{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:29:36Z","timestamp":1789450176434,"version":"build-2803163510"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106302","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T17:59:00Z","timestamp":1409767140000},"page":"e106302","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation"],"prefix":"10.1371","volume":"9","author":[{"given":"Aline","family":"Rideau Batista Novais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Crouzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Cavalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Boubal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janique","family":"Guiramand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cohen-Solal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-C\u00e9leste","family":"de Jesus Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Cambonie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Vignes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Barbanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s10803-010-1006-y","article-title":"Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders","volume":"40","author":"HO Atladottir","year":"2010","journal-title":"J Autism Dev Disord"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: a review of epidemiologic and translational studies","volume":"167","author":"AS Brown","year":"2010","journal-title":"Am J Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.22620","article-title":"Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults","volume":"71","author":"H Hagberg","year":"2012","journal-title":"Ann Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","article-title":"Effects of prenatal infection on brain development and behavior: A review of findings from animal models","volume":"24","author":"P Boksa","year":"2010","journal-title":"Brain Behav Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.schres.2008.10.003","article-title":"Prenatal immune challenge induces developmental changes in the morphology of pyramidal neurons of the prefrontal cortex and hippocampus in rats","volume":"107","author":"M Baharnoori","year":"2009","journal-title":"Schizophr Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.neuropharm.2011.11.022","article-title":"A stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy","volume":"62","author":"L Harvey","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.euroneuro.2011.08.001","article-title":"Prenatal exposure to bacterial endotoxin reduces the number of GAD67- and reelin-immunoreactive neurons in the hippocampus of rat offspring","volume":"22","author":"D Nouel","year":"2012","journal-title":"European Neuropsychopharmacology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/pr.2013.40","article-title":"N-acetyl-cysteine prevents pyramidal cell disarray and reelin-immunoreactive neuron deficiency in CA3 after prenatal immune challenge in rats","volume":"73","author":"A Rideau Batista Novais","year":"2013","journal-title":"Pediatr Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1128134","article-title":"Learning induces long-term potentiation in the hippocampus","volume":"313","author":"JR Whitlock","year":"2006","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"16697","DOI":"10.1073\/pnas.1008200107","article-title":"Hippocampal long-term depression is required for the consolidation of spatial memory","volume":"107","author":"Y Ge","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/hipo.20421","article-title":"Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation","volume":"18","author":"F Lante","year":"2008","journal-title":"Hippocampus"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.freeradbiomed.2007.01.027","article-title":"Neurodevelopmental damage after prenatal infection: role of oxidative stress in the fetal brain","volume":"42","author":"F Lante","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neuropharm.2011.02.022","article-title":"Prenatal exposure to a viral mimetic alters behavioural flexibility in male, but not female, rats","volume":"62","author":"Y Zhang","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yhbeh.2012.03.015","article-title":"Sex effects on neurodevelopmental outcomes of innate immune activation during prenatal and neonatal life","volume":"62","author":"SA Rana","year":"2012","journal-title":"Horm Behav"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.biopsych.2011.01.009","article-title":"Early, time-dependent disturbances of hippocampal synaptic transmission and plasticity after in utero immune challenge","volume":"70","author":"M Escobar","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/schbul\/sbr028","article-title":"Adolescent onset of cortical disinhibition in schizophrenia: insights from animal models","volume":"37","author":"P O'Donnell","year":"2011","journal-title":"Schizophr Bull"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nn.2447","article-title":"Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes","volume":"13","author":"JE Belforte","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref18","unstructured":"Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. San Diego: Academic Press."