{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:35:36Z","timestamp":1781850936969,"version":"3.54.5"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110044","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T17:52:46Z","timestamp":1414000366000},"page":"e110044","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Genetic Association Study of TNFAIP3, IFIH1, IRF5 Polymorphisms with Polymyositis\/Dermatomyositis in Chinese Han Population"],"prefix":"10.1371","volume":"9","author":[{"given":"Si","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuiwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ncl.2014.04.007","article-title":"Idiopathic Inflammatory Myopathies","volume":"32","author":"MM Dimachkie","year":"2014","journal-title":"Neurol Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/1529-0131(199803)41:3<400::AID-ART4>3.0.CO;2-5","article-title":"Familial autoimmunity in pedigrees of idiopathic inflammatory myopathy patients suggests common genetic risk factors for many autoimmune diseases","volume":"41","author":"LR Ginn","year":"1998","journal-title":"Arthritis Rheum"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1542\/peds.2010-3022","article-title":"Familial aggregation of autoimmune disease in juvenile dermatomyositis","volume":"127","author":"TB Niewold","year":"2011","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar3327","article-title":"Recent advances in the immunogenetics of idiopathic inflammatory myopathy","volume":"13","author":"H Chinoy","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/art.20208","article-title":"Association of the proinflammatory haplotype (MICA5.1\/TNF2\/TNFa2\/DRB1*03) with polymyositis and dermatomyositis","volume":"50","author":"AB Hassan","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/1529-0131(200010)43:10<2368::AID-ANR26>3.0.CO;2-8","article-title":"TNFalpha-308A allele in juvenile dermatomyositis: association with increased production of tumor necrosis factor alpha, disease duration, and pathologic calcifications","volume":"43","author":"LM Pachman","year":"2000","journal-title":"Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1002\/art.24039","article-title":"Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis","volume":"58","author":"G Mamyrova","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/rheumatology\/kem145","article-title":"Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies","volume":"46","author":"H Chinoy","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/ard.2006.068858","article-title":"Interferon-gamma and interleukin-4 gene polymorphisms in Caucasian idiopathic inflammatory myopathy patients in UK","volume":"66","author":"H Chinoy","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3109\/s10165-010-0311-9","article-title":"Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis\/polymyositis","volume":"20","author":"T Gono","year":"2010","journal-title":"Mod Rheumatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1046\/j.1523-1747.2002.19608.x","article-title":"Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis","volume":"119","author":"VP Werth","year":"2002","journal-title":"J Invest Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1002\/art.23900","article-title":"The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients","volume":"58","author":"H Chinoy","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1136\/annrheumdis-2011-200839","article-title":"Positive association between STAT4 polymorphisms and polymyositis\/dermatomyositis in a Japanese population","volume":"71","author":"T Sugiura","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1002\/art.38137","article-title":"Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders","volume":"65","author":"FW Miller","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/ng.202","article-title":"Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus","volume":"40","author":"SL Musone","year":"2008","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/gene.2010.64","article-title":"Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases","volume":"12","author":"SL Musone","year":"2011","journal-title":"Genes Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1002\/art.34490","article-title":"Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity","volume":"64","author":"E Koumakis","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/rheumatology\/ker379","article-title":"Genetic association study of NF-kappaB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy","volume":"51","author":"H Chinoy","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/ng1800","article-title":"A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region","volume":"38","author":"DJ Smyth","year":"2006","journal-title":"Nat Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus","volume":"41","author":"V Gateva","year":"2009","journal-title":"Nat Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1210\/jc.2007-0173","article-title":"Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves&apos; disease susceptibility","volume":"92","author":"A Sutherland","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3109\/08916934.2013.796937","article-title":"Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis","volume":"46","author":"H Cen","year":"2013","journal-title":"Autoimmunity"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"23382","DOI":"10.1074\/jbc.M101216200","article-title":"Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes","volume":"276","author":"BJ Barnes","year":"2001","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1189\/jlb.0603255","article-title":"Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells","volume":"74","author":"A Izaguirre","year":"2003","journal-title":"J Leukoc Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1073\/pnas.0701266104","article-title":"Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus","volume":"104","author":"RR Graham","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1136\/annrheumdis-2011-200901","article-title":"IRF5 polymorphism predicts prognosis in patients with systemic sclerosis","volume":"71","author":"R Sharif","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1093\/hmg\/ddm259","article-title":"An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases","volume":"16","author":"V Dideberg","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref28","first-page":"R191","article-title":"cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies","volume":"10","author":"X Zhou","year":"2004","journal-title":"Med Sci Monit"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1196\/annals.1398.050","article-title":"Chemokine profile of different inflammatory myopathies reflects humoral versus cytotoxic immune responses","volume":"1109","author":"B De Paepe","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/art.22558","article-title":"Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis","volume":"56","author":"DPC Lopez","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymyositis and dermatomyositis (first of two parts)","volume":"292","author":"A Bohan","year":"1975","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM197502202920807","article-title":"Polymyositis and dermatomyositis (second of two parts)","volume":"292","author":"A Bohan","year":"1975","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"MC Hochberg","year":"1997","journal-title":"Arthritis Rheum"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/art.1780230510","article-title":"Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee","volume":"23","journal-title":"Arthritis Rheum"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren&apos;s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"C Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9343(72)90064-2","article-title":"Mixed connective tissue disease\u2013an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)","volume":"52","author":"GC Sharp","year":"1972","journal-title":"Am J Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1067\/mjd.2002.120621","article-title":"Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis sine myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness?","volume":"46","author":"RD Sontheimer","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ng1706","article-title":"Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies","volume":"38","author":"AD Skol","year":"2006","journal-title":"Nat Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"S Purcell","year":"2003","journal-title":"Bioinformatics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/ni1110","article-title":"The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses","volume":"5","author":"DL Boone","year":"2004","journal-title":"Nat Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.it.2009.05.007","article-title":"The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology","volume":"30","author":"L Vereecke","year":"2009","journal-title":"Trends Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","article-title":"Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice","volume":"289","author":"EG Lee","year":"2000","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/ng.874","article-title":"A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis","volume":"43","author":"M Matmati","year":"2011","journal-title":"Nat Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1182\/blood-2010-09-306019","article-title":"B cells lacking the tumor suppressor TNFAIP3\/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice","volume":"117","author":"Y Chu","year":"2011","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-4362.1987.tb00580.x","article-title":"Scleroderma-polymyositis overlap syndrome. Clinical and serologic aspects","volume":"26","author":"T Mimori","year":"1987","journal-title":"Int J Dermatol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1191\/0961203302lu186oa","article-title":"SLE\/myositis overlap: are the manifestations of SLE different in overlap disease?","volume":"11","author":"NA Dayal","year":"2002","journal-title":"Lupus"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.coi.2008.01.002","article-title":"MDA5\/RIG-I and virus recognition","volume":"20","author":"O Takeuchi","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.4049\/jimmunol.175.5.2851","article-title":"Shared and unique functions of the DExD\/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity","volume":"175","author":"M Yoneyama","year":"2005","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1002\/art.22928","article-title":"Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis","volume":"56","author":"RJ Walsh","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1086\/428480","article-title":"Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus","volume":"76","author":"S Sigurdsson","year":"2005","journal-title":"Am J Hum Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:34:13Z","timestamp":1588995253000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110044"}},"subtitle":[],"editor":[{"given":"Xin-Yuan","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110044","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}