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In: Hoffman R, et al., eds. Hematology. 2nd ed. New York, NY: Churchill LivingstoneInc; 1995: 690\u2013694."},{"key":"ref58","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35051594","article-title":"Identification of the hemoglobin receptor","volume":"409","author":"M Kristiansen","year":"2001","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1089\/ars.2012.4605","article-title":"Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption","volume":"18","author":"A Etzerodt","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1089\/ars.2005.7.1761","article-title":"The heme oxygenase system: update","volume":"7","author":"MD Maines","year":"2005","journal-title":"Antioxid Redox Signaling"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"26630","DOI":"10.1074\/jbc.M112.341255","article-title":"Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-\u03baB activation, and neutrophil infiltration","volume":"287","author":"S Dey","year":"2012","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e42199","DOI":"10.1371\/journal.pone.0042199","article-title":"Subcellular localization of iron and heme metabolism related proteins at early stages of erythrophagocytosis","volume":"7","author":"C Delaby","year":"2012","journal-title":"PLoS One"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0002-9440(10)62319-X","article-title":"Plasma protein haptoglobin modulates renal iron loading","volume":"166","author":"S Fagoonee","year":"2005","journal-title":"Am J Pathol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1089\/ars.2013.5666","article-title":"Coupling heme and iron metabolism via ferritin H chain","volume":"20","author":"R Gozzelino","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0162-0134(98)10053-3","article-title":"Analysis of the distribution of Cu, Fe and Zn and other elements in brindled mouse kidney using a scanning proton microprobe","volume":"71","author":"BJ Kirby","year":"1998","journal-title":"J Inorg Biochem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1177\/002215549704501106","article-title":"Copper-metallothionein in the kidney of macular mice: a model for Menkes disease","volume":"45","author":"M Suzuki-Kurasaki","year":"1997","journal-title":"J Histochem Cytochem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"F53","DOI":"10.1152\/ajprenal.00314.2007","article-title":"Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-\/- kidney","volume":"294","author":"R Linz","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000098522","article-title":"Hepcidin in anemia and inflammation in chronic kidney disease","volume":"30","author":"J Ma\u0142yszko","year":"2007","journal-title":"Kidney Blood Press Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1073\/pnas.0409808102","article-title":"Regulation of hepcidin transcription by interleukin-1 and interleukin-6","volume":"102","author":"P Lee","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/08035250500538957","article-title":"Urological complication and copper replacement in childhood Menkes syndrome","volume":"95","author":"M Zaffanello","year":"2006","journal-title":"Acta Pediatr"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0107641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T17:11:11Z","timestamp":1650215471000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0107641"}},"subtitle":[],"editor":[{"given":"James F.","family":"Collins","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,23]]},"references-count":70,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0107641","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,23]]}}}