{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:05:39Z","timestamp":1791270339532,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109528","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T18:27:36Z","timestamp":1414607256000},"page":"e109528","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Teeth, Sex, and Testosterone: Aging in the World's Smallest Primate"],"prefix":"10.1371","volume":"9","author":[{"given":"Sarah","family":"Zohdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Tecot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina B.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Winchester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Jernvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Comfort A (1956) The biology of senescence. Edinburgh: Churchill Livingstone.","DOI":"10.5962\/bhl.title.6435"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/35000303","article-title":"New approaches to old age","volume":"403","author":"L Hayflick","year":"2000","journal-title":"Nature"},{"key":"ref3","unstructured":"Rose MR (1994) Evolutionary biology of aging: Oxford University Press, USA."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/420377a","article-title":"Rapid and costly ageing in wild male flies","volume":"420","author":"R Bonduriansky","year":"2002","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1086\/380650","article-title":"Comparative studies of senescence in natural populations of guppies","volume":"163","author":"MJ Bryant","year":"2004","journal-title":"The American Naturalist"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"R1000","DOI":"10.1016\/j.cub.2007.10.005","article-title":"Environmental conditions in early life influence ageing rates in a wild population of red deer","volume":"17","author":"DH Nussey","year":"2007","journal-title":"Current Biology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2435.2008.01418.x","article-title":"The evolutionary ecology of senescence","volume":"22","author":"P Monaghan","year":"2008","journal-title":"Functional Ecology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0003-3472(05)80206-4","article-title":"Habitat use and resource availability in baboons","volume":"43","author":"R Barton","year":"1992","journal-title":"Animal Behaviour"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1023\/A:1019650032735","article-title":"Tutoring in wild golden lion tamarins","volume":"23","author":"LG Rapaport","year":"2002","journal-title":"International Journal of Primatology"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Roberts S, Hays N (2001) Regulation of energy intake in old age. In: Hof PR and Mobbs CV, editors. Functional Neurobiology of Aging. San Diego, CA: Academic. pp. 829\u2013838.","DOI":"10.1016\/B978-012351830-9\/50060-3"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.2307\/2409837","article-title":"Senescence in natural populations of mammals: a comparative study","volume":"45","author":"DEL Promislow","year":"1991","journal-title":"Evolution"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0197-4580(99)00075-5","article-title":"The evolution of Alzheimer&apos;s disease and ApoE isoforms","volume":"20","author":"N Bons","year":"1999","journal-title":"Neurobiology of Aging"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1601-183X.2005.00149.x","article-title":"<italic>Microcebus murinus<\/italic>: a useful primate model for human cerebral aging and Alzheimer&apos;s disease?","volume":"5","author":"N Bons","year":"2006","journal-title":"Genes, Brain and Behavior"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0197-4580(92)90016-Q","article-title":"Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, <italic>Microcebus murinus<\/italic>","volume":"13","author":"N Bons","year":"1992","journal-title":"Neurobiology of Aging"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.exger.2005.05.002","article-title":"Aging and season affect plasma dehydroepiandrosterone sulfate (DHEA-S) levels in a primate","volume":"40","author":"M Perret","year":"2005","journal-title":"Experimental Gerontology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0531-5565(02)00244-9","article-title":"Physical activity and balance performance as a function of age in a prosimian primate (<italic>Microcebus murinus<\/italic>)","volume":"38","author":"F N\u00e9moz-Bertholet","year":"2003","journal-title":"Experimental Gerontology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.exger.2004.01.010","article-title":"Are age-related deficits in balance performance mediated by time of day in a prosimian primate (<italic>Microcebus murinus<\/italic>)?","volume":"39","author":"F N\u00e9moz-Bertholet","year":"2004","journal-title":"Experimental Gerontology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.exger.2006.09.013","article-title":"Aging affects executive functions and memory in mouse lemur primates","volume":"42","author":"JL Picq","year":"2007","journal-title":"Experimental Gerontology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.physbeh.2004.03.003","article-title":"Response to urinary volatiles and chemosensory function decline with age in a prosimian primate","volume":"81","author":"F Aujard","year":"2004","journal-title":"Physiology & Behavior"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1463-5224.2007.00491.x","article-title":"Ocular findings in two colonies of gray mouse lemurs (<italic>Microcebus murinus<\/italic>)","volume":"10","author":"WA Beltran","year":"2007","journal-title":"Veterinary Ophthalmology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0197-4580(94)90115-5","article-title":"Identification of amyloid beta protein in the brain of the small, short-lived Lemurian primate <italic>Microcebus murinus<\/italic>","volume":"15","author":"N Bons","year":"1994","journal-title":"Neurobiology of Aging"},{"key":"ref22","unstructured":"Goodman SM (2003) Predation on Lemurs. In: Goodman SM, Benstead JP, editors. The Natural History of Madagascar. Chicago: The University of Chicago Press. pp. 1221\u20131227."