{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:54:35Z","timestamp":1762606475149},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109944","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T18:04:53Z","timestamp":1412705093000},"page":"e109944","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Human Adenovirus-Specific \u03b3\/\u03b4 and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation"],"prefix":"10.1371","volume":"9","author":[{"given":"Jan","family":"D\u00f6rrie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Krug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Wellner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Knippertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Schierer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Zipperer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Printz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Fritsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerold","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Schaft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Geyeregger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"ref1","first-page":"410","article-title":"Adoptive T-cell immunotherapy from third-party donors: characterization of donors and set up of a T-cell donor registry","volume":"3","author":"B Eiz-Vesper","year":"2012","journal-title":"Front Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/tid.12022","article-title":"European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011)","volume":"14","author":"S Matthes-Martin","year":"2012","journal-title":"Transpl Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1399-3062.2006.00184.x","article-title":"Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir","volume":"9","author":"N Symeonidis","year":"2007","journal-title":"Transpl Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2141.2006.06108.x","article-title":"Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation","volume":"134","author":"T Feuchtinger","year":"2006","journal-title":"Br J Haematol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1182\/blood-2009-07-232454","article-title":"Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation","volume":"114","author":"AM Leen","year":"2009","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e59592","DOI":"10.1371\/journal.pone.0059592","article-title":"Short-term in-vitro expansion improves monitoring and allows affordable generation of virus-specific T-cells against several viruses for a broad clinical application","volume":"8","author":"R Geyeregger","year":"2013","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/CJI.0000000000000034","article-title":"First-in-man clinical results with good manufacturing practice (GMP)-compliant polypeptide-expanded adenovirus-specific T cells after haploidentical hematopoietic stem cell transplantation","volume":"37","author":"R Geyeregger","year":"2014","journal-title":"J Immunother"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1182\/blood-2004-02-0646","article-title":"Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells","volume":"104","author":"AM Leen","year":"2004","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1128\/JVI.76.21.10608-10616.2002","article-title":"Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes","volume":"76","author":"CT Garnett","year":"2002","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/JVI.02023-06","article-title":"Structure-based identification of a major neutralizing site in an adenovirus hexon","volume":"81","author":"SL Pichla-Gollon","year":"2007","journal-title":"J Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1128\/JCM.01249-06","article-title":"Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa","volume":"44","author":"AR Thorner","year":"2006","journal-title":"J Clin Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1016\/j.vaccine.2011.03.042","article-title":"Epidemiology of adenovirus type 5 neutralizing antibodies in healthy people and AIDS patients in Guangzhou, southern China","volume":"29","author":"C Sun","year":"2011","journal-title":"Vaccine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tibtech.2011.04.009","article-title":"Treating cancer with genetically engineered T cells","volume":"29","author":"TS Park","year":"2011","journal-title":"Trends Biotechnol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/ni1001-957","article-title":"Immunotherapy through TCR gene transfer","volume":"2","author":"HW Kessels","year":"2001","journal-title":"Nat Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1073\/pnas.0500357102","article-title":"A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection","volume":"102","author":"EC Morris","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/ni1001-962","article-title":"Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer","volume":"2","author":"T Stanislawski","year":"2001","journal-title":"Nat Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1129003","article-title":"Cancer regression in patients after transfer of genetically engineered lymphocytes","volume":"314","author":"RA Morgan","year":"2006","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.4049\/jimmunol.0902233","article-title":"CMV-specific TCR-transgenic T cells for immunotherapy","volume":"183","author":"A Schub","year":"2009","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/gt.2008.189","article-title":"Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer","volume":"16","author":"K Birkholz","year":"2009","journal-title":"Gene Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1038\/mtna.2013.43","article-title":"A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus","volume":"2","author":"S Koh","year":"2013","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF03256431","article-title":"Molecular diagnosis and management of viral infections in hematopoietic stem cell transplant recipients","volume":"16","author":"S Breuer","year":"2012","journal-title":"Mol Diagn Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.2012.06606.x","article-title":"Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation","volume":"1266","author":"L Oevermann","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1158\/0008-5472.CAN-05-4190","article-title":"Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity","volume":"66","author":"LT van der Veken","year":"2006","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"van der Veken LT, Coccoris M, Swart E, Falkenburg JH, Schumacher TN, et al. (2009) Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo. J Immunol 182: 164\u2013170. 182\/1\/164 [pii].","DOI":"10.4049\/jimmunol.182.1.164"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1349-7006.2012.02337.x","article-title":"Antitumor activity of human gammadelta T cells transducted with CD8 and with T-cell receptors of tumor-specific cytotoxic T lymphocytes","volume":"103","author":"T Hanagiri","year":"2012","journal-title":"Cancer Sci"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Krug C, Wiesinger M, Abken H, Schuler-Thurner B, Schuler G, et al. (2014) A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor. Cancer Immunol Immunother. 