{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:13:25Z","timestamp":1776258805113,"version":"3.50.1"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106256","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T18:00:12Z","timestamp":1409680812000},"page":"e106256","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation between Histopathological and FT-Raman Spectroscopy Analysis of the Liver of Swiss Mice Infected with Paracoccidioides brasiliensis"],"prefix":"10.1371","volume":"9","author":[{"given":"Elaine Sciuniti Benites","family":"Mansano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gutierrez Rodrigues de","family":"Morais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilaine Martins","family":"Moratto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francielle","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Medina Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terezinha Ines Estivalet","family":"Svidzinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro Luciano","family":"Baesso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzmarina","family":"Hernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"ref1","first-page":"1441","article-title":"Paracoccidioidomycosis mortality in Brazil (1990\u20131995). Cad Sa\u00fade P\u00fablica","volume":"18(5)","author":"ZF Coutinho","year":"2002","journal-title":"Rio de Janeiro"},{"key":"ref2","first-page":"1","article-title":"Biochemical characterization of <italic>Paracoccidioides brasiliensis<\/italic> \u03b1-1,3-glucanase Agn1p, and its functionality by heterologous expression in Schzosaccharomyces pombe","volume":"8(6)","author":"H Villalobos-Duno","year":"2013","journal-title":"PloS ONE"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0037-86822006000300017","article-title":"Consenso em paracoccidioidomicose \u2013 Relat\u00f3rio T\u00e9cnico","volume":"39(3)","author":"MA Shikanai-Yasuda","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1111\/j.1567-1364.2007.00292.x","article-title":"Analysis of the <italic>Paracoccidioides brasiliensis<\/italic> triosephosphate isomerase suggests the potential for adhesion function","volume":"7","author":"LA Pereira","year":"2007","journal-title":"FEMS Yeast Res"},{"key":"ref5","first-page":"1245","article-title":"Chapter 6 \u2013 Paracoccidioidomycosis. Continuing Education Course \u2013 Mycoses","volume":"35(12)","author":"B Wanke","year":"2009","journal-title":"J Bras Pneumol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.1124105","article-title":"Global control of dimorphism and virulence in fungi","volume":"312","author":"JC Nemecek","year":"2006","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1128\/IAI.00221-10","article-title":"<italic>Paracoccidioides brasiliensis<\/italic> enolase is a surface protein that binds plasminogen and mediates interaction of yeast forms with host cells","volume":"78(9)","author":"SV Nogueira","year":"2010","journal-title":"Infect Immun"},{"key":"ref8","first-page":"486","article-title":"Preferential transcription of <italic>Paracoccidioides brasiliensis<\/italic> genes: host niche and time-dependent expression. Mem Inst Oswaldo Cruz","volume":"104(3)","author":"M Pereira","year":"2009","journal-title":"Rio de Janeiro"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-3083.2008.02199.x","article-title":"Inhibition of human neutrophil apoptosis by <italic>Paracoccidioides brasiliensis<\/italic>: Role of interleukin-8","volume":"69","author":"MJ Acorci","year":"2008","journal-title":"Scand J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11046-009-9228-2","article-title":"Characteristics of environmental <italic>Paracoccidioides brasiliensis<\/italic>isolates","volume":"169","author":"PF Costa","year":"2010","journal-title":"Mycopathologia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.micinf.2005.03.002","article-title":"The multitude of targets for the immune system and drug therapy in the fungal cell wall","volume":"7","author":"L Nimrichter","year":"2005","journal-title":"Microbes Infect"},{"key":"ref12","first-page":"49","article-title":"Actualizaciones Paracoccidioidomicosis","volume":"1(1)","author":"J Vargas","year":"2009","journal-title":"Rev enferm infecc trop"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0008-8749(02)00576-2","article-title":"Gp43 from <italic>Paracoccidioides brasiliensis<\/italic> inhibits macrophage functions. An evasion mechanism of the fungus","volume":"218","author":"AF Popi","year":"2002","journal-title":"Cell Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/1471-2180-9-277","article-title":"Polymorphism in the flanking regions of the PbGp43 gene from the human pathogen <italic>Paracoccidioides brasiliensis<\/italic>: search for protein binding sequences and poly (A) cleavage sites","volume":"9","author":"AA Rocha","year":"2009","journal-title":"BMC Microbiol"},{"key":"ref15","first-page":"1","article-title":"Western blot is an efficient tool in differential diagnosis between paracoccidioidomycosis and pulmonary tuberculosis","volume":"19","author":"TA Bertoni","year":"2012","journal-title":"ClinVaccine Immunol"},{"key":"ref16","first-page":"616","article-title":"Serological diagnosis of Paracoccidioidomycosis through a Western Blot technique","volume":"19(4)","author":"MCZ Perenha-Viana","year":"2012","journal-title":"ClinVaccine Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jpedsurg.2004.02.043","article-title":"Raman spectroscopy for neoplastic tissue differentiation: A piloto study","volume":"39(6)","author":"AL Lorincz","year":"2004","journal-title":"J