{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:48:34Z","timestamp":1696240114891},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0108146","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T14:46:58Z","timestamp":1412088418000},"page":"e108146","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of Somatostatin Receptor-2 in Gentamicin-Induced Auditory Hair Cell Loss in the Mammalian Inner Ear"],"prefix":"10.1371","volume":"9","author":[{"given":"Yves","family":"Brand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Radojevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Setz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Glutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Leitmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Bodmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"ref1","first-page":"317","article-title":"Aminoglycoside- and cisplatin-ototoxicity: from basic science to clinics","volume":"83","author":"J Lautermann","year":"2004","journal-title":"Laryngorhinootologie"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/01.moo.0000136873.56878.56","article-title":"Sensory hair cell death and regeneration: two halves of the same equation","volume":"12","author":"JI Matsui","year":"2004","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/01.moo.0000186799.45377.63","article-title":"Mechanisms of hair cell death and protection","volume":"13","author":"AG Cheng","year":"2005","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S1359-6446(05)03552-X","article-title":"Ototoxicity: therapeutic opportunities","volume":"10","author":"LP Rybak","year":"2005","journal-title":"Drug Discov Today"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/0006-2952(95)02160-4","article-title":"Formation of free radicals by gentamicin and iron and evidence for iron\/gentamicin complex","volume":"50","author":"EM Priuska","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.20-01-00043.2000","article-title":"Rescue of hearing, auditory hair cells, and neurons by CEP-1347\/KT7515, an inhibitor of c-Jun N-terminal kinase activation","volume":"20","author":"U Pirvola","year":"2000","journal-title":"J Neurosci"},{"key":"ref7","first-page":"853","article-title":"Rescue of auditory hair cells from ototoxicity by CEP-11004, an inhibitor of the JNK signalling pathway","volume":"81","author":"D Bodmer","year":"2002","journal-title":"Laryngorhinootologie"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-5955(02)00514-2","article-title":"Rescue of auditory hair cells from aminoglycoside toxicity by Clostridium difficile toxin B, an inhibitor of the small GTPases Rho\/Rac\/Cdc42","volume":"172","author":"D Bodmer","year":"2002","journal-title":"Hear Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.neuroscience.2003.08.041","article-title":"Involvement of ras activation in toxic hair cell damage of the mammalian cochlea","volume":"122","author":"A Battaglia","year":"2003","journal-title":"Neuroscience"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0736-5748(99)00094-5","article-title":"Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies","volume":"18","author":"T Huang","year":"2000","journal-title":"Int J Dev Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.anl.2004.11.006","article-title":"Inhibition of caspases alleviates gentamicin-induced cochlear damage in guinea pigs","volume":"32","author":"T Okuda","year":"2005","journal-title":"Auris Nasus Larynx"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s10162-006-0050-y","article-title":"A PI3K pathway mediates hair cell survival an opposes gentamicin toxicity in neonatal rat organ of Corti","volume":"7","author":"WH Chung","year":"2006","journal-title":"J Assoc Res Otolaryngol"},{"key":"ref13","first-page":"25","article-title":"The neurobiology of somatostatin","volume":"8","author":"J Epelbaum","year":"1994","journal-title":"Crit Rev Neurobiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/frne.1999.0183","article-title":"Somatostatin and its receptor family. Front","volume":"20","author":"YC Patel","year":"1999","journal-title":"Neuroendocrinol"},{"key":"ref15","first-page":"813","article-title":"Somatostatin","volume":"269","author":"T Reisine","year":"1995","journal-title":"Am J Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-2187-7-5","article-title":"Coexpression of human somatostatin receptor-2 (SSTR2) and SSTR3 modulates antiproliferative singaling and apoptosis","volume":"7","author":"SA War","year":"2012","journal-title":"J Mol Signal"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1023\/A:1021243126512","article-title":"Nitric oxide and octreotide in retinal ischemia\/reperfusion injury","volume":"105","author":"U Celiker","year":"2002","journal-title":"Doc Ophthalmol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/lary.20058","article-title":"Somatostatin and gentamicin-induced auditory hair cell loss","volume":"119","author":"A Caelers","year":"2009","journal-title":"Laryngoscope"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-2202-12-89","article-title":"The somatostatinergic system in the mammalian cochlea","volume":"12","author":"V Radojevic","year":"2011","journal-title":"BMC Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000341291","article-title":"Somatostatin receptor types 1 and 2 in the developing mammalian cochlea","volume":"34","author":"D Bodmer","year":"2012","journal-title":"Dev Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0014-5793(99)01582-3","article-title":"Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs","volume":"462","author":"HJ Kreienkamp","year":"1999","journal-title":"FEBS Lett"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1210\/mend.11.11.0016","article-title":"Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons","volume":"11","author":"H Zheng","year":"1997","journal-title":"Mol Endocrinol"},{"key":"ref23","unstructured":"Sobkowicz HM, Loftus JM, Slapnick SM (1993) Tissue culture of the organ of Corti. Acta Otolaryngol Suppl 502: 3\u201336."