},{"key":"ref23","first-page":"213","article-title":"Presence of neuritic plaques and neurofibrillary changes in the cerebral cortex of an aged lemuride primate]","volume":"313","author":"N Bons","year":"1991","journal-title":"Comptes Rendus de l'Acad\u00e9mie des Sciences S\u00e9rie III, Sciences de la Vie"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2307\/1382873","article-title":"Survival of naked mole-rats marked by implantable transponders and toe-clipping","volume":"79","author":"S Braude","year":"1998","journal-title":"Journal of Mammalogy"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jhevol.2006.07.001","article-title":"Severe wear and tooth loss in wild ring-tailed lemurs (<italic>Lemur catta<\/italic>): A function of feeding ecology, dental structure, and individual life history","volume":"51","author":"FP Cuozzo","year":"2006","journal-title":"Journal of Human Evolution"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"16579","DOI":"10.1073\/pnas.0508377102","article-title":"Dental senescence in a long-lived primate links infant survival to rainfall","volume":"102","author":"SJ King","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2307\/3565648","article-title":"Tooth wear by food limitation and its life history consequences in wild reindeer","volume":"51","author":"T Skogland","year":"1988","journal-title":"Oikos"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ajpa.21368","article-title":"Age and individual foraging behavior predict tooth wear in Amboseli baboons","volume":"144","author":"J Galbany","year":"2011","journal-title":"American Journal of Physical Anthropology"},{"key":"ref29","unstructured":"Trivers R (1972) Parental investment and sexual selection. In: Campbell B, editor. Sexual selection and the descent of man. Chicago, IL: Aldine-Atherton. pp. 136\u2013179."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1098\/rspb.2007.1138","article-title":"Sex differences in ageing in natural populations of vertebrates","volume":"274","author":"T Clutton-Brock","year":"2007","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1098\/rspb.1992.0030","article-title":"Costs of sexual selection in natural populations of mammals","volume":"247","author":"DE Promislow","year":"1992","journal-title":"Proceedings of the Royal Society of London Series B: Biological Sciences"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0531-5565(00)00245-X","article-title":"Comparison of aging-related mortality among birds and mammals","volume":"36","author":"RE Ricklefs","year":"2001","journal-title":"Experimental Gerontology"},{"key":"ref33","unstructured":"Trivers R (1985) Social evolution. Menlo Park: The Benjamin\/Cummings Publishing Company, Inc."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/beheco\/art008","article-title":"Risky business: sex differences in mortality and dispersal in a polygynous, monomorphic lemur","volume":"24","author":"SR Tecot","year":"2013","journal-title":"Behavioral Ecology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1749-6632.1999.tb07667.x","article-title":"Sex hormones modulate inflammatory mediators produced by macrophages","volume":"876","author":"P D'Agostino","year":"1999","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.0141-9838.2004.00710.x","article-title":"Hormonal and immunological mechanisms mediating sex differences in parasite infection","volume":"26","author":"S Klein","year":"2004","journal-title":"Parasite Immunology"},{"key":"ref37","first-page":"12","article-title":"Sex differences in mortality rate","volume":"2002","author":"IP Owens","year":"2002","journal-title":"Science's SAGE KE"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1006\/anbe.2003.2121","article-title":"Patterns and dynamics of sex-biased dispersal in a nocturnal primate, the grey mouse lemur, <italic>Microcebus murinus<\/italic>","volume":"65","author":"U Radespiel","year":"2003","journal-title":"Animal Behaviour"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/evan.1360010108","article-title":"Primate ecology, rainforest conservation, and economic development: building a national park in Madagascar","volume":"1","author":"PC Wright","year":"1992","journal-title":"Evolutionary Anthropology: Issues, News, and Reviews"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"13723","DOI":"10.1073\/pnas.0704346104","article-title":"Evolution in the hypervariable environment of Madagascar","volume":"104","author":"RE Dewar","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1020518419038","article-title":"Diet of the brown mouse lemur (<italic>Microcebus rufus<\/italic>) in Ranomafana National Park, Madagascar","volume":"20","author":"S Atsalis","year":"1999","journal-title":"International Journal of Primatology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1023\/A:1020826502103","article-title":"Seasonal fluctuations in body fat and activity levels in a rain-forest species of mouse lemur, M<italic>icrocebus rufus<\/italic>","volume":"20","author":"S Atsalis","year":"1999","journal-title":"International Journal of Primatology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1098\/rspb.2008.0200","article-title":"The costs of risky male behaviour: sex differences in seasonal survival in a small sexually monomorphic primate","volume":"275","author":"C Kraus","year":"2008","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s002650050474","article-title":"Fluctuating sexual dimorphism and differential hibernation by sex in a primate, the gray mouse lemur (<italic>Microcebus murinus<\/italic>)","volume":"43","author":"J Schmid","year":"1998","journal-title":"Behavioral Ecology and Sociobiology"},{"key":"ref45","unstructured":"Wright PC, Andriamihaja BA (2003) The conservation value of long-term research: A case study from Parc National de Ranomafana. In: Goodman S, Benstead J, editors. Natural History of Madagascar. Chicago: University of Chicago Press."