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One"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1128\/IAI.01129-08","article-title":"Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness","volume":"77","author":"DI Stanisic","year":"2009","journal-title":"Infect Immun"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4269\/ajtmh.1996.54.449","article-title":"Pattern of immunoglobulin isotype response to Plasmodium falciparum blood-stage antigens in individuals living in a holoendemic area of Senegal (Dielmo, west Africa)","volume":"54","author":"G Aribot","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.0141-9838.2001.00440.x","article-title":"Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2","volume":"24","author":"FM Ndungu","year":"2002","journal-title":"Parasite Immunol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/IAI.68.3.1252-1258.2000","article-title":"High immunoglobulin G2 (IgG2) and low IgG4 levels are associated with human resistance to Plasmodium falciparum malaria","volume":"68","author":"C Aucan","year":"2000","journal-title":"Infect Immun"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/IAI.63.2.456-466.1995","article-title":"Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1 (19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum","volume":"63","author":"AF Egan","year":"1995","journal-title":"Infect Immun"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1128\/IAI.73.12.8119-8129.2005","article-title":"Epitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins","volume":"73","author":"JE Tongren","year":"2005","journal-title":"Infect Immun"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Kimani D, Jagne YJ, Cox M, Kimani E, Bliss CM, <etal>et al<\/etal>.. (2014) Translating the Immunogenicity of Prime-boost Immunization With ChAd63 and MVA ME-TRAP From Malaria Naive to Malaria-endemic Populations. 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