{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:31:32Z","timestamp":1781375492559,"version":"3.54.1"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109697","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T18:19:49Z","timestamp":1412965189000},"page":"e109697","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cell Cycle Regulation of DNA Polymerase Beta in Rotenone-Based Parkinson's Disease Models"],"prefix":"10.1371","volume":"9","author":[{"given":"Hongcai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansheng","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsha","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1073\/pnas.0611671104","article-title":"The pRb\/E2F cell-cycle pathway mediates cell death in Parkinson's disease","volume":"104","author":"GU H\u00f6glinger","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2990.2007.00908.x","article-title":"Neuronal binucleation in Alzheimer disease hippocampus","volume":"34","author":"X Zhu","year":"2008","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.4161\/cc.9.10.11582","article-title":"A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR)","volume":"9","author":"JM Frade","year":"2010","journal-title":"Cell Cycle"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1101\/gad.1829209","article-title":"Endoreplication: polyploidy with purpose","volume":"23","author":"HO Lee","year":"2009","journal-title":"Genes Dev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.080531","article-title":"Endoreplication and polyploidy: insights into development and disease","volume":"140","author":"DT Fox","year":"2013","journal-title":"Development"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1111\/j.1742-4658.2007.05744.x","article-title":"A dideoxynucleotide-sensitive DNA pol-ymerase activity characterized from endoreduplicating cells of mungbean (Vigna radiata L.) during ontogeny of cotyledons","volume":"274","author":"S Roy","year":"2007","journal-title":"FEBS J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"10949","DOI":"10.1523\/JNEUROSCI.2793-06.2006","article-title":"DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid","volume":"26","author":"A Copani","year":"2006","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.mad.2013.04.005","article-title":"Base excision repair in the mammalian brain: Implication for age related neurodegeneration","volume":"134","author":"P Sykora","year":"2013","journal-title":"Mech Ageing Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1096\/fasebj.13.9.1107","article-title":"Overexpression of DNA polymerase beta: a genomic instability enhancer process","volume":"13","author":"Y Canitrot","year":"1999","journal-title":"FASEB J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/exnr.2002.8072","article-title":"Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation","volume":"179","author":"TB Sherer","year":"2003","journal-title":"Exp Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1266\/jjg.68.185","article-title":"Mitosis of rotenone-induced endoreduplication in Chinese hamster cells","volume":"68","author":"K Matsumoto","year":"1993","journal-title":"Jpn J Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e7878","DOI":"10.1371\/journal.pone.0007878","article-title":"Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease","volume":"4","author":"N Xiong","year":"2009","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.tplants.2011.07.001","article-title":"Molecular control and function of endoreplication in development and physiology","volume":"16","author":"VeylderL De","year":"2011","journal-title":"Trends Plant Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1091\/mbc.E12-02-0125","article-title":"Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons","volume":"23","author":"PK Modi","year":"2012","journal-title":"Mol Biol Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1471-4159.2005.03112.x","article-title":"Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10","volume":"93","author":"Y Moon","year":"2005","journal-title":"J Neurochem"},{"key":"ref16","first-page":"39","article-title":"Subcellular localization of tyrosine hydroxylase (TH) gene transcripts: new insights into the pattern of TH gene expression in the locus coeruleus under pharmacological stimulation","volume":"90(1)","year":"1998","journal-title":"Biol Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:48:22Z","timestamp":1589046502000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109697"}},"subtitle":[],"editor":[{"given":"Oscar","family":"Arias-Carrion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,10]]},"references-count":16,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109697","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,10]]}}}