{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:33:22Z","timestamp":1778697202476,"version":"3.51.4"},"reference-count":90,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109811","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T18:03:22Z","timestamp":1412705002000},"page":"e109811","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Involvement of YAP, TAZ and HSP90 in Contact Guidance and Intercellular Junction Formation in Corneal Epithelial Cells"],"prefix":"10.1371","volume":"9","author":[{"given":"Vijay Krishna","family":"Raghunathan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Dreier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua T.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binh C.","family":"Tuyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad W.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00055735-199508000-00002","article-title":"Extracellular matrix and growth factors in corneal wound healing","volume":"6","author":"IK Gipson","year":"1995","journal-title":"Current Opinion in Ophthalmology"},{"key":"ref2","first-page":"1266","article-title":"Matrix metalloproteinases in epithelia from human recurrent corneal erosion","volume":"40","author":"RM Garrana","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/ICO.0b013e31814b8a28","article-title":"Expression of matrix metalloproteinase 2 and 9 in experimentally wounded canine corneas and spontaneous chronic corneal epithelial defects","volume":"26","author":"RT Carter","year":"2007","journal-title":"Cornea"},{"key":"ref4","first-page":"2495","article-title":"Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing","volume":"41","author":"K Suzuki","year":"2000","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"a005066","DOI":"10.1101\/cshperspect.a005066","article-title":"Integrins and Extracellular Matrix in Mechanotransduction","volume":"2","author":"MA Schwartz","year":"2010","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1242\/jcs.114.14.2553","article-title":"Integrins and cell proliferation","volume":"114","author":"MA Schwartz","year":"2001","journal-title":"Journal of Cell Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ceb.2008.05.005","article-title":"Cell adhesion receptors in mechanotransduction","volume":"20","author":"MA Schwartz","year":"2008","journal-title":"Current Opinion in Cell Biology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1016\/j.biomaterials.2010.01.101","article-title":"The ability of corneal epithelial cells to recognize high aspect ratio nanostructures","volume":"31","author":"EJ Tocce","year":"2010","journal-title":"Biomaterials"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jbm.a.30744","article-title":"The scale of substratum topographic features modulates proliferation of corneal epithelial cells and corneal fibroblasts","volume":"79","author":"SJ Liliensiek","year":"2006","journal-title":"J Biomed Mater Res A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1167\/iovs.09-4074","article-title":"Nanoscale topography-induced modulation of fundamental cell behaviors of rabbit corneal keratocytes, fibroblasts, and myofibroblasts","volume":"51","author":"SA Pot","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1242\/jcs.01146","article-title":"Biological length scale topography enhances cell-substratum adhesion of human corneal epithelial cells","volume":"117","author":"NW Karuri","year":"2004","journal-title":"J Cell Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1167\/iovs.11-7982","article-title":"Substratum Topography Modulates Corneal Fibroblast to Myofibroblast Transformation","volume":"53","author":"KE Myrna","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"S Dupont","year":"2011","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1242\/dev.070987","article-title":"Hippo pathway regulation by cell morphology and stress fibers","volume":"138","author":"K-I Wada","year":"2011","journal-title":"Development"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling","volume":"150","author":"FX Yu","year":"2012","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Hong W, Guan KL (2012) The YAP and TAZ transcription coactivators: key downstream effectors of the mammalian Hippo pathway; Elsevier.","DOI":"10.1016\/j.semcdb.2012.05.004"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1242\/dev.027151","article-title":"Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling","volume":"135","author":"M Ota","year":"2008","journal-title":"Development"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1074\/jbc.M900843200","article-title":"TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition","volume":"284","author":"H Zhang","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"B Zhao","year":"2008","journal-title":"Genes and Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.devcel.2010.03.007","article-title":"The Hippo Pathway Regulates Wnt\/[beta]-Catenin Signaling","volume":"18","author":"X Varelas","year":"2010","journal-title":"Developmental Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2010.11.012","article-title":"The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-\u03b2-SMAD pathway","volume":"19","author":"X Varelas","year":"2010","journal-title":"Developmental Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1242\/jcs.069070","article-title":"Hippo signaling at a glance","volume":"123","author":"B Zhao","year":"2010","journal-title":"Journal of Cell Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1167\/iovs.10-6486","article-title":"Wnt\/\u03b2-Catenin Signaling Regulates Proliferation of Human Cornea Epithelial Stem\/Progenitor Cells","volume":"52","author":"MN