{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:31:14Z","timestamp":1791351074238,"version":"4.3.1"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T00:00:00Z","timestamp":1410134400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0107418","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T18:02:44Z","timestamp":1410199364000},"page":"e107418","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":146,"title":["Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis: A Systematic Review and Meta-Analysis"],"prefix":"10.1371","volume":"9","author":[{"given":"Sapna","family":"Oberoi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Zamperlini\u2013Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Beyene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel S.","family":"Treister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"ST Sonis","year":"2004","journal-title":"Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review","volume":"66","author":"A Trotti","year":"2003","journal-title":"Radiother Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1200\/JCO.2007.13.6028","article-title":"Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy\u2013European Blood and Marrow Transplantation Mucositis Advisory Group","volume":"26","author":"N Blijlevens","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/1097-0142(19930901)72:5<1612::AID-CNCR2820720520>3.0.CO;2-Q","article-title":"A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients","volume":"72","author":"SB Woo","year":"1993","journal-title":"Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cncr.21622","article-title":"Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma","volume":"106","author":"M Vera-Llonch","year":"2006","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/cncr.22620","article-title":"Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire","volume":"109","author":"JB Epstein","year":"2007","journal-title":"Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/bmt.2008.299","article-title":"The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT","volume":"43","author":"S McCann","year":"2009","journal-title":"Bone Marrow Transplant"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/cncr.11671","article-title":"The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis","volume":"98","author":"LS Elting","year":"2003","journal-title":"Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00520-006-0176-9","article-title":"Oral mucositis and outcomes of allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies","volume":"15","author":"M Vera-Llonch","year":"2007","journal-title":"Support Care Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/oxfordjournals.jncimonographs.a003440","article-title":"Mucositis in head and neck cancer: economic and quality-of-life outcomes","author":"A Peterman","year":"2001","journal-title":"J Natl Cancer Inst Monogr"},{"key":"ref11","article-title":"MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy","author":"RV Lalla","year":"2014","journal-title":"Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00520-012-1605-6","article-title":"Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients","volume":"21","author":"C Migliorati","year":"2013","journal-title":"Support Care Cancer"},{"key":"ref13","first-page":"CD000978","article-title":"Interventions for preventing oral mucositis for patients with cancer receiving treatment","author":"HV Worthington","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.radonc.2013.08.010","article-title":"Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation","volume":"109","author":"HS Antunes","year":"2013","journal-title":"Radiother Oncol"},{"key":"ref15","first-page":"157","article-title":"Evaluation of the effect of low level laser on prevention of chemotherapy-induced mucositis","volume":"51","author":"F Arbabi-Kalati","year":"2013","journal-title":"Acta Medica Iranica"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.radonc.2012.06.011","article-title":"Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients - a triple blinded randomized controlled trial","volume":"104","author":"AP Gautam","year":"2012","journal-title":"Radiother Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.oraloncology.2012.03.008","article-title":"Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients - a randomized controlled trial","volume":"48","author":"AP Gautam","year":"2012","journal-title":"Oral Oncol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijrobp.2010.10.012","article-title":"Oral mucositis prevention by low-level laser therapy in head-and-neck cancer patients undergoing concurrent chemoradiotherapy: a phase III randomized study","volume":"82","author":"A Gouvea de Lima","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00520-011-1223-8","article-title":"Amelioration of oral mucositis pain by NASA near-infrared light-emitting diodes in bone marrow transplant patients","volume":"20","author":"BD Hodgson","year":"2012","journal-title":"Support Care Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/hed.21737","article-title":"Effect of intraoral low-level laser therapy on quality of life of patients with head and neck cancer undergoing radiotherapy","volume":"34","author":"AF Oton-Leite","year":"2012","journal-title":"Head Neck"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/pho.2009.2699","article-title":"The prevention of induced oral mucositis with low-level laser therapy in bone marrow transplantation patients: a randomized clinical trial","volume":"29","author":"GBL Silva","year":"2011","journal-title":"Photomed Laser Surg"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"JR Landis","year":"1977","journal-title":"Biometrics"},{"key":"ref24","unstructured":"WHO (1979) WHO Handbook for Reporting Results of Cancer Treatment. Publication No. 48. Geneva: WHO."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"JD Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref26","first-page":"791","article-title":"Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S. Support Care Cancer","volume":"16","author":"DH Henry","year":"2008"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Higginson IJ, Armes J, Krishnasamy M (2004) Introduction, in fatigue in cancer. In: Armes J, Krishnasamy M, Higginson IJ, editors. Fatigue in Cancer. Oxford: Oxford University Press. pp. xvii\u2013xxi.","DOI":"10.1093\/oso\/9780192630940.002.0005"},{"key":"ref28","first-page":"4","article-title":"Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. The Fatigue Coalition","volume":"34","author":"NJ Vogelzang","year":"1997","journal-title":"Semin Hematol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0964-1955(96)00026-7","article-title":"Quantitative scale of oral mucositis associated with autologous bone marrow transplantation","volume":"32B","author":"C