Pediatr Surg"},{"key":"ref18","first-page":"0950041","article-title":"Crude extract of Fusarium oxysporum induces apoptosis and structural alterations in the skin of healthy rats","volume":"18(9)","author":"LF De Paulo","year":"2013","journal-title":"J Biomed Optics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/php.12110","article-title":"Morphological and structural changes in lung tissue infected by <italic>Paracoccidioides brasiliensis<\/italic>: FTIR Photoacoustic Spectroscopy and Histological Analysis","volume":"89","author":"EM Moratto","year":"2013","journal-title":"Photochem Photobiol Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1590\/S0037-86822012000300020","article-title":"Paracoccidioidomycosis in the State of Maranh\u00e3o, Brazil: geographical and clinical aspects","volume":"45(3)","author":"WB Matos","year":"2012","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1590\/S0037-86822006000500011","article-title":"Laboratory evolutive aspects of children under paracoccidioidomycosis treatment","volume":"39(5)","author":"MGS Nogueira","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1590\/S1516-89132006000700006","article-title":"Biochemical responses in mice experimentally infected with <italic>Paracoccidioides brasiliensis<\/italic> and treated with Canova","volume":"49(6)","author":"G Takahachi","year":"2006","journal-title":"Braz Arch Biol Technol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1258\/002367781780959107","article-title":"Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience","volume":"5","author":"CJ Green","year":"1981","journal-title":"Laboratory Animals"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/JCM.12.2.279-281.1980","article-title":"Growth of <italic>Paracoccidioides brasiliensis<\/italic> yeast phase in a chemically defined culture medium","volume":"(2)","author":"A Restrepo","year":"1980","journal-title":"J Clin Microbiol 12"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1128\/jcm.8.5.598-603.1978","article-title":"Combined methenamine-silver nitrate and hematoxylin &amp; eosin stain for fungi in tissues","volume":"8(5)","author":"M Huppert","year":"1978","journal-title":"J Clin Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/ajcp\/25.8_ts.0975","article-title":"A stain for fungi in tissue sections and smears","volume":"25","author":"RG Grocott","year":"1955","journal-title":"Am J Clin Path"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"22892","DOI":"10.1364\/OE.19.022892","article-title":"Full range characterization of the Raman spectra of organs in a murine model","volume":"23","author":"N Huang","year":"2011","journal-title":"Opt Express"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jemt.20229","article-title":"Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma","volume":"68","author":"W-T Cheng","year":"2005","journal-title":"Microsc Res Tech"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1366\/000370209788559647","article-title":"Surface-enhanced Raman scattering of rat tissues","volume":"63(6)","author":"\u00d6 Aydin","year":"2009","journal-title":"J Appl Spectrosc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2249.1994.tb06588.x","article-title":"Pathogenicity of <italic>Paracoccidioides brasilienis<\/italic> isolates in the human disease and in an experimental murine model","volume":"97","author":"LM Singer-Vermes","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0966-842X(01)02292-2","article-title":"The pathobiology of <italic>Paracoccidiodes brasiliensis<\/italic>","volume":"(2)","author":"MI Borges-Walmsley","year":"2002","journal-title":"Curr Trends Microbiol 10"},{"key":"ref32","first-page":"16","article-title":"Forma linf\u00e1tico-abdominal da Blastomicose Sul-Americana","volume":"10(1)","author":"W Barbosa","year":"1968","journal-title":"Rev Inst MedTrop S\u00e3o Paulo"},{"key":"ref33","first-page":"188","article-title":"Biopsia hep\u00e1tica na blastomicose sul-americana","volume":"10(3)","author":"T Brito","year":"1968","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/CVI.00285-06","article-title":"Expression of antibodies directed to Paracoccidioides brasiliensis glycosphingolipids during the course of Paracoccidioidomycosis treatment","volume":"14(2)","author":"S Bertini","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"ref35","first-page":"350","article-title":"Icter\u00edcia e comprometimento hep\u00e1tico na blastomicose sul-americana. A prop\u00f3sito de 10 casos","volume":"56","author":"I Bocalandro","year":"1960","journal-title":"Rev Paul Med"},{"key":"ref36","first-page":"256","article-title":"Hepatic involvement in pediatric patients with paracoccidioidomycosis: a histological study","volume":"64(2)","author":"GM Braga","year":"2013","journal-title":"Histopathology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4269\/ajtmh.2009.80.798","article-title":"Morphologic organization of pulmonar granulomas in mice infected with <italic>Paracoccidioides brasiliensis<\/italic>","volume":"80(5)","author":"FC Da Silva","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref38","first-page":"1","article-title":"<italic>Paracoccidoides brasiliensis<\/italic> 30 kDa Adhesin: Identification as a 14-3-3 protein, cloning and subcellular localization in infection models","volume":"8(4)","author":"JF Da Silva","year":"2013","journal-title":"PloS ONE"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2613.2008.00573.x","article-title":"Expression and arrangement of extracellular matrix proteins in the lungs of mice infected with <italic>Paracoccidioides