{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:02:07Z","timestamp":1770415327232,"version":"3.49.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109410","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T17:50:51Z","timestamp":1414000251000},"page":"e109410","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Reassessment of the Role of TSC, mTORC1 and MicroRNAs in Amino Acids-Meditated Translational Control of TOP mRNAs"],"prefix":"10.1371","volume":"9","author":[{"given":"Ilona","family":"Patursky-Polischuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Kasir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Miloslavski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Hayouka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirit","family":"Hausner-Hanochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miri","family":"Stolovich-Rain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinchas","family":"Tsukerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Biton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajini","family":"Mudhasani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen N.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oded","family":"Meyuhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"ref1","first-page":"109","article-title":"Ribosomal protein S6 kinase: from TOP mRNAs to cell size","volume":"90","author":"O Meyuhas","year":"2009","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.1128\/MCB.22.23.8101-8113.2002","article-title":"Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the PI3-kinase-mediated pathway, but requires neither S6K1 nor rpS6 phosphorylation","volume":"22","author":"M Stolovich","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jmcb\/mju008","article-title":"Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner","volume":"6","author":"R Miloslavski","year":"2014","journal-title":"J Mol Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"K Inoki","year":"2003","journal-title":"Genes Dev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","article-title":"Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb","volume":"13","author":"AR Tee","year":"2003","journal-title":"Curr Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1146\/annurev-biochem-062209-094414","article-title":"Amino acid signaling in TOR activation","volume":"80","author":"J Kim","year":"2011","journal-title":"Annu Rev Biochem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.4161\/cc.10.14.16586","article-title":"mTOR complex 2 signaling and functions","volume":"10","author":"WJ Oh","year":"2011","journal-title":"Cell Cycle"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/embor.2011.257","article-title":"Regulation of TOR by small GTPases","volume":"13","author":"RV Duran","year":"2012","journal-title":"EMBO Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Y Sancak","year":"2008","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1073\/pnas.92.11.4947","article-title":"Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue","volume":"92","author":"J Chen","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1101\/gad.887201","article-title":"Regulation of translation initiation by FRAP\/mTOR","volume":"15","author":"AC Gingras","year":"2001","journal-title":"Genes Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1074\/jbc.273.26.16621","article-title":"Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies","volume":"273","author":"Q Weng","year":"1998","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/BST0370227","article-title":"mTORC1 signalling and mRNA translation","volume":"37","author":"CG Proud","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.devcel.2006.10.007","article-title":"Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCalpha, but Not S6K1","volume":"11","author":"DA Guertin","year":"2006","journal-title":"Dev Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/emboj.2008.119","article-title":"Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling","volume":"27","author":"T Ikenoue","year":"2008","journal-title":"EMBO J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nrd3531","article-title":"Rapamycin passes the torch: a new generation of mTOR inhibitors","volume":"10","author":"D Benjamin","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1128\/MCB.02136-06","article-title":"Tuberous Sclerosis Complex Proteins 1 and 2 Control Serum-Dependent Translation in a TOP-Dependent and -Independent Manner","volume":"27","author":"B Bilanges","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1128\/MCB.00980-08","article-title":"The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner","volume":"29","author":"I Patursky-Polischuk","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1074\/jbc.M412434200","article-title":"Lithium can relieve translational repression of TOP mRNAs elicited by various blocks along the cell cycle in a glycogen synthase kinase-3- and S6-kinase-independent manner","volume":"280","author":"M Stolovich","year":"2005","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1128\/MCB.21.24.8671-8683.2001","article-title":"Amino acid-induced translation of TOP mRNAs is fully dependent on PI3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation","volume":"21","author":"H Tang","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molcel.2011.06.038","article-title":"p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway","volume":"44","author":"A Duran","year":"2011","journal-title":"Mol Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase","volume":"334","author":"R Zoncu","year":"2011","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Y Sancak","year":"2010","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.1232044","article-title":"A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1","volume":"340","author":"L Bar-Peled","year":"2013","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"W Filipowicz","year":"2008","journal-title":"Nat Rev Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molcel.2008.05.001","article-title":"MicroRNA-10a binds the 5\u2032UTR of ribosomal protein mRNAs and enhances their translation","volume":"30","author":"UA Orom","year":"2008","journal-title":"Mol Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0042-6822(73)90341-3","article-title":"A new technique for the assay of infectivity of human adenovirus 5 DNA","volume":"52","author":"FL Graham","year":"1973","journal-title":"Virology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1172\/JCI200317222","article-title":"Loss of Tsc1\/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR","volume":"112","author":"H Zhang","year":"2003","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/11.5.525","article-title":"A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells","volume":"11","author":"DJ Kwiatkowski","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref30","first-page":"870","article-title":"Glycosaminoglycans of normal and malignant cultured human mammary cells","volume":"39","author":"EV Chandrasekaran","year":"1979","journal-title":"Cancer Res"},{"key":"ref31","first-page":"355","article-title":"Initiation and characterization of cultures of human colonic carcinoma with different biological characteristics utilizing feeder layers of confluent fibroblasts","volume":"2","author":"MG Brattain","year":"1981","journal-title":"Oncodev Biol Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1128\/MCB.9.5.2075","article-title":"Importance of introns for expression of mouse ribosomal protein gene rpL32","volume":"9","author":"S Chung","year":"1989","journal-title":"Mol Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1093\/nar\/15.12.4990","article-title":"Complete sequence of mouse S6 ribosomal protein","volume":"15","author":"J Lalanne","year":"1987","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0021-9258(19)70080-5","article-title":"Mouse