{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:10:56Z","timestamp":1790673056339,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0108197","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T19:08:14Z","timestamp":1412017694000},"page":"e108197","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Two Spx Regulators Modulate Stress Tolerance and Virulence in Streptococcus suis Serotype 2"],"prefix":"10.1371","volume":"9","author":[{"given":"Chengkun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luohong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Bei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1371\/journal.pmed.0030151","article-title":"Streptococcal toxic shock syndrome caused by <italic>Streptococcus suis<\/italic> serotype 2","volume":"3","author":"J Tang","year":"2006","journal-title":"PLoS Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.vetmic.2005.01.003","article-title":"Biochemical analysis, <italic>cpn60<\/italic> and 16S rDNA sequence data indicate that <italic>Streptococcus suis<\/italic> serotypes 32 and 34, isolated from pigs, are <italic>Streptococcus orisratti<\/italic>","volume":"107","author":"JE Hill","year":"2005","journal-title":"Vet Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1016\/j.vaccine.2009.06.074","article-title":"Identification of a surface protective antigen, HP0197 of <italic>Streptococcus suis<\/italic> serotype 2","volume":"27","author":"A Zhang","year":"2009","journal-title":"Vaccine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tim.2009.12.003","article-title":"Uncovering newly emerging variants of <italic>Streptococcus suis<\/italic>, an important zoonotic agent","volume":"18","author":"Y Feng","year":"2010","journal-title":"Trends Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1473-3099(07)70001-4","article-title":"<italic>Streptococcus suis<\/italic>: an emerging zoonotic pathogen","volume":"7","author":"ZR Lun","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"ref6","first-page":"349","article-title":"<italic>Streptococcus suis<\/italic> meningitis complicated with permanent perceptive deafness: report of a case","volume":"93","author":"MY Yen","year":"1994","journal-title":"J Formos Med Assoc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1086\/596763","article-title":"<italic>Streptococcus suis<\/italic>: an emerging human pathogen","volume":"48","author":"HF Wertheim","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3988\/jcn.2012.8.1.79","article-title":"Meningitis caused by <italic>Streptococcus suis<\/italic>: case report and review of the literature","volume":"8","author":"SM Choi","year":"2012","journal-title":"J Clin Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2217\/fmb.11.149","article-title":"Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent <italic>Streptococcus suis<\/italic>","volume":"7","author":"N Fittipaldi","year":"2012","journal-title":"Future Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1086\/594371","article-title":"<italic>Streptococcus suis<\/italic>: an emerging human threat","volume":"199","author":"M Segura","year":"2009","journal-title":"J Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1128\/IAI.00193-10","article-title":"Contribution of the Rgg transcription regulator to metabolism and virulence of <italic>Streptococcus suis<\/italic> serotype 2","volume":"79","author":"F Zheng","year":"2011","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e315","DOI":"10.1371\/journal.pone.0000315","article-title":"A glimpse of streptococcal toxic shock syndrome from comparative genomics of <italic>S. suis<\/italic> 2 Chinese isolates","volume":"2","author":"C Chen","year":"2007","journal-title":"PloS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0882-4010(02)90526-7","article-title":"Response regulator important in pathogenesis of <italic>Streptococcus suis<\/italic> serotype 2","volume":"33","author":"A de Greeff","year":"2002","journal-title":"Microb Pathog"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1574-6968.2008.01486.x","article-title":"The orphan response regulator RevSC21 controls the attachment of <italic>Streptococcus suis<\/italic> serotype 2 to human laryngeal epithelial cells and the expression of virulence genes","volume":"292","author":"T Wu","year":"2009","journal-title":"FEMS Microbiol Lett"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e2080","DOI":"10.1371\/journal.pone.0002080","article-title":"SalK\/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive <italic>Streptococcus suis<\/italic> serotype 2","volume":"3","author":"M