{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:30:52Z","timestamp":1791307852236,"version":"4.3.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T00:00:00Z","timestamp":1412812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109977","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T14:19:28Z","timestamp":1412864368000},"page":"e109977","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Scorpion Venom Heat-Resistant Peptide (SVHRP) Enhances Neurogenesis and Neurite Outgrowth of Immature Neurons in Adult Mice by Up-Regulating Brain-Derived Neurotrophic Factor (BDNF)"],"prefix":"10.1371","volume":"9","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Fei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Ying","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1046\/j.1432-1327.2001.02132.x","article-title":"Molecular characterization of an anti-epilepsy peptide from the scorpion Buthus martensi Karsch","volume":"268","author":"CG Wang","year":"2001","journal-title":"Eur J Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0041-0101(02)00142-3","article-title":"An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch","volume":"40","author":"C Goudet","year":"2002","journal-title":"Toxicon"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.toxicon.2005.11.013","article-title":"Genetic mechanisms of scorpion venom peptide diversification","volume":"47","author":"ZJ Cao","year":"2006","journal-title":"Toxicon"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1046-5928(02)00609-5","article-title":"Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli","volume":"27","author":"YF Liu","year":"2003","journal-title":"Protein Expr Purif"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/bmc.1519","article-title":"Purification, characterization and functional expression of a new peptide with an analgesic effect from Chinese scorpion Buthus martensii Karsch (BmK AGP-SYPU1)","volume":"25","author":"Y Wang","year":"2011","journal-title":"Biomed Chromatogr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/15216540500058899","article-title":"Scorpion venom peptides without disulfide bridges","volume":"57","author":"XC Zeng","year":"2005","journal-title":"IUBMB Life"},{"key":"ref7","unstructured":"Zhang WQ, Zhao J, Liu H, Wu XF, Peng Y, <etal>et al<\/etal>. (2004) Method of preparing the effective and less neurotoxic scorpion venom and the antiepileptic drugs prepared by the method: China, ZL01106166.9.2004-10-20."},{"key":"ref8","first-page":"278","article-title":"Inhibition of sodium channels in acutely isolated hippocampal neurons by scorpion venom heat resistant protein","volume":"59","author":"XY Zhang","year":"2007","journal-title":"Sheng Li Xue Bao"},{"key":"ref9","first-page":"87","article-title":"Inhibitory effects of scorpion venom heat resistant protein on the excitability of acutely isolated rat hippocampal neurons","volume":"59","author":"Y Wang","year":"2007","journal-title":"Sheng Li X ue Bao"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"C Zhao","year":"2008","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"GL Ming","year":"2011","journal-title":"Neuron"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neulet.2010.10.079","article-title":"Sustained increase in adult neurogenesis in the rat hippocampal dentate gyrus after transient brain ischemia","volume":"488","author":"C Wang","year":"2011","journal-title":"Neurosci Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1523\/JNEUROSCI.22-08-03174.2002","article-title":"Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway","volume":"22","author":"JM Parent","year":"2002","journal-title":"J Neurosci"},{"key":"ref14","first-page":"1123","article-title":"In vitro differentiation of multipotent human neural progenitors in serum-free medium, Neuroreport","volume":"11","author":"CL Brannen","year":"2000"},{"key":"ref15","first-page":"16","article-title":"Stem cells for spinal cord repair, Cell Stem Cell","volume":"3","author":"F Barnab\u00e9-Heider","year":"2008"},{"key":"ref16","first-page":"287","article-title":"Long-term fate of neural precursor cells following transplantation into developing and adult CNS, Neuroscience","volume":"142","author":"AC Lepore","year":"2006"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pharmtox.44.101802.121631","article-title":"Neurogenesis in the adult brain: new strategies for central nervous system diseases","volume":"44","author":"DC Lie","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/2045-3701-3-28","article-title":"Scorpion venom peptide SPVII promotes irradiated cells proliferation and increases the expression of the IL-3 receptor","volume":"3","author":"Y Qiu","year":"2013","journal-title":"Cell Biosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.toxicon.2011.05.001","article-title":"Purification and characterization of Ts15, the first member of a new \u03b1-KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus","volume":"58","author":"CT