},{"key":"ref24","first-page":"191","article-title":"Neuropeptides and retinal development","volume":"143","author":"G Casini","year":"2005","journal-title":"Arch Ital Biol"},{"key":"ref25","first-page":"615","article-title":"Functional aspects of the somatostatinergic system in the retina and the potential therapeutic role of somatostatin in retinal disease","volume":"20","author":"G Casini","year":"2005","journal-title":"Histol Histopathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00210-004-1011-9","article-title":"Effect of somatostatin analogues on chemically induced ischaemia in the rat retina","volume":"371","author":"N Mastrodimou","year":"2005","journal-title":"Arch Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.mce.2007.12.009","article-title":"Physiology and pathology of somatostatin in the mammalian retina: A current view","volume":"286","author":"D Cerviva","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"ref28","first-page":"233","article-title":"Caspase activation. Biochem","volume":"70","author":"KM Boatright","year":"2003","journal-title":"Soc Symp"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ceb.2003.10.009","article-title":"Mechanisms of caspase activation","volume":"15","author":"KM Boatright","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-2202-12-114","article-title":"Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signalling in vitro","volume":"12","author":"Y Brand","year":"2011","journal-title":"BMC Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/0024-3205(96)00188-9","article-title":"Membrane delimited and intracellular soluble pathways in the somatostatin modulation of ACh release","volume":"58","author":"G Pilar","year":"1996","journal-title":"Life Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0028-3908(03)00296-X","article-title":"Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina","volume":"45","author":"M Dal Monte","year":"2003","journal-title":"Neuropharmacology"},{"key":"ref33","first-page":"1219","article-title":"Expression of neuropeptides and their receptors in the developing retina of mammals","volume":"18","author":"P Bagnoli","year":"2003","journal-title":"Histol Histopathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/j.1460-9568.2007.05419.x","article-title":"Changes in neuronal response to ischemia in retinas with genetic alterations of somatostatin receptor expression","volume":"25","author":"E Catalani","year":"2007","journal-title":"Eur J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1167\/iovs.06-1469","article-title":"Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice","volume":"48","author":"M Dal Monte","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1046\/j.1471-4159.2000.0740134.x","article-title":"Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons","volume":"74","author":"L Tenneti","year":"2000","journal-title":"J Neurochem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/00005537-200209000-00001","article-title":"Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss","volume":"112","author":"RD Kopke","year":"2002","journal-title":"Laryngoscope"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/nrd1255","article-title":"Opportunities in somatostatin research: biological, chemical and therapeutic aspects. Nat","volume":"2","author":"G Weckbecker","year":"2003","journal-title":"Rev Drug Discov"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1210\/jc.2008-1919","article-title":"Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro","volume":"94","author":"S Lesche","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yfrne.2013.07.005","article-title":"Somatostatin receptors: From signalling to clinical practice","volume":"34","author":"M Theodoropoulou","year":"2013","journal-title":"Front Neuroendocrinol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1128\/MCB.20.16.5974-5985.2000","article-title":"Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways","volume":"20","author":"LA Sellers","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-0082(99)00042-8","article-title":"JNK and p38 stress kinases degenerative effectors of signal transduction-cascades in the nervous system","volume":"61","author":"K Mielke","year":"2000","journal-title":"Prog Neurobiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/385350a0","article-title":"Stress-signalling kinase Sekl protects thymocytes from apoptosis mediated by CD95 and CD3","volume":"385","author":"H Nishina","year":"1997","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11957","DOI":"10.1074\/jbc.M304935200","article-title":"Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK- independent","volume":"279","author":"L Du","year":"2004","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2011.10.054","article-title":"Ras\/p38 and PI3K\/Akt but not Mek\/Erk signalling mediate BDNF-induced neurite formation on neonatal cochlear spiral ganglion explants","volume":"1430","author":"LM Mullen","year":"2012","journal-title":"Brain Res"},{"key":"ref46","first-page":"859","article-title":"Somatostatin acts by inhibiting the cyclic 3\u2032, 5\u2032-adenosin monophosphate (cAMT)\/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency","volume":"11","author":"JJ Tentler","year":"1997","journal-title":"Mol Endocrinol"},{"key":"ref47","first-page":"212","article-title":"New insights into peripherin expression in cochlear","volume":"150","author":"F Lallemend","year":"2007","journal-title":"Neurons Neurosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0108146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T13:18:56Z","timestamp":1565875136000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0108146"}},"subtitle":[],"editor":[{"given":"Prasun K.","family":"Datta","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,30]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0108146","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,30]]}}}