Nakatsu","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1242\/dev.02381","article-title":"Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium","volume":"133","author":"M Mukhopadhyay","year":"2006","journal-title":"Development"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.1167\/iovs.11-8017","article-title":"Crosstalk between TGF-beta and MAPK signaling during corneal wound healing","volume":"52","author":"K Terai","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/bjo.85.2.209","article-title":"Intact corneal epithelium is essential for the prevention of stromal haze after laser assisted in situ keratomileusis","volume":"85","author":"K Nakamura","year":"2001","journal-title":"British Journal of Ophthalmology"},{"key":"ref27","first-page":"2603","article-title":"Injured corneal epithelial cells promote myodifferentiation of corneal fibroblasts","volume":"43","author":"K Nakamura","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1167\/iovs.12-11007","article-title":"Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ","volume":"54","author":"VK Raghunathan","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.exer.2013.05.014","article-title":"Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells","volume":"113","author":"SM Thomasy","year":"2013","journal-title":"Experimental Eye Research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2013.06.012","article-title":"What do mechanotransduction, Hippo, Wnt, and TGF\u03b2 have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease","volume":"115","author":"JT Morgan","year":"2013","journal-title":"Experimental Eye Research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/hmg\/ddh106","article-title":"A novel TEAD1 mutation is the causative allele in Sveinsson\u2019s chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)","volume":"13","author":"R Fossdal","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.bbrc.2007.07.129","article-title":"A Sveinsson\u2019s chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ","volume":"361","author":"M Kitagawa","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000918","DOI":"10.1371\/journal.pgen.1000918","article-title":"Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the <italic>Drosophila<\/italic> Retina","volume":"6","author":"BN Nicolay","year":"2010","journal-title":"PLoS Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1167\/iovs.09-4321","article-title":"Taz-tead1 links cell-cell contact to zeb1 expression, proliferation, and dedifferentiation in retinal pigment epithelial cells","volume":"51","author":"Y Liu","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.devcel.2010.06.015","article-title":"The Merlin\/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals","volume":"19","author":"N Zhang","year":"2010","journal-title":"Dev Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ydbio.2011.10.017","article-title":"Negative regulation of Yap during neuronal differentiation","volume":"361","author":"H Zhang","year":"2012","journal-title":"Dev Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1016\/j.actbio.2012.07.004","article-title":"Focal adhesion kinase knockdown modulates the response of human corneal epithelial cells to topographic cues","volume":"8","author":"B Dreier","year":"2012","journal-title":"Acta Biomater"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/jbm.a.34417","article-title":"Nuclear and cellular alignment of primary corneal epithelial cells on topography","volume":"101","author":"VK Raghunathan","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1109\/TNB.2006.886570","article-title":"Nano- and microscale holes modulate cell-substrate adhesion, cytoskeletal organization, and -beta1 integrin localization in SV40 human corneal epithelial cells","volume":"5","author":"NW Karuri","year":"2006","journal-title":"IEEE Trans Nanobioscience"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8642","DOI":"10.1158\/0008-5472.CAN-10-1345","article-title":"Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway","volume":"70","author":"CJ Huntoon","year":"2010","journal-title":"Cancer Research"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1021\/la020169l","article-title":"Improved Pattern Transfer in Soft Lithography Using Composite Stamps","volume":"18","author":"TW Odom","year":"2002","journal-title":"Langmuir"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.bpj.2011.09.042","article-title":"Topographic Modulation of the Orientation and Shape of Cell Nuclei and Their Influence on the Measured Elastic Modulus of Epithelial Cells","volume":"101","author":"CT McKee","year":"2011","journal-title":"Biophysical Journal"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1089\/ten.tea.2012.0584","article-title":"Influence of extracellular matrix proteins and substratum topography on corneal epithelial cell alignment and migration","volume":"19","author":"V Raghunathan","year":"2013","journal-title":"Tissue Eng Part A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1167\/iovs.04-0528","article-title":"Characterization of Growth and Differentiation in a Telomerase-Immortalized Human Corneal Epithelial Cell Line","volume":"46","author":"DM Robertson","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"T Mosmann","year":"1983","journal-title":"Journal of Immunological Methods"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nature Methods"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1242\/jcs.00383","article-title":"Epithelial contact guidance on well-defined micro- and nanostructured substrates","volume":"116","author":"AI Teixeira","year":"2003","journal-title":"Journal of Cell