Tardieu","year":"1996","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2103::AID-CNCR2>3.0.CO;2-0","article-title":"Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study Group","volume":"85","author":"ST Sonis","year":"1999","journal-title":"Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0885-3924(01)00375-X","article-title":"The measurement of symptoms in young children with cancer: the validation of the Memorial Symptom Assessment Scale in children aged 7\u201312","volume":"23","author":"JJ Collins","year":"2002","journal-title":"J Pain Symptom Manage"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3959(97)00005-5","article-title":"The visual analogue pain intensity scale: what is moderate pain in millimetres?","volume":"72","author":"SL Collins","year":"1997","journal-title":"Pain"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0885-3924(00)00127-5","article-title":"The measurement of symptoms in children with cancer","volume":"19","author":"JJ Collins","year":"2000","journal-title":"J Pain Symptom Manage"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"KF Schulz","year":"1995","journal-title":"JAMA"},{"key":"ref35","first-page":"399","article-title":"Effect of low level helium-neon (He-Ne) laser therapy in the prevention &amp; treatment of radiation induced mucositis in head &amp; neck cancer patients","volume":"124","author":"G Arun Maiya","year":"2006","journal-title":"Indian J Med Res"},{"key":"ref36","first-page":"S199","article-title":"Cost-effectiveness of low-level laser therapy (LLLT) in head and neck cancer patients submitted to concurrent chemoradiation","volume":"21","author":"HS Antunes","year":"2013","journal-title":"Support Care Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00520-012-1684-4","article-title":"Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy\u2013a randomized controlled trial","volume":"21","author":"AP Gautam","year":"2013","journal-title":"Support Care Cancer"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"S252","DOI":"10.4317\/medoral.17643752","article-title":"Use of Laser photobiomodulation in the evolution of oral mucositis associated with CMF chemotherapy protocol in patients with breast cancer-Case Report","volume":"17","author":"GM Pires-Santos","year":"2012","journal-title":"Medicina Oral, Patologia Oral y Cirugia Bucal"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1600-0609.2009.01336.x","article-title":"Low-power laser to prevent oral mucositis in autologous hematopoietic stem cell transplantation","volume":"84","author":"A Chor","year":"2010","journal-title":"Eur J Haematol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1182\/blood-2006-07-035022","article-title":"Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial","volume":"109","author":"HS Antunes","year":"2007","journal-title":"Blood"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/pbc.20943","article-title":"Influence of low-energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy","volume":"48","author":"LB Cruz","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00520-007-0238-7","article-title":"A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation","volume":"15","author":"MM Schubert","year":"2007","journal-title":"Support Care Cancer"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1590\/S0100-39842006000200012","article-title":"Preven\u00e7\u00e3o da xerostomia e da mucosite oral induzidas por radioterapia com uso do laser de baixa pot\u00eancia","volume":"39","author":"CdO Lopes","year":"2006","journal-title":"Radiol bras"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s005200050256","article-title":"Low-energy He\/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancer","volume":"7","author":"RJ Bensadoun","year":"1999","journal-title":"Support Care Cancer"},{"key":"ref45","first-page":"115","article-title":"Radiation-and chemotherapy-induced mucositis in oncology: results of multicenter phase III studies","author":"RJ Bensadoun","year":"2002","journal-title":"J Oral Laser App"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0360-3016(97)00076-X","article-title":"Low energy Helium-Neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant: results of a double blind randomized trial","volume":"38","author":"D Cowen","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1590\/S0103-64402009000300008","article-title":"Use of therapeutic laser for prevention and treatment of oral mucositis","volume":"20","author":"VY Khouri","year":"2009","journal-title":"Braz Dent J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1754-4505.2012.00303.x","article-title":"Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy","volume":"33","author":"AF Oton-Leite","year":"2013","journal-title":"Spec Care Dentist"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00520-011-1202-0","article-title":"A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis","volume":"19","author":"JM Bjordal","year":"2011","journal-title":"Support Care Cancer"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00520-012-1592-7","article-title":"Methodology for the MASCC\/ISOO Mucositis Clinical Practice Guidelines Update","volume":"21","author":"JM Bowen","year":"2013","journal-title":"Support Care Cancer"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S1011-1344(00)00082-8","article-title":"Measurement of the penetration depths of red and near infrared light in human \u201cex vivo\u201d tissues","volume":"57","author":"S Stolik","year":"2000","journal-title":"J Photochem Photobiol B"},{"key":"ref52","first-page":"95","article-title":"Attenuation and penetration of visible 632.8 nm and invisible infra-red 904 nm light in soft tissues","author":"CS Enwemeka","year":"2001","journal-title":"Laser Ther"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/pho.2005.23.431","article-title":"The importance of coherence","volume":"23","author":"L Hode","year":"2005","journal-title":"Photomed Laser Surg"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/pho.2006.24.457","article-title":"The place of coherence in light induced tissue repair and pain modulation","volume":"24","author":"CS Enwemeka","year":"2006","journal-title":"Photomed Laser Surg"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1002\/1097-0142(19920515)69:10<2469::AID-CNCR2820691015>3.0.CO;2-W","article-title":"Clinical assessment scale for the rating of oral mucosal changes associated with bone marrow transplantation. Development of an oral mucositis index","volume":"69","author":"MM Schubert","year":"1992","journal-title":"Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0107418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T09:45:44Z","timestamp":1717321544000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0107418"}},"subtitle":[],"editor":[{"given":"Michael","family":"Hamblin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,8]]},"references-count":55,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0107418","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,8]]}}}