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1113\/jphysiol.2009.179887","article-title":"Both synaptic and intrinsic mechanisms underlie the different properties of population bursts in the hippocampal CA3 area of immature versus adult rats","volume":"587","author":"LR Shao","year":"2009","journal-title":"J Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1054-3589(10)58008-6","article-title":"GABA transporter GAT1: a crucial determinant of GABAB receptor activation in cortical circuits?","volume":"58","author":"G Gonzalez-Burgos","year":"2010","journal-title":"Adv Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00702-008-0095-7","article-title":"Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release","volume":"115","author":"PC Waldmeier","year":"2008","journal-title":"J Neural Transm"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1113\/jphysiol.1995.sp020675","article-title":"Different mechanisms for use-dependent depression of two GABAA-mediated IPSCs in rat hippocampus","volume":"2)","author":"RA Pearce","year":"1995","journal-title":"J Physiol 484 (Pt"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1523\/JNEUROSCI.15-02-01577.1995","article-title":"GABAergic and developmental influences on homosynaptic LTD and depotentiation in rat hippocampus","volume":"15","author":"JJ Wagner","year":"1995","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0006-3223(98)00138-3","article-title":"A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives","volume":"44","author":"FM Benes","year":"1998","journal-title":"Biological Psychiatry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10164","DOI":"10.1073\/pnas.0703806104","article-title":"Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars","volume":"104","author":"FM Benes","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","volume":"9","unstructured":"Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey EF, <etal>et al<\/etal>.. (2004) Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry <volume>9<\/volume>: : 609\u2013620, 544."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/(SICI)1098-2396(199808)29:4<323::AID-SYN4>3.0.CO;2-7","article-title":"Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain","volume":"29","author":"MS Todtenkopf","year":"1998","journal-title":"Synapse"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbi.2007.09.012","article-title":"Adult brain and behavioral pathological markers of prenatal immune challenge during early\/middle and late fetal development in mice","volume":"22","author":"U Meyer","year":"2008","journal-title":"Brain Behav Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"R1345","DOI":"10.1152\/ajpregu.00268.2005","article-title":"Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA\/GABA(A) dysregulation and impaired spatial learning","volume":"290","author":"AM Samuelsson","year":"2006","journal-title":"American Journal of Physiology-Regulatory Integrative and Comparative Physiology"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Richetto J, Calabrese F, Riva MA, Meyer U (2013) Prenatal Immune Activation Induces Maturation-Dependent Alterations in the Prefrontal GABAergic Transcriptome. Schizophr Bull. doi:10.1093\/schbul\/sbs195.","DOI":"10.1093\/schbul\/sbs195"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.biopsych.2010.09.052","article-title":"A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia","volume":"69","author":"RW Buchanan","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pharmthera.2009.09.001","article-title":"Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA","volume":"125","author":"JR Atack","year":"2010","journal-title":"Pharmacol Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1124\/pr.109.002063","article-title":"Regulation of GABA(A) receptor subunit expression by pharmacological agents","volume":"62","author":"M Uusi-Oukari","year":"2010","journal-title":"Pharmacol Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1073\/pnas.89.10.4363","article-title":"Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade","volume":"89","author":"SM Dudek","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0896-6273(92)90248-C","article-title":"Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus","volume":"9","author":"RM Mulkey","year":"1992","journal-title":"Neuron"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jnr.10823","article-title":"Prenatal infection obliterates glutamate-related protection against free hydroxyl radicals in neonatal rat brain","volume":"75","author":"G Cambonie","year":"2004","journal-title":"J Neurosci Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1038\/tp.2012.69","article-title":"GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction","volume":"2","author":"MJ Gandal","year":"2012","journal-title":"Transl Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cercor\/10.5.482","article-title":"Long-term depression in freely moving rats is dependent upon strain variation, induction protocol and behavioral state","volume":"10","author":"D Manahan-Vaughan","year":"2000","journal-title":"Cerebral Cortex"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0028-3908(98)00222-6","article-title":"Induction of LTD in the adult hippocampus by the synaptic activation of AMPA\/kainate and metabotropic glutamate receptors","volume":"38","author":"N Kemp","year":"1999","journal-title":"Neuropharmacology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:20:27Z","timestamp":1588969227000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106302"}},"subtitle":[],"editor":[{"given":"Christopher Mark","family":"Norris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,3]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106302","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,3]]}}}