{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:17:18Z","timestamp":1781723838704,"version":"3.54.5"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110089","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T18:14:04Z","timestamp":1412964844000},"page":"e110089","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["3-O-Galloylated Procyanidins from Rumex acetosa L. Inhibit the Attachment of Influenza A Virus"],"prefix":"10.1371","volume":"9","author":[{"given":"Andrea","family":"Derksen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hensel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wali","family":"Hafezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ehrhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1056\/NEJMra1002842","article-title":"Influenza vaccines for the future","volume":"363","author":"LC Lambert","year":"2010","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3201\/eid1209.05-0979","article-title":"1918 Influenza: the mother of all pandemics","volume":"12","author":"JK Taubenberger","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref3","first-page":"187","article-title":"Influenza treatment and prophylaxis with neuraminidase inhibitors: a review","volume":"6","author":"A Kamali","year":"2013","journal-title":"Infect Drug Resist"},{"key":"ref4","first-page":"1","article-title":"Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"60","author":"AE Fiore","year":"2011","journal-title":"MMWR Recomm Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2334-11-134","article-title":"Systematic review of influenza resistance to the neuraminidase inhibitors","volume":"11","author":"K Thorlund","year":"2011","journal-title":"BMC Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/18715265112129990006","article-title":"Emergence of oseltamivir resistance: control and management of influenza before, during and after the pandemic","volume":"13","author":"R Dixit","year":"2013","journal-title":"Infect Disord Drug Targets"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bcp.2012.12.011","article-title":"Antivirals: past, present and future","volume":"85","author":"E De Clercq","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/med.21281","article-title":"A Cutting-Edge View on the Current State of Antiviral Drug Development","volume":"33","author":"E De Clercq","year":"2013","journal-title":"Med Res Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.antiviral.2013.03.021","article-title":"Broadly neutralizing antibodies against influenza viruses","volume":"98","author":"NS Laursen","year":"2013","journal-title":"Antiviral Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ptr.1892","article-title":"Anti-influenza agents from plants and traditional Chinese medicine","volume":"20","author":"X Wang","year":"2006","journal-title":"Phytother Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1039\/c0np00005a","article-title":"Anti-influenza agents from Traditional Chinese Medicine","volume":"27","author":"H Ge","year":"2010","journal-title":"Nat Prod Rep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1046\/j.1365-2672.2003.02026.x","article-title":"Novel antiviral agents: a medicinal plant perspective","volume":"95","author":"SA Jassim","year":"2003","journal-title":"J Appl Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.copbio.2011.08.007","article-title":"Polyphenols as antimicrobial agents","volume":"23","author":"M Daglia","year":"2012","journal-title":"Curr Opin Biotechnol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1586\/14787210.5.3.497","article-title":"Tea catechins as a potential alternative anti-infectious agent","volume":"5","author":"JM Song","year":"2007","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/bph.12009","article-title":"Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea","volume":"168","author":"J Steinmann","year":"2013","journal-title":"Br J Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fitote.2013.12.011","article-title":"Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure-activity relationship analysis","volume":"93","author":"ZF Yang","year":"2014","journal-title":"Fitoterapia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0166-3542(93)90008-7","article-title":"Inhibition of the infectivity of influenza virus by tea polyphenols","volume":"21","author":"M Nakayama","year":"1993","journal-title":"Antiviral Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1348-0421.2002.tb02724.x","article-title":"Additional inhibitory effect of tea extract on the growth of influenza A and B viruses in MDCK cells","volume":"46","author":"N Imanishi","year":"2002","journal-title":"Microbiol Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.antiviral.2005.06.010","article-title":"Antiviral effect of catechins in green tea on influenza virus","volume":"68","author":"JM Song","year":"2005","journal-title":"Antiviral Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0944-7113(11)80026-7","article-title":"SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago)","volume":"1","author":"R Ubillas","year":"1994","journal-title":"Phytomedicine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.antiviral.2010.10.007","article-title":"Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1","volume":"89","author":"K Gescher","year":"2011","journal-title":"Antiviral Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jep.2010.12.038","article-title":"Proanthocyanidin-enriched extract from Myrothamnus flabellifolia Welw. exerts antiviral activity against herpes simplex virus type 1 by inhibition of viral adsorption and penetration","volume":"134","author":"K Gescher","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2011.10.010","article-title":"Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(R) against viruses causing respiratory infections","volume":"19","author":"B Glatthaar-Saalmuller","year":"2011","journal-title":"Phytomedicine"},{"key":"ref24","first-page":"483","article-title":"Proanthocyanidins and a phloroglucinol derivative from Rumex acetosa L. Fitoterapia","volume":"80","author":"J Bicker","year":"2009"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/j.ejim.2011.08.014","article-title":"Acute Respiratory Distress Syndrome as a presenting manifestation in young patients infected with H1N1 influenza virus","volume":"22","author":"D