{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:48:25Z","timestamp":1769381305970,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0105977","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T18:05:19Z","timestamp":1408989919000},"page":"e105977","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Plasma Brain-Derived Neurotrophic Factor and Reverse Dipping Pattern of Nocturnal Blood Pressure in Patients with Cardiovascular Risk Factors"],"prefix":"10.1371","volume":"9","author":[{"given":"Manabu","family":"Kadoya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kurajoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Hatayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuhito","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Namba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/344339a0","article-title":"Identification and characterization of a novel member of the nerve growth factor\/brain-derived neurotrophic factor family","volume":"344","author":"A Hohn","year":"1990","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: Roles in neuronal development and function","volume":"24","author":"EJ Huang","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","article-title":"Transport of brain-derived neurotrophic factor across the blood-brain barrier","volume":"37","author":"W Pan","year":"1998","journal-title":"Neuropharmacology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-5793(00)01302-8","article-title":"Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor","volume":"470","author":"T Nakahashi","year":"2000","journal-title":"FEBS Lett"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tem.2013.10.006","article-title":"BDNFmediates adaptive brain and body responses to energetic challenges","volume":"25","author":"K Marosi","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"15239","DOI":"10.1073\/pnas.96.26.15239","article-title":"Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities","volume":"96","author":"WE Lyons","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1210\/en.2005-0419","article-title":"Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex","volume":"146","author":"B Bariohay","year":"2005","journal-title":"Endocrinology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.2337\/db06-0550","article-title":"Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (bdnf) gene","volume":"55","author":"J Gray","year":"2006","journal-title":"Diabetes"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nn1336","article-title":"A de novo mutation affecting human trkb associated with severe obesity and developmental delay","volume":"7","author":"GS Yeo","year":"2004","journal-title":"Nat Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1523\/JNEUROSCI.19-06-02131.1999","article-title":"BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons","volume":"19","author":"R Brady","year":"1999","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/jnr.23158","article-title":"Upregulation of brain-derived neurotrophic factor expression in nodose ganglia and the lower brainstem of hypertensive rats","volume":"91","author":"A Vermehren-Schmaedick","year":"2013","journal-title":"J Neurosci Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0306-4522(02)00085-4","article-title":"Injection of brain-derived neurotrophic factor in the rostral ventrolateral medulla increases arterial blood pressure in anaesthetized rats","volume":"112","author":"H Wang","year":"2002","journal-title":"Neuroscience"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1161\/CIRCULATIONAHA.104.476903","article-title":"Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease","volume":"112","author":"J Ejiri","year":"2005","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1161\/ATVBAHA.112.248930","article-title":"Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway","volume":"32","author":"S Okada","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijcard.2004.10.041","article-title":"Reduced plasma levels of ngf and bdnf in patients with acute coronary syndromes","volume":"102","author":"L Manni","year":"2005","journal-title":"Int J Cardiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e10099","DOI":"10.1371\/journal.pone.0010099","article-title":"Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: Data from the baltimore longitudinal study of aging","volume":"5","author":"E Golden","year":"2010","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1161\/01.CIR.81.2.700","article-title":"The clinical significance of diurnal blood pressure variations. Dippers and nondippers","volume":"81","author":"TG Pickering","year":"1990","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/hy1001.092640","article-title":"Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives","volume":"38","author":"K Kario","year":"2001","journal-title":"Hypertension"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/HYPERTENSIONAHA.108.124552","article-title":"Nocturnal blood pressure dipping in the hypertension of autonomic failure","volume":"53","author":"LE Okamoto","year":"2009","journal-title":"Hypertension"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1291\/hypres.29.977","article-title":"Evaluation of morning blood pressure elevation and autonomic nervous activity in hypertensive patients using wavelet transform of heart rate variability","volume":"29","author":"T Takagi","year":"2006","journal-title":"Hypertens Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1161\/01.HYP.30.6.1504","article-title":"Autonomic nervous system dysfunction in elderly hypertensive patients with abnormal diurnal blood pressure variation: Relation to silent