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In: H Rodriguez-Martinez, M. N Soede and W. L Floers, editors. 9th International Conference on Pig Reproduction. Olsztyn, Poland: Nottingham Univ. Press. pp. 19\u201332."},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","article-title":"The thrifty phenotype hypothesis","volume":"60","author":"CN Hales","year":"2001","journal-title":"Br Med Bull"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0378-3782(84)90114-2","article-title":"The body proportions for small-for-dates infants","volume":"10","author":"OG Brooke","year":"1984","journal-title":"Early Hum Dev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0002-9378(80)90279-3","article-title":"Comparative newborn anthropometric data in symmetric versus asymmetric intrauterine growth retardation","volume":"138","author":"JP Crane","year":"1980","journal-title":"Am J Obstet Gynecol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"620","DOI":"10.2527\/jas1977.444620x","article-title":"Conceptus development in intact and unilaterally hysterectomized-ovariectomized gilts: interrelations among hormonal status, placental development, fetal fluids and fetal growth","volume":"44","author":"JW Knight","year":"1977","journal-title":"J Anim Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2527\/1999.774954x","article-title":"The impacts of uterine environment and fetal genotype on conceptus size and placental vascularity during late gestation in pigs","volume":"77","author":"NJ Biensen","year":"1999","journal-title":"J Anim Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.anireprosci.2004.05.019","article-title":"Embryonic and fetal development in a commercial dam-line genotype","volume":"85","author":"SC Town","year":"2005","journal-title":"Anim Reprod Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.placenta.2009.03.016","article-title":"Quantitative changes of sialoadhesin and CD163 positive macrophages in the implantation sites and organs of porcine embryos\/fetuses during gestation","volume":"30","author":"UU Karniychuk","year":"2009","journal-title":"Placenta"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/pr.2013.2","article-title":"Fetal metabolic programming and epigenetic modifications: a systems biology approach","volume":"73","author":"S Sookoian","year":"2013","journal-title":"Pediatr Res"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Li S, Kong L, Yu X, Zheng Y (2014) Host-virus interactions: from the perspectives of epigenetics. 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