{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:30:20Z","timestamp":1792002620695,"version":"4.4.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T00:00:00Z","timestamp":1411084800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106478","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T17:49:03Z","timestamp":1411148943000},"page":"e106478","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["The Incidence of Other Gastroenterological Disease following Diagnosis of Irritable Bowel Syndrome in the UK: A Cohort Study"],"prefix":"10.1371","volume":"9","author":[{"given":"Caroline","family":"Canavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Card","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","article-title":"Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis","volume":"10","author":"RM Lovell","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"GF Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.cgh.2012.12.038","article-title":"A Positive Diagnostic Strategy is Non-Inferior to a Strategy of Exclusion for Patients with Irritable Bowel Syndrome","volume":"11","author":"LM Begtrup","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref4","first-page":"guidence.nice.org.uk\/cg61","article-title":"Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care","volume":"61","year":"2008","journal-title":"Clinical guideline"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/bmj.304.6819.87","article-title":"Irritable bowel syndrome in the population","volume":"304","author":"R Jones","year":"1992","journal-title":"Br Med J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/0016-5085(95)90738-6","article-title":"Medical costs in community subjects with irritable bowel syndrome","volume":"109","author":"NJ Talley","year":"1995","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/gut.46.1.78","article-title":"Irritable bowel syndrome in general practice: prevalence, characteristics, and referral","volume":"46","author":"WG Thompson","year":"2000","journal-title":"Gut"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/ajg.2010.47","article-title":"Is irritable bowel syndrome a diagnosis of exclusion: a survey of primary care providers, gastroenterologists, and IBS experts","volume":"105","author":"BMR Spiegel","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1111\/j.1572-0241.2002.07027.x","article-title":"The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review","volume":"97","author":"BD Cash","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archinternmed.2009.22","article-title":"Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis","volume":"169","author":"AC Ford","year":"2009","journal-title":"Arch Intern Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-230X-12-55","article-title":"Risk of inflammatory bowel disease following a diagnosis of irritable bowel syndrome","volume":"12","author":"CK Porter","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/003655200750024191","article-title":"Detection of colorectal tumor and inflammatory bowel disease during follow-up of patients with initial diagnosis of irritable bowel syndrome","volume":"35","author":"a Garc\u00eda Rodr\u00edguez L","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.7326\/0003-4819-122-2-199501150-00005","article-title":"The irritable bowel syndrome: long-term prognosis and the physician-patient interaction","volume":"122","author":"DM Owens","year":"1995","journal-title":"Ann Intern Med"},{"key":"ref14","unstructured":"Clinical Practice Research Dataset (2013). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cprd.com\/home\/\" xlink:type=\"simple\">http:\/\/www.cprd.com\/home\/<\/ext-link>. Accessed 23 May 2013."},{"key":"ref15","unstructured":"Clinical Practice Research Dataset (2012) CPRD Gold Flat files release notes. July."},{"key":"ref16","unstructured":"Puri S (2012) Hospital Episode Statistics (HES) data and GOLD documentation."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/pds.666","article-title":"Risk of irritable bowel syndrome among asthma patients","volume":"11","author":"C Huerta","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/pds.1115","article-title":"The relationship between time since registration and measured incidence rates in the General Practice Research Database","volume":"14","author":"JD Lewis","year":"2005","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref19","unstructured":"Rothman K, Greenlad S, Lash T (2008) Design strategies to improve study accuracy. Modern Epidemiology. Philidelphia, USA: Lippincoll, Williams and Wilkins. pp. 168\u2013182."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/oxfordjournals.aje.a009786","article-title":"Factors influencing the optimal control-to-case ratio in matched case-control studies","volume":"149","author":"S Hennessy","year":"1999","journal-title":"Am J Epidemiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e41308","DOI":"10.1371\/journal.pone.0041308","article-title":"Resource use and costs associated with coeliac disease before and after diagnosis in 3,646 cases: results of a UK primary care database analysis","volume":"7","author":"M Violato","year":"2012","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/pds.698","article-title":"Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease","volume":"11","author":"JD Lewis","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0140-6736(97)80084-0","article-title":"Calcium-channel blockers and risk of cancer","volume":"349","author":"H Jick","year":"1997","journal-title":"Lancet"},{"key":"ref24","first-page":"71","article-title":"The epidemiology of irritable bowel syndrome","volume":"6","author":"C Canavan","year":"2014","journal-title":"Clin Epidemiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0378-5122(02)00321-3","article-title":"Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome?","volume":"44","author":"A Ruig\u00f3mez","year":"2003","journal-title":"Maturitas"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0016-5085(03)00891-6","article-title":"Fracture risk in people with celiac disease: a population-based cohort study","volume":"125","author":"J West","year":"2003","journal-title":"Gastroenterology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/oxfordjournals.aje.a117548","article-title":"Irritable bowel syndrome in a community: symptom subgroups, risk factors, and health care utilization","volume":"142","author":"NJ Talley","year":"1995","journal-title":"Am J Epidemiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ajg.2010.55","article-title":"The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial","volume":"105","author":"WD Chey","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1365-2036.2004.01958.x","article-title":"Serological testing for coeliac disease in patients with symptoms of irritable bowel syndrome: a cost-effectiveness analysis","volume":"19","author":"SM Mein","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"ref30","unstructured":"Fukuba N, Ishihara S, Sonoyama H, Oka A, Kusunoki R, <etal>et al<\/etal>.. (2013) Prevalence of irritable bowel-like symptoms in ulcerative colitis patients with clinical and endoscopic evidence of remission: prospectice multi-centre findings. New insights into Pathophysiol Funct GI Disord Abstr from UEGW."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2036.2009.04041.x","article-title":"Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study","volume":"30","author":"R Corinaldesi","year":"2009","journal-title":"Aliment Pharmacol Ther"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:18:56Z","timestamp":1589023136000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106478"}},"subtitle":[],"editor":[{"given":"John","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,19]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106478","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,19]]}}}