{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:24:43Z","timestamp":1791109483436,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106835","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T18:06:20Z","timestamp":1410458780000},"page":"e106835","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["In Vitro Surfactant and Perfluorocarbon Aerosol Deposition in a Neonatal Physical Model of the Upper Conducting Airways"],"prefix":"10.1371","volume":"9","author":[{"given":"Estibalitz","family":"Goikoetxea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xabier","family":"Murgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Serna-Grande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"Valls-i-Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rey-Santano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Ant\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Basterretxea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Mi\u00f1ambres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Est\u00edbaliz","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lopez-Arraiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Larrabe-Barrena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Gomez-Solaetxe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000349928","article-title":"European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants-2013 update","volume":"103","author":"DG Sweet","year":"2013","journal-title":"Neonatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia","volume":"163","author":"AH Jobe","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00008480-200104000-00006","article-title":"Prevention of bronchopulmonary dysplasia","volume":"13","author":"AH Jobe","year":"2001","journal-title":"Curr Opin Pediatr"},{"key":"ref4","first-page":"CD000510","article-title":"Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants","volume":"3","author":"MX Rojas-Reyes","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1203\/00006450-199503000-00003","article-title":"Surfactant treatment at birth reduces lung vascular injury and edema in preterm lambs","volume":"37","author":"DP Carlton","year":"1995","journal-title":"Pediatr Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1164\/ajrccm.152.1.7599809","article-title":"Decreased surfactant dose-response after delayed administration to preterm rabbits","volume":"152","author":"SR Seidner","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/jamp.2009.0758","article-title":"An open label, pilot study of Aerosurf(R) combined with nCPAP to prevent RDS in preterm neonates","volume":"23","author":"NN Finer","year":"2010","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(11)60986-0","article-title":"Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial","volume":"378","author":"W Gopel","year":"2011","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/(SICI)1099-0496(199709)24:3<222::AID-PPUL9>3.0.CO;2-O","article-title":"Surfactant aerosol treatment of respiratory distress syndrome in spontaneously breathing premature infants","volume":"24","author":"G Jorch","year":"1997","journal-title":"Pediatr Pulmonol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1097\/00003246-199105000-00019","article-title":"Perfluorocarbon-associated gas exchange","volume":"19","author":"BP Fuhrman","year":"1991","journal-title":"Crit Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1164\/rccm.200508-1196OC","article-title":"Partial liquid ventilation in adult patients with acute respiratory distress syndrome","volume":"173","author":"RM Kacmarek","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s001340050459","article-title":"Surfactant nebulisation prevents the adverse effects of surfactant therapy on blood pressure and cerebral blood flow in rabbits with severe respiratory failure","volume":"23","author":"PH Dijk","year":"1997","journal-title":"Intensive Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00003246-199603000-00020","article-title":"Aerosolized and instilled surfactant therapies for acute lung injury caused by intratracheal endotoxin in rats","volume":"24","author":"K Tashiro","year":"1996","journal-title":"Crit Care Med"},{"key":"ref14","first-page":"346","article-title":"Inhalation of aerosolized surfactant (Exosurf) to neonates treated with nasal continuous positive airway pressure","volume":"3","author":"M Arroe","year":"1998","journal-title":"Prenat Neonat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1651-2227.2000.tb00084.x","article-title":"Pilot study of nebulized surfactant therapy for neonatal respiratory distress syndrome","volume":"89","author":"E Berggren","year":"2000","journal-title":"Acta Paediatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00431-010-1292-6","article-title":"Aerosol delivery to ventilated newborn infants: historical challenges and new directions","volume":"170","author":"J Mazela","year":"2011","journal-title":"Eur J Pediatr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/(SICI)1099-0496(199605)21:5<301::AID-PPUL5>3.0.CO;2-P","article-title":"Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia","volume":"21","author":"TF Fok","year":"1996","journal-title":"Pediatr Pulmonol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"F275","DOI":"10.1136\/adc.2007.121285","article-title":"Lung deposition after inhalation with various nebulisers in preterm infants","volume":"93","author":"E Kohler","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jcrc.2004.02.008","article-title":"Perfluorocarbon species and nebulizer type influence aerosolization rate and particle size of perfluorocarbon aerosol","volume":"19","author":"M Rudiger","year":"2004","journal-title":"J Crit Care"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1164\/ajrccm.164.1.2010049","article-title":"Persistent