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature05433","article-title":"High-level similarity of dentitions in carnivorans and rodents","volume":"445","author":"AR Evans","year":"2006","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10880","article-title":"Adaptive radiation of multituberculate mammals before the extinction of dinosaurs","volume":"483","author":"GP Wilson","year":"2012","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10764-008-9238-9","article-title":"Reproductive schedules of female <italic>Microcebus rufus<\/italic> at Ranomafana National Park, Madagascar","volume":"29","author":"MB Blanco","year":"2008","journal-title":"International Journal of Primatology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/00032717208062116","article-title":"Chromatographic separation of steroid hormones for use in radioimmunoassay","volume":"5","author":"G Abraham","year":"1972","journal-title":"Analytical Letters"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-8644(1998)107:27+<1::AID-AJPA2>3.0.CO;2-H","article-title":"Recent advances in noninvasive techniques to monitor hormone-behavior interactions","volume":"107","author":"P Whitten","year":"1998","journal-title":"American Journal of Physical Anthropology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1095\/biolreprod54.1.91","article-title":"Metabolism of reproductive steroids during the ovarian cycle in two species of callitrichids, <italic>Saguinus oedipus<\/italic> and Callithrix jacchus, and estimation of the ovulatory period from fecal steroids","volume":"54","author":"TE Ziegler","year":"1996","journal-title":"Biology of Reproduction"},{"key":"ref52","first-page":"563","article-title":"Estimating temporary emigration using capture-recapture data with Pollock&apos;s robust design","volume":"78","author":"WL Kendall","year":"1997","journal-title":"Ecology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1080\/00063659909477239","article-title":"Program MARK: survival estimation from populations of marked animals","volume":"46","author":"GC White","year":"1999","journal-title":"Bird Study"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2307\/2532158","article-title":"Some practical aspects of a conditional likelihood approach to capture experiments","author":"R Huggins","year":"1991","journal-title":"Biometrics"},{"key":"ref55","first-page":"3","article-title":"Statistical inference from capture data on closed animal populations","author":"DL Otis","year":"1978","journal-title":"Wildlife Monographs"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.0006-341X.2000.00434.x","article-title":"Unified maximum likelihood estimates for closed capture\u2013recapture models using mixtures","volume":"56","author":"S Pledger","year":"2000","journal-title":"Biometrics"},{"key":"ref57","unstructured":"Burnham KP, Anderson DR (2002) Model selection and multi-model inference: a practical information-theoretic approach. Springer."},{"key":"ref58","first-page":"1","article-title":"Design and analysis methods for fish survival experiments based on release-recapture","volume":"5","author":"KP Burnham","year":"1987","journal-title":"American Fisheries Society Monograph"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1098\/rspb.2011.0190","article-title":"Hibernation is associated with increased survival and the evolution of slow life histories among mammals","volume":"278","author":"C Turbill","year":"2011","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.7221552","article-title":"Hibernation and longevity in the Turkish hamster <italic>Mesocricetus brandti<\/italic>","volume":"212","author":"CP Lyman","year":"1981","journal-title":"Science"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.1201571","article-title":"Aging in the natural world: comparative data reveal similar mortality patterns across primates","volume":"331","author":"AM Bronikowski","year":"2011","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1098\/rstb.1991.0028","article-title":"Evolution of senescence: late survival sacrificed for reproduction","volume":"332","author":"TBL Kirkwood","year":"1991","journal-title":"Philosophical Transactions of the Royal Society of London Series B: Biological Sciences"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ajp.1029","article-title":"Female dominance in captive gray mouse lemurs (<italic>Microcebus murinus<\/italic>)","volume":"54","author":"U Radespiel","year":"2001","journal-title":"American Journal of Primatology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1086\/285057","article-title":"Female dominance and maternal investment in strepsirhine primates","author":"AL Young","year":"1990","journal-title":"American Naturalist"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:21:19Z","timestamp":1540344079000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109528"}},"subtitle":[],"editor":[{"given":"Karen E.","family":"Samonds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,29]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109528","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,29]]}}}