Cologna","year":"2011","journal-title":"Toxicon"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1471-4159.2006.03967.x","article-title":"Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation","volume":"99","author":"S Liebau","year":"2006","journal-title":"J Neurochem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/stem.65","article-title":"Wip1 Regulates the Generation of New Neural Cells in the Adult Olfactory Bulb through p53-Dependent Cell Cycle Control","volume":"27","author":"YH Zhu","year":"2009","journal-title":"Stem Cell"},{"key":"ref22","first-page":"1030","article-title":"Inhibitory effects of scorpion venom heat-resistant protein on neurotoxicity of exogenous amyloid beta peptide 1\u201340","volume":"4","author":"SB Yu","year":"2009","journal-title":"Neural Regeneration Research"},{"key":"ref23","unstructured":"Franklin KBJ, Paxinos G (1997) The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic Press."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0306-4522(00)00057-9","article-title":"Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures","volume":"97","author":"B Liu","year":"2000","journal-title":"Neuroscience"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature11689","article-title":"Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis","volume":"496","author":"M Knobloch","year":"2013","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1523\/JNEUROSCI.13-06-02351.1993","article-title":"Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat","volume":"13","author":"T Seki","year":"1993","journal-title":"J Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1007\/s11064-013-0977-4","article-title":"Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders","volume":"38","author":"J Nacher","year":"2013","journal-title":"Neurochem Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainresrev.2007.05.014","article-title":"Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons","volume":"56","author":"E Gascon","year":"2007","journal-title":"Brain Res Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.cell.2011.05.024","article-title":"In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics","volume":"145","author":"MA Bonaguidi","year":"2011","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/glia.21247","article-title":"Glial cells in adult neurogenesis","volume":"60","author":"J Morrens","year":"2012","journal-title":"Glia"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1096\/fj.09-150573","article-title":"Thrombospondin 1\u2013a key astrocyte-derived neurogenic factor","volume":"24","author":"Z Lu","year":"2010","journal-title":"FASEB J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1073\/pnas.0813286106","article-title":"Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6 beta1 in mouse neural stem cells","volume":"106","author":"FI Staquicini","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000082136","article-title":"Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone","volume":"26","author":"W Zheng","year":"2004","journal-title":"Dev Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrn2978","article-title":"The stem cell potential of glia: lessons from reactive gliosis","volume":"12","author":"S Robel","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.brainresbull.2008.02.037","article-title":"Retrovirus delivered neurotrophin-3 promotes survival, proliferation and neuronal differentiation of human fetal neural stem cells in vitro","volume":"77","author":"H Lu","year":"2008","journal-title":"Brain Res Bull"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/347762a0","article-title":"Proliferation and differentiation of neural stem cells regulated by nerve growth factor","volume":"347","author":"E Cattaneo","year":"1990","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/jnr.20316","article-title":"Effect of growth factors on proliferation and phenotypic differentiation of human fetal neural stem cells","volume":"78","author":"YI Tarasenko","year":"2004","journal-title":"J Neurosci Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.scr.2011.03.004","article-title":"Roles of activated astrocyte in neural stem cell proliferation and differentiation","volume":"7","author":"FW Wang","year":"2011","journal-title":"Stem Cell Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.07.070","article-title":"Astrocyte-conditioned medium protecting hippocampal neurons in primary cultures against corticosterone-induced damages via PI3-K\/Akt signal pathway","volume":"1114","author":"ZH Zhu","year":"2006","journal-title":"Brain Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T22:00:22Z","timestamp":1565906422000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109977"}},"subtitle":[],"editor":[{"given":"Silvana","family":"Allodi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,9]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109977","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,9]]}}}