Science"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/stem.794","article-title":"Limbal epithelial stem cells: role of the niche microenvironment","volume":"30","author":"P Ordonez","year":"2012","journal-title":"Stem Cells"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cr.7310137","article-title":"Niche regulation of corneal epithelial stem cells at the limbus","volume":"17","author":"W Li","year":"2007","journal-title":"Cell Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.2337\/db09-1736","article-title":"E-Cadherin Expression Is Regulated by miR-192\/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-\u03b2","volume":"59","author":"B Wang","year":"2010","journal-title":"Diabetes"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.biomaterials.2009.10.037","article-title":"Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells","volume":"31","author":"EK Yim","year":"2010","journal-title":"Biomaterials"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Chou CL, Rivera AL, Sakai T, Caplan AI, Goldberg VM, <etal>et al<\/etal>.. (2012) Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Eng Part A.","DOI":"10.1089\/ten.tea.2012.0177"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0014-4827(02)00053-8","article-title":"Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography","volume":"284","author":"MJ Dalby","year":"2003","journal-title":"Experimental Cell Research"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1167\/iovs.07-1192","article-title":"Response of human trabecular meshwork cells to topographic cues on the nanoscale level","volume":"49","author":"P Russell","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1016\/j.biomaterials.2010.03.045","article-title":"Modulation of human vascular endothelial cell behaviors by nanotopographic cues","volume":"31","author":"SJ Liliensiek","year":"2010","journal-title":"Biomaterials"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Dreier B, Gasiorowski JZ, Morgan JT, Nealey PF, Russell P, <etal>et al<\/etal>.. (2013) Early responses of vascular endothelial cells to topographic cues. American Journal of Physiology - Cell Physiology.","DOI":"10.1152\/ajpcell.00264.2012"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1016\/j.biomaterials.2009.05.049","article-title":"The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK\/MAPK signalling in STRO-1+ enriched skeletal stem cells","volume":"30","author":"MJP Biggs","year":"2009","journal-title":"Biomaterials"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1242\/jcs.110.23.2905","article-title":"Contact guidance of CNS neurites on grooved quartz: influence of groove dimensions, neuronal age and cell type","volume":"110","author":"A Rajnicek","year":"1997","journal-title":"Journal of cell science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1242\/jcs.110.23.2915","article-title":"Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways","volume":"110","author":"A Rajnicek","year":"1997","journal-title":"J Cell Sci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1016\/j.biomaterials.2006.01.044","article-title":"The effect of environmental factors on the response of human corneal epithelial cells to nanoscale substrate topography","volume":"27","author":"AI Teixeira","year":"2006","journal-title":"Biomaterials"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jbm.a.30089","article-title":"Responses of human keratocytes to micro- and nanostructured substrates","volume":"71A","author":"AI Teixeira","year":"2004","journal-title":"Journal of Biomedical Materials Research"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/jbm.a.31519","article-title":"Sub-micron and nanoscale feature depth modulates alignment of stromal fibroblasts and corneal epithelial cells in serum-rich and serum-free media","volume":"86A","author":"SA Fraser","year":"2008","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/sca.20123","article-title":"Structural organization of the cytoskeleton in SV40 human corneal epithelial cells cultured on nano- and microscale grooves","volume":"30","author":"NW Karuri","year":"2008","journal-title":"Scanning"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1016\/j.actbio.2012.10.007","article-title":"The influence of biomimetic topographical features and the extracellular matrix peptide RGD on human corneal epithelial contact guidance","volume":"9","author":"EJ Tocce","year":"2013","journal-title":"Acta Biomater"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/jbm.a.33233","article-title":"Functionalization of reactive polymer multilayers with RGD and an antifouling motif: RGD density provides control over human corneal epithelial cell\u2013substrate interactions","volume":"100A","author":"EJ Tocce","year":"2012","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1167\/iovs.02-0860","article-title":"Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy","volume":"44","author":"TD Blalock","year":"2003","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/path.2000","article-title":"Epithelial and connective tissue cell CTGF\/CCN2 expression in gingival fibrosis","volume":"210","author":"A Kantarci","year":"2006","journal-title":"The Journal of Pathology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/08977199909103520","article-title":"Immunohistochemical Localization of Connective Tissue Growth Factor (CTGF) in the Mouse Embryo between Days 7.5 and 14.5 of Gestation","volume":"17","year":"1999","journal-title":"Growth Factors"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1159\/000085445","article-title":"TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras\/MEK\/ERK and Smad signalling","volume":"100","author":"MK