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(2010) Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. 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Kumar","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1196\/annals.1326.018","article-title":"Neutrophil transepithelial migration and epithelial barrier function in IBD: potential targets for inhibiting neutrophil trafficking","volume":"1072","author":"AC Chin","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1172\/JCI117080","article-title":"Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit","volume":"93","author":"CP Kelly","year":"1994","journal-title":"J Clin Invest"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.4049\/jimmunol.0900600","article-title":"CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching\/effacing lesion-forming bacterial pathogen","volume":"183","author":"ME Spehlmann","year":"2009","journal-title":"J 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