Pabst","year":"2011","journal-title":"Eur J Intern Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1462-5822.2010.01436.x","article-title":"CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses","volume":"12","author":"ER Hrincius","year":"2010","journal-title":"Cell Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"T Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.antiviral.2013.07.018","article-title":"New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions","volume":"100","author":"G Beyleveld","year":"2013","journal-title":"Antiviral Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0166-0934(88)90134-6","article-title":"Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds","volume":"20","author":"R Pauwels","year":"1988","journal-title":"J Virol Methods"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1126\/science.1186430","article-title":"Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus","volume":"328","author":"R Xu","year":"2010","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Pariani E, Amendola A, Ranghiero A, Anselmi G, Zanetti A (2013) Surveillance of influenza viruses in the post-pandemic era (2010-2012) in Northern Italy. Hum Vaccin Immunother 9.","DOI":"10.4161\/hv.23262"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Khandaker I, Suzuki A, Kamigaki T, Tohma K, Odagiri T, et al.. (2013) Molecular evolution of the hemagglutinin and neuraminidase genes of pandemic (H1N1) 2009 influenza viruses in Sendai, Japan, during 2009\u20132011. Virus Genes.","DOI":"10.1007\/s11262-013-0980-5"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays","volume":"4","author":"JH Zhang","year":"1999","journal-title":"J Biomol Screen"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.antiviral.2012.03.006","article-title":"EPs(R) 7630 (Umckaloabo(R)), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo","volume":"94","author":"LL Theisen","year":"2012","journal-title":"Antiviral Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1021\/np980481o","article-title":"Biological evaluation of proanthocyanidin dimers and related polyphenols","volume":"62","author":"T De Bruyne","year":"1999","journal-title":"J Nat Prod"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.fitote.2012.06.013","article-title":"In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells","volume":"83","author":"S Zumdick","year":"2012","journal-title":"Fitoterapia"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.fitote.2012.12.020","article-title":"Wound-healing plants from TCM: in vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes","volume":"84","author":"R Wang","year":"2013","journal-title":"Fitoterapia"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.phymed.2010.08.020","article-title":"Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: Geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts","volume":"18","author":"C Agyare","year":"2011","journal-title":"Phytomedicine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2013.08.090","article-title":"Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses","volume":"440","author":"S Park","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00705-011-0989-9","article-title":"Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus","volume":"156","author":"G Liu","year":"2011","journal-title":"Arch Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e88062","DOI":"10.1371\/journal.pone.0088062","article-title":"Tannins from Hamamelis virginiana Bark Extract: Characterization and Improvement of the Antiviral Efficacy against Influenza A Virus and Human Papillomavirus","volume":"9","author":"LL Theisen","year":"2014","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.antiviral.2007.05.002","article-title":"A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance","volume":"76","author":"C Ehrhardt","year":"2007","journal-title":"Antiviral Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2007.04.001","article-title":"CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice","volume":"76","author":"K Droebner","year":"2007","journal-title":"Antiviral Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.phymed.2009.06.002","article-title":"Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir","volume":"16","author":"M Haidari","year":"2009","journal-title":"Phytomedicine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1021\/np960040+","article-title":"Natural polyphenols (vegetable tannins) as drugs: possible modes of action","volume":"59","author":"E Haslam","year":"1996","journal-title":"J Nat Prod"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"9609","DOI":"10.1021\/bi00155a013","article-title":"Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography","volume":"31","author":"NK Sauter","year":"1992","journal-title":"Biochemistry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jaci.2006.08.016","article-title":"Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy","volume":"118","author":"MP Williamson","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nsmb.2500","article-title":"A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin","volume":"20","author":"R Xu","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nature11414","article-title":"Cross-neutralization of influenza A viruses mediated by a single antibody loop","volume":"489","author":"DC Ekiert","year":"2012","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e63657","DOI":"10.1371\/journal.pone.0063657","article-title":"A plant extract of Ribes nigrum folium possesses anti-influenza virus activity in vitro and in vivo by preventing virus entry to host cells","volume":"8","author":"C Ehrhardt","year":"2013","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0031-9422(94)85094-1","article-title":"Flavan-3-ols, prodelphinidins and further polyphenols from Cistus salvifolius","volume":"37","author":"A Danne","year":"1994","journal-title":"Phytochemistry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T18:09:10Z","timestamp":1598378950000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110089"}},"subtitle":[],"editor":[{"given":"Cheryl A.","family":"Stoddart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,10]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110089","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,10]]}}}