{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:24:50Z","timestamp":1768274690197,"version":"3.49.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106854","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T18:12:17Z","timestamp":1410545537000},"page":"e106854","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Comparisons of GnRH Antagonist versus GnRH Agonist Protocol in Supposed Normal Ovarian Responders Undergoing IVF: A Systematic Review and Meta-Analysis"],"prefix":"10.1371","volume":"9","author":[{"given":"Jin-song","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cun-mei","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-tao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"ref1","first-page":"CD001750","article-title":"Gonadotrophin-releasing hormone antagonists for assisted conception","volume":"4","author":"HG Al-Inany","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"ref2","first-page":"CD001750","article-title":"Gonadotrophin-releasing hormone antagonists for assisted conception","volume":"19","author":"HG Al-Inany","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humupd\/dml038","article-title":"Among patients treated for IVF with gonadotrophins and GnRH analogues,is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis","volume":"12","author":"EM Kolibianakis","year":"2006","journal-title":"Hum Reprod Update"},{"key":"ref4","first-page":"CD001750","article-title":"Gonadotrophin-releasing hormone antagonists for assisted reproductive technology","volume":"11","author":"HG Al-Inany","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.rbmo.2012.11.001","article-title":"GnRH agonist versus GnRH antagonist in ovarian stimulation: an ongoing debate","volume":"26","author":"R Orvieto","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.rbmo.2011.09.017","article-title":"Meta-analysis of GnRH antagonist protocols: do they reduce the risk of OHSS in PCOS?","volume":"24","author":"J Pundir","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"ref7","unstructured":"Higgins JPT, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration 2011."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/humrep\/15.3.526","article-title":"Ovarian stimulation with HMG: results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin. European Cetrorelix Study Group","volume":"15","author":"C Albano","year":"2000","journal-title":"Hum Reprod"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/humrep\/15.7.1490","article-title":"Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarianstimulation with recombinant follicle stimulating hormoneis effective, safe and convenient: results of a controlled,randomized, multicentre trial","volume":"15","author":"G Borm","year":"2000","journal-title":"Hum Reprod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0015-0282(99)00524-5","article-title":"Prospective randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LHRH) antagonist (cetrorelix) or a depot formula of an LHRH agonist (triptorelin)","volume":"73","author":"F Olivennes","year":"2000","journal-title":"Fertil Steril"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/humrep\/16.4.644","article-title":"Comparable clinical outcome using the GnRH antagonist ganirelix or a long protocol of the GnRH agonist triptorelin for the prevention of premature LH surges in women undergoing ovarian stimulation","volume":"16","year":"2001","journal-title":"Hum Reprod"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0015-0282(00)01638-1","article-title":"North American Ganirelix Study Group. Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation","volume":"75","author":"M Fluker","year":"2001","journal-title":"Fertil Steril"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1210\/jc.2002-020788","article-title":"A randomized comparison of two ovarian stimulation protocols with gonadotropin-releasing hormone (GnRH) antagonist cotreatment for in vitro fertilization commencing recombinant follicle-stimulating hormone on cycle day 2 or 5 with the standard long GnRH agonist protocol","volume":"88","author":"FP Hohmann","year":"2003","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"ref14","first-page":"257","article-title":"Effect of antagonists vs agonists on in vitro fertilization outcome","volume":"31","author":"ML Check","year":"2004","journal-title":"Clinical and Experimental Obstetrics & Gynecology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.fertnstert.2004.12.037","article-title":"Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration","volume":"83","author":"TH Lee","year":"2005","journal-title":"Fertil Steril"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.fertnstert.2004.04.051","article-title":"A modified gonadotropin-releasing hormone(GnRH) antagonist protocol failed to increase clinical pregnancy rates in comparison with the long GnRH protocol","volume":"82","author":"D Loutradis","year":"2004","journal-title":"Fertil Steril"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1472-6483(10)61631-8","article-title":"Comparative efficacy and safety of cetrorelix with or without mid-cycle recombinant LH and leuprolide acetate for inhibition of premature LH surges in assisted reproduction","volume":"9","author":"MV Sauer","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/humrep\/del484","article-title":"Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial","volume":"22","author":"EB