Phanish","year":"2005","journal-title":"Nephron Exp Nephrol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1167\/iovs.13-12494","article-title":"Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells","volume":"54","author":"DM Wallace","year":"2013","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1620\/tjem.222.45","article-title":"Connective tissue growth factor cooperates with fibronectin in enhancing attachment and migration of corneal epithelial cells","volume":"222","author":"K Sugioka","year":"2010","journal-title":"The Tohoku Journal of Experimental Medicine"},{"key":"ref72","first-page":"522","article-title":"Telmisartan counteracts TGF-\u03b21 induced epithelial\u2013to\u2013mesenchymal transition via PPAR-\u03b3 in human proximal tubule epithelial cells","volume":"5","author":"Y Chen","year":"2012","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1006\/exer.2002.2066","article-title":"TGF\u03b2 induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGF\u03b2, PDGF and integrin signaling","volume":"75","author":"JV Jester","year":"2002","journal-title":"Experimental Eye Research"},{"key":"ref74","first-page":"2201","article-title":"Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor","volume":"32","author":"SW Cousins","year":"1991","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/eji.1830220125","article-title":"Studies on the induction of anterior chamber-associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor-\u03b2","volume":"22","author":"GA Wilbanks","year":"2005","journal-title":"European journal of immunology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0955-0674(94)90099-X","article-title":"Wound repair in the context of extracellular matrix","volume":"6","author":"J Gailit","year":"1994","journal-title":"Current Opinion in Cell Biology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1101\/gad.1903310","article-title":"The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation","volume":"24","author":"I Lian","year":"2010","journal-title":"Genes and Development"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/cbic.201300163","article-title":"The TEAD4-YAP\/TAZ Protein-Protein Interaction: Expected Similarities and Unexpected Differences","volume":"14","author":"JC Hau","year":"2013","journal-title":"Chembiochem"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1158\/1541-7786.MCR-06-0362","article-title":"Geldanamycin Anisimycins Activate Rho and Stimulate Rho- and ROCK-Dependent Actin Stress Fiber Formation","volume":"5","author":"A Amiri","year":"2007","journal-title":"Molecular Cancer Research"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000047929","article-title":"Electron microscopy of the canine corneal basement membranes","volume":"170","author":"GA Abrams","year":"2002","journal-title":"Cells Tissues Organs"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s004410050004","article-title":"Nanoscale topography of the basement membrane underlying the corneal epithelium of the rhesus macaque","volume":"299","author":"GA Abrams","year":"2000","journal-title":"Cell and Tissue Research"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00003226-200001000-00012","article-title":"Nanoscale Topography of the Corneal Epithelial Basement Membrane and Descemet\u2019s Membrane of the Human","volume":"19","author":"GA Abrams","year":"2000","journal-title":"Cornea"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.actbio.2010.11.035","article-title":"On the role of RhoA\/ROCK signaling in contact guidance of bone-forming cells on anisotropic Ti6Al4V surfaces","volume":"7","author":"A Calzado-Martin","year":"2011","journal-title":"Acta Biomater"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Meng W, Takeichi M (2009) Adherens junction: molecular architecture and regulation. Cold Spring Harbor perspectives in biology 1.","DOI":"10.1101\/cshperspect.a002899"},{"key":"ref85","first-page":"1955","article-title":"Composition and formation of intercellular junctions in epithelial cells","volume":"298","author":"E Knust","year":"2002","journal-title":"Science Signalling"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.emboj.7600605","article-title":"E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions","volume":"24","author":"JA Tunggal","year":"2005","journal-title":"The EMBO journal"},{"key":"ref87","unstructured":"Tian X, Liu Z, Niu B, Zhang J, Tan TK, <etal>et al<\/etal>.. (2011) E-Cadherin\/(beta)-catenin complex and the epithelial barrier. Journal of Biomedicine and Biotechnology 2011."},{"key":"ref88","first-page":"2714","article-title":"The many faces and functions of [beta]-catenin","volume":"31","author":"T Valenta","year":"2012","journal-title":"EMBO J"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1097\/JTO.0b013e31822adfb0","article-title":"Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach","volume":"6","author":"AK Reka","year":"2011","journal-title":"J Thorac Oncol"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Tomcik M, Zerr P, Pitkowski J, Palumbo-Zerr K, Avouac J, <etal>et al<\/etal>.. (2013) Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-\u03b2 signalling to prevent fibrosis. Annals of the Rheumatic Diseases.","DOI":"10.1136\/annrheumdis-2012-203095"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T06:24:12Z","timestamp":1650349452000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109811"}},"subtitle":[],"editor":[{"given":"Alexander V.","family":"Ljubimov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,7]]},"references-count":90,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109811","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,7]]}}}