Li","year":"2008","journal-title":"PloS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1128\/JB.01309-08","article-title":"The orphan response regulator CovR: a globally negative modulator of virulence in <italic>Streptococcus suis<\/italic> serotype 2","volume":"191","author":"X Pan","year":"2009","journal-title":"J Bacteriol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.vetmic.2010.08.005","article-title":"The two-component regulatory system CiaRH contributes to the virulence of <italic>Streptococcus suis<\/italic> 2","volume":"148","author":"J Li","year":"2011","journal-title":"Vet Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1099\/mic.0.057448-0","article-title":"The two-component system Ihk\/Irr contributes to the virulence of <italic>Streptococcus suis<\/italic> serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism","volume":"158","author":"H Han","year":"2012","journal-title":"Microbiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1574-6968.2012.02611.x","article-title":"Identification and proteome analysis of the two-component VirR\/VirS system in epidemic <italic>Streptococcus suis<\/italic> serotype 2","volume":"333","author":"H Wang","year":"2012","journal-title":"FEMS Microbiol Lett"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.micres.2013.11.002","article-title":"The two-component system NisK\/NisR contributes to the virulence of <italic>Streptococcus suis<\/italic> serotype 2","volume":"169","author":"J Xu","year":"2013","journal-title":"Microbiol Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7567","DOI":"10.1128\/JB.01532-07","article-title":"Functional definition and global regulation of Zur, a zinc uptake regulator in a <italic>Streptococcus suis<\/italic> serotype 2 strain causing streptococcal toxic shock syndrome","volume":"190","author":"Y Feng","year":"2008","journal-title":"J Bacteriol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1007\/s12275-011-1523-1","article-title":"Functional definition of LuxS, an autoinducer-2 (AI-2) synthase and its role in full virulence of <italic>Streptococcus suis<\/italic> serotype 2","volume":"49","author":"M Cao","year":"2011","journal-title":"J Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.vetmic.2011.04.029","article-title":"Functional analysis of <italic>luxS<\/italic> in <italic>Streptococcus suis<\/italic> reveals a key role in biofilm formation and virulence","volume":"152","author":"Y Wang","year":"2011","journal-title":"Vet Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s12275-012-2035-3","article-title":"Catabolite control protein A of <italic>Streptococcus suis<\/italic> type 2 contributes to sugar metabolism and virulence","volume":"50","author":"Y Tang","year":"2012","journal-title":"J Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1099\/mic.0.046417-0","article-title":"Role of glucose and CcpA in capsule expression and virulence of <italic>Streptococcus suis<\/italic>","volume":"157","author":"J Willenborg","year":"2011","journal-title":"Microbiology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2180-12-85","article-title":"A Fur-like protein PerR regulates two oxidative stress response related operons <italic>dpr<\/italic> and <italic>metQIN<\/italic> in <italic>Streptococcus suis<\/italic>","volume":"12","author":"T Zhang","year":"2012","journal-title":"BMC Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.vetmic.2009.12.037","article-title":"The cation-uptake regulators AdcR and Fur are necessary for full virulence of <italic>Streptococcus suis<\/italic>","volume":"144","author":"J Aranda","year":"2010","journal-title":"Vet Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1128\/JB.186.7.1911-1918.2004","article-title":"Spx-RNA polymerase interaction and global transcriptional control during oxidative stress","volume":"186","author":"P Zuber","year":"2004","journal-title":"J Bacteriol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1073\/pnas.0637648100","article-title":"A regulatory protein that interferes with activator-stimulated transcription in bacteria","volume":"100","author":"S Nakano","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2958.2009.06789.x","article-title":"SpxA1, a novel transcriptional regulator involved in X-state (competence) development in <italic>Streptococcus pneumoniae<\/italic>","volume":"73","author":"C Turlan","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1128\/AEM.00413-07","article-title":"Inactivation of an iron transporter in <italic>Lactococcus lactis<\/italic> results in resistance to tellurite and oxidative stress","volume":"73","author":"MS