cerebrovascular disease","volume":"30","author":"K Kario","year":"1997","journal-title":"Hypertension"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.5551\/jat.15792","article-title":"Executive summary of the japan atherosclerosis society (jas) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in japan -2012 version","volume":"20","author":"T Teramoto","year":"2013","journal-title":"J Atheroscler Thromb"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/diacare.27.2007.S5","article-title":"Diagnosis and classification of diabetes mellitus","volume":"27","year":"2004","journal-title":"Diabetes Care"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equations for estimated gfr from serum creatinine in japan","volume":"53","author":"S Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.sleep.2013.04.003","article-title":"Clinical significance of sleep-disordered breathing induced by sedatives during ablation of atrial fibrillation","volume":"14","author":"A Sairaku","year":"2013","journal-title":"Sleep Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/hr.2012.8","article-title":"Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in japanese patients with grade i-ii essential hypertension: A randomized, double-blind clinical study","volume":"35","author":"H Rakugi","year":"2012","journal-title":"Hypertens Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00126097-200102000-00004","article-title":"Comparison of the actigraph versus patients' diary information in defining circadian time periods for analyzing ambulatory blood pressure monitoring data","volume":"6","author":"MA Eissa","year":"2001","journal-title":"Blood Press Monit"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-510X(00)00505-0","article-title":"Effects of slow repetitive transcranial magnetic stimulation on heart rate variability according to power spectrum analysis","volume":"184","author":"T Yoshida","year":"2001","journal-title":"J Neurol Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","article-title":"Heart rate variability. Standards of measurement, physiological interpretation, and clinical use","volume":"17","year":"1996","journal-title":"Eur Heart J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuroscience.2008.04.003","article-title":"Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin i following cortical contusion injury in rats","volume":"154","author":"GS Griesbach","year":"2008","journal-title":"Neuroscience"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.amjhyper.2004.09.007","article-title":"Time for focus on morning hypertension: Pitfall of current antihypertensive medication","volume":"18","author":"K Kario","year":"2005","journal-title":"Am J Hypertens"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1161\/HYPERTENSIONAHA.108.116368","article-title":"Adrenergic, metabolic, and reflex abnormalities in reverse and extreme dipper hypertensives","volume":"52","author":"G Grassi","year":"2008","journal-title":"Hypertension"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0304-3940(02)00529-3","article-title":"Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets","volume":"328","author":"F Karege","year":"2002","journal-title":"Neurosci Lett"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1210\/en.2007-0161","article-title":"Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess","volume":"148","author":"B Martin","year":"2007","journal-title":"Endocrinology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nn0602-853","article-title":"A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor","volume":"5","author":"B Yang","year":"2002","journal-title":"Nat Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e34844","DOI":"10.1371\/journal.pone.0034844","article-title":"Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor trkb in rat brain","volume":"7","author":"H Furmaga","year":"2012","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0735-1097(97)00554-8","article-title":"Twenty-four hour time domain heart rate variability and heart rate: Relations to age and gender over nine decades","volume":"31","author":"K Umetani","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2337\/dc11-1652","article-title":"Heart rate variability and sensorimotor polyneuropathy in type 1 diabetes","volume":"35","author":"S Orlov","year":"2012","journal-title":"Diabetes Care"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.jrn.2012.12.008","article-title":"Autonomic function is associated with health-related quality of life in patients with end-stage renal disease: A case-control study","volume":"23","author":"H Fujii","year":"2013","journal-title":"J Renal Nutr"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.sleep.2013.10.005","article-title":"Estimation of parasympathetic nerve function during sleep in patients with obstructive sleep apnea by instantaneous time-frequency analysis","volume":"15","author":"K Yamaguchi","year":"2004","journal-title":"Sleep Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.2337\/db11-1235","article-title":"Cardiovascular autonomic neuropathy and subclinical cardiovascular disease in normoalbuminuric type 1 diabetic patients","volume":"61","author":"UM Mogensen","year":"2012","journal-title":"Diabetes"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0105977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:11:44Z","timestamp":1589015504000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0105977"}},"subtitle":[],"editor":[{"given":"Renping","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,25]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0105977","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,25]]}}}