{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:59:21Z","timestamp":1776088761499,"version":"3.50.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:00:00Z","timestamp":1414022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110317","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T21:15:31Z","timestamp":1414098931000},"page":"e110317","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Resistance Training Improves Hemodynamic Function, Collagen Deposition and Inflammatory Profiles: Experimental Model of Heart Failure"],"prefix":"10.1371","volume":"9","author":[{"given":"Jadson P.","family":"Alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro B.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe P.","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Dal Lago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1161\/CIRCULATIONAHA.109.192065","article-title":"2009 focused update incorporated into the ACC\/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation","volume":"119","author":"SA Hunt","year":"2009","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-201x.2001.00831.x","article-title":"Skeletal muscle training in chronic heart failure","volume":"171","author":"MF Piepoli","year":"2001","journal-title":"Acta physiologica Scandinavica"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11897-012-0090-z","article-title":"Skeletal muscle abnormalities in chronic heart failure","volume":"9","author":"P Georgiadou","year":"2012","journal-title":"Curr Heart Fail Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1365-201x.2001.00830.x","article-title":"Skeletal muscle disorders in heart failure","volume":"171","author":"PK Lunde","year":"2001","journal-title":"Acta physiologica Scandinavica"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e85820","DOI":"10.1371\/journal.pone.0085820","article-title":"Autophagy signaling in skeletal muscle of infarcted rats","volume":"9","author":"PR Jannig","year":"2014","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1056\/NEJMcp0909392","article-title":"Clinical practice. Systolic heart failure","volume":"362","author":"JJ McMurray","year":"2010","journal-title":"The New England journal of medicine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications","volume":"81","author":"MA Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2613.2009.00647.x","article-title":"Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy","volume":"90","author":"B Gurtl","year":"2009","journal-title":"International journal of experimental pathology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1161\/01.CIR.84.5.2123","article-title":"Role of collagen in acute myocardial infarct expansion","volume":"84","author":"P Whittaker","year":"1991","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.jacc.2008.09.012","article-title":"Fibrosis: a living tissue and the infarcted heart","volume":"52","author":"KT Weber","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ijcard.2011.10.075","article-title":"Intermittent versus continuous exercise training in chronic heart failure: a meta-analysis","volume":"166","author":"NA Smart","year":"2013","journal-title":"Int J Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e62452","DOI":"10.1371\/journal.pone.0062452","article-title":"Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice","volume":"8","author":"AS Vanzelli","year":"2013","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1161\/CIRCULATIONAHA.112.093310","article-title":"Cardiac rehabilitation 2012: advancing the field through emerging science","volume":"125","author":"G Kwan","year":"2012","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1152\/japplphysiol.00062.2008","article-title":"Physical exercise improves plasmatic levels of IL-10, left ventricular end-diastolic pressure, and muscle lipid peroxidation in chronic heart failure rats","volume":"104","author":"RB Nunes","year":"2008","journal-title":"Journal of applied physiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF03086131","article-title":"Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes","volume":"16","author":"C Mihl","year":"2008","journal-title":"Netherlands heart journal: monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1152\/japplphysiol.01240.2001","article-title":"Effect of aerobic and resistance exercise on central hemodynamic responses in severe chronic heart failure","volume":"93","author":"C Cheetham","year":"2002","journal-title":"Journal of applied physiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijcard.2007.07.158","article-title":"The 12-week progressive quadriceps resistance training improves muscle strength, exercise capacity and quality of life in patients with stable chronic heart failure","volume":"130","author":"EA Jankowska","year":"2008","journal-title":"International journal of cardiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijcard.2004.11.022","article-title":"The effect of resistance training on left ventricular function and structure of patients with chronic heart failure","volume":"105","author":"I Levinger","year":"2005","journal-title":"International journal of cardiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/HCR.0b013e3181ac784b","article-title":"Resistance exercise training improves heart function and physical fitness in stable patients with heart failure","volume":"29","author":"G Palevo","year":"2009","journal-title":"Journal of cardiopulmonary rehabilitation and prevention"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1249\/MSS.0b013e31820eeea1","article-title":"Effect of resistance training on physical disability in chronic heart failure","volume":"43","author":"PA Savage","year":"2011","journal-title":"Medicine and science in sports and exercise"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1748-1716.2010.02176.x","article-title":"Neuromuscular electrical stimulation improves GLUT-4 and morphological characteristics of skeletal muscle in rats with heart failure","volume":"201","author":"EB de Leon","year":"2011","journal-title":"Acta physiologica"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","article-title":"Myocardial infarct size and ventricular function in rats","volume":"44","author":"MA Pfeffer","year":"1979","journal-title":"Circulation research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"R1734","DOI":"10.1152\/ajpregu.2001.281.5.R1734","article-title":"Progression of heart failure after myocardial infarction in the rat","volume":"281","author":"J Francis","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1152\/japplphysiol.01054.2003","article-title":"Resistance training enhances components of the insulin signaling cascade in normal and high-fat-fed rodent skeletal muscle","volume":"96","author":"AD