{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:52:51Z","timestamp":1778500371672,"version":"3.51.4"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T00:00:00Z","timestamp":1413504000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110294","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T21:46:36Z","timestamp":1413841596000},"page":"e110294","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Generation and Characterisation of Mice Deficient in the Multi-GTPase Domain Containing Protein, GIMAP8"],"prefix":"10.1371","volume":"9","author":[{"given":"Louise M. C.","family":"Webb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Pascall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Hepburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey W.","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.it.2006.12.002","article-title":"The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN\/GIMAP family proteins","volume":"28","author":"T Nitta","year":"2007","journal-title":"Trends Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1105\/tpc.8.2.241","article-title":"Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes","volume":"8","author":"TL Reuber","year":"1996","journal-title":"Plant Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2164-11-63","article-title":"Differences in the transcriptome signatures of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties","volume":"11","author":"L Biller","year":"2010","journal-title":"BMC Genomics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fcimb.2012.00089","article-title":"Gene flow and biological conflict systems in the origin and evolution of eukaryotes","volume":"2","author":"L Aravind","year":"2012","journal-title":"Front Cell Infect Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4161\/sgtp.2.1.14938","article-title":"GTP-dependent scaffold formation in the GTPase of Immunity Associated Protein family","volume":"2","author":"D Schwefel","year":"2011","journal-title":"Small GTPases"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gene.2004.07.005","article-title":"Comparative analysis of the human gimap gene cluster encoding a novel GTPase family","volume":"341","author":"J Krucken","year":"2004","journal-title":"Gene"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/jmg.2006.046185","article-title":"The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus","volume":"44","author":"A Hellquist","year":"2007","journal-title":"J Med Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0961203309106830","article-title":"IAN5 polymorphisms are associated with systemic lupus erythematosus","volume":"18","author":"MK Lim","year":"2009","journal-title":"Lupus"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/annrheumdis-2011-200288","article-title":"Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet&apos;s disease","volume":"72","author":"YJ Lee","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/sj.gene.6364413","article-title":"IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5","volume":"8","author":"JH Shin","year":"2007","journal-title":"Genes Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2337\/diab.30.10.887","article-title":"The BB diabetic rat. Profound T-cell lymphocytopenia","volume":"30","author":"R Jackson","year":"1981","journal-title":"Diabetes"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.4049\/jimmunol.130.4.1723","article-title":"Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat","volume":"130","author":"ME Elder","year":"1983","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.2337\/diabetes.51.6.1972","article-title":"The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1","volume":"51","author":"L Hornum","year":"2002","journal-title":"Diabetes"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1101\/gr.412702","article-title":"Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene","volume":"12","author":"AJ MacMurray","year":"2002","journal-title":"Genome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1182\/blood.V99.9.3293","article-title":"Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells","volume":"99","author":"M Cambot","year":"2002","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.4049\/jimmunol.163.9.4960","article-title":"Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker and defines a novel gene family conserved in plants","volume":"163","author":"GM Poirier","year":"1999","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jcb.20552","article-title":"Malaria-suppressible expression of the anti-apoptotic triple GTPase mGIMAP8","volume":"96","author":"J Krucken","year":"2005","journal-title":"J Cell Biochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0378-1119(01)00837-X","article-title":"Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32\u201336","volume":"282","author":"O Stamm","year":"2002","journal-title":"Gene"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1182\/blood-2009-08-237586","article-title":"Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes","volume":"115","author":"A Saunders","year":"2010","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1832::AID-IMMU1832>3.0.CO;2-F","article-title":"The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes","volume":"29","author":"G Hernandez-Hoyos","year":"1999","journal-title":"Eur J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/intimm\/dxm009","article-title":"Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells","volume":"19","author":"U Dalberg","year":"2007","journal-title":"Int Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1182\/blood-2008-03-146555","article-title":"Impaired survival of peripheral T cells, disrupted NK\/NKT cell development, and liver failure in mice lacking Gimap5","volume":"112","author":"RD Schulteis","year":"2008","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.4049\/jimmunol.0903164","article-title":"Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice","volume":"184","author":"MJ Barnes","year":"2010","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1182\/blood-2005-11-4616","article-title":"Gimap4 accelerates T-cell death","volume":"108","author":"S Schnell","year":"2006","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.4049\/jimmunol.179.3.1784","article-title":"A natural hypomorphic variant of the apoptosis regulator Gimap4\/IAN1","volume":"179","author":"C