{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:42:20Z","timestamp":1792424540108,"version":"4.5.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from excessive stimulation of immune cells. Traditionally, reactive oxygen species (ROS) have been implicated in the progression of inflammatory diseases, but several opposing observations suggest the protective role of ROS in inflammatory disease. Recently, we demonstrated ROS prevented imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function. Thus, we hypothesized AD might also be attenuated in elevated levels of ROS through tissue hyperoxygenation, such as by hyperbaric oxygen therapy (HBOT) or applying an oxygen-carrying chemical, perfluorodecalin (PFD). Elevated levels of ROS in the skin have been demonstrated directly by staining with dihydroethidum as well as indirectly by immunohistochemistry (IHC) for indoleamine 2,3-dioxygenase (IDO). A murine model of AD was developed by repeated application of a chemical irritant (1% 2,4-dinitrochlorobenzene) and house dust mite (\n                    <jats:italic>Dermatophagoide farinae<\/jats:italic>\n                    ) extract on one ear of BALB\/c mice. The results showed treatment with HBOT or PFD significantly attenuated AD, comparably with 0.1% prednicarbate without any signs of side effects, such as telangiectasia. The expressions of interleukin-17A and interferon-\u03b3 were also decreased in the AD lesions by treatment with HBOT or PFD. Enhanced expression of IDO and reduced level of hypoxia-inducible factor-1\u03b1, in association with increased frequency of FoxP3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells in the AD lesions, might be involved in the underlying mechanism of oxygen therapy. Taken together, it was suggested that tissue hyperoxygenation, by HBOT or treatment with PFD, might attenuate AD through enhancing skin ROS level.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0109297","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T14:20:12Z","timestamp":1412259612000},"page":"e0109297","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hyperoxygenation Attenuated a Murine Model of Atopic Dermatitis through Raising Skin Level of ROS"],"prefix":"10.1371","volume":"9","author":[{"given":"Hyung-Ran","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jeong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hae","family":"Kie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Ho","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Young","family":"Seoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,2]]},"reference":[{"key":"pone.0109297.ref001","first-page":"35","article-title":"Atopic dermatitis: an 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Fallarino","year":"2006","journal-title":"Transpl Immunol"},{"key":"pone.0109297.ref022","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000632","article-title":"Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease","volume":"2","author":"D Favre","year":"2010","journal-title":"Sci Transl Med"},{"key":"pone.0109297.ref023","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4049\/jimmunol.1100168","article-title":"Dichotomous effects of IFN-gamma on dendritic cell function determine the extent of IL-12-driven antitumor T cell immunity","volume":"187","author":"JL Harden","year":"2011","journal-title":"J Immunol"},{"key":"pone.0109297.ref024","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"EV Dang","year":"2011","journal-title":"Cell"},{"key":"pone.0109297.ref025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0140-6736(10)61085-9","article-title":"Decompression illness","volume":"377","author":"RD Vann","year":"2011","journal-title":"Lancet"},{"key":"pone.0109297.ref026","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ccc.2012.07.007","article-title":"Carbon monoxide poisoning","volume":"28","author":"JA Guzman","year":"2012","journal-title":"Crit Care Clin"},{"key":"pone.0109297.ref027","first-page":"7","article-title":"Hyperbaric oxygen therapy in acute necrotizing infections. 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Crohn's intractable enteric ulcer","volume":"94","author":"F Takeshima","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"pone.0109297.ref034","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00004836-200110000-00018","article-title":"Hyperbaric oxygen therapy for severe ulcerative colitis","volume":"33","author":"AL Buchman","year":"2001","journal-title":"J Clin Gastroenterol"},{"key":"pone.0109297.ref035","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/gut.43.4.512","article-title":"Hyperbaric oxygen: a novel modality to ameliorate experimental colitis","volume":"43","author":"D Rachmilewitz","year":"1998","journal-title":"Gut"},{"key":"pone.0109297.ref036","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1186\/1752-1947-0003-0000007023","article-title":"Therapeutic effect of hyperbaric oxygen in psoriasis vulgaris: two case reports and a review of the literature","volume":"3","author":"G Butler","year":"2009","journal-title":"J Med Case Rep"},{"key":"pone.0109297.ref037","first-page":"79","article-title":"Efficacy of hyperbaric oxygenation in atopic dermatitis","volume":"43","author":"R Olszanski","year":"1992","journal-title":"Bull Inst Marit Trop Med Gdynia"},{"key":"pone.0109297.ref038","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2337\/db11-0516","article-title":"Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy","volume":"61","author":"G Faleo","year":"2012","journal-title":"Diabetes"},{"key":"pone.0109297.ref039","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1152\/japplphysiol.91004.2008","article-title":"Oxidative stress is fundamental to hyperbaric oxygen therapy","volume":"106","author":"SR Thom","year":"2009","journal-title":"J Appl Physiol (1985)"},{"key":"pone.0109297.ref040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/PRS.0b013e3181fbe2bf","article-title":"Hyperbaric oxygen: its mechanisms and efficacy","volume":"127","author":"SR Thom","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"pone.0109297.ref041","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/107632703322066570","article-title":"Engineering blood: synthetic substitutes from fluorinated compounds","volume":"9","author":"KC Lowe","year":"2003","journal-title":"Tissue Eng"},{"key":"pone.0109297.ref042","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1126\/science.152.3730.1755","article-title":"Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure","volume":"152","author":"LC Clark","year":"1966","journal-title":"Science"},{"key":"pone.0109297.ref043","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00417-011-1874-7","article-title":"Colored perfluorocarbon liquids as novel intraoperative tools","volume":"250","author":"S Rizzo","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"pone.0109297.ref044","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1148\/radiology.185.1.1523296","article-title":"Human eye: visualization of perfluorodecalin with F-19 MR imaging","volume":"185","author":"BK Gewiese","year":"1992","journal-title":"Radiology"},{"key":"pone.0109297.ref045","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1467-2494.1996.tb00143.x","article-title":"The effectiveness of molecular oxygen in cosmetic formulations","volume":"18","author":"K Stanzl","year":"1996","journal-title":"Int J Cosmet Sci"},{"key":"pone.0109297.ref046","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.intimp.2011.04.005","article-title":"DA-9601 suppresses 2, 4-dinitrochlorobenzene and dust mite extract-induced atopic dermatitis-like skin lesions","volume":"11","author":"EJ Choi","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"pone.0109297.ref047","doi-asserted-by":"crossref","first-page":"17621","DOI":"10.1074\/jbc.C100084200","article-title":"Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase","volume":"276","author":"KA Pritchard","year":"2001","journal-title":"J Biol Chem"},{"key":"pone.0109297.ref048","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/01.RES.82.12.1298","article-title":"Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis","volume":"82","author":"FJ Miller","year":"1998","journal-title":"Circ Res"},{"key":"pone.0109297.ref049","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.autrev.2008.04.019","article-title":"Autoimmunity and oxidatively modified autoantigens","volume":"7","author":"BT Kurien","year":"2008","journal-title":"Autoimmun 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