{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:55:01Z","timestamp":1771260901203,"version":"3.50.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T00:00:00Z","timestamp":1412812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0109984","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T18:20:13Z","timestamp":1412878813000},"page":"e109984","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fetal Exposure to Environmental Neurotoxins in Taiwan"],"prefix":"10.1371","volume":"9","author":[{"given":"Chuen-Bin","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsing-Cheng","family":"Hsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Chu","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,9]]},"reference":[{"key":"ref1","unstructured":"U.S. Environmental Protection Agency (2013) EPA views childhood as a sequence of lifestages, rather than considering children as a subpopulation. Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/yosemite.epa.gov\/ochp\/ochpweb.nsf\/content\/lifestage.htm\" xlink:type=\"simple\">http:\/\/yosemite.epa.gov\/ochp\/ochpweb.nsf\/content\/lifestage.htm<\/ext-link>."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1542\/peds.2011-0523","article-title":"Chemical-management policy: prioritizing children\u2019s health","volume":"127","year":"2011","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/bdra.20119","article-title":"The fetal basis of adult disease: Role of environmental exposures - Introduction","volume":"73","author":"JJ Heindel","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/toxsci\/kfh294","article-title":"Pharmacokinetics of dibutylphthalate in pregnant rats","volume":"82","author":"TR Fennell","year":"2004","journal-title":"Toxicol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/toxsci\/43.1.47","article-title":"Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?","volume":"43","author":"E Mylchreest","year":"1998","journal-title":"Toxicol Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1542\/peds.2004-0667","article-title":"Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: Prevalence and antecedents","volume":"115","author":"AR Laptook","year":"2005","journal-title":"Pediatrics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ntt.2011.05.010","article-title":"Prenatal exposure to multiple toxic heavy metals and neonatal neurobehavioral development in Shanghai, China","volume":"33","author":"XD Yu","year":"2011","journal-title":"Neurotoxicol Teratol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.envint.2007.03.004","article-title":"Inorganic arsenic exposure and its relation to metabolic syndrome in an industrial area of Taiwan","volume":"33","author":"SL Wang","year":"2007","journal-title":"Environ Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1289\/ehp.6964","article-title":"Water arsenic exposure and children\u2019s intellectual function in Araihazar, Bangladesh","volume":"112","author":"GA Wasserman","year":"2004","journal-title":"Environ Health Perspect"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0165-0173(98)00011-3","article-title":"Low-level lead-induced neurotoxicity in children: An update on central nervous system effects","volume":"27","author":"Y Finkelstein","year":"1998","journal-title":"Brain Res Brain Res Rev"},{"key":"ref11","unstructured":"Pueschel SM, James GL, Angela CA (1996) Lead Poisoning in Childhood, Paul H. Brookes Publishing."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1542\/peds.2008-0377","article-title":"Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: Added role of neonatal infection","volume":"123","author":"D Bassler","year":"2009","journal-title":"Pediatrics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1076\/chin.9.1.10.14498","article-title":"Cognitive development of lead exposed children from ages 6 to 15 years: An application of growth curve analysis","volume":"9","author":"JM Coscia","year":"2003","journal-title":"Child Neuropsychol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1542\/peds.91.5.969","article-title":"Birth weight and illness severity: Independent predictors of neonatal mortality","volume":"91","author":"DK Richardson","year":"1993","journal-title":"Pediatrics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0892-0362(97)00097-4","article-title":"Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury","volume":"19","author":"P Grandjean","year":"1997","journal-title":"Neurotoxicol Teratol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/S0140-6736(03)13371-5","article-title":"Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study","volume":"361","author":"GJ Myers","year":"2003","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/jama.280.8.701","article-title":"Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: Outcomes at 66 months of age in the Seychelles child development study","volume":"280","author":"PW Davidson","year":"1998","journal-title":"JAMA"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1023\/B:RIAN.0000005917.52151.e6","article-title":"Influence of prenatal mercury exposure upon scholastic and psychological test performance: Benchmark analysis of a New Zealand cohort","volume":"18","author":"KS Crump","year":"1998","journal-title":"Risk Anal"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1289\/ehp.7743","article-title":"Public health and economic consequences of methyl mercury toxicity to the developing brain","volume":"113(5)","author":"L Trasande","year":"2005","journal-title":"Environ Health Perspect"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.reprotox.2007.03.003","article-title":"Concentrations of xenobiotic chemicals in the maternal-fetal unit","volume":"23","author":"DB Barr","year":"2007","journal-title":"Reprod Toxicol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0161-813X(02)00077-3","article-title":"Prevalence of fetal exposure to environmental toxins as determined by meconium analysis","volume":"23","author":"EM Ostrea Jr","year":"2002","journal-title":"Neurotoxicology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1203\/00006450-199804001-01332","article-title":"Exposure to Environmental Pollutants Adversely Affects Fetal Outcome","volume":"43","author":"EM Ostrea Jr","year":"1998","journal-title":"Pediatr Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0022-3476(05)83509-7","article-title":"Adaptation of the