{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:21:32Z","timestamp":1791267692653,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0106960","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T17:48:30Z","timestamp":1413222510000},"page":"e106960","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["Long-Term Corticosterone Exposure Decreases Insulin Sensitivity and Induces Depressive-Like Behaviour in the C57BL\/6NCrl Mouse"],"prefix":"10.1371","volume":"9","author":[{"given":"Eva L.","family":"van Donkelaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen R. D.","family":"Vaessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi L.","family":"Pawluski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annerieke S.","family":"Sierksma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Blokland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Ca\u00f1ete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry W. M.","family":"Steinbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/01.psy.0000163456.22154.d2","article-title":"Hypercortisolemia and depression","volume":"67","author":"CF Gillespie","year":"2005","journal-title":"Psychosomatic medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.brainresrev.2007.04.005","article-title":"The stress system in depression and neurodegeneration: focus on the human hypothalamus","volume":"57","author":"AM Bao","year":"2008","journal-title":"Brain Res Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1517\/13543784.10.10.1789","article-title":"Antiglucocorticoid drugs in the treatment of depression","volume":"10","author":"VI Reus","year":"2001","journal-title":"Expert opinion on investigational drugs"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/MOL.0b013e32832b2024","article-title":"Dissecting the role of insulin resistance in the metabolic syndrome","volume":"20","author":"JT Haas","year":"2009","journal-title":"Curr Opin Lipidol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2337\/diacare.24.6.1069","article-title":"The prevalence of comorbid depression in adults with diabetes: a meta-analysis","volume":"24","author":"RJ Anderson","year":"2001","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2337\/diacare.16.8.1167","article-title":"Prevalence of depression in adults with diabetes. An epidemiological evaluation","volume":"16","author":"JA Gavard","year":"1993","journal-title":"Diabetes Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2008.02.050","article-title":"The As and Ds of stress: metabolic, morphological and behavioral consequences","volume":"585","author":"LP Reagan","year":"2008","journal-title":"European journal of pharmacology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neurobiolaging.2005.08.021","article-title":"Insulin resistance syndrome and Alzheimer&apos;s disease: age- and obesity-related effects on memory, amyloid, and inflammation","volume":"26","author":"S Craft","year":"2005","journal-title":"Neurobiology of aging"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ncpneuro0124","article-title":"Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer&apos;s disease","volume":"2","author":"MN Haan","year":"2006","journal-title":"Nature clinical practice Neurology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2009.10.022","article-title":"Depression and Alzheimer&apos;s disease: neurobiological links and common pharmacological targets","volume":"626","author":"F Caraci","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1042\/BST0331041","article-title":"Increased risk of Alzheimer&apos;s disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?","volume":"33","author":"GJ Biessels","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1476-5381.2011.01602.x","article-title":"Stress-induced anhedonia is associated with an increase in Alzheimer&apos;s disease-related markers","volume":"165","author":"A Briones","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/npp.2010.13","article-title":"Interactions between age, stress and insulin on cognition: implications for Alzheimer&apos;s disease","volume":"35","author":"M Solas","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.bbadis.2013.09.013","article-title":"Stress contributes to the development of central insulin resistance during aging: Implications for Alzheimer&apos;s disease","volume":"1832","author":"M Solas","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hipo.20470","article-title":"Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats","volume":"18","author":"AM Stranahan","year":"2008","journal-title":"Hippocampus"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1471-4159.1993.tb03537.x","article-title":"Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo","volume":"61","author":"EM Elliott","year":"1993","journal-title":"Journal of neurochemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00790-9","article-title":"The effect of corticosteroids on amyloid beta precursor protein\/amyloid precursor-like protein expression and processing in vivo","volume":"276","author":"G Budas","year":"1999","journal-title":"Neuroscience letters"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1523\/JNEUROSCI.21-08-02561.2001","article-title":"Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling","volume":"21","author":"L Gasparini","year":"2001","journal-title":"The Journal of neuroscience"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"11120","DOI":"10.1523\/JNEUROSCI.2860-04.2004","article-title":"Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer&apos;s disease intervention","volume":"24","author":"L Zhao","year":"2004","journal-title":"The Journal of Neuroscience"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbadis.2004.06.017","article-title":"Tau phosphorylation: physiological and pathological consequences","volume":"1739","author":"WH Stoothoff","year":"2005","journal-title":"Biochimica et biophysica acta"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3233\/JAD-2010-100390","article-title":"Depression and Alzheimer&apos;s disease: is stress the initiating factor in a common neuropathological cascade?","volume":"23","author":"S Aznar","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12640-010-9203-1","article-title":"Diabetes type II: a risk factor for depression-Parkinson-Alzheimer?","volume":"19","author":"P Riederer","year":"2011","journal-title":"Neurotox Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2009.10.021","article-title":"Major depression, cognitive dysfunction and Alzheimer&apos;s disease: is there a link?","volume":"626","author":"AS Sierksma","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejphar.2007.12.005","article-title":"A mouse model of depression induced by repeated corticosterone injections","volume":"581","author":"Y Zhao","year":"2008","journal-title":"European journal of pharmacology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"E367","DOI":"10.1152\/ajpendo.00185.2001","article-title":"Low-dose dexamethasone in the rat: a model to study insulin resistance","volume":"283","author":"C Severino","year":"2002","journal-title":"American journal of physiology Endocrinology and metabolism"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1210\/en.2009-1436","article-title":"Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse","volume":"151","author":"IN Karatsoreos","year":"2010","journal-title":"Endocrinology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neurobiolaging.2012.05.012","article-title":"Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe\/PS1dE9 mice","volume":"34","author":"AS Sierksma","year":"2013","journal-title":"Neurobiol Aging"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1258\/002367798780599866","article-title":"Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guinea pig, ferret and mink","volume":"32","author":"A Hem","year":"1998","journal-title":"Laboratory animals"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"E1323","DOI":"10.1152\/ajpendo.90617.2008","article-title":"Evaluating the glucose tolerance test in mice","volume":"295","author":"S Andrikopoulos","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Ferrannini E, Mari A (1998) How to measure insulin sensitivity. Journal of hypertension: 895\u2013906.","DOI":"10.1097\/00004872-199816070-00001"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1210\/en.2007-1214","article-title":"Effect of dexamethasone on glucose tolerance and fat metabolism in a diet-induced obesity mouse model","volume":"149","author":"JS Gounarides","year":"2008","journal-title":"Endocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"DR Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"E261","DOI":"10.1152\/ajpendo.00676.2007","article-title":"Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice","volume":"294","author":"S Lee","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF02244871","article-title":"Behavioural and pharmacological characterisation of the elevated \u201czero-maze\u201d as an animal model of anxiety","volume":"116","author":"JK Shepherd","year":"1994","journal-title":"Psychopharmacology (Berl)"},{"key":"ref35","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"RD Porsolt","year":"1977","journal-title":"Archives internationales de pharmacodynamie et de th\u00e9rapie"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"RD Porsolt","year":"1977","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0166-4328(96)00067-8","article-title":"Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth","volume":"73","author":"MJ Detke","year":"1996","journal-title":"Behavioural Brain Research"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"I Lucki","year":"1997","journal-title":"Behavioural pharmacology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The Open-Field Test: a critical review","volume":"83","author":"RN Walsh","year":"1976","journal-title":"Psychol Bull"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbr.2006.03.016","article-title":"Models of anxiety: responses of rats to novelty in an open space and an enclosed space","volume":"171","author":"A Ennaceur","year":"2006","journal-title":"Behav Brain Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002130000560","article-title":"Appropriate use of \u201cknockout\u201d mice as models of depression or models of testing the efficacy of antidepressants","volume":"153","author":"AM Gardier","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.steroids.2008.11.009","article-title":"The challenge of continuous exogenous glucocorticoid administration in mice","volume":"74","author":"M Herrmann","year":"2009","journal-title":"Steroids"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11696","DOI":"10.1073\/pnas.1934666100","article-title":"Chronic stress and obesity: a new view of \u201ccomfort food\u201d","volume":"100","author":"MF Dallman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/physrev.00032.2003","article-title":"Mouse models of insulin resistance","volume":"84","author":"A Nandi","year":"2004","journal-title":"Physiol Rev"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Grundy SM (2004) Metabolic syndrome: part I. Endocrinol Metab Clin North Am 33: ix-xi.","DOI":"10.1016\/S0889-8529(04)00035-0"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YCO.0b013e3280117733","article-title":"Animal models of mood disorders: Recent developments","volume":"20","author":"JF Cryan","year":"2007","journal-title":"Current opinion in psychiatry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.biopsych.2008.06.016","article-title":"Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone","volume":"64","author":"SL Gourley","year":"2008","journal-title":"Biol Psychiatry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"DJ David","year":"2009","journal-title":"Neuron"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1037\/h0057952","article-title":"An evaluation of defecation and urination as measures of fearfulness","volume":"46","author":"D Bindra","year":"1953","journal-title":"J Comp Physiol Psychol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0106960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T04:32:03Z","timestamp":1565929923000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0106960"}},"subtitle":[],"editor":[{"given":"Christian","family":"Holscher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,13]]},"references-count":49,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0106960","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,13]]}}}