{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:43:49Z","timestamp":1752983029198},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106324","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T18:02:27Z","timestamp":1409680947000},"page":"e106324","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Differential Binding of Tenofovir and Adefovir to Reverse Transcriptase of Hepatitis B Virus"],"prefix":"10.1371","volume":"9","author":[{"given":"Formijn J.","family":"van Hemert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Berkhout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans L.","family":"Zaaijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.2165\/10482940-000000000-00000","article-title":"Tenofovir disoproxil fumarate: in chronic hepatitis B","volume":"69","author":"CM Perry","year":"2009","journal-title":"Drugs"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coviro.2014.04.005","article-title":"Nucleoside\/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance","volume":"8C","author":"L Menendez-Arias","year":"2014","journal-title":"Curr Opin Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1053\/j.gastro.2007.02.039","article-title":"Drug targets and molecular mechanisms of drug resistance in chronic hepatitis B","volume":"132","author":"M Ghany","year":"2007","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jinf.2013.05.008","article-title":"Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen","volume":"67","author":"V Cento","year":"2013","journal-title":"J Infect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/hep.26686","article-title":"No detectable resistance to tenofovir disoproxil fumarate after 6 years of therapy in patients with chronic hepatitis B","volume":"59","author":"KM Kitrinos","year":"2014","journal-title":"Hepatology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9556","DOI":"10.1074\/jbc.272.14.9556","article-title":"Stereoisomers of deoxynucleoside 5&apos;-triphosphates as substrates for template-dependent and -independent DNA polymerases","volume":"272","author":"DG Semizarov","year":"1997","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/bbrc.1996.0882","article-title":"The catalytic properties of human hepatitis B virus polymerase","volume":"223","author":"JH Jeong","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/ci0502146","article-title":"PEARLS: program for energetic analysis of receptor-ligand system","volume":"46","author":"LY Han","year":"2006","journal-title":"J Chem Inf Model"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0166-3542(96)00944-8","article-title":"Nucleotide substitution patterns can predict the requirements for drug-resistance of HIV-1 proteins","volume":"31","author":"W Keulen","year":"1996","journal-title":"Antiviral Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2009.08.063","article-title":"Hepatitis B virus resistance to nucleos(t)ide analogues","volume":"137","author":"F Zoulim","year":"2009","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/135965350801300212","article-title":"Prevalence, genotypic associations and phenotypic characterization of K65R, L74V and other HIV-1 RT resistance mutations in a commercial database","volume":"13","author":"DJ McColl","year":"2008","journal-title":"Antivir Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gki481","article-title":"PatchDock and SymmDock: servers for rigid and symmetric docking","volume":"33","author":"D Schneidman-Duhovny","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0040-4039(98)00131-2","article-title":"Practical Synthesis of the anti-HIV Drug, PMPA","volume":"39","author":"LM Schultze","year":"1998","journal-title":"Tetrahedon Letters"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1081\/NCN-100002338","article-title":"Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340","volume":"20","author":"H Chapman","year":"2001","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1002\/elps.200800790","article-title":"Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector","volume":"30","author":"V Solinova","year":"2009","journal-title":"Electrophoresis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/hep.20464","article-title":"Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection","volume":"40","author":"F van B\u00f6mmel","year":"2004","journal-title":"Hepatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/hep.26277","article-title":"Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral load","volume":"58","author":"SC Gordon","year":"2013","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1097\/QAD.0b013e32836011c2","article-title":"Tenofovir-based combination therapy for HIV\/HBV co-infection: factors associated with a partial HBV virological response in patients with undetectable HIV viraemia","volume":"27","author":"K Childs","year":"2013","journal-title":"AIDS"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1073\/pnas.0306552101","article-title":"Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection","volume":"101","author":"Y Shen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1128\/JVI.02395-06","article-title":"Inhibition of hepatitis B virus polymerase by entecavir","volume":"81","author":"DR Langley","year":"2007","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e9195","DOI":"10.1371\/journal.pone.0009195","article-title":"Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir","volume":"5","author":"AW Walsh","year":"2010","journal-title":"PLoS ONE"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Y Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1093\/nar\/gkg581","article-title":"MATRAS: A program for protein 3D structure comparison","volume":"31","author":"T Kawabata","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1093\/bioinformatics\/btn507","article-title":"Searching protein structure databases with DaliLite v.3","volume":"24","author":"L Holm","year":"2008","journal-title":"Bioinformatics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"W471","DOI":"10.1093\/nar\/gks372","article-title":"COFACTOR: an accurate comparative algorithm for structure-based protein function annotation","volume":"40","author":"A Roy","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: Molecular Evolutionary Genetics Analysis version 6.0","volume":"30","author":"K Tamura","year":"2013","journal-title":"Mol Biol Evol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"EF Pettersen","year":"2004","journal-title":"J Comput Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T04:17:05Z","timestamp":1650082625000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106324"}},"subtitle":[],"editor":[{"given":"Nicolas","family":"Sluis-Cremer","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,2]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106324","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,2]]}}}