{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T01:20:40Z","timestamp":1791681640110,"version":"4.3.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106750","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T18:11:46Z","timestamp":1410545506000},"page":"e106750","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Distinct Patterns of IgG and IgA against Food and Microbial Antigens in Serum and Feces of Patients with Inflammatory Bowel Diseases"],"prefix":"10.1371","volume":"9","author":[{"given":"Lisa","family":"Frehn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Bennek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana D.","family":"Mandic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur","family":"Temizel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Tischendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Verdier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Streetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Sellge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2013.240","article-title":"IBD across the age spectrum-is it the same disease?","volume":"11","author":"J Ruel","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.it.2013.04.001","article-title":"From genetics of inflammatory bowel disease towards mechanistic insights","volume":"34","author":"DB Graham","year":"2013","journal-title":"Trends Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/bmj.297.6656.1105","article-title":"Antibody to Saccharomyces cerevisiae (bakers&apos; yeast) in Crohn&apos;s disease","volume":"297","author":"J Main","year":"1988","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1128\/CDLI.3.2.219-226.1996","article-title":"Specific antibody response to oligomannosidic epitopes in Crohn&apos;s disease","volume":"3","author":"B Sendid","year":"1996","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/gut.42.6.788","article-title":"Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role","volume":"42","author":"JF Quinton","year":"1998","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00054725-200309000-00003","article-title":"Association of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classification subtypes of Crohn&apos;s disease","volume":"9","author":"FH Klebl","year":"2003","journal-title":"Inflamm Bowel Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1572-0241.2007.01577.x","article-title":"IgG antibodies against common gut bacteria are more diagnostic for Crohn&apos;s disease than IgG against mannan or flagellin","volume":"103","author":"RJ Adams","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000342603","article-title":"Circulating antibodies against bacterial wall products: are there arguments for early immunosuppression?","volume":"30","author":"F Rieder","year":"2012","journal-title":"Dig Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1136\/gut.2010.224774","article-title":"Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection","volume":"60","author":"A Haas","year":"2011","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1111\/j.1572-0241.2004.40417.x","article-title":"Sero-reactivity to microbial components in Crohn&apos;s disease is associated with disease severity and progression, but not NOD2\/CARD15 genotype","volume":"99","author":"ID Arnott","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/gut.38.3.365","article-title":"Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria","volume":"38","author":"A Macpherson","year":"1996","journal-title":"Gut"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/MPG.0b013e318285e9d8","article-title":"Cow&apos;s milk allergy, asthma, and pediatric IBD","volume":"56","author":"LJ Virta","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000023832","article-title":"IgE\/anti-IgE immune complexes in sera from patients with Crohn&apos;s disease do not contain food-specific IgE","volume":"115","author":"A Huber","year":"1998","journal-title":"Int Arch Allergy Immunol"},{"key":"ref14","first-page":"128","article-title":"Dietary allergy evaluated by PRIST and RAST in inflammatory bowel disease","volume":"33","author":"C Brignola","year":"1986","journal-title":"Hepatogastroenterology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000264649","article-title":"Clinical relevance of IgG antibodies against food antigens in Crohn&apos;s disease: a double-blind cross-over diet intervention study","volume":"81","author":"S Bentz","year":"2010","journal-title":"Digestion"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.10.007","article-title":"Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel","volume":"126","author":"NI-SE Panel","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1651-2227.1989.tb11097.x","article-title":"Serum antibodies to cow&apos;s milk proteins in pediatric inflammatory bowel disease. Crohn&apos;s disease versus ulcerative colitis","volume":"78","author":"A Lerner","year":"1989","journal-title":"Acta Paediatr Scand"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/gut.33.7.909","article-title":"Antibody (IgG, IgA, and IgM) to baker&apos;s yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease","volume":"33","author":"E Lindberg","year":"1992","journal-title":"Gut"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1572-0241.2007.01642.x","article-title":"Dietary antigens in Crohn&apos;s disease: antibodies to porcine pancreatic amylase","volume":"103","author":"H Suzuki","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(80)92767-1","article-title":"A simple index of Crohn&apos;s-disease activity","volume":"1","author":"RF Harvey","year":"1980","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/bmj.298.6666.82","article-title":"Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial","volume":"298","author":"D Rachmilewitz","year":"1989","journal-title":"BMJ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications","volume":"55","author":"J Satsangi","year":"2006","journal-title":"Gut"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-2222.1977.tb01478.x","article-title":"Immunoglobulin E specific to wheat and rye flour proteins","volume":"7","author":"F Bjorksten","year":"1977","journal-title":"Clin Allergy"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","article-title":"Innate and adaptive immunity in inflammatory bowel disease","volume":"13","author":"A Geremia","year":"2014","journal-title":"Autoimmun Rev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3748\/wjg.v16.i12.1442","article-title":"Role of diet in the management of inflammatory bowel disease","volume":"16","author":"N Rajendran","year":"2010","journal-title":"World J Gastroenterol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/00042737-200306000-00005","article-title":"Is nutrition an aetiological factor for inflammatory bowel disease?","volume":"15","author":"KD Cashman","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1136\/gut.34.6.783","article-title":"Food intolerance and Crohn&apos;s disease","volume":"34","author":"M Pearson","year":"1993","journal-title":"Gut"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/ibd.20892","article-title":"Phenotypic associations of Crohn&apos;s disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort","volume":"15","author":"AM Schoepfer","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1053\/j.gastro.2003.11.015","article-title":"Association of antibody responses to microbial antigens and complications of small bowel Crohn&apos;s disease","volume":"126","author":"WS Mow","year":"2004","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/gut.2005.076901","article-title":"The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis","volume":"55","author":"M Hvatum","year":"2006","journal-title":"Gut"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1097\/MEG.0b013e32832b125c","article-title":"Infliximab in clinical routine: experience with Crohn&apos;s disease and biomarkers of inflammation over 5 years","volume":"21","author":"MH Lonnkvist","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00042737-200601000-00013","article-title":"Disappearance of anti-Saccharomyces cerevisiae antibodies in coeliac disease during a gluten-free diet","volume":"18","author":"R Mallant-Hent","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CVI.05517-11","article-title":"Crohn&apos;s disease patients have more IgG-binding fecal bacteria than controls","volume":"19","author":"HJ Harmsen","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e62780","DOI":"10.1371\/journal.pone.0062780","article-title":"Specific IgG response against Mycobacterium avium paratuberculosis in children and adults with Crohn&apos;s disease","volume":"8","author":"J Verdier","year":"2013","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/j.gastro.2006.02.009","article-title":"Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn&apos;s disease","volume":"130","author":"A Standaert-Vitse","year":"2006","journal-title":"Gastroenterology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3748\/wjg.v12.i2.292","article-title":"Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD","volume":"12","author":"RC Mallant-Hent","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.chom.2007.09.013","article-title":"IgA response to symbiotic bacteria as a mediator of gut homeostasis","volume":"2","author":"DA Peterson","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1084\/jem.2001889","article-title":"T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis","volume":"195","author":"N Iqbal","year":"2002","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI200420295","article-title":"Bacterial flagellin is a dominant antigen in Crohn disease","volume":"113","author":"MJ Lodes","year":"2004","journal-title":"J Clin Invest"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T10:04:06Z","timestamp":1598263446000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106750"}},"subtitle":[],"editor":[{"given":"Udai P.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106750","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,12]]}}}