{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:21:59Z","timestamp":1778286119845,"version":"3.51.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110066","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T18:06:23Z","timestamp":1413223583000},"page":"e110066","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Poor Survival in Rheumatoid Arthritis Associated with Bronchiectasis: A Family-Based Cohort Study"],"prefix":"10.1371","volume":"9","author":[{"given":"Xavier","family":"Pu\u00e9chal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"G\u00e9nin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Bienvenu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Le Jeunne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Dusser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"GS Firestein","year":"2003","journal-title":"Nature"},{"key":"ref2","first-page":"62","article-title":"Occurrence of extraarticular disease manifestations is associated with excess mortality in a community based cohort of patients with rheumatoid arthritis","volume":"29","author":"C Turesson","year":"2002","journal-title":"J Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"59","author":"JA Avi\u00f1a-Zubieta","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/rheumatology\/30.3.214","article-title":"High definition computed tomography in rheumatoid arthritis associated pulmonary disease","volume":"30","author":"HE Fewins","year":"1991","journal-title":"Br J Rheumatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/rheumatology\/33.2.118","article-title":"High resolution computed tomography of the lungs in patients with rheumatoid arthritis and interstitial lung disease","volume":"33","author":"J McDonagh","year":"1994","journal-title":"Br J Rheumatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/ard.54.4.308","article-title":"High resolution computed tomography of the lung in lifelong non-smoking patients with rheumatoid arthritis","volume":"54","author":"WU Hassan","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1183\/09031936.97.10051072","article-title":"Airway obstruction and rheumatoid arthritis","volume":"10","author":"A Vergnen\u00e8gre","year":"1997","journal-title":"Eur Respir J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1164\/ajrccm.157.5.9710018","article-title":"Airways involvement in rheumatoid arthritis: clinical, functional, and HRCT findings","volume":"157","author":"T Perez","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jbspin.2004.02.001","article-title":"Correlations between high-resolution computed tomography of the chest and clinical function in patients with rheumatoid arthritis: prospective study in 75 patients","volume":"72","author":"SH Zrour","year":"2005","journal-title":"Joint Bone Spine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/rheumatology\/31.10.691","article-title":"Bronchiectasis and rheumatoid disease: is there an association?","volume":"31","author":"T Solanki","year":"1992","journal-title":"Br J Rheumatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1164\/ajrccm.162.4.9906120","article-title":"An investigation into causative factors in patients with bronchiectasis","volume":"162","author":"MC Pasteur","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0007-0971(78)90007-4","article-title":"Pulmonary infection and rheumatoid arthritis","volume":"72","author":"JP Mathieu","year":"1978","journal-title":"Br J Dis Chest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/ard.52.11.776","article-title":"Bronchiectasis and rheumatoid arthritis: a clinical study","volume":"52","author":"MJ McMahon","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/rheumatology\/36.6.689","article-title":"Decreased survival in patients with co-existent rheumatoid arthritis and bronchiectasis","volume":"36","author":"DR Swinson","year":"1997","journal-title":"Br J Rheumatol"},{"key":"ref15","first-page":"447","article-title":"Bronchiectasis in rheumatoid arthritis","volume":"65","author":"X Pu\u00e9chal","year":"1998","journal-title":"Rev Rhum Engl Ed"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1183\/09031936.99.13612889","article-title":"Increased frequency of cystic fibrosis deltaF508 mutation in bronchiectasis associated with rheumatoid arthritis","volume":"13","author":"X Pu\u00e9chal","year":"1999","journal-title":"Eur Respir J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00005792-199405000-00005","article-title":"Bronchiectasis. A late feature of severe rheumatoid arthritis","volume":"73","author":"NA Shadick","year":"1994","journal-title":"Medicine (Baltimore)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/art.34344","article-title":"Airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity?","volume":"64","author":"MK Demoruelle","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/art.38201","article-title":"Structural changes and antibody enrichment in the lungs are early features of anti-citrullinated protein antibody-positive rheumatoid arthritis","volume":"66","author":"G Reynisdottir","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMe020070","article-title":"What is cystic fibrosis?","volume":"347","author":"MR Knowles","year":"2002","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0140-6736(03)13368-5","article-title":"Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study","volume":"361","author":"EF McKone","year":"2003","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/S1569-1993(11)60014-3","article-title":"Recommendations for the classification of diseases as CFTR-related disorders","volume":"10","author":"C Bombieri","year":"2011","journal-title":"J Cyst Fibros"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/ard.2010.142760","article-title":"Mutations of the cystic fibrosis gene in patients with bronchiectasis associated with rheumatoid arthritis","volume":"70","author":"X Pu\u00e9chal","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref24","unstructured":"Therneau T (2013) A package for survival analysis in S. R package version 2.37\u20134. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/CRAN.R-project.org\/package=survival\" xlink:type=\"simple\">http:\/\/CRAN.R-project.org\/package=survival<\/ext-link>. Accessed 2014 Sep 19."},{"key":"ref25","unstructured":"Therneau T (2012) Coxme: Mixed Effects Cox Models. R package version 2.2\u20133. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/CRAN.R-project.org\/package=coxme\" xlink:type=\"simple\">http:\/\/CRAN.R-project.org\/package=coxme<\/ext-link>. Accessed 2014 Sep 19."},{"key":"ref26","unstructured":"R Core Team (2012) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.R-project.org\/\" xlink:type=\"simple\">http:\/\/www.R-project.org\/<\/ext-link>. Accessed 2014 Sep 19."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/ard.2006.062497","article-title":"Treatment with TNF blockers and mortality risk in patients with rheumatoid arthritis","volume":"66","author":"LT Jacobsson","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1183\/09031936.97.10050994","article-title":"Effect of roxithromycin on airway responsiveness in children with bronchiectasis: a double-blind, placebo-controlled study","volume":"10","author":"YY Koh","year":"1997","journal-title":"Eur Respir J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1183\/09031936.99.13236199","article-title":"A pilot study of low-dose erythromycin in bronchiectasis","volume":"13","author":"KW Tsang","year":"1999","journal-title":"Eur Respir J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(12)60953-2","article-title":"Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial","volume":"380","author":"C Wong","year":"2012","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.2013.1937","article-title":"Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial","volume":"309","author":"J Altenburg","year":"2013","journal-title":"JAMA"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1001\/jama.2013.2290","article-title":"Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial","volume":"309","author":"DJ Serisier","year":"2013","journal-title":"JAMA"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.2013.2780","article-title":"Macrolides and bronchiectasis: clinical benefit with a resistance price","volume":"309","author":"JS Elborn","year":"2013","journal-title":"JAMA"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3810\/pgm.2011.09.2478","article-title":"Treatment of rheumatoid arthritis with roxithromycin: a randomized trial","volume":"123","author":"M Ogrendik","year":"2011","journal-title":"Postgrad Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1185\/030079906X167642","article-title":"Effects of clarithromycin in patients with active rheumatoid arthritis","volume":"23","author":"M Ogrendik","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0140-6736(12)61261-6","article-title":"Azithromycin in bronchiectasis: when should it be used?","volume":"380","author":"R Wilson","year":"2012","journal-title":"Lancet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0161-6420(84)34160-4","article-title":"Mortality rate in rheumatoid arthritis patients developing necrotizing scleritis or peripheral ulcerative keratitis. Effects of systemic immunosuppression","volume":"91","author":"CS Foster","year":"1984","journal-title":"Ophthalmology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/ard.48.1.7","article-title":"Factors predicting a poor life prognosis in rheumatoid arthritis: an eight year prospective study","volume":"48","author":"CC Erhardt","year":"1989","journal-title":"Ann Rheum Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/rheumatology\/38.7.668","article-title":"Extra-articular rheumatoid arthritis: prevalence and mortality","volume":"38","author":"C Turesson","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/art.10705","article-title":"Survival in rheumatoid arthritis: a population-based analysis of trends over 40 years","volume":"48","author":"SE Gabriel","year":"2003","journal-title":"Arthritis Rheum"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/ard.2006.052506","article-title":"Severe extra-articular disease manifestations are associated with an increased risk of first ever cardiovascular events in patients with rheumatoid arthritis","volume":"66","author":"C Turesson","year":"2007","journal-title":"Ann Rheum Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:40:48Z","timestamp":1589042448000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110066"}},"subtitle":[],"editor":[{"given":"Dominique","family":"Heymann","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,13]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110066","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,13]]}}}