meconium drug test for mass screening","volume":"122(1)","author":"EM Ostrea Jr","year":"1993","journal-title":"J Pediatr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1542\/peds.89.1.107","article-title":"Drug screening of newborns by meconium analysis: A large-scale, prospective, epidemiologic study","volume":"89","author":"EM Ostrea Jr","year":"1992","journal-title":"Pediatrics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0022-3476(05)80245-8","article-title":"Measurement of gestational cocaine exposure: Sensitivity of infants\u2019 hair, meconium, and urine","volume":"120","author":"CM Callahan","year":"1992","journal-title":"J Pediatr"},{"key":"ref26","first-page":"650","article-title":"Meconium for drug testing Am J Dis Child","volume":"145","author":"EC Maynard","year":"1991"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1016\/j.scitotenv.2009.07.025","article-title":"Changing blood lead levels and DNA damage (comet assay) among immigrant women in Taiwan","volume":"407","author":"WT Wu","year":"2009","journal-title":"Sci Total Environ"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.scitotenv.2009.10.043","article-title":"Mercury concentration in meconium and risk assessment of fish consumption among pregnant women in Taiwan","volume":"408","author":"CB Jiang","year":"2010","journal-title":"Sci Total Environ"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1515\/JPM.2007.131","article-title":"Elevated blood lead levels in pregnant women: identification of a high-risk population and interventions","volume":"35","author":"S Rastogi","year":"2007","journal-title":"J Perinat Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1016\/j.scitotenv.2010.07.079","article-title":"Perinatal lead and mercury exposure in Austria","volume":"408","author":"C Gundacker","year":"2010","journal-title":"Sci Total Environ"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000089953","article-title":"Concentrations of toxic metals and trace elements in the meconium of newborns from an industrial city","volume":"89","author":"G Turker","year":"2006","journal-title":"Biol Neonate"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00006254-200104000-00024","article-title":"Lead exposure in pregnancy: A review of the literature and argument for routine prenatal screening","volume":"56","author":"C Gardella","year":"2001","journal-title":"Obstet Gynecol Surv"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/1097-0274(200009)38:3<300::AID-AJIM9>3.0.CO;2-C","article-title":"The evidence that lead increases the risk for spontaneous abortion","volume":"38","author":"I Hertz-Picciotto","year":"2000","journal-title":"Am J Ind Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/oxfordjournals.aje.a010057","article-title":"Blood lead levels measured prospectively and risk of spontaneous abortion","volume":"150","author":"VH Borja-Aburto","year":"1999","journal-title":"Am J Epidemiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.chemosphere.2005.11.059","article-title":"Analysis of the health risk of exposure to breast milk mercury in infants in Taiwan","volume":"64","author":"LC Chien","year":"2006","journal-title":"Chemosphere"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e1285","DOI":"10.1542\/peds.2005-1770","article-title":"Interpreting and managing blood lead levels of less than 10 microg\/dL in children and reducing childhood exposure to lead: recommendations of the Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention","volume":"120","author":"HJ Binns","year":"2007","journal-title":"Pediatrics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1471-0528.2006.01142.x","article-title":"Mercury concentration and fish consumption in Taiwanese pregnant women","volume":"114","author":"CS Hsu","year":"2007","journal-title":"BJOG: Int J Obstet Gynaecol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1289\/ehp.11674","article-title":"Adult women\u2019s blood mercury concentrations vary regionally in the United States: Association with patterns of fish consumption (NHANES 1999\u20132004)","volume":"117","author":"KR Mahaffey","year":"2009","journal-title":"Environ Health Perspect"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/oem.2010.059758","article-title":"Does prenatal cadmium exposure affect fetal and child growth?","volume":"68","author":"CM Lin","year":"2011","journal-title":"Occup Environ Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12011-009-8391-0","article-title":"Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years","volume":"132","author":"LL Tian","year":"2009","journal-title":"Biol Trace Elem Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/aje\/kwj089","article-title":"Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India","volume":"163","author":"OS Von Ehrenstein","year":"2006","journal-title":"Am J Epidemiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/aje\/kwn332","article-title":"Arsenic exposure during pregnancy and size at birth: A prospective cohort study in Bangladesh","volume":"169","author":"A Rahman","year":"2009","journal-title":"Am J Epidemiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-nutr-080508-141102","article-title":"Effects of arsenic on maternal and fetal health","volume":"29","author":"M Vahter","year":"2009","journal-title":"Annu Rev Nutr"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.reprotox.2008.11.057","article-title":"Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities","volume":"27","author":"MN Llanos","year":"2009","journal-title":"Reprod Toxicol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1289\/ehp.9357","article-title":"Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals","volume":"115","author":"A Kortenkamp","year":"2007","journal-title":"Environ Health Perspect"},{"key":"ref46","unstructured":"National Research Council (2008) Phthalates and Cumulative Risk Assessment: The Task Ahead. Washington, DC: National Academies Press."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0109984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T18:24:00Z","timestamp":1650392640000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0109984"}},"subtitle":[],"editor":[{"given":"Qinghua","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,9]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0109984","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,9]]}}}