{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:49:36Z","timestamp":1789897776340,"version":"4.0.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106235","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T17:49:29Z","timestamp":1411408169000},"page":"e106235","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["P2Y6 Receptor-Mediated Proinflammatory Signaling in Human Bronchial Epithelia"],"prefix":"10.1371","volume":"9","author":[{"given":"Yuan","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn F.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison W.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-tai","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-hung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1165\/rcmb.2008-0020OC","article-title":"Apical versus basolateral P2Y<sub>6<\/sub> receptor-mediated Cl<sup>\u2212<\/sup> secretion in immortalized bronchial epithelia","volume":"40","author":"AM Wong","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/sj.bjp.0704524","article-title":"P2 receptors: new potential players in atherosclerosis","volume":"135","author":"F Di Virgilio","year":"2002","journal-title":"Br J Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12264-009-0120-3","article-title":"P2Y<sub>6<\/sub> receptor and immunoinflammation","volume":"25","author":"GD Liu","year":"2009","journal-title":"Neurosci Bull"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.4049\/jimmunol.1000212","article-title":"Uridine 5&apos;-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor","volume":"186","author":"B Kim","year":"2011","journal-title":"J Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4049\/jimmunol.1003746","article-title":"P2Y<sub>6<\/sub> receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals","volume":"188","author":"H Uratsuji","year":"2012","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/sj.bjp.0705145","article-title":"Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils","volume":"138","author":"M Idzko","year":"2003","journal-title":"Br J Pharmacol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/jcp.20979","article-title":"Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells","volume":"211","author":"B Marcet","year":"2007","journal-title":"J Cell Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1167\/iovs.08-1902","article-title":"Extracellular nucleotides and interleukin-8 production by ARPE cells: potential role of danger signals in blood-retinal barrier activation","volume":"50","author":"LJ Relvas","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2005.03.004","article-title":"The pyrimidinergic P2Y<sub>6<\/sub> receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP","volume":"330","author":"MA Cox","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.180.4.2659","article-title":"Intestinal inflammation increases the expression of the P2Y<sub>6<\/sub> receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP","volume":"180","author":"DM Grbic","year":"2008","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nm1617","article-title":"Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells","volume":"13","author":"M Idzko","year":"2007","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Coyle AJ, Gutierrez-Ramos JC (2000) Eosinophils in asthma. In: Page C.F., Banner K.H., Spina D., editors. Cellular Mechanisms in Airways Inflammation. Basel - Boston - Berlin: Birkhauser Verlag. pp. 147\u2013158.","DOI":"10.1007\/978-3-0348-8476-1_5"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e12091","DOI":"10.1371\/journal.pone.0012091","article-title":"Polarized Secretion of Interleukin (IL)-6 and IL-8 by Human Airway Epithelia 16HBE14o- Cells in Response to Cationic Polypeptide Challenge","volume":"5","author":"AW Chow","year":"2010","journal-title":"PLoS ONE"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1165\/ajrcmb.10.1.7507342","article-title":"CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells","volume":"10","author":"AL Cozens","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0026-895X(25)09210-7","article-title":"Uridine nucleotide selectivity of three phospholipase C- activating P2 receptors - identification of a udp-selective, a UTP-selective, and an ATP- and UTP-specific receptor","volume":"50","author":"RA Nicholas","year":"1996","journal-title":"Molecular Pharmacology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1021\/ol9004849","article-title":"An &quot;Off-On&quot; type UTP\/UDP selective fluorescent probe and its application to monitor glycosylation process","volume":"11","author":"X Chen","year":"2009","journal-title":"Org Lett"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"31294","DOI":"10.1074\/jbc.M505657200","article-title":"Interplay of Ca<sup>2+<\/sup> and cAMP signaling in the insulin-secreting MIN6 beta-cell line","volume":"280","author":"LR Landa Jr","year":"2005","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1916","DOI":"10.1371\/journal.pone.0001916","article-title":"A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example","volume":"3","author":"GN van der Krogt","year":"2008","journal-title":"PLoS ONE"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e22363","DOI":"10.1371\/journal.pone.0022363","article-title":"Differential Inhibitory Effects of CysLT<sub>1<\/sub> Receptor Antagonists on P2Y<sub>6<\/sub> Receptor-Mediated Signaling and Ion Transport in Human Bronchial Epithelia","volume":"6","author":"WK Lau","year":"2011","journal-title":"PLoS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.cell.2007.09.037","article-title":"Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia","volume":"131","author":"C Li","year":"2007","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jim.2007.10.015","article-title":"Quantitative imaging assay for NF-kappaB nuclear translocation in primary human macrophages","volume":"329","author":"M Noursadeghi","year":"2008","journal-title":"J Immunol Methods"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1083\/jcb.56.3.787","article-title":"A role for anionic sites in epithelial architecture. Effects of cationic polymers on cell membrane structure","volume":"56","author":"PM Quinton","year":"1973","journal-title":"J Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/9780470032244.ch7","article-title":"Regulated release of nucleotides and UDP sugars from astrocytoma cells","volume":"276","author":"E