improvement of gas exchange and lung mechanics by aerosolized perfluorocarbon","volume":"164","author":"MA Kandler","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/pr.2013.24","article-title":"Acute and sustained effects of aerosolized vs. bolus surfactant therapy in premature lambs with respiratory distress syndrome","volume":"73","author":"C Rey-Santano","year":"2013","journal-title":"Pediatr Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00130478-200110000-00010","article-title":"The cardiovascular effects of partial liquid ventilation in newborn lambs after experimental meconium aspiration","volume":"2","author":"E Gastiasoro-Cuesta","year":"2001","journal-title":"Pediatr Crit Care Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/pr.2012.90","article-title":"Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome","volume":"72","author":"X Murgia","year":"2012","journal-title":"Pediatr Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/jamp.2010.0831","article-title":"Surfactant and perfluorocarbon aerosolization by means of inhalation catheters for the treatment of respiratory distress syndrome: an in vitro study","volume":"24","author":"X Murgia","year":"2011","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"ref25","volume":"2 (4)","unstructured":"Rozanek M, Roubik K (2007) Mathematical Model of the Respiratory System - Comparison of the Total Lung Impedance in the Adult and Neonatal Lung. International Journal of Biomedical Sciences <volume>2 (4)<\/volume>: 249\u2013252."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF02460796","article-title":"Models of human lung airways and their application to inhaled particle deposition","volume":"42","author":"HC Yeh","year":"1980","journal-title":"Bull Math Biol"},{"key":"ref27","unstructured":"Hinds WC (1999) Aerosol Technology, Properties, Behavior, and Measurement of Airborne Particles. New York: John Wiley &amp; Sons. 483 p."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1007\/s001340050458","article-title":"Surfactant nebulisation: lung function, surfactant distribution and pulmonary blood flow distribution in lung lavaged rabbits","volume":"23","author":"PH Dijk","year":"1997","journal-title":"Intensive Care Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1203\/01.PDR.0000132667.47744.F4","article-title":"Dose response to aerosolized perflubron in a neonatal swine model of lung injury","volume":"56","author":"MA Kandler","year":"2004","journal-title":"Pediatr Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1586\/ers.11.89","article-title":"Inhaler technique and training in people with chronic obstructive pulmonary disease and asthma","volume":"6 (1)","author":"TGD Capstick","year":"2012","journal-title":"Expert Rev Respir Med"},{"key":"ref31","volume":"50 (1)","unstructured":"Enh\u00f6rning G, Robertson B (1972) Lung expansion in the premature rabbit fetus after tracheal deposition of surfactant. Pediatrics <volume>50 (1)<\/volume>: 58\u201366."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/RRN.S24050","article-title":"Alternative therapies for respiratory distress syndrome in preterm infants","volume":"1","author":"IP Sinha","year":"2011","journal-title":"Research and Reports in Neonatology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1097\/01.CCM.0000124876.31138.F6","article-title":"Comparison of aerosol therapy with different perfluorocarbons in surfactant-depleted animals","volume":"32","author":"K von der Hardt","year":"2004","journal-title":"Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1203\/01.PDR.0000156244.84422.55","article-title":"Aerosol deposition in neonatal ventilation","volume":"58","author":"JC Dubus","year":"2005","journal-title":"Pediatr Res"},{"key":"ref35","volume":"73 (5)","unstructured":"Rey-Santano C, Mielgo VE, Andres L, Ruiz-Del-Yerro E, Valls-i-Soler A, <etal>et al<\/etal>.. (2013) Acute and sustained effects of aerosolized vs. bolus surfactant therapy in premature lambs with respiratory distress syndrome. Pediatr Res <volume>73 (5)<\/volume>: 639\u2013646."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/08942680152744640","article-title":"The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants","volume":"14","author":"HM Janssens","year":"2001","journal-title":"J Aerosol Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1203\/PDR.0b013e318175dcfa","article-title":"Development of the premature infant nose throat-model (PrINT-Model): an upper airway replica of a premature neonate for the study of aerosol delivery","volume":"64","author":"S Minocchieri","year":"2008","journal-title":"Pediatr Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/MOP.0b013e32807fb013","article-title":"Aerosolized surfactants","volume":"19","author":"J Mazela","year":"2007","journal-title":"Curr Opin Pediatr"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4187\/respcare.02189","article-title":"AARC Clinical Practice Guideline. Surfactant Replacement Therapy: 2013","volume":"58","author":"BK Walsh","year":"2013","journal-title":"Respir Care"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1203\/00006450-200301000-00015","article-title":"Perfluorochemical (PFC) combinations for acute lung injury: an in vitro and in vivo study in juvenile rabbits","volume":"53","author":"MJ Jeng","year":"2003","journal-title":"Pediatr Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:35:06Z","timestamp":1589024106000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106835"}},"subtitle":[],"editor":[{"given":"David","family":"Warburton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,11]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106835","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,11]]}}}