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The contribution of the primitive interventricular septum in the ventricular septation. In: De la Cruz MV, Markwald RR, editors. Living morphogenesis of the hearts. Birkhauser. pp.121\u2013130."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1096-3642.1990.tb01220.x","article-title":"Comparative anatomy of the heart of mammals","volume":"98","author":"U Rowlatt","year":"1990","journal-title":"Zool Journal Linnean Society"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/dvdy.22363","article-title":"Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field","volume":"239","author":"NA Bax","year":"2010","journal-title":"Dev Dyn"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.yexcr.2013.03.027","article-title":"The Wilms&apos; tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium","volume":"319","author":"WH Hsu","year":"2013","journal-title":"Exp Cell Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"V Hamburger","year":"1951","journal-title":"J Morphol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/01.RES.73.3.559","article-title":"Development of the cardiac coronary vascular endothelium, studied with antiendothelial antibodies, in chicken-quail chimeras","volume":"73","author":"RE Poelmann","year":"1993","journal-title":"Circ Res"},{"key":"ref36","first-page":"305","article-title":"Dynamic labeling techniques for fate mapping, testing cell commitment, and following living cells in avian embryos","volume":"135","author":"DK Darnell","year":"2000","journal-title":"Methods Mol Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/002215540104900101","article-title":"Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol","volume":"49","author":"AF Moorman","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12336","article-title":"Digit loss in archosaur evolution and the interplay between selection and constraints","volume":"500","author":"MA de Bakker","year":"2013","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ydbio.2012.05.001","article-title":"Growth of the developing mouse heart: an interactive qualitative and quantitative 3D atlas","volume":"368","author":"BA de Boer","year":"2012","journal-title":"Dev Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:26:45Z","timestamp":1588976805000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106569"}},"subtitle":[],"editor":[{"given":"Leonard","family":"Eisenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,5]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106569","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,5]]}}}