Lazarowski","year":"2006","journal-title":"Novartis Found Symp"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0898-6568(00)00083-8","article-title":"Advances in signalling by extracellular nucleotides. the role and transduction mechanisms of P2Y receptors","volume":"12","author":"D Communi","year":"2000","journal-title":"Cell Signal"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1021\/jm060485n","article-title":"Structure-activity relationships of uridine 5&apos;-diphosphate analogues at the human P2Y<sub>6<\/sub> receptor","volume":"49","author":"P Besada","year":"2006","journal-title":"J Med Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1159\/000107532","article-title":"Enhancement of P2Y<sub>6<\/sub>-induced Cl<sup>\u2212<\/sup> secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells","volume":"20","author":"S Dulong","year":"2007","journal-title":"Cell Physiol Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.bcp.2004.01.011","article-title":"Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y<sub>6<\/sub> nucleotide receptors","volume":"67","author":"LK Mamedova","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"ref28","first-page":"387","article-title":"Airway epithelial cell release of cytokines: modulation by various therapeutic agents","volume":"25","author":"M Frieri","year":"2004","journal-title":"Allergy Asthma Proc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ddr.10191","article-title":"Extracellular ATP, P2 receptors, and inflammation","volume":"59","author":"F Di Virgilio","year":"2003","journal-title":"Drug Development Research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/cimm.1999.1531","article-title":"Extracellular uridine nucleotides initiate cytokine production by murine dendritic cells","volume":"195","author":"I Marriott","year":"1999","journal-title":"Cell Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.180.4.2659","article-title":"Intestinal inflammation increases the expression of the P2Y<sub>6<\/sub> receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP","volume":"180","author":"DM Grbic","year":"2008","journal-title":"J Immunol"},{"key":"ref32","first-page":"1375","article-title":"Expression of the P2Y<sub>6<\/sub> purinergic receptor in human T cells infiltrating inflammatory bowel disease","volume":"78","author":"GR Somers","year":"1998","journal-title":"Lab Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"26051","DOI":"10.1074\/jbc.M102568200","article-title":"P2Y<sub>6<\/sub> nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide","volume":"276","author":"M Warny","year":"2001","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1023\/A:1023696806609","article-title":"P2Y<sub>6<\/sub> nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis","volume":"23","author":"SG Kim","year":"2003","journal-title":"Cell Mol Neurobiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.04.019","article-title":"ATP and the pathogenesis of COPD","volume":"638","author":"E Mortaz","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/BF03401831","article-title":"Basal nucleotide levels, release, and metabolism in normal and cystic fibrosis airways","volume":"6","author":"SH Donaldson","year":"2000","journal-title":"Mol Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1471-4159.2012.07700.x","article-title":"Nucleotides released from A<sub>\u00df1\u201342<\/sub> -treated microglial cells increase cell migration and A<sub>\u00df1\u201342<\/sub> uptake through P2Y<sub>2<\/sub> receptor activation","volume":"121","author":"HJ Kim","year":"2012","journal-title":"J Neurochem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1182\/blood-2010-10-313957","article-title":"Selective induction of endothelial P2Y<sub>6<\/sub> nucleotide receptor promotes vascular inflammation","volume":"117","author":"AK Riegel","year":"2011","journal-title":"Blood"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/09622935020138172","article-title":"Effects of the cationic protein poly-L-arginine on airway epithelial cells in vitro","volume":"11","author":"S Shahana","year":"2002","journal-title":"Mediators Inflamm"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11302-005-6217-x","article-title":"Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8","volume":"1","author":"F Kukulski","year":"2005","journal-title":"Purinergic Signal"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1152\/ajplung.00389.2005","article-title":"Nucleotides Induce IL-6 Release from Human Airway Epithelia via P2Y2 and p38 MAPK-Dependent Pathways","volume":"291","author":"CD Douillet","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1165\/rcmb.2005-0181OC","article-title":"The P2Y<sub>14<\/sub> receptor of airway epithelial cells: coupling to intracellular Ca<sup>2+<\/sup> and IL-8 secretion","volume":"33","author":"T Muller","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1182\/blood-2005-06-2314","article-title":"Human neutrophil peptides induce interleukin-8 production through the P2Y<sub>6<\/sub> signaling pathway","volume":"107","author":"AA Khine","year":"2006","journal-title":"Blood"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.4049\/jimmunol.168.7.3577","article-title":"Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells","volume":"168","author":"N Asokananthan","year":"2002","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1165\/ajrcmb\/5.5.484","article-title":"The response of a human bronchial epithelial cell line to histamine: intracellular calcium changes and extracellular release of inflammatory mediators","volume":"5","author":"TL Noah","year":"1991","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/jcp.20979","article-title":"Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells","volume":"211","author":"B Marcet","year":"2007","journal-title":"J Cell Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11302-006-9037-8","article-title":"Activation of transcription factors by extracellular nucleotides in immune and related cell types","volume":"3","author":"S Armstrong","year":"2007","journal-title":"Purinergic Signal"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T19:22:43Z","timestamp":1746386563000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106235"}},"subtitle":[],"editor":[{"given":"Shama","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,22]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106235","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,22]]}}}