/hep.21691","article-title":"Identification of PFTAIRE protein kinase 1, a novel cell division cycle-2 related gene, in the motile phenotype of hepatocellular carcinoma cells","volume":"46","author":"EY Pang","year":"2007","journal-title":"Hepatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"PJ Morin","year":"1997","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1073\/pnas.0908682107","article-title":"Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment","volume":"107","author":"KE Hung","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/(SICI)1097-010X(19970215)277:3<245::AID-JEZ5>3.0.CO;2-O","article-title":"A mouse model of human familial adenomatous polyposis","volume":"277","author":"K Yang","year":"1997","journal-title":"J Exp Zool"},{"key":"ref32","first-page":"1","article-title":"Surveillance of screening-detected cancers (colon and rectum, breast, and cervix) - 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