Krisan","year":"2004","journal-title":"Journal of applied physiology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1249\/MSS.0b013e318213fefb","article-title":"American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise","volume":"43","author":"CE Garber","year":"2011","journal-title":"Medicine and science in sports and exercise"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Jaenisch RB, Hentschke VS, Quagliotto E, Cavinato PR, Schmeing LA, et al. (2011) Respiratory Muscle Training Improves Hemodynamics, Autonomic Function, Baroreceptors Sensitivity and Respiratory Mechanics in Rats with Heart Failure. Journal of applied physiology.","DOI":"10.1152\/japplphysiol.01245.2010"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/jmcc.1993.1017","article-title":"Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling in the rat","volume":"25","author":"K Lindpaintner","year":"1993","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yjmcc.2007.10.004","article-title":"Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats","volume":"44","author":"X Xu","year":"2008","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00788278","article-title":"Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light","volume":"89","author":"P Whittaker","year":"1994","journal-title":"Basic research in cardiology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"H1534","DOI":"10.1152\/ajpheart.2000.279.4.H1534","article-title":"Alterations in myocardial collagen content affect rat papillary muscle function","volume":"279","author":"LS Matsubara","year":"2000","journal-title":"American journal of physiology Heart and circulatory physiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/RES.0b013e3182582523","article-title":"Animal models of heart failure: a scientific statement from the American Heart Association","volume":"111","author":"SR Houser","year":"2012","journal-title":"Circ Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(96)07015-8","article-title":"Wasting as independent risk factor for mortality in chronic heart failure","volume":"349","author":"SD Anker","year":"1997","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejheart.2003.07.008","article-title":"Muscle strength as a predictor of long-term survival in severe congestive heart failure","volume":"6","author":"M Hulsmann","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/00005768-200104000-00006","article-title":"Skeletal muscle oxidative capacity and exercise tolerance in rats with heart failure","volume":"33","author":"PC Pfeifer","year":"2001","journal-title":"Medicine and science in sports and exercise"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1152\/japplphysiol.00686.2001","article-title":"Skeletal muscle ouabain binding sites are reduced in rats with chronic heart failure","volume":"92","author":"TI Musch","year":"2002","journal-title":"Journal of applied physiology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00421-008-0761-3","article-title":"Cardiovascular adaptive responses in rats submitted to moderate resistance training","volume":"103","author":"R de Cassia Cypriano Ervati Pinter","year":"2008","journal-title":"European journal of applied physiology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3121\/cmr.2007.707","article-title":"Effects of resistance training on ventricular function and hypertrophy in a rat model","volume":"5","author":"VG Barauna","year":"2007","journal-title":"Clinical medicine & research"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0002-9149(99)80277-X","article-title":"Comparison of hemodynamic responses to cycling and resistance exercise in congestive heart failure secondary to ischemic cardiomyopathy","volume":"76","author":"RS McKelvie","year":"1995","journal-title":"The American journal of cardiology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.yjmcc.2009.06.001","article-title":"Extracellular matrix remodeling during the progression of volume overload-induced heart failure","volume":"48","author":"KR Hutchinson","year":"2010","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"H1348","DOI":"10.1152\/ajpheart.00578.2010","article-title":"Low-intensity aerobic interval training attenuates pathological left ventricular remodeling and mitochondrial dysfunction in aortic-banded miniature swine","volume":"299","author":"CA Emter","year":"2010","journal-title":"American journal of physiology Heart and circulatory physiology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/oxfordjournals.eurheartj.a014753","article-title":"Diastolic dysfunction and natriuretic peptides in systolic heart failure. Higher ANP and BNP levels are associated with the restrictive filling pattern","volume":"17","author":"CM Yu","year":"1996","journal-title":"European heart journal"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1249\/MSS.0b013e318244bc8a","article-title":"Exercise training post-MI favorably modifies heart extracellular matrix in the rat","volume":"44","author":"CM Yengo","year":"2012","journal-title":"Medicine and science in sports and exercise"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/hrt.2002.007005","article-title":"Inflammatory mediators in chronic heart failure: an overview","volume":"90","author":"SD Anker","year":"2004","journal-title":"Heart"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0735-1097(03)00848-9","article-title":"Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure","volume":"42","author":"S Gielen","year":"2003","journal-title":"Journal of the American College of Cardiology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0735-1097(01)01795-8","article-title":"Physical training modulates proinflammatory cytokines and the soluble Fas\/soluble Fas ligand system in patients with chronic heart failure","volume":"39","author":"S Adamopoulos","year":"2002","journal-title":"Journal of the American College of Cardiology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cyto.2009.10.007","article-title":"Exercise training changes IL-10\/TNF-alpha ratio in the skeletal muscle of post-MI rats","volume":"49","author":"ML Batista Jr","year":"2010","journal-title":"Cytokine"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2009.06.029","article-title":"TNF-alpha\/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction","volume":"408","author":"B Goswami","year":"2009","journal-title":"Clin Chim Acta"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T15:23:59Z","timestamp":1565969039000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110317"}},"subtitle":[],"editor":[{"given":"Xiongwen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,23]]},"references-count":47,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110317","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,23]]}}}