Baart","year":"2007","journal-title":"Hum Reprod"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejogrb.2004.11.005","article-title":"A randomised study of GnRH antagonist(cetrorelix) versus agonist (busereline) for controlled ovarian stimulation: effect on safety and efficacy","volume":"120","author":"P Xavier","year":"2005","journal-title":"Eurpean Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1472-6483(10)60976-5","article-title":"Luteal phase characteristics following GnRH antagonist or agonist treatment - a comparative study","volume":"12","author":"S Friedler","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.fertnstert.2006.02.110","article-title":"Ovarian stimulation with daily late follicular phase administration of low-dose human chorionic gonadotropin for in vitro fertilization: a prospective, randomized trial","volume":"86","author":"P Serafini","year":"2006","journal-title":"Fertil Steril"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/humrep\/dei302","article-title":"A comparative randomized trial to assess the impact of oral contraceptive pretreatment on follicular growth and hormone profiles in GnRH antagonist-treated patients","volume":"21","author":"L Rombauts","year":"2006","journal-title":"Hum Reprod"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.fertnstert.2004.06.076","article-title":"A randomized prospective trial comparing gonadotropin releasing hormone (GnRH) antagonist\/recombinant follicle-stimulating hormone (rFSH) versus GnRH-agonist\/rFSH in women pretreated with oral contraceptives before in vitro fertilization","volume":"83","author":"LI Barmat","year":"2005","journal-title":"Fertil Steril"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1028-4559(08)60057-1","article-title":"Comparisons of different dosages of gonadotropin-releasing hormone (GnRH) antagonist, short-acting form and single, half-dose, long acting form of GnRH agonist during controlled ovarian hyperstimulation and in vitro fertilization","volume":"47","author":"YY Hsieh","year":"2008","journal-title":"Taiwan Journal of Obstetrics and Gynecology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12325-008-0028-8","article-title":"Comparison of GnRH agonists and antagonists in normo-responder IVF\/ICSI in Turkish female patients","volume":"25","author":"O Moraloglu","year":"2008","journal-title":"Advances in Therapy"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/09513590802617762","article-title":"Follicular growth and oocyte maturation in GnRH agonist and antagonist protocols for in vitro fertilisation and embryo transfer","volume":"25","author":"R Depalo","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10815-009-9300-3","article-title":"IVF\/ICSI outcomes between cycles with luteal estradiol (E2) pre-treatment before GnRH antagonist protocol and standard long GnRH agonist protocol: a prospective and randomized study","volume":"2","author":"H Ye","year":"2009","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00404-009-1073-5","article-title":"Comparing GnRH agonist long protocol and GnRH antagonist protocol in outcome the first cycle of ART","volume":"281","author":"RD Firouzabadi","year":"2010","journal-title":"Arch Gynecol and Obstet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3109\/09513590.2012.665103","article-title":"A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates","volume":"28","author":"J Qiao","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1093\/humrep\/des066","article-title":"GnRH-agonist versus GnRH-antagonist IVF cycles:is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study","volume":"27","author":"EG Papanikolaou","year":"2012","journal-title":"Hum Reprod"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.fertnstert.2013.08.024","article-title":"The effectiveness of gonadotropin-releasing hormone antagonist in poor ovarian responders undergoing in vitro fertilization: a systematic review and meta-analysis","volume":"100","author":"J Xiao","year":"2013","journal-title":"Fertil Steril"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/09513590.2012.736561","article-title":"Effectiveness of GnRH antagonist in the treatment of patients with polycystic ovary syndrome undergoing IVF: a systematic review and meta analysis","volume":"29","author":"J Xiao","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1095\/biolreprod.109.081299","article-title":"Controlled ovarian hyperstimulation for in vitro fertilization alters endometrial receptivity in humans: protocol effects","volume":"82","author":"D Haouzi","year":"2010","journal-title":"Biol Reprod"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3109\/09513590.2010.540602","article-title":"The dynamics of endometrial growth and the triple layer appearance in three different controlled ovarian hyperstimulation protocols and their influence on IVF outcomes","volume":"27","author":"P Ku\u0107","year":"2011","journal-title":"Gynecol Endocrinol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:55:11Z","timestamp":1540310111000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106854"}},"subtitle":[],"editor":[{"given":"Xiuchun","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106854","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,12]]}}}