Turner","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"13603","DOI":"10.1073\/pnas.2235180100","article-title":"Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in <italic>Bacillus subtilis<\/italic>","volume":"100","author":"S Nakano","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"15839","DOI":"10.1073\/pnas.0506592102","article-title":"Crystal structure of the <italic>Bacillus subtilis<\/italic> anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase","volume":"102","author":"KJ Newberry","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9571","DOI":"10.1093\/nar\/gks755","article-title":"Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in <italic>Bacillus subtilis<\/italic>","volume":"40","author":"T Rochat","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1128\/JB.00194-06","article-title":"Spx is a global effector impacting stress tolerance and biofilm formation in <italic>Staphylococcus aureus<\/italic>","volume":"188","author":"SJ Pamp","year":"2006","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1128\/AAC.00220-13","article-title":"The <italic>Staphylococcus aureus<\/italic> thiol\/oxidative stress global regulator Spx controls <italic>trfA<\/italic>, a gene implicated in cell wall antibiotic resistance","volume":"57","author":"A Jousselin","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1128\/JB.00028-10","article-title":"Two Spx proteins modulate stress tolerance, survival, and virulence in <italic>Streptococcus mutans<\/italic>","volume":"192","author":"JK Kajfasz","year":"2010","journal-title":"J Bacteriol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e40034","DOI":"10.1371\/journal.pone.0040034","article-title":"SpxA1 involved in hydrogen peroxide production, stress tolerance and endocarditis virulence in <italic>Streptococcus sanguinis<\/italic>","volume":"7","author":"L Chen","year":"2012","journal-title":"PloS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/IAI.00026-12","article-title":"The Spx regulator modulates stress responses and virulence in <italic>Enterococcus faecalis<\/italic>","volume":"80","author":"JK Kajfasz","year":"2012","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jsb.2009.07.001","article-title":"Crystal structure of the in vivo-assembled <italic>Bacillus subtilis<\/italic> Spx\/RNA polymerase alpha subunit C-terminal domain complex","volume":"168","author":"V Lamour","year":"2009","journal-title":"J Struct Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/mmi.12521","article-title":"The role of thiol oxidative stress response in heat-induced protein aggregate formation during thermotolerance in <italic>Bacillus subtilis<\/italic>","volume":"91","author":"S Runde","year":"2014","journal-title":"Mol Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/plas.2001.1532","article-title":"Thermosensitive suicide vectors for gene replacement in <italic>Streptococcus suis<\/italic>","volume":"46","author":"D Takamatsu","year":"2001","journal-title":"Plasmid"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1128\/IAI.00636-09","article-title":"The secreted esterase of group a <italic>streptococcus<\/italic> is important for invasive skin infection and dissemination in mice","volume":"77","author":"H Zhu","year":"2009","journal-title":"Infect Immun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1128\/IAI.06294-11","article-title":"Fhb, a novel factor H-binding surface protein, contributes to the antiphagocytic ability and virulence of <italic>Streptococcus suis<\/italic>","volume":"80","author":"Y Pian","year":"2012","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1086\/598967","article-title":"The SaeR\/S gene regulatory system is essential for innate immune evasion by <italic>Staphylococcus aureus<\/italic>","volume":"199","author":"JM Voyich","year":"2009","journal-title":"J Infect Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e6072","DOI":"10.1371\/journal.pone.0006072","article-title":"Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen <italic>Streptococcus suis<\/italic>","volume":"4","author":"MT Holden","year":"2009","journal-title":"PloS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1128\/JB.183.19.5709-5717.2001","article-title":"Genome of the bacterium <italic>Streptococcus pneumoniae<\/italic> strain R6","volume":"183","author":"J Hoskins","year":"2001","journal-title":"J Bacteriol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2958.2004.04395.x","article-title":"Redox-sensitive transcriptional control by a thiol\/disulphide switch in the global regulator, Spx","volume":"55","author":"S Nakano","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4049\/jimmunol.179.3.1842","article-title":"<italic>Streptococcus