actin messenger RNAs: construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse \u03b1-actin mRNA","volume":"256","author":"AJ Minty","year":"1981","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1002\/j.1460-2075.1985.tb04133.x","article-title":"Regulation of three \u00df-tubulin mRNAs during rat brain development","volume":"4","author":"I Ginzburg","year":"1985","journal-title":"EMBO J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"24731","DOI":"10.1074\/jbc.274.35.24731","article-title":"Osmotic stress inhibits p70\/85 S6 kinase through activation of a protein phosphatase","volume":"274","author":"LA Parrott","year":"1999","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ni.1642","article-title":"Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D","volume":"9","author":"N Stern-Ginossar","year":"2008","journal-title":"Nat Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1158\/0008-5472.CAN-11-2671","article-title":"MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells","volume":"72","author":"P Tsukerman","year":"2012","journal-title":"Cancer Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/cdd.2010.172","article-title":"MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2","volume":"18","author":"NH Foley","year":"2011","journal-title":"Cell Death Differ"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni.1994","article-title":"Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk","volume":"12","author":"M Biton","year":"2011","journal-title":"Nat Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncb847","article-title":"Tsc tumoursuppressor proteins antagonize amino-acid-TOR signalling","volume":"4","author":"X Gao","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"14238","DOI":"10.1073\/pnas.0506925102","article-title":"Amino acids mediate mTOR\/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase","volume":"102","author":"T Nobukuni","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.onc.1209106","article-title":"Regulation of the small GTPase Rheb by amino acids","volume":"25","author":"M Roccio","year":"2006","journal-title":"Oncogene"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"18717","DOI":"10.1074\/jbc.M414499200","article-title":"The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses","volume":"280","author":"EM Smith","year":"2005","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0092-8674(92)90643-Q","article-title":"Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 kinases","volume":"69","author":"J Chung","year":"1992","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1128\/MCB.24.15.6710-6718.2004","article-title":"mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells","volume":"24","author":"M Murakami","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"31861","DOI":"10.1074\/jbc.M801546200","article-title":"Isolation of hyperactive mutants of mammalian target of rapamycin","volume":"283","author":"Y Ohne","year":"2008","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1083\/jcb.200903131","article-title":"Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy","volume":"187","author":"V Risson","year":"2009","journal-title":"J Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1074\/jbc.275.10.7416","article-title":"FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions","volume":"275","author":"RT Peterson","year":"2000","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.277.5322.99","article-title":"Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin","volume":"277","author":"GJ Brunn","year":"1997","journal-title":"Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1074\/jbc.M900301200","article-title":"An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1","volume":"284","author":"CC Thoreen","year":"2009","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","article-title":"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB","volume":"22","author":"DD Sarbassov","year":"2006","journal-title":"Mol Cell"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ncb1753","article-title":"Regulation of TORC1 by Rag GTPases in nutrient response","volume":"10","author":"E Kim","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nmeth1079","article-title":"MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells","volume":"4","author":"MS Ebert","year":"2007","journal-title":"Nat Methods"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1083\/jcb.200802105","article-title":"Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells","volume":"181","author":"R Mudhasani","year":"2008","journal-title":"J Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1101\/sqb.2001.66.477","article-title":"Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs","volume":"66","author":"E Hornstein","year":"2001","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"R415","DOI":"10.1016\/j.cub.2007.04.011","article-title":"Building ribosomes: even more expensive than expected?","volume":"17","author":"S Granneman","year":"2007","journal-title":"Curr Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1126\/science.2683075","article-title":"G1 events and regulation of cell proliferation","volume":"246","author":"AB Pardee","year":"1989","journal-title":"Science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/MCB.24.8.3112-3124.2004","article-title":"S6K1<sup>\u2212\/\u2212<\/sup>\/S6K2<sup>\u2212\/\u2212<\/sup> mice exhibit perinatal lethality and rapamycin-sensitive 5\u2032-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway","volume":"24","author":"M Pende","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1101\/gad.351605","article-title":"Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis","volume":"19","author":"I Ruvinsky","year":"2005","journal-title":"Genes Dev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1101\/gad.2042311","article-title":"mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry","volume":"25","author":"N Dai","year":"2011","journal-title":"Genes Dev"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tcb.2014.03.003","article-title":"Regulation of mTORC1 by amino acids","volume":"24","author":"L Bar-Peled","year":"2014","journal-title":"Trends Cell Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrm3522","article-title":"Amino acid signalling upstream of mTOR","volume":"14","author":"JL Jewell","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.cell.2014.01.024","article-title":"Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2","volume":"156","author":"C Demetriades","year":"2014","journal-title":"Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1101\/gad.17355911","article-title":"Translational coregulation of 5\u2032TOP mRNAs by TIA-1 and TIAR","volume":"25","author":"CK Damgaard","year":"2011","journal-title":"Genes Dev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11083","article-title":"A unifying model for mTORC1-mediated regulation of mRNA translation","volume":"485","author":"CC Thoreen","year":"2012","journal-title":"Nature"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1101\/gad.231407.113","article-title":"Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5\u2032TOP mRNA translation","volume":"28","author":"J Tcherkezian","year":"2014","journal-title":"Genes Dev"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1242\/jcs.92.3.513","article-title":"A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors","volume":"92","author":"MH Oliver","year":"1989","journal-title":"J Cell Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T12:30:15Z","timestamp":1650457815000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109410"}},"subtitle":[],"editor":[{"given":"Thomas","family":"Preiss","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109410","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}