10.1007\/s00262-014-1572-5 [doi].","DOI":"10.1007\/s00262-014-1572-5"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00262-007-0385-1","article-title":"Introduction of functional chimeric E\/L-selectin by RNA electroporation to target dendritic cells from blood to lymph nodes","volume":"57","author":"J Dorrie","year":"2008","journal-title":"Cancer Immunol Immunother"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Felzmann T, Buchberger M, Jechlinger M, Kircheis R, Wagner E, et al. (2000) Xenogenization by tetanus toxoid loading into lymphoblastoid cell lines and primary human tumor cells mediated by polycations and liposomes. Cancer Lett 161: 241\u2013250. S0304383500006182 [pii].","DOI":"10.1016\/S0304-3835(00)00618-2"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jim.2009.05.001","article-title":"A fast and robust method to clone and functionally validate T-cell receptors","volume":"346","author":"K Birkholz","year":"2009","journal-title":"J Immunol Methods"},{"key":"ref30","first-page":"455","article-title":"Human T-cell receptor variable gene segment families","volume":"42","author":"B Arden","year":"1995","journal-title":"Immunogenetics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1007\/s00262-005-0098-2","article-title":"A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes","volume":"55","author":"N Schaft","year":"2006","journal-title":"Cancer Immunol Immunother"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/CJI.0b013e3181a28422","article-title":"Generation of human dendritic cells that simultaneously secrete IL-12 and have migratory capacity by adenoviral gene transfer of hCD40L in combination with IFN-gamma","volume":"32","author":"I Knippertz","year":"2009","journal-title":"J Immunother"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ijc.23074","article-title":"Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses","volume":"122","author":"S Schierer","year":"2008","journal-title":"Int J Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1097\/QAD.0b013e3283063a17","article-title":"Generation of HIV-1-specific T cells by electroporation of T-cell receptor RNA","volume":"22","author":"C Hofmann","year":"2008","journal-title":"AIDS"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Hoyer S, Prommersberger S, Pfeiffer IA, Schuler-Thurner B, Schuler G, et al. (2014) Concurrent interaction of DCs with CD4 and CD8 T cells improves secondary CTL expansion: It takes three to tango. Eur J Immunol. 10.1002\/eji.201444477 [doi].","DOI":"10.1002\/eji.201444477"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1365-2141.2011.08579.x","article-title":"Third-party virus-specific T cells eradicate adenoviraemia but trigger bystander graft-versus-host disease","volume":"154","author":"W Qasim","year":"2011","journal-title":"Br J Haematol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1182\/blood-2010-01-262089","article-title":"Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation","volume":"116","author":"T Feuchtinger","year":"2010","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/cid\/cis625","article-title":"Rapid salvage treatment with virus-specific T cells for therapy-resistant disease","volume":"55","author":"M Uhlin","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1182\/blood-2009-03-213256","article-title":"Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes","volume":"114","author":"PJ Hanley","year":"2009","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1182\/blood-2013-02-486324","article-title":"Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation","volume":"121","author":"AM Leen","year":"2013","journal-title":"Blood"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1182\/blood-2006-03-013318","article-title":"Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex","volume":"109","author":"MH Heemskerk","year":"2007","journal-title":"Blood"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"van Lent AU, Nagasawa M, van Loenen MM, Schotte R, Schumacher TN, et al. (2007) Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors. J Immunol 179: 4959\u20134968. 179\/8\/4959 [pii].","DOI":"10.4049\/jimmunol.179.8.4959"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1002\/eji.201242666","article-title":"Strong and sustained effector function of memory- versus naive-derived T cells upon T-cell receptor RNA transfer: implications for cellular therapy","volume":"42","author":"S Thomas","year":"2012","journal-title":"Eur J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/intimm\/dxh401","article-title":"T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production","volume":"18","author":"N Schaft","year":"2006","journal-title":"Int Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.174.7.4415","article-title":"Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell lines","volume":"174","author":"Y Zhao","year":"2005","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e31210","DOI":"10.1371\/journal.pone.0031210","article-title":"Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection","volume":"7","author":"M Lehner","year":"2012","journal-title":"PLoS One"},{"key":"ref47","unstructured":"Kobayashi H, Tanaka Y, Shimmura H, Minato N, Tanabe K (2010) Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. Anticancer Res 30: 575\u2013579. 30\/2\/575 [pii]."},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.ejcts.2009.11.051","article-title":"A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells","volume":"37","author":"J Nakajima","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jim.2009.05.006","article-title":"Large scale expansion of Vgamma9Vdelta2 T lymphocytes from human peripheral blood mononuclear cells after a positive selection using MACS \u201cTCR gamma\/delta+ T cell isolation kit\u201d","volume":"347","author":"S Salot","year":"2009","journal-title":"J Immunol Methods"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.canlet.2010.05.005","article-title":"Adoptive immunotherapy of cancer using ex vivo expanded human gammadelta T cells: A new approach","volume":"297","author":"P Dokouhaki","year":"2010","journal-title":"Cancer Lett"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.4049\/jimmunol.1001919","article-title":"Involvement of CD56brightCD11c+ cells in IL-18-mediated expansion of human gammadelta T cells","volume":"186","author":"J Tsuda","year":"2011","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00262-012-1353-y","article-title":"Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI","volume":"62","author":"GM Siegers","year":"2013","journal-title":"Cancer Immunol Immunother"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1084\/jem.166.2.595","article-title":"Independent association of T cell receptor beta and gamma chains with CD3 in the same cell","volume":"166","author":"F Koning","year":"1987","journal-title":"J Exp Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1084\/jem.168.3.1003","article-title":"Surface expression of only gamma delta and\/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains","volume":"168","author":"T Saito","year":"1988","journal-title":"J Exp Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T23:07:03Z","timestamp":1565910423000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109944"}},"subtitle":[],"editor":[{"given":"Ramon","family":"Arens","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,7]]},"references-count":54,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109944","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,7]]}}}