brasiliensis<\/italic> conidia","volume":"89","author":"A Gonz\u00e1lez","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/mmy.38.s1.113.123","article-title":"Pathogegesis II: fungal responses to host responses: interaction of host cells with fungi","volume":"38","author":"MJS Mendes-Giannini","year":"2000","journal-title":"Med J Mycol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S1286-4579(00)00390-7","article-title":"Adherence and intracellular parasitism of <italic>Paracoccidioides brasiliensis<\/italic> in vero cells","volume":"2","author":"SA Hanna","year":"2000","journal-title":"Microbes Infect"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00588649","article-title":"Experimental pulmonar paracoccidioidomycosis in mice: Morphology and correlation of lesion with humoral and cellular immune response","volume":"77","author":"J Defaveri","year":"1982","journal-title":"Mycopathologia"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00443831","article-title":"Histological and ultrastructural study of the inflammation evoked by <italic>Paracoccidioides brasiliensis<\/italic> antigen in previously immunized mice","volume":"105","author":"J Defaveri","year":"1989","journal-title":"Mycopathologia"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00492223","article-title":"Pulmonary paracoccidioidomycosis in immunized mice","volume":"119","author":"J Defaveri","year":"1992","journal-title":"Mycopathologia"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-2180-9-84","article-title":"<italic>Paracoccidioides brasiliensis<\/italic> pancreatic destruction in <italic>Calomyscallosus<\/italic> experimentally infected","volume":"9","author":"RM Fortes","year":"2009","journal-title":"BMC Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1590\/S0365-05962011000300014","article-title":"Immunology of paracoccidioidomycosis","volume":"86(3)","author":"MRP Fortes","year":"2011","journal-title":"An Bras Dermatol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0304-3835(96)04455-2","article-title":"Characterization of normal and malignant human hepatocytes by Raman microespectroscopy","volume":"110(1\u20132)","author":"SR Hawi","year":"1996","journal-title":"Cancer Lett"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/bip.20398","article-title":"Discrimination of normal, inflammatory, premalignant, and malignant oral tissue: A Raman spectroscopy study","volume":"81(3)","author":"R Malini","year":"2006","journal-title":"Biopolymers"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1590\/S0102-86502010000500009","article-title":"Differential diagnosis in primary and metastatic cutaneous melanoma by FT-Raman spectroscopy","volume":"25(5)","author":"AF De Oliveira","year":"2010","journal-title":"Acta Cir Bras"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"017009","DOI":"10.1117\/1.3316296","article-title":"Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy","volume":"15(1)","author":"Y Oshima","year":"2010","journal-title":"J Biomed Opt"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.micinf.2005.02.005","article-title":"Isolation and partial characterization of a 30 kDa adhesin from <italic>Paracoccidioides brasiliensis<\/italic>","volume":"7","author":"PF Andreotti","year":"2005","journal-title":"Microbes Infect"},{"key":"ref52","first-page":"1010","article-title":"Murine laminin binds to <italic>Histoplasma capsulatum<\/italic>. A possible mechanism of dissemination","volume":"96","author":"JP Mc Mahon","year":"1995","journal-title":"J Clin Infect Dis"},{"key":"ref53","first-page":"115","article-title":"Two patterns of extracellular matrix expression in experimental paracoccidioidomycosis. Med","volume":"38","author":"HL Lenzi","year":"2000","journal-title":"Mycol J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1590\/S0074-02762009000400019","article-title":"Resistance of menalized yeast cells of <italic>Paracoccidioides brasiliensis<\/italic> to antimicrobial oxidants and inhibition of phagocytosis using carbohydrates and monoclonal antibody to CD18","volume":"104(4)","author":"MB Da Silva","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.micinf.2005.06.018","article-title":"Melanin in the dimorphic fungal pathogen <italic>Paracoccidioides brasiliensis<\/italic>: effects on phagocytosis, intracellular resistance and drug susceptibility","volume":"8","author":"MB Da Silva","year":"2006","journal-title":"Microbes Infect"},{"key":"ref56","first-page":"1","article-title":"3,4-dihydroxy-L-phenylalanine-derived melanin from <italic>Yarrowia lipolytica<\/italic> mediates the synthesis of silver and gold nanostructures","volume":"11(2)","author":"M Apte","year":"2013","journal-title":"J Nanobiotechnol"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Lien-Vien D, Colthup NB, Fateley WG, Grasseli JG (1991) The handbook of IR and Raman characteristic frequencies of organic molecules (Compounds containing \u2013NH<sub>2<\/sub>, \u2013NHR and NR<sub>2<\/sub>). Academic Press LTD California. pp. 155\u2013175.","DOI":"10.1016\/B978-0-08-057116-4.50016-X"},{"key":"ref58","unstructured":"Socrates G (2001) Macromolecules in Infrared and Raman characteristic group frequencies. John Wiley &amp; Son LTD Chichester. 366 p."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T04:16:57Z","timestamp":1650082617000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106256"}},"subtitle":[],"editor":[{"given":"Kirsten","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,2]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106256","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,2]]}}}