Carter","year":"2007","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4161\/self.1.3.12819","article-title":"The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein","volume":"1","author":"VW Wong","year":"2010","journal-title":"Self Nonself"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1084\/jem.20101192","article-title":"Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells","volume":"208","author":"Y Chen","year":"2011","journal-title":"J Exp Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1371\/journal.pbio.0040103","article-title":"IAN family critically regulates survival and development of T lymphocytes","volume":"4","author":"T Nitta","year":"2006","journal-title":"PLoS Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1091\/mbc.E02-10-0700","article-title":"Irod\/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis","volume":"14","author":"T Sandal","year":"2003","journal-title":"Mol Biol Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10382","DOI":"10.1073\/pnas.1832170100","article-title":"Ian4 is required for mitochondrial integrity and T cell survival","volume":"100","author":"M Pandarpurkar","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/sj.gene.6364044","article-title":"hIan5: the human ortholog to the rat Ian4\/Iddm1\/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies","volume":"5","author":"T Zenz","year":"2004","journal-title":"Genes Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/BJ20120516","article-title":"GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation","volume":"449","author":"XL Chen","year":"2013","journal-title":"Biochem J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e77782","DOI":"10.1371\/journal.pone.0077782","article-title":"The immune system GTPase GIMAP6 interacts with the Atg8 homologue GABARAPL2 and is recruited to autophagosomes","volume":"8","author":"JC Pascall","year":"2013","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e1001161","DOI":"10.1371\/journal.pgen.1001161","article-title":"Gimap3 regulates tissue-specific mitochondrial DNA segregation","volume":"6","author":"R Jokinen","year":"2010","journal-title":"PLoS Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1107\/S174430911001537X","article-title":"Purification, crystallization and preliminary X-ray analysis of human GIMAP2","volume":"66","author":"D Schwefel","year":"2010","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"20299","DOI":"10.1073\/pnas.1010322107","article-title":"Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)","volume":"107","author":"D Schwefel","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.str.2013.01.014","article-title":"Structural insights into the mechanism of GTPase activation in the GIMAP family","volume":"21","author":"D Schwefel","year":"2013","journal-title":"Structure"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/jmbi.2001.5378","article-title":"Classification and evolution of P-loop GTPases and related ATPases","volume":"317","author":"DD Leipe","year":"2002","journal-title":"J Mol Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/intimm\/dxh302","article-title":"Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP\/GDP-binding motifs","volume":"17","author":"C Dion","year":"2005","journal-title":"Int Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nri1633","article-title":"Transcriptional networks in developing and mature B cells","volume":"5","author":"P Matthias","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0969-2126(02)00905-X","article-title":"Domain arrangement of Der, a switch protein containing two GTPase domains","volume":"10","author":"VL Robinson","year":"2002","journal-title":"Structure"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"31415","DOI":"10.1074\/jbc.M104455200","article-title":"An essential GTPase, der, containing double GTP-binding domains from Escherichia coli and Thermotoga maritima","volume":"276","author":"J Hwang","year":"2001","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"12359","DOI":"10.1073\/pnas.0602585103","article-title":"The essential GTPase YphC displays a major domain rearrangement associated with nucleotide binding","volume":"103","author":"SP Muench","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/genetics\/154.2.523","article-title":"A homologue of the recombination-dependent growth gene, rdgC, is involved in gonococcal pilin antigenic variation","volume":"154","author":"IJ Mehr","year":"2000","journal-title":"Genetics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/intimm\/dxp049","article-title":"Foxo3-\/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution","volume":"21","author":"RM Hinman","year":"2009","journal-title":"Int Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1084\/jem.20092210","article-title":"S1P1 receptor directs the release of immature B cells from bone marrow into blood","volume":"207","author":"ML Allende","year":"2010","journal-title":"J Exp Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/ni1571","article-title":"Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches","volume":"9","author":"A Sapoznikov","year":"2008","journal-title":"Nat Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"837","DOI":"10.4049\/jimmunol.179.2.837","article-title":"Transcriptional analysis of clonal deletion in vivo","volume":"179","author":"TA Baldwin","year":"2007","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1101\/gr.749203","article-title":"A highly efficient recombineering-based method for generating conditional knockout mutations","volume":"13","author":"P Liu","year":"2003","journal-title":"Genome Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2007.10.009","article-title":"microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells","volume":"27","author":"E Vigorito","year":"2007","journal-title":"Immunity"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e85436","DOI":"10.1371\/journal.pone.0085436","article-title":"Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort","volume":"9","author":"S Rose","year":"2014","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T11:34:51Z","timestamp":1689593691000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110294"}},"subtitle":[],"editor":[{"given":"J\u00f6rn","family":"Coers","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,17]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110294","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,17]]}}}