{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:17:01Z","timestamp":1793146621469,"version":"4.5.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109813","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T14:01:06Z","timestamp":1413208866000},"page":"e109813","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Comparison of Serological Response to Doxycycline versus Benzathine Penicillin G in the Treatment of Early Syphilis in HIV-Infected Patients: A Multi-Center Observational Study"],"prefix":"10.1371","volume":"9","author":[{"given":"Jen-Chih","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Huei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Liang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni-Jiin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Yao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuag-Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsiang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hsu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Hsun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ching","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"ref1","unstructured":"WHO Global incidence and prevalence of selected curable sexually transmitted infections \u2013 2008. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/reproductivehealth\/publications\/rtis\/stisestimates\/en\/index.html\" xlink:type=\"simple\">http:\/\/www.who.int\/reproductivehealth\/publications\/rtis\/stisestimates\/en\/index.html<\/ext-link>. Accessed 21 June 2013."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Savage EJ, Marsh K, Duffell S, Ison CA, Zaman A, et al. (2012) Rapid increase in gonorrhoea and syphilis diagnoses in England in 2011. Euro Surveill 17.","DOI":"10.2807\/ese.17.29.20224-en"},{"key":"ref3","unstructured":"Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance, 2008. Atlanta, GA: U.S. Department of Health and Human Services; November 2009."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/01.olq.0000140009.28121.0f","article-title":"A case-control study of syphilis among men who have sex with men in New York City: association With HIV infection","volume":"31","author":"G Paz-Bailey","year":"2004","journal-title":"Sex Transm Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/sti.2005.015040","article-title":"High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India","volume":"82","author":"SJ Reynolds","year":"2006","journal-title":"Sex Transm Infect"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/sextrans-2011-050354","article-title":"Maximising the potential of voluntary counselling and testing for HIV: sexually transmitted infections and HIV epidemiology in a population testing for HIV and its implications for practice","volume":"88","author":"H Wu","year":"2012","journal-title":"Sex Transm Infect"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1053\/j.gastro.2009.02.006","article-title":"Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men","volume":"136","author":"T van de Laar","year":"2009","journal-title":"Gastroenterology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/JCM.06014-11","article-title":"Recent hepatitis C virus infections in HIV-infected patients in Taiwan: incidence and risk factors","volume":"50","author":"HY Sun","year":"2012","journal-title":"J Clin Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/cid\/ciu127","article-title":"Increasing Incidence of Recent Hepatitis D Virus Infection in HIV-Infected Patients in an Area Hyperendemic for Hepatitis B Virus Infection","volume":"58","author":"CC Hung","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00007435-200103000-00007","article-title":"Clinical manifestations of early syphilis by HIV status and gender: results of the syphilis and HIV study","volume":"28","author":"AM Rompalo","year":"2001","journal-title":"Sex Transm Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1086\/515245","article-title":"Neurosyphilis during the AIDS epidemic, San Francisco, 1985\u20131992","volume":"177","author":"JM Flood","year":"1998","journal-title":"J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1086\/513427","article-title":"Syphilis and HIV infection: an update","volume":"44","author":"NM Zetola","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/sti.2006.021402","article-title":"Serological response to syphilis treatment in HIV-positive and HIV-negative patients attending sexually transmitted diseases clinics","volume":"83","author":"KG Ghanem","year":"2007","journal-title":"Sex Transm Infect"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MD.0b013e3181c2af86","article-title":"Clinical and serologic baseline and follow-up features of syphilis according to HIV status in the post-HAART era","volume":"88","author":"D Farhi","year":"2009","journal-title":"Medicine (Baltimore)"},{"key":"ref15","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"KA Workowski","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1258\/ijsa.2008.008279","article-title":"UK National Guidelines on the Management of Syphilis 2008","volume":"19","author":"M Kingston","year":"2008","journal-title":"Int J STD AIDS"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1086\/500406","article-title":"Doxycycline compared with benzathine penicillin for the treatment of early syphilis","volume":"42","author":"KG Ghanem","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.amjmed.2008.04.042","article-title":"Primary syphilis: serological treatment response to doxycycline\/tetracycline versus benzathine penicillin","volume":"121","author":"T Wong","year":"2008","journal-title":"Am J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.medmal.2011.10.003","article-title":"Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis","volume":"42","author":"KC Psomas","year":"2012","journal-title":"Med Mal Infect"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1093\/cid\/cir701","article-title":"Management of adult syphilis","volume":"53","author":"KG Ghanem","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref21","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2006","volume":"55","author":"KA Workowski","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/infdis\/165.6.1124","article-title":"Association of biologic false-positive reactions for syphilis with human immunodeficiency virus infection","volume":"165","author":"AM Rompalo","year":"1992","journal-title":"J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1086\/644618","article-title":"Factors determining serologic response to treatment in patients with syphilis","volume":"49","author":"JJ Gonzalez-Lopez","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref24","first-page":"2123","article-title":"Factors influencing syphilis treatment failure and\/or re-infection in HIV co-infected patients: immunosuppression or behaviors","volume":"124","author":"JH Kim","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/cid\/cis757","article-title":"Serological response to treatment of syphilis according to disease stage and HIV status","volume":"55","author":"DF Knaute","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"O524","DOI":"10.1111\/1469-0691.12504","article-title":"Spirochetemia due to Treponema pallidum using polymerase-chain-reaction assays in patients with early syphilis: prevalence, associated factors and treatment response","volume":"20","author":"BR Wu","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/1469-0691.12529","article-title":"Multicentre surveillance of prevalence of the 23S rRNA A2058G and A2059G point mutations and molecular subtypes of Treponema pallidum in Taiwan, 2009\u20132013","volume":"20","author":"BR Wu","year":"2014","journal-title":"Clin Microbiol Infect"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T18:16:30Z","timestamp":1650392190000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109813"}},"subtitle":[],"editor":[{"given":"Roberto F.","family":"Speck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,13]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109813","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,13]]}}}