suis<\/italic> serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection","volume":"179","author":"MC Dominguez-Punaro","year":"2007","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"S463","DOI":"10.1097\/01.CCM.0000186784.62662.A1","article-title":"Interleukin-6","volume":"33","author":"M Song","year":"2005","journal-title":"Crit Care Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.vetmic.2012.02.028","article-title":"Inactivation of the <italic>sodA<\/italic> gene of <italic>Streptococcus suis<\/italic> type 2 encoding superoxide dismutase leads to reduced virulence to mice","volume":"158","author":"Y Tang","year":"2012","journal-title":"Vet Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1365-2958.2007.05704.x","article-title":"<italic>Streptococcus pyogenes<\/italic> pili promote pharyngeal cell adhesion and biofilm formation","volume":"64","author":"AG Manetti","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bbrc.2009.12.029","article-title":"Pili of oral <italic>Streptococcus sanguinis<\/italic> bind to fibronectin and contribute to cell adhesion","volume":"391","author":"N Okahashi","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1074\/jbc.M113.545632","article-title":"Extracellular nucleotide catabolism by the group B <italic>Streptococcus<\/italic> ectonucleotidase NudP increases bacterial survival in blood","volume":"289","author":"A Firon","year":"2014","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/1874285800802010089","article-title":"The Two-Component Regulatory System VicRK is Important to Virulence of <italic>Streptococcus equi<\/italic> Subspecies equi","volume":"2","author":"M Liu","year":"2008","journal-title":"Open Microbiol J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e70363","DOI":"10.1371\/journal.pone.0070363","article-title":"Competence-Independent Activity of Pneumococcal Enda Mediates Degradation of Extracellular DNA and Nets and Is Important for Virulence","volume":"8","author":"L Zhu","year":"2013","journal-title":"PloS One"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/vbz.2009.0225","article-title":"Microarray analysis of temperature-induced transcriptome of <italic>Streptococcus suis<\/italic> serotype 2","volume":"11","author":"X Zeng","year":"2011","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s13213-010-0165-6","article-title":"DNA microarray analysis of acid-responsive genes of <italic>Streptococcus suis<\/italic> serotype 2","volume":"61","author":"Y Wei","year":"2011","journal-title":"Ann Microbiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/00365549509018991","article-title":"Correlation between serum TNF alpha and IL6 levels and severity of group A streptococcal infections","volume":"27","author":"A Norrby-Teglund","year":"1995","journal-title":"Scand J Infect Dis"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/IAI.68.2.637-643.2000","article-title":"<italic>Streptococcus suis<\/italic> serotype 2 interactions with human brain microvascular endothelial cells","volume":"68","author":"N Charland","year":"2000","journal-title":"Infect Immun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1099\/mic.0.28706-0","article-title":"Defects in <italic>ex vivo<\/italic> and <italic>in vivo<\/italic> growth and sensitivity to osmotic stress of group A <italic>Streptococcus<\/italic> caused by interruption of response regulator gene <italic>vicR<\/italic>","volume":"152","author":"M Liu","year":"2006","journal-title":"Microbiology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1128\/IAI.67.9.4646-4654.1999","article-title":"Heat-killed <italic>Streptococcus suis<\/italic> capsular type 2 strains stimulate tumor necrosis factor alpha and interleukin-6 production by murine macrophages","volume":"67","author":"M Segura","year":"1999","journal-title":"Infect Immun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1365-2958.2008.06463.x","article-title":"Significant contribution of the <italic>pgdA<\/italic> gene to the virulence of <italic>Streptococcus suis<\/italic>","volume":"70","author":"N Fittipaldi","year":"2008","journal-title":"Mol Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0108197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T03:40:24Z","timestamp":1598326824000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0108197"}},"subtitle":[],"editor":[{"given":"Jos\u00e9 A.","family":"Lemos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,29]]},"references-count":64,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0108197","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,29]]}}}